Motif ID: Sox5_Sry

Z-value: 1.282

Transcription factors associated with Sox5_Sry:

Gene SymbolEntrez IDGene Name
Sox5 ENSMUSG00000041540.10 Sox5
Sry ENSMUSG00000069036.3 Sry

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Sox5mm10_v2_chr6_-_143947061_1439470880.663.2e-03Click!


Activity profile for motif Sox5_Sry.

activity profile for motif Sox5_Sry


Sorted Z-values histogram for motif Sox5_Sry

Sorted Z-values for motif Sox5_Sry



Network of associatons between targets according to the STRING database.



First level regulatory network of Sox5_Sry

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_-_6722187 6.815 ENSMUST00000182657.1
 Celf2
CUGBP, Elav-like family member 2
chr11_+_94044111 6.148 ENSMUST00000132079.1
 Spag9
sperm associated antigen 9
chr10_+_69706326 5.290 ENSMUST00000182992.1
 Ank3
ankyrin 3, epithelial
chr1_+_34005872 5.084 ENSMUST00000182296.1
 Dst
dystonin
chr9_-_49798905 4.668 ENSMUST00000114476.2
 Ncam1
neural cell adhesion molecule 1
chr9_-_49798729 4.521 ENSMUST00000166811.2
 Ncam1
neural cell adhesion molecule 1
chr12_-_99393010 4.007 ENSMUST00000177451.1
 Foxn3
forkhead box N3
chr2_-_6721890 3.880 ENSMUST00000114927.2
 Celf2
CUGBP, Elav-like family member 2
chr5_+_66968559 3.877 ENSMUST00000127184.1
 Limch1
LIM and calponin homology domains 1
chr9_+_27790947 3.798 ENSMUST00000115243.2
 Opcml
opioid binding protein/cell adhesion molecule-like
chr3_+_101377074 3.525 ENSMUST00000043983.5
 Igsf3
immunoglobulin superfamily, member 3
chr12_+_29528382 3.243 ENSMUST00000049784.9
 Myt1l
myelin transcription factor 1-like
chr8_+_12385769 2.927 ENSMUST00000080795.8
 Gm5607
predicted gene 5607
chr5_+_17574268 2.879 ENSMUST00000030568.7
 Sema3c
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
chr2_-_36104060 2.781 ENSMUST00000112961.3
ENSMUST00000112966.3
 Lhx6

LIM homeobox protein 6

chr1_+_19103022 2.772 ENSMUST00000037294.7
 Tfap2d
transcription factor AP-2, delta
chr1_-_119837613 2.736 ENSMUST00000064091.5
 Ptpn4
protein tyrosine phosphatase, non-receptor type 4
chr19_-_4334001 2.653 ENSMUST00000176653.1
 Kdm2a
lysine (K)-specific demethylase 2A
chr4_-_82505707 2.644 ENSMUST00000107248.1
ENSMUST00000107247.1
 Nfib

