Motif ID: Vsx1_Uncx_Prrx2_Shox2_Noto

Z-value: 0.980

Transcription factors associated with Vsx1_Uncx_Prrx2_Shox2_Noto:

Gene SymbolEntrez IDGene Name
Noto ENSMUSG00000068302.7 Noto
Prrx2 ENSMUSG00000039476.7 Prrx2
Shox2 ENSMUSG00000027833.10 Shox2
Uncx ENSMUSG00000029546.11 Uncx
Vsx1 ENSMUSG00000033080.8 Vsx1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Uncxmm10_v2_chr5_+_139543889_1395439040.815.5e-05Click!
Prrx2mm10_v2_chr2_+_30834972_308349720.484.6e-02Click!
Shox2mm10_v2_chr3_-_66981279_669813180.126.2e-01Click!


Activity profile for motif Vsx1_Uncx_Prrx2_Shox2_Noto.

activity profile for motif Vsx1_Uncx_Prrx2_Shox2_Noto


Sorted Z-values histogram for motif Vsx1_Uncx_Prrx2_Shox2_Noto

Sorted Z-values for motif Vsx1_Uncx_Prrx2_Shox2_Noto



Network of associatons between targets according to the STRING database.



First level regulatory network of Vsx1_Uncx_Prrx2_Shox2_Noto

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr14_-_48665098 12.330 ENSMUST00000118578.1
 Otx2
orthodenticle homolog 2 (Drosophila)
chr5_+_139543889 12.155 ENSMUST00000174792.1
ENSMUST00000031523.8
 Uncx

UNC homeobox

chr2_+_20737306 9.792 ENSMUST00000114606.1
ENSMUST00000114608.1
 Etl4

enhancer trap locus 4

chr6_-_147264124 7.633 ENSMUST00000052296.6
 Pthlh
parathyroid hormone-like peptide
chr2_-_168767136 7.078 ENSMUST00000029061.5
ENSMUST00000103074.1
 Sall4

sal-like 4 (Drosophila)

chr14_-_118052235 7.054 ENSMUST00000022725.2
 Dct
dopachrome tautomerase
chr2_-_168767029 6.724 ENSMUST00000075044.3
 Sall4
sal-like 4 (Drosophila)
chr8_-_61902669 6.583 ENSMUST00000121785.1
ENSMUST00000034057.7
 Palld

palladin, cytoskeletal associated protein

chr17_+_34592248 6.342 ENSMUST00000038149.6
 Pbx2
pre B cell leukemia homeobox 2
chr3_+_125404292 6.319 ENSMUST00000144344.1
 Ndst4
N-deacetylase/N-sulfotransferase (heparin glucosaminyl) 4
chr3_+_125404072 6.190 ENSMUST00000173932.1
 Ndst4
N-deacetylase/N-sulfotransferase (heparin glucosaminyl) 4
chr3_+_55782500 5.642 ENSMUST00000075422.4
 Mab21l1
mab-21-like 1 (C. elegans)
chr3_+_159839729 4.769 ENSMUST00000068952.5
 Wls
wntless homolog (Drosophila)
chr7_-_49636847 4.768 ENSMUST00000032717.6
 Dbx1
developing brain homeobox 1
chr13_-_53473074 4.672 ENSMUST00000021922.8
 Msx2
msh homeobox 2
chr4_-_97778042 4.646 ENSMUST00000146447.1
 E130114P18Rik
RIKEN cDNA E130114P18 gene
chrX_-_60893430 4.224 ENSMUST00000135107.2
 Sox3
SRY-box containing gene 3
chr13_-_102905740 4.034 ENSMUST00000167462.1
 Mast4
microtubule associated serine/threonine kinase family member 4
chr13_-_102906046 3.969 ENSMUST00000171791.1
 Mast4
microtubule associated serine/threonine kinase family member 4
chr4_-_35845204 3.677 ENSMUST00000164772.1
ENSMUST00000065173.2
 Lingo2

