Motif ID: Tbx1_Eomes

Z-value: 0.888

Transcription factors associated with Tbx1_Eomes:

Gene SymbolEntrez IDGene Name
Eomes ENSMUSG00000032446.8 Eomes
Tbx1 ENSMUSG00000009097.9 Tbx1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Eomesmm10_v2_chr9_+_118478851_118478866-0.456.4e-02Click!


Activity profile for motif Tbx1_Eomes.

activity profile for motif Tbx1_Eomes


Sorted Z-values histogram for motif Tbx1_Eomes

Sorted Z-values for motif Tbx1_Eomes



Network of associatons between targets according to the STRING database.



First level regulatory network of Tbx1_Eomes

PNG image of the network

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Top targets:


Showing 1 to 20 of 157 entries
PromoterScoreRefseqGene SymbolGene Name
chr10_+_26229707 8.726 ENSMUST00000060716.5
ENSMUST00000164660.1
 Samd3

sterile alpha motif domain containing 3

chr1_-_138847579 5.686 ENSMUST00000093486.3
ENSMUST00000046870.6
 Lhx9

LIM homeobox protein 9

chr2_+_164562579 4.294 ENSMUST00000017867.3
ENSMUST00000109344.2
ENSMUST00000109345.2
 Wfdc2


WAP four-disulfide core domain 2


chr17_+_29093763 3.632 ENSMUST00000023829.6
 Cdkn1a
cyclin-dependent kinase inhibitor 1A (P21)
chr10_-_92162753 3.513 ENSMUST00000182197.1
 Rmst
rhabdomyosarcoma 2 associated transcript (non-coding RNA)
chr2_-_57114970 3.489 ENSMUST00000028166.2
 Nr4a2
nuclear receptor subfamily 4, group A, member 2
chr1_+_6730051 3.286 ENSMUST00000043578.6
ENSMUST00000131467.1
ENSMUST00000150761.1
ENSMUST00000151281.1
 St18



suppression of tumorigenicity 18



chr2_-_13011747 3.276 ENSMUST00000061545.5
 C1ql3
C1q-like 3
chr9_-_43239816 3.121 ENSMUST00000034512.5
 Oaf
OAF homolog (Drosophila)
chr11_-_94507337 2.568 ENSMUST00000040692.8
 Mycbpap
MYCBP associated protein
chr10_+_4710119 2.498 ENSMUST00000105588.1
ENSMUST00000105589.1
 Esr1

estrogen receptor 1 (alpha)

chr10_-_120899067 2.367 ENSMUST00000092143.5
 Msrb3
methionine sulfoxide reductase B3
chr6_-_94700137 2.352 ENSMUST00000101126.2
ENSMUST00000032105.4
 Lrig1

leucine-rich repeats and immunoglobulin-like domains 1

chr4_-_35845204 2.227 ENSMUST00000164772.1
ENSMUST00000065173.2
 Lingo2

leucine rich repeat and Ig domain containing 2

chr1_+_132316112 2.116 ENSMUST00000082125.5
ENSMUST00000072177.7
 Nuak2

NUAK family, SNF1-like kinase, 2

chr10_+_56377300 2.033 ENSMUST00000068581.7
 Gja1
gap junction protein, alpha 1
chr1_+_6730135 1.935 ENSMUST00000155921.1
 St18
suppression of tumorigenicity 18
chr11_-_84068357 1.926 ENSMUST00000100705.4
 Dusp14
dual specificity phosphatase 14
chr6_+_7555053 1.897 ENSMUST00000090679.2
ENSMUST00000184986.1
 Tac1

tachykinin 1

chr7_-_28302238 1.895 ENSMUST00000108315.3
 Dll3
delta-like 3 (Drosophila)

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 82 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.1 5.7 GO:0035262 gonad morphogenesis(GO:0035262)
0.4 5.2 GO:2001269 positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:2001269)
0.0 4.7 GO:0010466 negative regulation of peptidase activity(GO:0010466)
0.0 4.5 GO:0050807 regulation of synapse organization(GO:0050807)
0.3 3.8 GO:0007213 G-protein coupled acetylcholine receptor signaling pathway(GO:0007213)
0.4 3.6 GO:0071493 cellular response to UV-B(GO:0071493)
0.1 3.6 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
0.9 3.5 GO:0051866 general adaptation syndrome(GO:0051866)
0.6 2.5 GO:0060745 mammary gland branching involved in pregnancy(GO:0060745)
0.8 2.4 GO:0032474 otolith morphogenesis(GO:0032474)
0.6 2.4 GO:0030091 protein repair(GO:0030091)
0.1 2.1 GO:0042149 cellular response to glucose starvation(GO:0042149)
0.7 2.0 GO:0003104 positive regulation of glomerular filtration(GO:0003104) cell communication by chemical coupling(GO:0010643)
0.9 1.9 GO:0035934 corticosterone secretion(GO:0035934) regulation of corticosterone secretion(GO:2000852)
0.4 1.9 GO:0007386 compartment pattern specification(GO:0007386)
0.2 1.8 GO:0051967 negative regulation of synaptic transmission, glutamatergic(GO:0051967)
0.6 1.7 GO:0045014 detection of carbohydrate stimulus(GO:0009730) detection of hexose stimulus(GO:0009732) detection of monosaccharide stimulus(GO:0034287) carbon catabolite repression of transcription(GO:0045013) negative regulation of transcription by glucose(GO:0045014) detection of glucose(GO:0051594)
0.1 1.7 GO:2000001 regulation of DNA damage checkpoint(GO:2000001)
0.2 1.6 GO:0044027 hypermethylation of CpG island(GO:0044027)
0.2 1.5 GO:0010587 miRNA catabolic process(GO:0010587)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 32 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 4.9 GO:0032993 protein-DNA complex(GO:0032993)
0.1 3.8 GO:0032809 neuronal cell body membrane(GO:0032809)
1.2 3.6 GO:0070557 PCNA-p21 complex(GO:0070557)
0.0 3.5 GO:0005581 collagen trimer(GO:0005581)
0.4 2.5 GO:0097550 transcriptional preinitiation complex(GO:0097550)
0.2 2.1 GO:0005916 fascia adherens(GO:0005916)
0.1 1.8 GO:0032839 dendrite cytoplasm(GO:0032839)
0.3 1.7 GO:0032299 ribonuclease H2 complex(GO:0032299)
0.1 1.6 GO:0001741 XY body(GO:0001741)
0.0 1.5 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.0 1.5 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.1 1.2 GO:1990316 ATG1/ULK1 kinase complex(GO:1990316)
0.2 1.0 GO:0001674 female germ cell nucleus(GO:0001674)
0.0 1.0 GO:0035145 exon-exon junction complex(GO:0035145)
0.2 0.9 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.1 0.9 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.1 0.8 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.1 0.6 GO:0070765 gamma-secretase complex(GO:0070765)
0.0 0.5 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.1 0.4 GO:0031983 vesicle lumen(GO:0031983)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 56 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 4.3 GO:0019828 aspartic-type endopeptidase inhibitor activity(GO:0019828)
0.0 3.9 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.1 3.8 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
1.2 3.6 GO:0019912 cyclin-dependent protein kinase activating kinase activity(GO:0019912)
0.2 3.6 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.8 2.5 GO:0031798 type 1 metabotropic glutamate receptor binding(GO:0031798) RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding(GO:0038052)
0.4 2.4 GO:0033743 peptide-methionine (R)-S-oxide reductase activity(GO:0033743)
0.5 2.0 GO:0086075 gap junction channel activity involved in cardiac conduction electrical coupling(GO:0086075) gap junction channel activity involved in cell communication by electrical coupling(GO:1903763)
0.1 1.9 GO:0005112 Notch binding(GO:0005112)
0.4 1.8 GO:0001640 adenylate cyclase inhibiting G-protein coupled glutamate receptor activity(GO:0001640)
0.2 1.7 GO:0004523 RNA-DNA hybrid ribonuclease activity(GO:0004523)
0.0 1.7 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.2 1.6 GO:0003886 DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.1 1.6 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.1 1.5 GO:0002151 G-quadruplex RNA binding(GO:0002151)
0.1 1.5 GO:0008432 JUN kinase binding(GO:0008432)
0.3 1.3 GO:0035241 protein-arginine omega-N monomethyltransferase activity(GO:0035241)
0.2 1.2 GO:0070728 leucine binding(GO:0070728)
0.1 1.1 GO:0008889 glycerophosphodiester phosphodiesterase activity(GO:0008889)
0.0 1.1 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 23 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.5 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.4 3.6 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.0 3.5 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 1.9 PID_NOTCH_PATHWAY Notch signaling pathway
0.0 1.5 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.0 1.2 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 1.2 PID_ERBB4_PATHWAY ErbB4 signaling events
0.0 1.2 PID_LKB1_PATHWAY LKB1 signaling events
0.0 1.2 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.0 1.0 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression
0.0 0.9 PID_AMB2_NEUTROPHILS_PATHWAY amb2 Integrin signaling
0.0 0.7 PID_AP1_PATHWAY AP-1 transcription factor network
0.0 0.6 PID_SYNDECAN_3_PATHWAY Syndecan-3-mediated signaling events
0.0 0.5 PID_IL23_PATHWAY IL23-mediated signaling events
0.0 0.5 PID_P38_MKK3_6PATHWAY p38 MAPK signaling pathway
0.0 0.4 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.0 0.4 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling
0.0 0.4 PID_REELIN_PATHWAY Reelin signaling pathway
0.0 0.3 PID_PI3K_PLC_TRK_PATHWAY Trk receptor signaling mediated by PI3K and PLC-gamma
0.0 0.2 PID_FOXO_PATHWAY FoxO family signaling

