Motif ID: Prop1

Z-value: 0.768


Transcription factors associated with Prop1:

Gene SymbolEntrez IDGene Name
Prop1 ENSMUSG00000044542.3 Prop1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Prop1mm10_v2_chr11_-_50953745_50953768-0.456.3e-02Click!


Activity profile for motif Prop1.

activity profile for motif Prop1


Sorted Z-values histogram for motif Prop1

Sorted Z-values for motif Prop1



Network of associatons between targets according to the STRING database.



First level regulatory network of Prop1

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr10_-_45470201 3.573 ENSMUST00000079390.6
 Lin28b
lin-28 homolog B (C. elegans)
chr14_-_48667508 3.380 ENSMUST00000144465.1
ENSMUST00000133479.1
ENSMUST00000119070.1
ENSMUST00000152018.1
 Otx2



orthodenticle homolog 2 (Drosophila)



chr18_-_13972617 2.502 ENSMUST00000025288.7
 Zfp521
zinc finger protein 521
chr4_+_3940747 2.058 ENSMUST00000119403.1
 Chchd7
coiled-coil-helix-coiled-coil-helix domain containing 7
chr1_+_107511416 2.033 ENSMUST00000009356.4
 Serpinb2
serine (or cysteine) peptidase inhibitor, clade B, member 2
chr4_-_110292719 1.850 ENSMUST00000106601.1
 Elavl4
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
chr12_+_79297345 1.817 ENSMUST00000079533.5
ENSMUST00000171210.1
 Rad51b

RAD51 homolog B

chr3_+_146121655 1.813 ENSMUST00000039450.4
 Mcoln3
mucolipin 3
chr17_+_27556613 1.678 ENSMUST00000117600.1
ENSMUST00000114888.3
 Hmga1

high mobility group AT-hook 1

chr17_+_27556668 1.670 ENSMUST00000117254.1
ENSMUST00000118570.1
 Hmga1

high mobility group AT-hook 1

chr4_-_41517326 1.597 ENSMUST00000030152.6
ENSMUST00000095126.4
 1110017D15Rik

RIKEN cDNA 1110017D15 gene

chr4_+_109978004 1.501 ENSMUST00000061187.3
 Dmrta2
doublesex and mab-3 related transcription factor like family A2
chr3_+_94377432 1.459 ENSMUST00000107292.1
 Rorc
RAR-related orphan receptor gamma
chr4_+_15881255 1.435 ENSMUST00000029876.1
 Calb1
calbindin 1
chr17_+_27556641 1.421 ENSMUST00000119486.1
ENSMUST00000118599.1
 Hmga1

high mobility group AT-hook 1

chr2_+_61804453 1.409 ENSMUST00000048934.8
 Tbr1
T-box brain gene 1
chr2_+_167777467 1.366 ENSMUST00000139927.1
ENSMUST00000127441.1
 Gm14321

predicted gene 14321

chr2_+_70474923 1.362 ENSMUST00000100043.2
 Sp5
trans-acting transcription factor 5
chrX_+_170010744 1.299 ENSMUST00000178789.1
 Gm21887
predicted gene, 21887
chr5_-_87482258 1.278 ENSMUST00000079811.6
ENSMUST00000144144.1
 Ugt2a1

