Motif ID: Atf4

Z-value: 1.026


Transcription factors associated with Atf4:

Gene SymbolEntrez IDGene Name
Atf4 ENSMUSG00000042406.7 Atf4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Atf4mm10_v2_chr15_+_80255184_802552630.282.6e-01Click!


Activity profile for motif Atf4.

activity profile for motif Atf4


Sorted Z-values histogram for motif Atf4

Sorted Z-values for motif Atf4



Network of associatons between targets according to the STRING database.



First level regulatory network of Atf4

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr7_+_144896523 5.445 ENSMUST00000033389.5
 Fgf15
fibroblast growth factor 15
chrX_+_103422010 5.265 ENSMUST00000182089.1
 Gm26992
predicted gene, 26992
chr6_-_23248264 3.443 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chr1_-_71653162 2.407 ENSMUST00000055226.6
 Fn1
fibronectin 1
chr13_+_49682191 2.109 ENSMUST00000172254.1
 Iars
isoleucine-tRNA synthetase
chr4_+_43957678 1.608 ENSMUST00000107855.1
 Glipr2
GLI pathogenesis-related 2
chr19_+_53140430 1.571 ENSMUST00000111741.2
 Add3
adducin 3 (gamma)
chr4_-_129189600 1.499 ENSMUST00000117497.1
ENSMUST00000117350.1
 S100pbp

S100P binding protein

chr5_-_148399901 1.383 ENSMUST00000048116.8
 Slc7a1
solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
chr4_+_46450892 1.320 ENSMUST00000102926.4
 Anp32b
acidic (leucine-rich) nuclear phosphoprotein 32 family, member B
chr13_+_49682100 1.232 ENSMUST00000165316.1
ENSMUST00000047363.7
 Iars

isoleucine-tRNA synthetase

chr4_-_129189512 1.169 ENSMUST00000117965.1
ENSMUST00000106061.2
ENSMUST00000072431.6
 S100pbp


S100P binding protein


chr5_+_93093428 1.154 ENSMUST00000074733.7
 Sept11
septin 11
chr4_-_129189646 1.132 ENSMUST00000106059.1
 S100pbp
S100P binding protein
chr19_+_44203265 1.106 ENSMUST00000026220.5
 Scd3
stearoyl-coenzyme A desaturase 3
chr13_-_53473074 1.036 ENSMUST00000021922.8
 Msx2
msh homeobox 2
chr19_-_15924928 1.003 ENSMUST00000025542.3
 Psat1
phosphoserine aminotransferase 1
chr3_-_138143352 0.999 ENSMUST00000098580.2
 Mttp
microsomal triglyceride transfer protein
chr8_+_75093591 0.916 ENSMUST00000005548.6
 Hmox1
heme oxygenase (decycling) 1
chr1_+_133131143 0.889 ENSMUST00000052529.3
 Ppp1r15b
protein phosphatase 1, regulatory (inhibitor) subunit 15b
chr11_+_100320596 0.838 ENSMUST00000152521.1
 Eif1
eukaryotic translation initiation factor 1
chr2_-_18048784 0.822 ENSMUST00000142856.1
 Skida1
SKI/DACH domain containing 1
chr6_-_83317589 0.820 ENSMUST00000005810.6
 Mthfd2
methylenetetrahydrofolate dehydrogenase (NAD+ dependent), methenyltetrahydrofolate cyclohydrolase
chr12_-_108893197 0.810 ENSMUST00000161154.1
ENSMUST00000161410.1
 Wars

tryptophanyl-tRNA synthetase

chrX_+_106187100 0.802 ENSMUST00000081593.6
 Pgk1
phosphoglycerate kinase 1
chr5_-_31179901 0.782 ENSMUST00000101411.2
ENSMUST00000140793.1
 Gtf3c2

