Motif ID: Hsf2

Z-value: 2.414


Transcription factors associated with Hsf2:

Gene SymbolEntrez IDGene Name
Hsf2 ENSMUSG00000019878.7 Hsf2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Hsf2mm10_v2_chr10_+_57486354_574864140.039.0e-01Click!


Activity profile for motif Hsf2.

activity profile for motif Hsf2


Sorted Z-values histogram for motif Hsf2

Sorted Z-values for motif Hsf2



Network of associatons between targets according to the STRING database.



First level regulatory network of Hsf2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr10_-_92164666 7.544 ENSMUST00000183123.1
ENSMUST00000182033.1
 Rmst

rhabdomyosarcoma 2 associated transcript (non-coding RNA)

chr17_-_70851189 6.237 ENSMUST00000059775.8
 Tgif1
TGFB-induced factor homeobox 1
chr17_-_70849644 5.801 ENSMUST00000134654.1
ENSMUST00000172229.1
ENSMUST00000127719.1
 Tgif1


TGFB-induced factor homeobox 1


chr10_+_121033960 5.698 ENSMUST00000020439.4
ENSMUST00000175867.1
 Wif1

Wnt inhibitory factor 1

chr14_-_48667508 5.397 ENSMUST00000144465.1
ENSMUST00000133479.1
ENSMUST00000119070.1
ENSMUST00000152018.1
 Otx2



orthodenticle homolog 2 (Drosophila)



chr9_+_44134562 4.852 ENSMUST00000034650.8
ENSMUST00000098852.2
 Mcam

melanoma cell adhesion molecule

chr7_+_16781341 4.732 ENSMUST00000108496.2
 Slc1a5
solute carrier family 1 (neutral amino acid transporter), member 5
chr4_-_154097105 4.689 ENSMUST00000105643.1
ENSMUST00000133533.1
ENSMUST00000097762.4
 Trp73


transformation related protein 73


chr7_-_4752972 4.185 ENSMUST00000183971.1
ENSMUST00000182173.1
ENSMUST00000182738.1
ENSMUST00000184143.1
ENSMUST00000182111.1
ENSMUST00000182048.1
ENSMUST00000063324.7
 Cox6b2






cytochrome c oxidase subunit VIb polypeptide 2






chr5_-_5514730 4.167 ENSMUST00000115445.1
ENSMUST00000179804.1
ENSMUST00000125110.1
ENSMUST00000115446.1
 Cldn12



claudin 12



chr12_-_91746020 4.156 ENSMUST00000166967.1
 Ston2
stonin 2
chr11_-_11970540 4.114 ENSMUST00000109653.1
 Grb10
growth factor receptor bound protein 10
chr5_-_116422858 4.067 ENSMUST00000036991.4
 Hspb8
heat shock protein 8
chr14_+_19751257 4.059 ENSMUST00000022340.3
 Nid2
nidogen 2
chr5_-_5514873 4.002 ENSMUST00000060947.7
 Cldn12
claudin 12
chr1_-_138847579 3.917 ENSMUST00000093486.3
ENSMUST00000046870.6
 Lhx9

LIM homeobox protein 9

chr9_-_114781986 3.892 ENSMUST00000035009.8
ENSMUST00000084867.7
 Cmtm7

CKLF-like MARVEL transmembrane domain containing 7

chr10_+_4710119 3.809 ENSMUST00000105588.1
ENSMUST00000105589.1
 Esr1

estrogen receptor 1 (alpha)

