Motif ID: E2f7

Z-value: 1.707


Transcription factors associated with E2f7:

Gene SymbolEntrez IDGene Name
E2f7 ENSMUSG00000020185.10 E2f7

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
E2f7mm10_v2_chr10_+_110745433_1107455720.484.3e-02Click!


Activity profile for motif E2f7.

activity profile for motif E2f7


Sorted Z-values histogram for motif E2f7

Sorted Z-values for motif E2f7



Network of associatons between targets according to the STRING database.



First level regulatory network of E2f7

PNG image of the network

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Top targets:


Showing 1 to 20 of 112 entries
PromoterScoreRefseqGene SymbolGene Name
chr9_+_3037111 11.392 ENSMUST00000177969.1
 Gm10715
predicted gene 10715
chr9_+_3013140 11.331 ENSMUST00000143083.2
 Gm10721
predicted gene 10721
chr9_+_3025417 10.210 ENSMUST00000075573.6
 Gm10717
predicted gene 10717
chr9_+_3015654 8.540 ENSMUST00000099050.3
 Gm10720
predicted gene 10720
chr9_+_3017408 8.150 ENSMUST00000099049.3
 Gm10719
predicted gene 10719
chr7_-_116308241 7.105 ENSMUST00000183057.1
ENSMUST00000182487.1
ENSMUST00000181998.1
 Plekha7


pleckstrin homology domain containing, family A member 7


chr4_+_108579445 4.378 ENSMUST00000102744.3
 Orc1
origin recognition complex, subunit 1
chr12_+_24708984 4.210 ENSMUST00000154588.1
 Rrm2
ribonucleotide reductase M2
chr13_-_100775844 3.854 ENSMUST00000075550.3
 Cenph
centromere protein H
chr12_+_24708241 3.557 ENSMUST00000020980.5
 Rrm2
ribonucleotide reductase M2
chr6_-_67037399 3.493 ENSMUST00000043098.6
 Gadd45a
growth arrest and DNA-damage-inducible 45 alpha
chr10_-_69352886 3.487 ENSMUST00000119827.1
ENSMUST00000020099.5
 Cdk1

cyclin-dependent kinase 1

chr13_-_21783391 3.444 ENSMUST00000099704.3
 Hist1h3i
histone cluster 1, H3i
chr11_+_102248842 3.123 ENSMUST00000100392.4
 BC030867
cDNA sequence BC030867
chr13_+_23581563 2.919 ENSMUST00000102968.1
 Hist1h4d
histone cluster 1, H4d
chr11_-_77513335 2.898 ENSMUST00000060417.4
 Trp53i13
transformation related protein 53 inducible protein 13
chr10_+_3973086 2.799 ENSMUST00000117291.1
ENSMUST00000120585.1
ENSMUST00000043735.7
 Mthfd1l


methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like


chr14_-_20388822 2.751 ENSMUST00000022345.6
 Dnajc9
DnaJ (Hsp40) homolog, subfamily C, member 9
chr11_-_6444352 2.639 ENSMUST00000093346.5
ENSMUST00000109737.2
 H2afv

H2A histone family, member V

chr8_+_75109528 2.616 ENSMUST00000164309.1
 Mcm5
minichromosome maintenance deficient 5, cell division cycle 46 (S. cerevisiae)