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 29 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.7 REACTOME_G_ALPHA_I_SIGNALLING_EVENTS Genes involved in G alpha (i) signalling events
0.1 3.6 REACTOME_AKT_PHOSPHORYLATES_TARGETS_IN_THE_CYTOSOL Genes involved in AKT phosphorylates targets in the cytosol
0.2 2.2 REACTOME_GAP_JUNCTION_ASSEMBLY Genes involved in Gap junction assembly
0.0 1.9 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.0 1.9 REACTOME_NUCLEAR_SIGNALING_BY_ERBB4 Genes involved in Nuclear signaling by ERBB4
0.1 1.8 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.0 1.8 REACTOME_FORMATION_OF_THE_TERNARY_COMPLEX_AND_SUBSEQUENTLY_THE_43S_COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.1 1.7 REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_BETA_CELLS Genes involved in Regulation of gene expression in beta cells
0.1 1.0 REACTOME_HYALURONAN_METABOLISM Genes involved in Hyaluronan metabolism
0.0 1.0 REACTOME_MRNA_3_END_PROCESSING Genes involved in mRNA 3'-end processing
0.0 0.9 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.0 0.9 REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ Genes involved in Response to elevated platelet cytosolic Ca2+
0.1 0.8 REACTOME_NA_CL_DEPENDENT_NEUROTRANSMITTER_TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.1 0.8 REACTOME_REGULATION_OF_RHEB_GTPASE_ACTIVITY_BY_AMPK Genes involved in Regulation of Rheb GTPase activity by AMPK
0.0 0.8 REACTOME_SIGNALING_BY_EGFR_IN_CANCER Genes involved in Signaling by EGFR in Cancer
0.0 0.8 REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.0 0.7 REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII
0.0 0.7 REACTOME_HORMONE_SENSITIVE_LIPASE_HSL_MEDIATED_TRIACYLGLYCEROL_HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.1 0.5 REACTOME_ORGANIC_CATION_ANION_ZWITTERION_TRANSPORT Genes involved in Organic cation/anion/zwitterion transport
0.0 0.5 REACTOME_IL_6_SIGNALING Genes involved in Interleukin-6 signaling