chr2_-_28466266 3.792 ENSMUST00000127683.1
ENSMUST00000086370.4
 1700007K13Rik

RIKEN cDNA 1700007K13 gene

chr9_-_100571049 3.662 ENSMUST00000093792.2
 Slc35g2
solute carrier family 35, member G2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 259 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 15.0 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.2 9.0 GO:0045600 positive regulation of fat cell differentiation(GO:0045600)
1.5 7.5 GO:2000981 negative regulation of mechanoreceptor differentiation(GO:0045632) negative regulation of inner ear receptor cell differentiation(GO:2000981)
0.2 6.8 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)
1.3 5.4 GO:0046552 eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate commitment(GO:0046552)
0.1 5.4 GO:1902750 negative regulation of cell cycle G2/M phase transition(GO:1902750)
0.2 5.2 GO:0060236 regulation of mitotic spindle organization(GO:0060236)
0.7 4.9 GO:1903690 negative regulation of wound healing, spreading of epidermal cells(GO:1903690)
1.2 4.7 GO:0033326 cerebrospinal fluid secretion(GO:0033326)
0.7 4.2 GO:0042535 positive regulation of tumor necrosis factor biosynthetic process(GO:0042535)
0.1 4.2 GO:0050830 defense response to Gram-positive bacterium(GO:0050830)
1.0 4.1 GO:0015825 L-serine transport(GO:0015825)
0.5 4.1 GO:0070874 negative regulation of glycogen biosynthetic process(GO:0045719) negative regulation of glycogen metabolic process(GO:0070874)
0.2 4.1 GO:0030213 hyaluronan biosynthetic process(GO:0030213)
1.0 3.9 GO:0002337 B-1a B cell differentiation(GO:0002337)
0.8 3.9 GO:0035262 gonad morphogenesis(GO:0035262)
0.2 3.9 GO:0046596 regulation of viral entry into host cell(GO:0046596)
1.0 3.8 GO:0060745 mammary gland branching involved in pregnancy(GO:0060745)
1.2 3.7 GO:0030421 defecation(GO:0030421)
0.9 3.7 GO:0045343 MHC class I biosynthetic process(GO:0045341) regulation of MHC class I biosynthetic process(GO:0045343) positive regulation of MHC class I biosynthetic process(GO:0045345) positive regulation of NK T cell activation(GO:0051135)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 122 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 16.6 GO:0005739 mitochondrion(GO:0005739)
0.0 8.7 GO:0009986 cell surface(GO:0009986)
0.1 8.2 GO:0016328 lateral plasma membrane(GO:0016328)
0.1 8.1 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.0 6.3 GO:0016607 nuclear speck(GO:0016607)
0.1 5.4 GO:0016459 myosin complex(GO:0016459)
0.1 5.4 GO:0030136 clathrin-coated vesicle(GO:0030136)
0.0 5.2 GO:0005667 transcription factor complex(GO:0005667)
0.3 5.1 GO:0030061 mitochondrial crista(GO:0030061)
0.1 4.4 GO:0005811 lipid particle(GO:0005811)
0.7 4.3 GO:0097512 cardiac myofibril(GO:0097512)
0.1 4.0 GO:0030315 T-tubule(GO:0030315)
0.5 3.9 GO:0005818 aster(GO:0005818)
0.3 3.9 GO:0045180 basal cortex(GO:0045180)
0.5 3.8 GO:0097550 transcriptional preinitiation complex(GO:0097550)
0.6 3.4 GO:0030062 mitochondrial tricarboxylic acid cycle enzyme complex(GO:0030062)
0.0 3.4 GO:0009897 external side of plasma membrane(GO:0009897)
0.8 3.3 GO:0042567 insulin-like growth factor ternary complex(GO:0042567)
0.0 3.3 GO:0016324 apical plasma membrane(GO:0016324)
0.1 3.1 GO:0005882 intermediate filament(GO:0005882)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 191 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 15.0 GO:0070410 co-SMAD binding(GO:0070410)
0.2 6.9 GO:0044183 protein binding involved in protein folding(GO:0044183)
0.0 6.0 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.2 5.7 GO:0008307 structural constituent of muscle(GO:0008307)
0.1 5.6 GO:0001158 enhancer sequence-specific DNA binding(GO:0001158)
0.1 5.5 GO:0004693 cyclin-dependent protein serine/threonine kinase activity(GO:0004693)
0.1 5.3 GO:0005125 cytokine activity(GO:0005125)
0.4 5.1 GO:0022889 L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889)
0.3 4.7 GO:0097371 MDM2/MDM4 family protein binding(GO:0097371)
0.0 4.6 GO:0003735 structural constituent of ribosome(GO:0003735)
0.1 4.5 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.1 4.4 GO:0017147 Wnt-protein binding(GO:0017147)
0.1 4.4 GO:0005158 insulin receptor binding(GO:0005158)
0.4 4.3 GO:0008474 palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.0 4.1 GO:0000987 core promoter proximal region sequence-specific DNA binding(GO:0000987) core promoter proximal region DNA binding(GO:0001159)
0.4 3.9 GO:0061676 importin-alpha family protein binding(GO:0061676)
1.3 3.8 GO:0031798 type 1 metabotropic glutamate receptor binding(GO:0031798) RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding(GO:0038052)
0.1 3.8 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.4 3.7 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.2 3.7 GO:0030957 Tat protein binding(GO:0030957)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 50 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 23.9 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.1 10.4 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 8.6 PID_ERA_GENOMIC_PATHWAY Validated nuclear estrogen receptor alpha network
0.2 6.8 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.2 6.6 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.2 6.3 PID_AURORA_A_PATHWAY Aurora A signaling
0.2 5.9 PID_ATM_PATHWAY ATM pathway
0.1 5.4 PID_PS1_PATHWAY Presenilin action in Notch and Wnt signaling
0.1 5.3 PID_RET_PATHWAY Signaling events regulated by Ret tyrosine kinase
0.1 4.2 PID_SYNDECAN_4_PATHWAY Syndecan-4-mediated signaling events
0.1 4.2 PID_IFNG_PATHWAY IFN-gamma pathway
0.1 4.1 NABA_BASEMENT_MEMBRANES Genes encoding structural components of basement membranes
0.1 4.1 PID_PLK1_PATHWAY PLK1 signaling events
0.1 4.1 PID_RHOA_REG_PATHWAY Regulation of RhoA activity
0.1 3.7 PID_BMP_PATHWAY BMP receptor signaling
0.0 3.2 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 2.5 PID_CIRCADIAN_PATHWAY Circadian rhythm pathway
0.1 2.4 PID_BARD1_PATHWAY BARD1 signaling events
0.1 2.3 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 2.3 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 67 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 15.1 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.2 7.8 REACTOME_TIGHT_JUNCTION_INTERACTIONS Genes involved in Tight junction interactions
0.1 7.2 REACTOME_DESTABILIZATION_OF_MRNA_BY_AUF1_HNRNP_D0 Genes involved in Destabilization of mRNA by AUF1 (hnRNP D0)
0.1 6.6 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.2 6.5 REACTOME_ASSOCIATION_OF_TRIC_CCT_WITH_TARGET_PROTEINS_DURING_BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.1 5.7 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.1 5.5 REACTOME_G1_PHASE Genes involved in G1 Phase
0.0 5.0 REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.4 4.1 REACTOME_RECEPTOR_LIGAND_BINDING_INITIATES_THE_SECOND_PROTEOLYTIC_CLEAVAGE_OF_NOTCH_RECEPTOR Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.2 4.1 REACTOME_SIGNAL_ATTENUATION Genes involved in Signal attenuation
0.1 3.8 REACTOME_NUCLEAR_SIGNALING_BY_ERBB4 Genes involved in Nuclear signaling by ERBB4
0.4 3.6 REACTOME_BILE_SALT_AND_ORGANIC_ANION_SLC_TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.2 3.6 REACTOME_SIGNALING_BY_BMP Genes involved in Signaling by BMP
0.2 3.4 REACTOME_CITRIC_ACID_CYCLE_TCA_CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.2 3.3 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.3 3.0 REACTOME_REMOVAL_OF_THE_FLAP_INTERMEDIATE_FROM_THE_C_STRAND Genes involved in Removal of the Flap Intermediate from the C-strand
0.1 2.9 REACTOME_FORMATION_OF_THE_TERNARY_COMPLEX_AND_SUBSEQUENTLY_THE_43S_COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.1 2.8 REACTOME_HS_GAG_BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.1 2.7 REACTOME_ACTIVATED_AMPK_STIMULATES_FATTY_ACID_OXIDATION_IN_MUSCLE Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle
0.4 2.5 REACTOME_REPAIR_SYNTHESIS_FOR_GAP_FILLING_BY_DNA_POL_IN_TC_NER Genes involved in Repair synthesis for gap-filling by DNA polymerase in TC-NER