UDP glucuronosyltransferase 2 family, polypeptide A1


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 104 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.8 GO:0006284 base-excision repair(GO:0006284)
0.4 3.6 GO:0010587 miRNA catabolic process(GO:0010587)
0.8 3.4 GO:0046552 eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate commitment(GO:0046552)
0.3 2.7 GO:0072615 interleukin-17 secretion(GO:0072615)
0.1 2.7 GO:0000028 ribosomal small subunit assembly(GO:0000028)
0.0 1.9 GO:0043488 regulation of mRNA stability(GO:0043488)
0.3 1.8 GO:0000707 meiotic DNA recombinase assembly(GO:0000707)
0.3 1.6 GO:0051387 negative regulation of neurotrophin TRK receptor signaling pathway(GO:0051387)
0.0 1.6 GO:0010466 negative regulation of peptidase activity(GO:0010466)
0.0 1.5 GO:0008608 attachment of spindle microtubules to kinetochore(GO:0008608)
0.0 1.5 GO:0048384 retinoic acid receptor signaling pathway(GO:0048384)
0.3 1.4 GO:0072235 distal convoluted tubule development(GO:0072025) metanephric distal convoluted tubule development(GO:0072221) metanephric distal tubule development(GO:0072235)
0.3 1.4 GO:0001661 conditioned taste aversion(GO:0001661) amygdala development(GO:0021764)
0.2 1.4 GO:0032782 bile acid secretion(GO:0032782)
0.1 1.4 GO:0036342 post-anal tail morphogenesis(GO:0036342)
0.3 1.3 GO:0052695 cellular glucuronidation(GO:0052695)
0.4 1.2 GO:0009106 lipoate metabolic process(GO:0009106)
0.2 1.2 GO:1990034 calcium ion export from cell(GO:1990034)
0.2 1.2 GO:0032439 endosome localization(GO:0032439)
0.1 1.2 GO:0021796 cerebral cortex regionalization(GO:0021796)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 43 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 4.8 GO:0035985 senescence-associated heterochromatin focus(GO:0035985)
0.1 2.9 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.0 2.9 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.0 2.9 GO:0070469 respiratory chain(GO:0070469)
0.4 1.8 GO:0033063 Rad51B-Rad51C-Rad51D-XRCC2 complex(GO:0033063)
0.1 1.8 GO:0042788 polysomal ribosome(GO:0042788)
0.0 1.8 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.2 1.6 GO:0002177 manchette(GO:0002177)
0.3 1.5 GO:0031262 Ndc80 complex(GO:0031262)
0.0 1.5 GO:0001669 acrosomal vesicle(GO:0001669)
0.2 1.2 GO:0045179 apical cortex(GO:0045179)
0.1 1.0 GO:0060293 P granule(GO:0043186) pole plasm(GO:0045495) germ plasm(GO:0060293)
0.1 0.9 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.2 0.8 GO:0030121 AP-1 adaptor complex(GO:0030121)
0.0 0.8 GO:0000314 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.1 0.7 GO:0044305 calyx of Held(GO:0044305)
0.1 0.7 GO:0046581 intercellular canaliculus(GO:0046581)
0.2 0.6 GO:1990423 RZZ complex(GO:1990423)
0.1 0.6 GO:0031298 replication fork protection complex(GO:0031298)
0.1 0.6 GO:0045261 mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275) proton-transporting ATP synthase complex, catalytic core F(1)(GO:0045261)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 66 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 5.1 GO:0051575 5'-deoxyribose-5-phosphate lyase activity(GO:0051575)
0.0 3.9 GO:0003735 structural constituent of ribosome(GO:0003735)
0.0 3.8 GO:0001158 enhancer sequence-specific DNA binding(GO:0001158)
0.1 3.1 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.7 2.7 GO:0008142 oxysterol binding(GO:0008142)
0.1 2.0 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.3 1.8 GO:0000150 recombinase activity(GO:0000150)
0.0 1.8 GO:0017091 AU-rich element binding(GO:0017091)
0.1 1.5 GO:0003708 retinoic acid receptor activity(GO:0003708)
0.0 1.4 GO:0043014 alpha-tubulin binding(GO:0043014)
0.0 1.4 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.0 1.4 GO:0005496 steroid binding(GO:0005496)
0.1 1.3 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.2 1.2 GO:0070915 lysophosphatidic acid receptor activity(GO:0070915)
0.0 1.2 GO:0004860 protein kinase inhibitor activity(GO:0004860)
0.2 1.0 GO:0008494 translation activator activity(GO:0008494)
0.1 1.0 GO:0045028 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.1 1.0 GO:0070181 small ribosomal subunit rRNA binding(GO:0070181)
0.0 1.0 GO:0048487 beta-tubulin binding(GO:0048487)
0.2 0.9 GO:0086056 voltage-gated calcium channel activity involved in AV node cell action potential(GO:0086056)

Gene overrepresentation in C2:CP category:

Showing 1 to 13 of 13 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 8.3 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.0 2.0 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 1.1 PID_BMP_PATHWAY BMP receptor signaling
0.0 0.8 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 0.6 PID_ATR_PATHWAY ATR signaling pathway
0.0 0.5 PID_MYC_PATHWAY C-MYC pathway
0.0 0.5 PID_SYNDECAN_3_PATHWAY Syndecan-3-mediated signaling events
0.0 0.5 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.0 0.4 PID_ERB_GENOMIC_PATHWAY Validated nuclear estrogen receptor beta network
0.0 0.4 PID_IL12_STAT4_PATHWAY IL12 signaling mediated by STAT4
0.0 0.4 PID_DNA_PK_PATHWAY DNA-PK pathway in nonhomologous end joining
0.0 0.4 PID_P38_ALPHA_BETA_PATHWAY Regulation of p38-alpha and p38-beta
0.0 0.2 PID_HIF1A_PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 27 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 4.8 REACTOME_APOBEC3G_MEDIATED_RESISTANCE_TO_HIV1_INFECTION Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.0 4.6 REACTOME_PEPTIDE_CHAIN_ELONGATION Genes involved in Peptide chain elongation
0.1 3.6 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.2 2.1 REACTOME_P2Y_RECEPTORS Genes involved in P2Y receptors
0.0 1.7 REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT Genes involved in Mitochondrial Protein Import
0.0 1.6 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.1 1.3 REACTOME_GLUCURONIDATION Genes involved in Glucuronidation
0.0 1.2 REACTOME_MEIOTIC_RECOMBINATION Genes involved in Meiotic Recombination
0.0 1.1 REACTOME_SIGNALING_BY_BMP Genes involved in Signaling by BMP
0.0 1.1 REACTOME_AQUAPORIN_MEDIATED_TRANSPORT Genes involved in Aquaporin-mediated transport
0.0 0.9 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.1 0.8 REACTOME_PASSIVE_TRANSPORT_BY_AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.1 0.8 REACTOME_CHYLOMICRON_MEDIATED_LIPID_TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.1 0.7 REACTOME_AMINE_LIGAND_BINDING_RECEPTORS Genes involved in Amine ligand-binding receptors
0.0 0.6 REACTOME_POST_CHAPERONIN_TUBULIN_FOLDING_PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.0 0.6 REACTOME_FORMATION_OF_ATP_BY_CHEMIOSMOTIC_COUPLING Genes involved in Formation of ATP by chemiosmotic coupling
0.1 0.5 REACTOME_INHIBITION_OF_INSULIN_SECRETION_BY_ADRENALINE_NORADRENALINE Genes involved in Inhibition of Insulin Secretion by Adrenaline/Noradrenaline
0.0 0.5 REACTOME_HYALURONAN_METABOLISM Genes involved in Hyaluronan metabolism
0.0 0.4 REACTOME_INTEGRATION_OF_PROVIRUS Genes involved in Integration of provirus
0.0 0.4 REACTOME_UNWINDING_OF_DNA Genes involved in Unwinding of DNA