general transcription factor IIIC, polypeptide 2, beta

chr8_+_117157972 0.756 ENSMUST00000064488.4
ENSMUST00000162997.1
 Gan

giant axonal neuropathy

chr2_+_119351222 0.746 ENSMUST00000028780.3
 Chac1
ChaC, cation transport regulator 1
chr14_+_63436394 0.729 ENSMUST00000121288.1
 Fam167a
family with sequence similarity 167, member A
chr18_-_42262053 0.722 ENSMUST00000097590.3
 Lars
leucyl-tRNA synthetase
chr8_+_111033890 0.711 ENSMUST00000034441.7
 Aars
alanyl-tRNA synthetase
chr10_-_121626316 0.681 ENSMUST00000039810.7
 Xpot
exportin, tRNA (nuclear export receptor for tRNAs)
chr4_+_117835387 0.675 ENSMUST00000169885.1
 Slc6a9
solute carrier family 6 (neurotransmitter transporter, glycine), member 9
chr15_+_99393610 0.665 ENSMUST00000159531.1
 Tmbim6
transmembrane BAX inhibitor motif containing 6
chr14_-_54870913 0.641 ENSMUST00000146642.1
 Homez
homeodomain leucine zipper-encoding gene
chr19_-_40588374 0.617 ENSMUST00000175932.1
ENSMUST00000176955.1
ENSMUST00000149476.2
 Aldh18a1


aldehyde dehydrogenase 18 family, member A1


chr7_-_126625676 0.586 ENSMUST00000032961.3
 Nupr1
nuclear protein transcription regulator 1
chr15_+_99393574 0.564 ENSMUST00000162624.1
 Tmbim6
transmembrane BAX inhibitor motif containing 6
chr19_-_12501996 0.559 ENSMUST00000045521.7
 Dtx4
deltex 4 homolog (Drosophila)
chr8_+_94386486 0.547 ENSMUST00000034220.7
 Herpud1
homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
chr12_+_85599047 0.543 ENSMUST00000177587.1
 Jdp2
Jun dimerization protein 2
chr12_+_85599388 0.536 ENSMUST00000050687.6
 Jdp2
Jun dimerization protein 2
chr10_-_127522428 0.525 ENSMUST00000026470.4
 Shmt2
serine hydroxymethyltransferase 2 (mitochondrial)
chr13_-_30545254 0.506 ENSMUST00000042834.3
 Uqcrfs1
ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1
chr15_+_99393219 0.496 ENSMUST00000159209.1
 Tmbim6
transmembrane BAX inhibitor motif containing 6
chr2_+_163995503 0.475 ENSMUST00000131288.1
 Ywhab
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide
chr7_+_126565919 0.470 ENSMUST00000180459.1
 G730046D07Rik
RIKEN cDNA G730046D07 gene
chr11_-_98400393 0.467 ENSMUST00000128897.1
 Pgap3
post-GPI attachment to proteins 3
chr5_-_31180110 0.462 ENSMUST00000043161.6
ENSMUST00000088010.5
 Gtf3c2

general transcription factor IIIC, polypeptide 2, beta

chr6_+_55037988 0.448 ENSMUST00000003572.8
 Gars
glycyl-tRNA synthetase
chr15_+_82147238 0.437 ENSMUST00000023100.6
 Srebf2
sterol regulatory element binding factor 2
chr14_-_69284982 0.434 ENSMUST00000183882.1
ENSMUST00000037064.4
 Slc25a37

solute carrier family 25, member 37

chr13_-_118387224 0.424 ENSMUST00000022245.8
 Mrps30
mitochondrial ribosomal protein S30
chr11_-_98400453 0.419 ENSMUST00000090827.5
 Pgap3
post-GPI attachment to proteins 3
chr8_+_94386438 0.410 ENSMUST00000161576.1
 Herpud1
homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
chr19_-_40588453 0.405 ENSMUST00000025979.6
 Aldh18a1
aldehyde dehydrogenase 18 family, member A1
chr5_-_145140238 0.402 ENSMUST00000031627.8
 Pdap1
PDGFA associated protein 1
chr19_-_40588338 0.370 ENSMUST00000176939.1
 Aldh18a1
aldehyde dehydrogenase 18 family, member A1
chr2_-_18048347 0.369 ENSMUST00000066885.5
 Skida1
SKI/DACH domain containing 1
chr7_-_126502094 0.367 ENSMUST00000179818.1
 Atxn2l
ataxin 2-like
chr14_-_37135126 0.361 ENSMUST00000042564.9
 Ghitm
growth hormone inducible transmembrane protein
chr10_+_96616998 0.341 ENSMUST00000038377.7
 Btg1
B cell translocation gene 1, anti-proliferative
chr1_-_191183244 0.331 ENSMUST00000027941.8
 Atf3
activating transcription factor 3
chr3_+_138143888 0.326 ENSMUST00000161141.1
 Trmt10a
tRNA methyltransferase 10A
chr19_-_43524462 0.323 ENSMUST00000026196.7
 Got1
glutamate oxaloacetate transaminase 1, soluble
chr8_+_85492568 0.318 ENSMUST00000034136.5
 Gpt2
glutamic pyruvate transaminase (alanine aminotransferase) 2
chr1_-_78488846 0.304 ENSMUST00000068333.7
ENSMUST00000170217.1
 Farsb