leucine rich repeat and Ig domain containing 2


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 141 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 13.8 GO:0001833 inner cell mass cell proliferation(GO:0001833)
3.4 13.5 GO:0046552 eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate commitment(GO:0046552)
1.5 12.2 GO:0035726 common myeloid progenitor cell proliferation(GO:0035726)
0.1 10.1 GO:0048706 embryonic skeletal system development(GO:0048706)
1.2 7.1 GO:0006570 tyrosine metabolic process(GO:0006570)
1.1 6.9 GO:0060648 mammary gland bud morphogenesis(GO:0060648)
0.8 6.7 GO:0003150 muscular septum morphogenesis(GO:0003150)
0.3 6.6 GO:0071803 keratinocyte development(GO:0003334) positive regulation of podosome assembly(GO:0071803)
1.6 4.8 GO:0061357 Wnt protein secretion(GO:0061355) regulation of Wnt protein secretion(GO:0061356) positive regulation of Wnt protein secretion(GO:0061357)
0.4 4.8 GO:0021521 ventral spinal cord interneuron specification(GO:0021521) cell fate specification involved in pattern specification(GO:0060573)
1.6 4.7 GO:0035880 embryonic nail plate morphogenesis(GO:0035880) positive regulation of catagen(GO:0051795) frontal suture morphogenesis(GO:0060364)
1.5 4.5 GO:0002302 CD8-positive, alpha-beta T cell differentiation involved in immune response(GO:0002302)
0.3 4.3 GO:0021796 cerebral cortex regionalization(GO:0021796)
0.2 4.2 GO:0007530 sex determination(GO:0007530)
0.0 4.1 GO:0051965 positive regulation of synapse assembly(GO:0051965)
0.1 3.9 GO:0042773 ATP synthesis coupled electron transport(GO:0042773)
0.1 3.8 GO:0009954 proximal/distal pattern formation(GO:0009954)
0.1 3.8 GO:0006270 DNA replication initiation(GO:0006270)
0.4 3.5 GO:0010587 miRNA catabolic process(GO:0010587)
0.0 3.4 GO:0018105 peptidyl-serine phosphorylation(GO:0018105)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 57 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 13.7 GO:0000792 heterochromatin(GO:0000792)
0.0 11.1 GO:0005667 transcription factor complex(GO:0005667)
0.3 7.1 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.1 6.6 GO:0002102 podosome(GO:0002102)
0.1 4.8 GO:0032839 dendrite cytoplasm(GO:0032839)
0.3 4.1 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.5 3.1 GO:0000172 ribonuclease MRP complex(GO:0000172)
0.1 3.0 GO:0032809 neuronal cell body membrane(GO:0032809)
0.5 2.9 GO:0000444 MIS12/MIND type complex(GO:0000444)
0.5 2.8 GO:0001674 female germ cell nucleus(GO:0001674)
0.1 2.7 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.0 2.7 GO:0043198 dendritic shaft(GO:0043198)
0.6 2.5 GO:0032280 symmetric synapse(GO:0032280)
0.1 2.4 GO:0000788 nuclear nucleosome(GO:0000788)
0.6 2.3 GO:0060187 cell pole(GO:0060187)
0.2 2.3 GO:0005915 zonula adherens(GO:0005915)
0.1 1.9 GO:0042788 polysomal ribosome(GO:0042788)
0.0 1.9 GO:0000776 kinetochore(GO:0000776)
0.0 1.3 GO:0005902 microvillus(GO:0005902)
0.3 1.2 GO:0033093 Weibel-Palade body(GO:0033093)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 91 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 47.9 GO:0043565 sequence-specific DNA binding(GO:0043565)
0.1 14.1 GO:0001158 enhancer sequence-specific DNA binding(GO:0001158)
1.7 12.2 GO:0015016 [heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.7 7.5 GO:0051428 peptide hormone receptor binding(GO:0051428)
0.5 7.1 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)
0.6 5.6 GO:0031852 mu-type opioid receptor binding(GO:0031852)
0.0 5.6 GO:0016779 nucleotidyltransferase activity(GO:0016779)
0.0 5.5 GO:0000287 magnesium ion binding(GO:0000287)
0.1 4.8 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.2 4.7 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.3 4.5 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.1 4.4 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.1 3.7 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.5 3.6 GO:0070915 lysophosphatidic acid receptor activity(GO:0070915)
