Motif ID: Atf4

Z-value: 1.026


Transcription factors associated with Atf4:

Gene SymbolEntrez IDGene Name
Atf4 ENSMUSG00000042406.7 Atf4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Atf4mm10_v2_chr15_+_80255184_802552630.282.6e-01Click!


Activity profile for motif Atf4.

activity profile for motif Atf4


Sorted Z-values histogram for motif Atf4

Sorted Z-values for motif Atf4



Network of associatons between targets according to the STRING database.



First level regulatory network of Atf4

PNG image of the network

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Top targets:


Showing 1 to 20 of 100 entries
PromoterScoreRefseqGene SymbolGene Name
chr7_+_144896523 5.445 ENSMUST00000033389.5
 Fgf15
fibroblast growth factor 15
chrX_+_103422010 5.265 ENSMUST00000182089.1
 Gm26992
predicted gene, 26992
chr6_-_23248264 3.443 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chr1_-_71653162 2.407 ENSMUST00000055226.6
 Fn1
fibronectin 1
chr13_+_49682191 2.109 ENSMUST00000172254.1
 Iars
isoleucine-tRNA synthetase
chr4_+_43957678 1.608 ENSMUST00000107855.1
 Glipr2
GLI pathogenesis-related 2
chr19_+_53140430 1.571 ENSMUST00000111741.2
 Add3
adducin 3 (gamma)
chr4_-_129189600 1.499 ENSMUST00000117497.1
ENSMUST00000117350.1
 S100pbp

S100P binding protein

chr5_-_148399901 1.383 ENSMUST00000048116.8
 Slc7a1
solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
chr4_+_46450892 1.320 ENSMUST00000102926.4
 Anp32b
acidic (leucine-rich) nuclear phosphoprotein 32 family, member B
chr13_+_49682100 1.232 ENSMUST00000165316.1
ENSMUST00000047363.7
 Iars

isoleucine-tRNA synthetase

chr4_-_129189512 1.169 ENSMUST00000117965.1
ENSMUST00000106061.2
ENSMUST00000072431.6
 S100pbp


S100P binding protein


chr5_+_93093428 1.154 ENSMUST00000074733.7
 Sept11
septin 11
chr4_-_129189646 1.132 ENSMUST00000106059.1
 S100pbp
S100P binding protein
chr19_+_44203265 1.106 ENSMUST00000026220.5
 Scd3
stearoyl-coenzyme A desaturase 3
chr13_-_53473074 1.036 ENSMUST00000021922.8
 Msx2
msh homeobox 2
chr19_-_15924928 1.003 ENSMUST00000025542.3
 Psat1
phosphoserine aminotransferase 1
chr3_-_138143352 0.999 ENSMUST00000098580.2
 Mttp
microsomal triglyceride transfer protein
chr8_+_75093591 0.916 ENSMUST00000005548.6
 Hmox1
heme oxygenase (decycling) 1
chr1_+_133131143 0.889 ENSMUST00000052529.3
 Ppp1r15b
protein phosphatase 1, regulatory (inhibitor) subunit 15b

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 47 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.4 5.4 GO:0070858 negative regulation of bile acid biosynthetic process(GO:0070858) negative regulation of bile acid metabolic process(GO:1904252)
0.6 3.4 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
1.1 3.3 GO:0006428 isoleucyl-tRNA aminoacylation(GO:0006428)
0.8 2.4 GO:0006931 substrate-dependent cell migration, cell attachment to substrate(GO:0006931) calcium-independent cell-matrix adhesion(GO:0007161) transforming growth factor-beta secretion(GO:0038044)
0.3 1.7 GO:1904721 regulation of mRNA cleavage(GO:0031437) negative regulation of mRNA cleavage(GO:0031438) negative regulation of immunoglobulin secretion(GO:0051025) regulation of mRNA endonucleolytic cleavage involved in unfolded protein response(GO:1904720) negative regulation of mRNA endonucleolytic cleavage involved in unfolded protein response(GO:1904721)
0.0 1.6 GO:0010718 positive regulation of epithelial to mesenchymal transition(GO:0010718)
0.3 1.5 GO:0006564 L-serine biosynthetic process(GO:0006564)
0.5 1.4 GO:0006592 ornithine biosynthetic process(GO:0006592)
0.1 1.4 GO:0015809 arginine transport(GO:0015809)
0.1 1.3 GO:0043486 histone exchange(GO:0043486)
0.0 1.2 GO:0006383 transcription from RNA polymerase III promoter(GO:0006383)
0.3 1.1 GO:1903966 monounsaturated fatty acid metabolic process(GO:1903964) monounsaturated fatty acid biosynthetic process(GO:1903966)
0.0 1.1 GO:0031065 positive regulation of histone deacetylation(GO:0031065)
0.3 1.0 GO:0035880 embryonic nail plate morphogenesis(GO:0035880) positive regulation of catagen(GO:0051795) frontal suture morphogenesis(GO:0060364)
0.2 1.0 GO:0034196 acylglycerol transport(GO:0034196) triglyceride transport(GO:0034197)
0.2 1.0 GO:1903071 positive regulation of ER-associated ubiquitin-dependent protein catabolic process(GO:1903071)
0.2 0.9 GO:1904706 heme oxidation(GO:0006788) negative regulation of vascular smooth muscle cell proliferation(GO:1904706)
0.1 0.9 GO:1903912 negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation(GO:1903912)
0.0 0.9 GO:0006506 GPI anchor biosynthetic process(GO:0006506)
0.3 0.8 GO:0006436 tryptophanyl-tRNA aminoacylation(GO:0006436)

Gene overrepresentation in cellular_component category:

Showing 1 to 18 of 18 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 5.6 GO:0016607 nuclear speck(GO:0016607)
0.3 4.1 GO:0017101 aminoacyl-tRNA synthetase multienzyme complex(GO:0017101)
0.8 2.4 GO:0005577 fibrinogen complex(GO:0005577)
0.0 1.6 GO:0000794 condensed nuclear chromosome(GO:0000794)
0.2 1.2 GO:0000127 transcription factor TFIIIC complex(GO:0000127)
0.0 1.2 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.2 1.0 GO:1990037 Lewy body core(GO:1990037)
0.1 1.0 GO:0031528 microvillus membrane(GO:0031528)
0.1 0.9 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.0 0.8 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.1 0.5 GO:0070552 BRISC complex(GO:0070552)
0.0 0.5 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.1 0.4 GO:0032937 SREBP-SCAP-Insig complex(GO:0032937)
0.1 0.3 GO:0009328 phenylalanine-tRNA ligase complex(GO:0009328)
0.1 0.2 GO:1990111 spermatoproteasome complex(GO:1990111)
0.0 0.2 GO:0005745 m-AAA complex(GO:0005745)
0.0 0.2 GO:0071541 eukaryotic translation initiation factor 3 complex, eIF3m(GO:0071541)
0.0 0.1 GO:0042825 TAP complex(GO:0042825)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 38 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 5.4 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.0 5.3 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0 3.8 GO:0048306 calcium-dependent protein binding(GO:0048306)
1.1 3.3 GO:0004822 isoleucine-tRNA ligase activity(GO:0004822)
0.4 2.4 GO:0045340 mercury ion binding(GO:0045340)
0.5 2.2 GO:0016774 phosphotransferase activity, carboxyl group as acceptor(GO:0016774)
0.3 1.7 GO:0060698 endoribonuclease inhibitor activity(GO:0060698)
0.2 1.4 GO:0015181 arginine transmembrane transporter activity(GO:0015181)
0.1 1.3 GO:0008483 transaminase activity(GO:0008483)
0.3 1.1 GO:0032896 palmitoyl-CoA 9-desaturase activity(GO:0032896)
0.0 1.1 GO:0003743 translation initiation factor activity(GO:0003743)
0.0 1.1 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.0 1.0 GO:0034185 apolipoprotein binding(GO:0034185)
0.0 1.0 GO:0000049 tRNA binding(GO:0000049)
0.2 0.9 GO:0004392 heme oxygenase (decyclizing) activity(GO:0004392)
0.0 0.9 GO:0019888 protein phosphatase regulator activity(GO:0019888)
0.3 0.8 GO:0004487 methylenetetrahydrofolate dehydrogenase (NAD+) activity(GO:0004487)
0.3 0.8 GO:0004830 tryptophan-tRNA ligase activity(GO:0004830)
0.2 0.7 GO:0004813 alanine-tRNA ligase activity(GO:0004813)
0.2 0.7 GO:0004832 valine-tRNA ligase activity(GO:0004832)

Gene overrepresentation in C2:CP category:

Showing 1 to 6 of 6 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.3 ST_INTERLEUKIN_4_PATHWAY Interleukin 4 (IL-4) Pathway
0.1 2.4 PID_INTEGRIN5_PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0 0.9 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 0.8 PID_HIF2PATHWAY HIF-2-alpha transcription factor network
0.0 0.5 PID_INSULIN_GLUCOSE_PATHWAY Insulin-mediated glucose transport
0.0 0.4 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 13 of 13 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 6.5 REACTOME_CYTOSOLIC_TRNA_AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.1 2.8 REACTOME_AMINO_ACID_SYNTHESIS_AND_INTERCONVERSION_TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.2 2.4 REACTOME_P130CAS_LINKAGE_TO_MAPK_SIGNALING_FOR_INTEGRINS Genes involved in p130Cas linkage to MAPK signaling for integrins
0.0 1.2 REACTOME_RNA_POL_III_TRANSCRIPTION_INITIATION_FROM_TYPE_2_PROMOTER Genes involved in RNA Polymerase III Transcription Initiation From Type 2 Promoter
0.1 1.0 REACTOME_CHYLOMICRON_MEDIATED_LIPID_TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.0 1.0 REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.0 0.8 REACTOME_METABOLISM_OF_PORPHYRINS Genes involved in Metabolism of porphyrins
0.0 0.8 REACTOME_GLYCOLYSIS Genes involved in Glycolysis
0.1 0.7 REACTOME_NA_CL_DEPENDENT_NEUROTRANSMITTER_TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.0 0.6 REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.0 0.5 REACTOME_RAF_MAP_KINASE_CASCADE Genes involved in RAF/MAP kinase cascade
0.0 0.2 REACTOME_N_GLYCAN_ANTENNAE_ELONGATION Genes involved in N-Glycan antennae elongation
0.0 0.2 REACTOME_ACTIVATION_OF_GENES_BY_ATF4 Genes involved in Activation of Genes by ATF4