phenylalanyl-tRNA synthetase, beta subunit

chr10_-_127311740 0.283 ENSMUST00000037290.5
ENSMUST00000171564.1
 Mars

methionine-tRNA synthetase

chr3_+_138143429 0.267 ENSMUST00000040321.6
 Trmt10a
tRNA methyltransferase 10A
chr11_-_118290167 0.248 ENSMUST00000144153.1
 Usp36
ubiquitin specific peptidase 36
chr7_-_126566364 0.241 ENSMUST00000032992.5
 Eif3c
eukaryotic translation initiation factor 3, subunit C
chr17_-_34187219 0.234 ENSMUST00000173831.1
 Psmb9
proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2)
chr10_+_102158858 0.228 ENSMUST00000138522.1
ENSMUST00000163753.1
ENSMUST00000138016.1
 Mgat4c


mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme C (putative)


chr19_-_4793851 0.190 ENSMUST00000178615.1
ENSMUST00000179189.1
ENSMUST00000164376.2
ENSMUST00000164209.2
ENSMUST00000180248.1
 Rbm4




RNA binding motif protein 4




chr8_+_123477859 0.185 ENSMUST00000001520.7
 Afg3l1
AFG3(ATPase family gene 3)-like 1 (yeast)
chr7_-_35056467 0.177 ENSMUST00000130491.1
 Cebpg
CCAAT/enhancer binding protein (C/EBP), gamma
chr4_-_108833608 0.177 ENSMUST00000102742.4
 Btf3l4
basic transcription factor 3-like 4
chr3_-_89998656 0.144 ENSMUST00000079724.4
 Hax1
HCLS1 associated X-1
chr3_+_88616133 0.142 ENSMUST00000176500.1
ENSMUST00000177498.1
 Arhgef2

rho/rac guanine nucleotide exchange factor (GEF) 2

chr11_-_101171302 0.118 ENSMUST00000164474.1
ENSMUST00000043397.7
 Plekhh3

pleckstrin homology domain containing, family H (with MyTH4 domain) member 3

chr12_-_104865076 0.115 ENSMUST00000109937.1
ENSMUST00000109936.1
 Clmn

calmin

chr5_+_145140362 0.107 ENSMUST00000162594.1
ENSMUST00000162308.1
ENSMUST00000159018.1
ENSMUST00000160075.1
 Bud31



BUD31 homolog (yeast)



chr11_-_118290188 0.104 ENSMUST00000106296.2
ENSMUST00000092382.3
 Usp36

ubiquitin specific peptidase 36

chr15_-_83510793 0.100 ENSMUST00000154401.1
 Ttll1
tubulin tyrosine ligase-like 1
chr7_-_143600049 0.091 ENSMUST00000105909.3
ENSMUST00000010899.7
 Cars

cysteinyl-tRNA synthetase

chr10_-_68278713 0.077 ENSMUST00000020106.7
 Arid5b
AT rich interactive domain 5B (MRF1-like)
chr4_+_42735545 0.074 ENSMUST00000068158.3
 4930578G10Rik
RIKEN cDNA 4930578G10 gene
chr3_+_138143483 0.072 ENSMUST00000162864.1
 Trmt10a
tRNA methyltransferase 10A
chr2_-_3512746 0.069 ENSMUST00000027961.5
ENSMUST00000056700.7
 Hspa14
Hspa14
heat shock protein 14
heat shock protein 14
chr18_-_64516547 0.049 ENSMUST00000025483.9
 Nars
asparaginyl-tRNA synthetase
chr7_-_126502312 0.048 ENSMUST00000166682.2
 Atxn2l
ataxin 2-like
chr9_-_71771535 0.042 ENSMUST00000122065.1
ENSMUST00000121322.1
ENSMUST00000072899.2
 Cgnl1


cingulin-like 1


chr15_-_83510861 0.036 ENSMUST00000109479.1
ENSMUST00000109480.1
ENSMUST00000016897.4
 Ttll1