0.1 3.3 GO:0015144 carbohydrate transmembrane transporter activity(GO:0015144) carbohydrate transporter activity(GO:1901476)
1.0 3.1 GO:0000171 ribonuclease MRP activity(GO:0000171)
0.4 3.0 GO:0016802 adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.2 2.9 GO:0043522 leucine zipper domain binding(GO:0043522)
0.1 2.8 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.1 2.6 GO:0042813 Wnt-activated receptor activity(GO:0042813)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 25 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 14.2 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.2 7.3 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.1 4.5 PID_CD8_TCR_DOWNSTREAM_PATHWAY Downstream signaling in naïve CD8+ T cells
0.1 4.1 PID_BMP_PATHWAY BMP receptor signaling
0.0 3.8 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.1 3.6 PID_AP1_PATHWAY AP-1 transcription factor network
0.0 3.1 PID_LYSOPHOSPHOLIPID_PATHWAY LPA receptor mediated events
0.1 2.8 ST_WNT_BETA_CATENIN_PATHWAY Wnt/beta-catenin Pathway
0.1 2.8 PID_WNT_NONCANONICAL_PATHWAY Noncanonical Wnt signaling pathway
0.0 2.3 PID_ECADHERIN_STABILIZATION_PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.1 1.9 PID_MYC_PATHWAY C-MYC pathway
0.0 1.6 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.0 1.0 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 0.9 PID_PDGFRA_PATHWAY PDGFR-alpha signaling pathway
0.0 0.8 PID_ATR_PATHWAY ATR signaling pathway
0.0 0.8 PID_HES_HEY_PATHWAY Notch-mediated HES/HEY network
0.0 0.8 PID_RAC1_REG_PATHWAY Regulation of RAC1 activity
0.0 0.8 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.0 0.6 PID_TCPTP_PATHWAY Signaling events mediated by TCPTP
0.0 0.6 PID_PLK1_PATHWAY PLK1 signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 38 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 12.2 REACTOME_HS_GAG_BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.1 10.5 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.1 9.8 REACTOME_G_ALPHA_I_SIGNALLING_EVENTS Genes involved in G alpha (i) signalling events
0.0 3.3 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.0 2.3 REACTOME_RNA_POL_I_PROMOTER_OPENING Genes involved in RNA Polymerase I Promoter Opening
0.0 2.0 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.1 1.9 REACTOME_ERKS_ARE_INACTIVATED Genes involved in ERKs are inactivated
0.2 1.7 REACTOME_PASSIVE_TRANSPORT_BY_AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.1 1.5 REACTOME_FGFR1_LIGAND_BINDING_AND_ACTIVATION Genes involved in FGFR1 ligand binding and activation
0.0 1.4 REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.0 1.3 REACTOME_ABC_FAMILY_PROTEINS_MEDIATED_TRANSPORT Genes involved in ABC-family proteins mediated transport
0.1 1.2 REACTOME_INTRINSIC_PATHWAY Genes involved in Intrinsic Pathway
0.0 1.2 REACTOME_BIOSYNTHESIS_OF_THE_N_GLYCAN_PRECURSOR_DOLICHOL_LIPID_LINKED_OLIGOSACCHARIDE_LLO_AND_TRANSFER_TO_A_NASCENT_PROTEIN Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
0.1 1.1 REACTOME_NOTCH_HLH_TRANSCRIPTION_PATHWAY Genes involved in Notch-HLH transcription pathway
0.0 1.1 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.1 1.0 REACTOME_GLUCURONIDATION Genes involved in Glucuronidation
0.0 1.0 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.0 1.0 REACTOME_RNA_POL_II_TRANSCRIPTION_PRE_INITIATION_AND_PROMOTER_OPENING Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
0.0 0.9 REACTOME_CITRIC_ACID_CYCLE_TCA_CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.0 0.9 REACTOME_NEP_NS2_INTERACTS_WITH_THE_CELLULAR_EXPORT_MACHINERY Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery