Motif ID: Pou3f4

Z-value: 0.525


Transcription factors associated with Pou3f4:

Gene SymbolEntrez IDGene Name
Pou3f4 ENSMUSG00000056854.3 Pou3f4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Pou3f4mm10_v2_chrX_+_110814390_110814413-0.653.7e-03Click!


Activity profile for motif Pou3f4.

activity profile for motif Pou3f4


Sorted Z-values histogram for motif Pou3f4

Sorted Z-values for motif Pou3f4



Network of associatons between targets according to the STRING database.



First level regulatory network of Pou3f4

PNG image of the network

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Top targets:


Showing 1 to 20 of 141 entries
PromoterScoreRefseqGene SymbolGene Name
chr7_-_110061319 3.266 ENSMUST00000098110.2
 AA474408
expressed sequence AA474408
chr14_-_12345847 1.081 ENSMUST00000022262.4
 Fezf2
Fez family zinc finger 2
chr2_-_80128834 1.076 ENSMUST00000102654.4
ENSMUST00000102655.3
 Pde1a

phosphodiesterase 1A, calmodulin-dependent

chr10_-_64090241 1.029 ENSMUST00000133588.1
 Lrrtm3
leucine rich repeat transmembrane neuronal 3
chr2_-_80129458 0.919 ENSMUST00000102653.1
 Pde1a
phosphodiesterase 1A, calmodulin-dependent
chr19_+_37436707 0.758 ENSMUST00000128184.1
 Hhex
hematopoietically expressed homeobox
chr3_+_136670076 0.728 ENSMUST00000070198.7
 Ppp3ca
protein phosphatase 3, catalytic subunit, alpha isoform
chr13_-_90905321 0.722 ENSMUST00000109541.3
 Atp6ap1l
ATPase, H+ transporting, lysosomal accessory protein 1-like
chr19_+_55741810 0.708 ENSMUST00000111657.3
ENSMUST00000061496.9
ENSMUST00000041717.7
ENSMUST00000111662.4
 Tcf7l2



transcription factor 7 like 2, T cell specific, HMG box



chr10_-_128923948 0.665 ENSMUST00000131271.1
 Bloc1s1
biogenesis of lysosome-related organelles complex-1, subunit 1
chr10_-_64090265 0.659 ENSMUST00000105439.1
 Lrrtm3
leucine rich repeat transmembrane neuronal 3
chr4_+_15881255 0.632 ENSMUST00000029876.1
 Calb1
calbindin 1
chr7_+_24507006 0.629 ENSMUST00000176880.1
 Zfp428
zinc finger protein 428
chr18_+_33794915 0.614 ENSMUST00000179138.1
 2410004N09Rik
RIKEN cDNA 2410004N09 gene
chr18_+_60774675 0.611 ENSMUST00000118551.1
 Rps14
ribosomal protein S14
chr10_+_96136603 0.610 ENSMUST00000074615.6
 Gm5426
predicted pseudogene 5426
chr18_+_33794882 0.608 ENSMUST00000146010.2
 2410004N09Rik
RIKEN cDNA 2410004N09 gene
chr10_-_61979073 0.599 ENSMUST00000105453.1
ENSMUST00000105452.2
ENSMUST00000105454.2
 Col13a1


collagen, type XIII, alpha 1


chr18_+_60774510 0.590 ENSMUST00000025511.3
 Rps14
ribosomal protein S14
chr13_+_93304066 0.590 ENSMUST00000109493.1
 Homer1
homer homolog 1 (Drosophila)

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 52 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.0 GO:0034390 smooth muscle cell apoptotic process(GO:0034390) regulation of smooth muscle cell apoptotic process(GO:0034391)
0.1 1.7 GO:1902004 positive regulation of beta-amyloid formation(GO:1902004)
0.1 1.2 GO:0048625 myoblast fate commitment(GO:0048625)
0.1 1.2 GO:0000028 ribosomal small subunit assembly(GO:0000028)
0.2 1.1 GO:1904936 forebrain anterior/posterior pattern specification(GO:0021797) cerebral cortex GABAergic interneuron migration(GO:0021853) interneuron migration(GO:1904936)
0.1 1.0 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.2 0.8 GO:0061010 gall bladder development(GO:0061010)
0.2 0.7 GO:1903244 positive regulation of cardiac muscle adaptation(GO:0010615) positive regulation of cardiac muscle hypertrophy in response to stress(GO:1903244) regulation of connective tissue replacement(GO:1905203)
0.0 0.7 GO:0099517 anterograde synaptic vesicle transport(GO:0048490) synaptic vesicle cytoskeletal transport(GO:0099514) synaptic vesicle transport along microtubule(GO:0099517)
0.1 0.6 GO:0061743 motor learning(GO:0061743)
0.1 0.6 GO:0072235 distal convoluted tubule development(GO:0072025) metanephric distal convoluted tubule development(GO:0072221) metanephric distal tubule development(GO:0072235)
0.0 0.6 GO:0048875 chemical homeostasis within a tissue(GO:0048875) regulation of store-operated calcium entry(GO:2001256)
0.0 0.6 GO:0036075 endochondral ossification(GO:0001958) replacement ossification(GO:0036075)
0.2 0.5 GO:0002030 inhibitory G-protein coupled receptor phosphorylation(GO:0002030)
0.1 0.5 GO:0021648 zygotic determination of anterior/posterior axis, embryo(GO:0007354) cranial nerve formation(GO:0021603) vestibulocochlear nerve morphogenesis(GO:0021648)
0.1 0.5 GO:0071787 endoplasmic reticulum tubular network assembly(GO:0071787)
0.1 0.5 GO:0006003 fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.1 0.5 GO:1902746 regulation of lens fiber cell differentiation(GO:1902746)
0.0 0.5 GO:0006012 galactose metabolic process(GO:0006012)
0.0 0.5 GO:0045109 intermediate filament organization(GO:0045109)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 23 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.9 GO:0045211 postsynaptic membrane(GO:0045211)
0.1 1.2 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
0.0 1.2 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.1 0.7 GO:0005955 calcineurin complex(GO:0005955)
0.0 0.7 GO:0031083 BLOC-1 complex(GO:0031083)
0.0 0.7 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 0.6 GO:0043034 costamere(GO:0043034)
0.2 0.5 GO:0043540 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex(GO:0043540)
0.1 0.5 GO:0071439 clathrin complex(GO:0071439)
0.0 0.5 GO:0045095 keratin filament(GO:0045095)
0.0 0.5 GO:0071782 endoplasmic reticulum tubular network(GO:0071782)
0.1 0.4 GO:0042567 insulin-like growth factor ternary complex(GO:0042567)
0.1 0.4 GO:0017071 intracellular cyclic nucleotide activated cation channel complex(GO:0017071)
0.1 0.3 GO:0030289 protein phosphatase 4 complex(GO:0030289)
0.0 0.3 GO:1990726 Lsm1-7-Pat1 complex(GO:1990726)
0.0 0.3 GO:0031080 nuclear pore outer ring(GO:0031080)
0.0 0.2 GO:0045251 mitochondrial electron transfer flavoprotein complex(GO:0017133) electron transfer flavoprotein complex(GO:0045251)
0.0 0.2 GO:0097227 sperm annulus(GO:0097227)
0.0 0.2 GO:0036157 outer dynein arm(GO:0036157)
0.0 0.2 GO:0042788 polysomal ribosome(GO:0042788)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 25 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 2.0 GO:0048101 calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117) calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101)
0.0 1.9 GO:0004860 protein kinase inhibitor activity(GO:0004860)
0.1 1.2 GO:0070181 small ribosomal subunit rRNA binding(GO:0070181)
0.1 1.2 GO:0070016 gamma-catenin binding(GO:0045295) armadillo repeat domain binding(GO:0070016)
0.1 1.0 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.1 0.8 GO:0008301 DNA binding, bending(GO:0008301)
0.1 0.7 GO:0033192 calmodulin-dependent protein phosphatase activity(GO:0033192)
0.1 0.6 GO:0031802 type 5 metabotropic glutamate receptor binding(GO:0031802)
0.2 0.5 GO:0004335 galactokinase activity(GO:0004335)
0.1 0.5 GO:0070095 fructose-6-phosphate binding(GO:0070095)
0.0 0.5 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.1 0.4 GO:0005052 peroxisome matrix targeting signal-1 binding(GO:0005052)
0.0 0.4 GO:0005159 insulin-like growth factor receptor binding(GO:0005159)
0.0 0.4 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.1 0.3 GO:0004704 NF-kappaB-inducing kinase activity(GO:0004704)
0.1 0.2 GO:0004568 chitinase activity(GO:0004568)
0.1 0.2 GO:0005008 hepatocyte growth factor-activated receptor activity(GO:0005008)
0.1 0.2 GO:0036468 aromatic-L-amino-acid decarboxylase activity(GO:0004058) L-dopa decarboxylase activity(GO:0036468)
0.0 0.2 GO:0004322 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.0 0.2 GO:0035727 lysophosphatidic acid binding(GO:0035727) lysophosphatidic acid receptor activity(GO:0070915)

Gene overrepresentation in C2:CP category:

Showing 1 to 8 of 8 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.2 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.0 1.2 PID_AP1_PATHWAY AP-1 transcription factor network
0.0 0.9 PID_SYNDECAN_1_PATHWAY Syndecan-1-mediated signaling events
0.0 0.7 PID_CD8_TCR_DOWNSTREAM_PATHWAY Downstream signaling in naïve CD8+ T cells
0.0 0.4 PID_PDGFRA_PATHWAY PDGFR-alpha signaling pathway
0.0 0.4 PID_IGF1_PATHWAY IGF1 pathway
0.0 0.2 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.0 0.2 PID_TCR_CALCIUM_PATHWAY Calcium signaling in the CD4+ TCR pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 8 of 8 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.0 REACTOME_CGMP_EFFECTS Genes involved in cGMP effects
0.0 1.2 REACTOME_FORMATION_OF_THE_TERNARY_COMPLEX_AND_SUBSEQUENTLY_THE_43S_COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.0 0.7 REACTOME_LYSOSOME_VESICLE_BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
0.0 0.7 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.0 0.5 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.0 0.3 REACTOME_MRNA_DECAY_BY_5_TO_3_EXORIBONUCLEASE Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
0.0 0.2 REACTOME_P2Y_RECEPTORS Genes involved in P2Y receptors
0.0 0.2 REACTOME_AMINE_DERIVED_HORMONES Genes involved in Amine-derived hormones