tubulin tyrosine ligase-like 1


chr17_+_34187545 0.030 ENSMUST00000170086.1
 Tap1
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
chr17_+_34187789 0.023 ENSMUST00000041633.8
 Tap1
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
chr8_-_92356103 0.023 ENSMUST00000034183.3
 4933436C20Rik
RIKEN cDNA 4933436C20 gene
chr11_-_53430417 0.020 ENSMUST00000109019.1
 Uqcrq
ubiquinol-cytochrome c reductase, complex III subunit VII
chr8_+_25808474 0.019 ENSMUST00000033979.4
 Star
steroidogenic acute regulatory protein
chr7_+_138846579 0.013 ENSMUST00000155672.1
 Ppp2r2d
protein phosphatase 2, regulatory subunit B, delta isoform
chr11_-_75422524 0.011 ENSMUST00000125982.1
ENSMUST00000137103.1
 Serpinf1

serine (or cysteine) peptidase inhibitor, clade F, member 1


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.4 5.4 GO:0070858 negative regulation of bile acid biosynthetic process(GO:0070858) negative regulation of bile acid metabolic process(GO:1904252)
1.1 3.3 GO:0006428 isoleucyl-tRNA aminoacylation(GO:0006428)
0.8 2.4 GO:0006931 substrate-dependent cell migration, cell attachment to substrate(GO:0006931) calcium-independent cell-matrix adhesion(GO:0007161) transforming growth factor-beta secretion(GO:0038044)
0.6 3.4 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.5 1.4 GO:0006592 ornithine biosynthetic process(GO:0006592)
0.3 1.0 GO:0035880 embryonic nail plate morphogenesis(GO:0035880) positive regulation of catagen(GO:0051795) frontal suture morphogenesis(GO:0060364)
0.3 1.7 GO:1904721 regulation of mRNA cleavage(GO:0031437) negative regulation of mRNA cleavage(GO:0031438) negative regulation of immunoglobulin secretion(GO:0051025) regulation of mRNA endonucleolytic cleavage involved in unfolded protein response(GO:1904720) negative regulation of mRNA endonucleolytic cleavage involved in unfolded protein response(GO:1904721)
0.3 1.5 GO:0006564 L-serine biosynthetic process(GO:0006564)
0.3 1.1 GO:1903966 monounsaturated fatty acid metabolic process(GO:1903964) monounsaturated fatty acid biosynthetic process(GO:1903966)
0.3 0.8 GO:0006436 tryptophanyl-tRNA aminoacylation(GO:0006436)
0.2 0.7 GO:0006419 alanyl-tRNA aminoacylation(GO:0006419)
0.2 0.9 GO:1904706 heme oxidation(GO:0006788) negative regulation of vascular smooth muscle cell proliferation(GO:1904706)
0.2 0.7 GO:0061537 glycine secretion(GO:0061536) glycine secretion, neurotransmission(GO:0061537)
0.2 1.0 GO:0034196 acylglycerol transport(GO:0034196) triglyceride transport(GO:0034197)
0.2 0.7 GO:0006751 glutathione catabolic process(GO:0006751)
0.2 0.7 GO:0006438 valyl-tRNA aminoacylation(GO:0006438)
0.2 0.7 GO:0006409 tRNA export from nucleus(GO:0006409) tRNA-containing ribonucleoprotein complex export from nucleus(GO:0071431)
0.2 1.0 GO:1903071 positive regulation of ER-associated ubiquitin-dependent protein catabolic process(GO:1903071)
0.1 0.9 GO:1903912 negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation(GO:1903912)
0.1 0.3 GO:0006106 fumarate metabolic process(GO:0006106) aspartate biosynthetic process(GO:0006532) aspartate catabolic process(GO:0006533) alditol biosynthetic process(GO:0019401)
0.1 1.4 GO:0015809 arginine transport(GO:0015809)
0.1 0.4 GO:0015960 diadenosine polyphosphate biosynthetic process(GO:0015960) diadenosine tetraphosphate metabolic process(GO:0015965) diadenosine tetraphosphate biosynthetic process(GO:0015966)
0.1 0.4 GO:0010886 positive regulation of cholesterol storage(GO:0010886) regulation of lipid transport by negative regulation of transcription from RNA polymerase II promoter(GO:0072368) negative regulation of cholesterol efflux(GO:0090370)
0.1 0.3 GO:1903984 positive regulation of TRAIL-activated apoptotic signaling pathway(GO:1903984)
0.1 0.3 GO:0006432 phenylalanyl-tRNA aminoacylation(GO:0006432)
0.1 0.6 GO:2000194 regulation of female gonad development(GO:2000194)
0.1 0.8 GO:0031639 plasminogen activation(GO:0031639)
0.1 1.3 GO:0043486 histone exchange(GO:0043486)
0.1 0.3 GO:2000271 positive regulation of fibroblast apoptotic process(GO:2000271)
0.1 0.8 GO:0009048 dosage compensation by inactivation of X chromosome(GO:0009048)
0.0 1.1 GO:0031065 positive regulation of histone deacetylation(GO:0031065)
0.0 0.2 GO:0032055 negative regulation of translation in response to stress(GO:0032055) circadian regulation of translation(GO:0097167)
0.0 1.2 GO:0006383 transcription from RNA polymerase III promoter(GO:0006383)
0.0 0.1 GO:0030854 positive regulation of granulocyte differentiation(GO:0030854)
0.0 0.3 GO:1901838 positive regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter(GO:1901838)
0.0 1.6 GO:0010718 positive regulation of epithelial to mesenchymal transition(GO:0010718)
0.0 0.2 GO:0045078 positive regulation of interferon-gamma biosynthetic process(GO:0045078)