nuclear factor I/B

chr9_-_29411736 2.567 ENSMUST00000115236.1
 Ntm
neurotrimin

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 157 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.2 13.4 GO:0010650 positive regulation of cell communication by electrical coupling(GO:0010650) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
1.3 10.3 GO:0090074 negative regulation of protein homodimerization activity(GO:0090074)
3.1 9.2 GO:0001928 regulation of exocyst assembly(GO:0001928)
0.2 9.1 GO:0006376 mRNA splice site selection(GO:0006376)
1.3 5.1 GO:2000795 negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795)
0.2 5.1 GO:0008090 retrograde axonal transport(GO:0008090)
0.1 4.6 GO:0030325 adrenal gland development(GO:0030325)
0.0 4.0 GO:0006470 protein dephosphorylation(GO:0006470)
0.2 3.7 GO:0021684 cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
0.3 3.5 GO:0032808 lacrimal gland development(GO:0032808)
0.2 3.3 GO:0048672 positive regulation of collateral sprouting(GO:0048672)
0.4 3.2 GO:0061368 maternal process involved in parturition(GO:0060137) behavioral response to chemical pain(GO:0061366) behavioral response to formalin induced pain(GO:0061368)
0.3 3.1 GO:0036371 protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371)
0.3 3.1 GO:0042118 endothelial cell activation(GO:0042118)
0.5 2.9 GO:0003350 pulmonary myocardium development(GO:0003350)
0.1 2.9 GO:0071300 cellular response to retinoic acid(GO:0071300)
0.5 2.8 GO:1904936 cerebral cortex GABAergic interneuron migration(GO:0021853) interneuron migration(GO:1904936)
0.0 2.8 GO:0010977 negative regulation of neuron projection development(GO:0010977)
0.3 2.7 GO:0033184 positive regulation of histone ubiquitination(GO:0033184)
0.1 2.6 GO:0030204 chondroitin sulfate metabolic process(GO:0030204)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 75 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 13.8 GO:0031225 anchored component of membrane(GO:0031225)
0.7 13.4 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.0 13.2 GO:0048471 perinuclear region of cytoplasm(GO:0048471)
1.3 5.1 GO:0031673 H zone(GO:0031673)
0.2 5.1 GO:0044300 cerebellar mossy fiber(GO:0044300)
0.0 3.5 GO:0030425 dendrite(GO:0030425)
0.1 3.1 GO:0031430 M band(GO:0031430)
0.0 3.1 GO:0000139 Golgi membrane(GO:0000139)
0.1 2.8 GO:0071565 nBAF complex(GO:0071565)
0.0 2.5 GO:0009898 cytoplasmic side of plasma membrane(GO:0009898)
0.4 2.4 GO:0016035 zeta DNA polymerase complex(GO:0016035)
0.1 2.3 GO:1990635 proximal dendrite(GO:1990635)
0.1 2.3 GO:0098839 postsynaptic density membrane(GO:0098839) postsynaptic specialization membrane(GO:0099634)
0.2 2.2 GO:0001739 sex chromatin(GO:0001739)
0.0 2.2 GO:0016459 myosin complex(GO:0016459)
0.3 2.0 GO:0019907 cyclin-dependent protein kinase activating kinase holoenzyme complex(GO:0019907)
0.0 2.0 GO:1990391 DNA repair complex(GO:1990391)
0.1 1.9 GO:0005865 striated muscle thin filament(GO:0005865)
0.0 1.9 GO:0031519 PcG protein complex(GO:0031519)
0.2 1.7 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 96 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 18.0 GO:0030507 spectrin binding(GO:0030507)
0.1 14.2 GO:0008017 microtubule binding(GO:0008017)
0.2 11.2 GO:0036002 pre-mRNA binding(GO:0036002)
0.5 9.9 GO:0030275 LRR domain binding(GO:0030275)
0.6 9.5 GO:0048273 mitogen-activated protein kinase p38 binding(GO:0048273)
0.0 5.7 GO:0003779 actin binding(GO:0003779)
0.7 4.8 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity(GO:0004726)
0.3 3.9 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.0 3.6 GO:0003714 transcription corepressor activity(GO:0003714)
0.8 3.1 GO:0001011 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.0 3.1 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.1 3.0 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.2 2.9 GO:0038191 neuropilin binding(GO:0038191)
0.4 2.7 GO:0045322 unmethylated CpG binding(GO:0045322)
0.1 2.7 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.4 2.6 GO:0015018 galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity(GO:0015018)
0.2 2.2 GO:0001206 transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206)
0.5 2.0 GO:0034647 histone demethylase activity (H3-trimethyl-K4 specific)(GO:0034647)
0.1 2.0 GO:0070064 proline-rich region binding(GO:0070064)
0.2 1.9 GO:0005523 tropomyosin binding(GO:0005523)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 29 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 10.2 PID_ARF6_TRAFFICKING_PATHWAY Arf6 trafficking events
0.1 7.0 PID_FGF_PATHWAY FGF signaling pathway
0.1 5.5 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.1 4.8 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.1 3.3 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.2 3.0 PID_ARF6_DOWNSTREAM_PATHWAY Arf6 downstream pathway
0.0 2.9 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 2.3 PID_HDAC_CLASSII_PATHWAY Signaling events mediated by HDAC Class II
0.0 1.8 PID_REG_GR_PATHWAY Glucocorticoid receptor regulatory network
0.0 1.3 PID_PDGFRB_PATHWAY PDGFR-beta signaling pathway
0.0 1.2 PID_INTEGRIN_A4B1_PATHWAY Alpha4 beta1 integrin signaling events
0.0 1.2 PID_FAK_PATHWAY Signaling events mediated by focal adhesion kinase
0.0 1.2 PID_LKB1_PATHWAY LKB1 signaling events
0.1 1.1 PID_AP1_PATHWAY AP-1 transcription factor network
0.0 1.1 PID_AR_TF_PATHWAY Regulation of Androgen receptor activity
0.0 1.0 PID_TRKR_PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.0 0.8 PID_THROMBIN_PAR1_PATHWAY PAR1-mediated thrombin signaling events
0.0 0.7 PID_INTEGRIN3_PATHWAY Beta3 integrin cell surface interactions
0.0 0.6 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.0 0.6 PID_MET_PATHWAY Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 38 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 13.4 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.2 9.2 REACTOME_INTERFERON_GAMMA_SIGNALING Genes involved in Interferon gamma signaling
0.2 5.1 REACTOME_RNA_POL_III_TRANSCRIPTION_TERMINATION Genes involved in RNA Polymerase III Transcription Termination
0.2 3.6 REACTOME_CRMPS_IN_SEMA3A_SIGNALING Genes involved in CRMPs in Sema3A signaling
0.0 3.0 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.1 2.9 REACTOME_A_TETRASACCHARIDE_LINKER_SEQUENCE_IS_REQUIRED_FOR_GAG_SYNTHESIS Genes involved in A tetrasaccharide linker sequence is required for GAG synthesis
0.1 2.2 REACTOME_SIGNALING_BY_HIPPO Genes involved in Signaling by Hippo
0.0 2.2 REACTOME_L1CAM_INTERACTIONS Genes involved in L1CAM interactions
0.1 2.0 REACTOME_NOTCH_HLH_TRANSCRIPTION_PATHWAY Genes involved in Notch-HLH transcription pathway
0.0 2.0 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.0 1.9 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.1 1.8 REACTOME_PLATELET_CALCIUM_HOMEOSTASIS Genes involved in Platelet calcium homeostasis
0.1 1.5 REACTOME_NEPHRIN_INTERACTIONS Genes involved in Nephrin interactions
0.1 1.4 REACTOME_SYNTHESIS_OF_PC Genes involved in Synthesis of PC
0.2 1.3 REACTOME_TANDEM_PORE_DOMAIN_POTASSIUM_CHANNELS Genes involved in Tandem pore domain potassium channels
0.0 1.1 REACTOME_SIGNALING_BY_FGFR1_FUSION_MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.1 1.0 REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX Genes involved in Degradation of the extracellular matrix
0.1 0.9 REACTOME_GLYCOGEN_BREAKDOWN_GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.1 0.8 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_EARLY_ENDOSOME_MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane
0.0 0.8 REACTOME_SMOOTH_MUSCLE_CONTRACTION Genes involved in Smooth Muscle Contraction