0.0 0.2 GO:1902416 positive regulation of mRNA binding(GO:1902416)
0.0 0.9 GO:0006506 GPI anchor biosynthetic process(GO:0006506)
0.0 0.1 GO:0071802 negative regulation of podosome assembly(GO:0071802)
0.0 0.3 GO:0006103 2-oxoglutarate metabolic process(GO:0006103)
0.0 0.1 GO:0018095 protein polyglutamylation(GO:0018095)
0.0 0.1 GO:0046967 cytosol to ER transport(GO:0046967)
0.0 0.2 GO:0034982 mitochondrial protein processing(GO:0034982)
0.0 0.2 GO:0010603 regulation of cytoplasmic mRNA processing body assembly(GO:0010603)
0.0 0.0 GO:0006421 asparaginyl-tRNA aminoacylation(GO:0006421)
0.0 0.4 GO:0006826 iron ion transport(GO:0006826)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 2.4 GO:0005577 fibrinogen complex(GO:0005577)
0.3 4.1 GO:0017101 aminoacyl-tRNA synthetase multienzyme complex(GO:0017101)
0.2 1.0 GO:1990037 Lewy body core(GO:1990037)
0.2 1.2 GO:0000127 transcription factor TFIIIC complex(GO:0000127)
0.1 0.5 GO:0070552 BRISC complex(GO:0070552)
0.1 0.3 GO:0009328 phenylalanine-tRNA ligase complex(GO:0009328)
0.1 0.9 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.1 0.2 GO:1990111 spermatoproteasome complex(GO:1990111)
0.1 1.0 GO:0031528 microvillus membrane(GO:0031528)
0.1 0.4 GO:0032937 SREBP-SCAP-Insig complex(GO:0032937)
0.0 0.2 GO:0005745 m-AAA complex(GO:0005745)
0.0 0.5 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.0 0.2 GO:0071541 eukaryotic translation initiation factor 3 complex, eIF3m(GO:0071541)
0.0 0.8 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 1.6 GO:0000794 condensed nuclear chromosome(GO:0000794)
0.0 5.6 GO:0016607 nuclear speck(GO:0016607)
0.0 0.1 GO:0042825 TAP complex(GO:0042825)
0.0 1.2 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 3.3 GO:0004822 isoleucine-tRNA ligase activity(GO:0004822)
0.5 2.2 GO:0016774 phosphotransferase activity, carboxyl group as acceptor(GO:0016774)
0.4 2.4 GO:0045340 mercury ion binding(GO:0045340)
0.3 1.7 GO:0060698 endoribonuclease inhibitor activity(GO:0060698)
0.3 1.1 GO:0032896 palmitoyl-CoA 9-desaturase activity(GO:0032896)
0.3 0.8 GO:0004487 methylenetetrahydrofolate dehydrogenase (NAD+) activity(GO:0004487)
0.3 0.8 GO:0004830 tryptophan-tRNA ligase activity(GO:0004830)
0.2 5.4 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.2 0.7 GO:0004813 alanine-tRNA ligase activity(GO:0004813)
0.2 0.9 GO:0004392 heme oxygenase (decyclizing) activity(GO:0004392)
0.2 0.7 GO:0004832 valine-tRNA ligase activity(GO:0004832)
0.2 0.5 GO:0008732 threonine aldolase activity(GO:0004793) L-allo-threonine aldolase activity(GO:0008732)
0.2 1.4 GO:0015181 arginine transmembrane transporter activity(GO:0015181)
0.1 0.7 GO:0003839 gamma-glutamylcyclotransferase activity(GO:0003839)
0.1 0.3 GO:0004069 L-aspartate:2-oxoglutarate aminotransferase activity(GO:0004069)
0.1 1.3 GO:0008483 transaminase activity(GO:0008483)
0.1 0.7 GO:0015187 glycine transmembrane transporter activity(GO:0015187)
0.1 0.3 GO:0004826 phenylalanine-tRNA ligase activity(GO:0004826)
0.0 0.1 GO:0019966 interleukin-1 binding(GO:0019966)
0.0 1.0 GO:0034185 apolipoprotein binding(GO:0034185)
0.0 0.2 GO:0008454 alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.0 0.5 GO:0050815 phosphoserine binding(GO:0050815)
0.0 3.8 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.0 0.4 GO:0015093 ferrous iron transmembrane transporter activity(GO:0015093)
0.0 0.3 GO:0008121 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.0 0.1 GO:0070740 tubulin-glutamic acid ligase activity(GO:0070740)
0.0 5.3 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0 0.4 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.0 0.4 GO:0004551 nucleotide diphosphatase activity(GO:0004551)
0.0 1.0 GO:0000049 tRNA binding(GO:0000049)
0.0 0.2 GO:0097157 pre-mRNA intronic binding(GO:0097157)
0.0 1.1 GO:0003743 translation initiation factor activity(GO:0003743)
0.0 0.0 GO:0004816 asparagine-tRNA ligase activity(GO:0004816)
0.0 0.2 GO:0008301 DNA binding, bending(GO:0008301)
0.0 0.1 GO:0015433 peptide antigen-transporting ATPase activity(GO:0015433) tapasin binding(GO:0046980)
0.0 1.1 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.0 0.2 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003) proteasome binding(GO:0070628)
0.0 0.9 GO:0019888 protein phosphatase regulator activity(GO:0019888)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.4 PID_INTEGRIN5_PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.1 3.3 ST_INTERLEUKIN_4_PATHWAY Interleukin 4 (IL-4) Pathway
0.0 0.9 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 0.8 PID_HIF2PATHWAY HIF-2-alpha transcription factor network
0.0 0.4 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.0 0.5 PID_INSULIN_GLUCOSE_PATHWAY Insulin-mediated glucose transport

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 6.5 REACTOME_CYTOSOLIC_TRNA_AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.2 2.4 REACTOME_P130CAS_LINKAGE_TO_MAPK_SIGNALING_FOR_INTEGRINS Genes involved in p130Cas linkage to MAPK signaling for integrins
0.1 2.8 REACTOME_AMINO_ACID_SYNTHESIS_AND_INTERCONVERSION_TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.1 1.0 REACTOME_CHYLOMICRON_MEDIATED_LIPID_TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.1 0.7 REACTOME_NA_CL_DEPENDENT_NEUROTRANSMITTER_TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.0 1.2 REACTOME_RNA_POL_III_TRANSCRIPTION_INITIATION_FROM_TYPE_2_PROMOTER Genes involved in RNA Polymerase III Transcription Initiation From Type 2 Promoter
0.0 0.8 REACTOME_METABOLISM_OF_PORPHYRINS Genes involved in Metabolism of porphyrins
0.0 0.5 REACTOME_RAF_MAP_KINASE_CASCADE Genes involved in RAF/MAP kinase cascade
0.0 1.0 REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.0 0.8 REACTOME_GLYCOLYSIS Genes involved in Glycolysis
0.0 0.6 REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.0 0.2 REACTOME_N_GLYCAN_ANTENNAE_ELONGATION Genes involved in N-Glycan antennae elongation
0.0 0.2 REACTOME_ACTIVATION_OF_GENES_BY_ATF4 Genes involved in Activation of Genes by ATF4