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 59 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 10.5 GO:0006342 chromatin silencing(GO:0006342)
0.4 7.8 GO:0009263 deoxyribonucleotide biosynthetic process(GO:0009263)
1.2 7.1 GO:0045218 zonula adherens maintenance(GO:0045218)
0.2 6.4 GO:0034723 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
1.1 4.4 GO:0070318 positive regulation of G0 to G1 transition(GO:0070318)
0.4 4.4 GO:0002227 innate immune response in mucosa(GO:0002227)
0.4 3.7 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
0.3 3.5 GO:0000185 activation of MAPKKK activity(GO:0000185)
0.6 2.8 GO:0046654 tetrahydrofolate biosynthetic process(GO:0046654)
0.2 2.7 GO:0051382 kinetochore assembly(GO:0051382)
0.1 2.6 GO:0006270 DNA replication initiation(GO:0006270)
0.1 2.6 GO:0090224 regulation of mitotic spindle organization(GO:0060236) regulation of spindle organization(GO:0090224)
0.5 2.5 GO:0048631 regulation of skeletal muscle tissue growth(GO:0048631)
0.5 2.5 GO:0000454 snoRNA guided rRNA pseudouridine synthesis(GO:0000454)
0.1 2.5 GO:2000001 regulation of DNA damage checkpoint(GO:2000001)
0.0 2.5 GO:0032781 positive regulation of ATPase activity(GO:0032781)
0.2 2.4 GO:0000212 meiotic spindle organization(GO:0000212)
0.3 2.3 GO:0000056 ribosomal small subunit export from nucleus(GO:0000056)
0.3 2.3 GO:0090166 Golgi disassembly(GO:0090166)
0.3 2.1 GO:1990086 lens fiber cell apoptotic process(GO:1990086)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 39 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.6 7.8 GO:0005971 ribonucleoside-diphosphate reductase complex(GO:0005971)
0.2 7.7 GO:0000788 nuclear nucleosome(GO:0000788)
0.2 7.5 GO:0000786 nucleosome(GO:0000786)
0.6 7.1 GO:0005915 zonula adherens(GO:0005915)
0.8 6.1 GO:0005664 origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
0.0 4.5 GO:0016607 nuclear speck(GO:0016607)
0.1 4.3 GO:0005876 spindle microtubule(GO:0005876)
0.3 4.2 GO:0042555 MCM complex(GO:0042555)
0.0 3.4 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.0 2.7 GO:0000776 kinetochore(GO:0000776)
0.6 2.5 GO:0090661 box H/ACA telomerase RNP complex(GO:0090661)
0.2 2.5 GO:0005662 DNA replication factor A complex(GO:0005662)
0.0 2.4 GO:0072686 mitotic spindle(GO:0072686)
0.8 2.3 GO:0031074 nucleocytoplasmic shuttling complex(GO:0031074)
0.3 1.9 GO:0031298 replication fork protection complex(GO:0031298)
0.0 1.9 GO:0005741 mitochondrial outer membrane(GO:0005741)
0.1 1.7 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.5 1.5 GO:0043625 delta DNA polymerase complex(GO:0043625)
0.2 1.4 GO:0005638 lamin filament(GO:0005638)
0.1 1.4 GO:0005686 U2 snRNP(GO:0005686)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 44 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 8.5 GO:0070097 delta-catenin binding(GO:0070097)
1.6 7.8 GO:0061731 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.0 6.3 GO:0046982 protein heterodimerization activity(GO:0046982)
0.1 4.8 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.3 4.4 GO:0003688 DNA replication origin binding(GO:0003688)
0.0 4.1 GO:0001047 core promoter binding(GO:0001047)
0.2 3.4 GO:0035173 histone kinase activity(GO:0035173)
0.0 3.4 GO:0031072 heat shock protein binding(GO:0031072)
0.0 2.9 GO:0042393 histone binding(GO:0042393)
0.7 2.8 GO:0004477 methenyltetrahydrofolate cyclohydrolase activity(GO:0004477) methylenetetrahydrofolate dehydrogenase (NADP+) activity(GO:0004488)
0.0 2.6 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.4 2.5 GO:0034513 box H/ACA snoRNA binding(GO:0034513)
0.4 2.3 GO:0070883 pre-miRNA binding(GO:0070883)
0.4 2.1 GO:0043515 kinetochore binding(GO:0043515)
0.2 2.0 GO:0098505 G-rich strand telomeric DNA binding(GO:0098505)
0.1 1.9 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.1 1.9 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)
0.2 1.5 GO:0008296 3'-5'-exodeoxyribonuclease activity(GO:0008296)
0.1 1.4 GO:0043274 phospholipase binding(GO:0043274)
0.2 1.3 GO:0003910 DNA ligase activity(GO:0003909) DNA ligase (ATP) activity(GO:0003910)

Gene overrepresentation in C2:CP category:

Showing 1 to 15 of 15 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 16.2 PID_E2F_PATHWAY E2F transcription factor network
0.1 7.1 PID_ECADHERIN_STABILIZATION_PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.2 6.4 PID_ATR_PATHWAY ATR signaling pathway
0.1 5.8 PID_AURORA_A_PATHWAY Aurora A signaling
0.5 4.6 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.0 2.8 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.0 2.6 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 2.2 PID_SMAD2_3NUCLEAR_PATHWAY Regulation of nuclear SMAD2/3 signaling
0.0 1.5 PID_ANGIOPOIETIN_RECEPTOR_PATHWAY Angiopoietin receptor Tie2-mediated signaling
0.0 1.4 PID_CASPASE_PATHWAY Caspase cascade in apoptosis
0.1 1.3 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.0 1.0 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.0 0.6 PID_PRL_SIGNALING_EVENTS_PATHWAY Signaling events mediated by PRL
0.0 0.4 PID_ATM_PATHWAY ATM pathway
0.0 0.2 PID_NFKAPPAB_ATYPICAL_PATHWAY Atypical NF-kappaB pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 26 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 11.1 REACTOME_PACKAGING_OF_TELOMERE_ENDS Genes involved in Packaging Of Telomere Ends
0.8 7.9 REACTOME_E2F_ENABLED_INHIBITION_OF_PRE_REPLICATION_COMPLEX_FORMATION Genes involved in E2F-enabled inhibition of pre-replication complex formation
0.5 7.8 REACTOME_G1_S_SPECIFIC_TRANSCRIPTION Genes involved in G1/S-Specific Transcription
0.5 6.3 REACTOME_UNWINDING_OF_DNA Genes involved in Unwinding of DNA
0.2 5.5 REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.2 4.8 REACTOME_RNA_POL_I_PROMOTER_OPENING Genes involved in RNA Polymerase I Promoter Opening
0.4 4.0 REACTOME_REMOVAL_OF_THE_FLAP_INTERMEDIATE_FROM_THE_C_STRAND Genes involved in Removal of the Flap Intermediate from the C-strand
0.0 2.5 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.1 2.3 REACTOME_MICRORNA_MIRNA_BIOGENESIS Genes involved in MicroRNA (miRNA) Biogenesis
1.1 2.1 REACTOME_CDC6_ASSOCIATION_WITH_THE_ORC_ORIGIN_COMPLEX Genes involved in CDC6 association with the ORC:origin complex
0.1 1.9 REACTOME_G0_AND_EARLY_G1 Genes involved in G0 and Early G1
0.0 1.4 REACTOME_MEIOTIC_SYNAPSIS Genes involved in Meiotic Synapsis
0.0 1.3 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.1 1.2 REACTOME_G2_M_DNA_DAMAGE_CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.0 1.0 REACTOME_TIE2_SIGNALING Genes involved in Tie2 Signaling
0.0 1.0 REACTOME_KINESINS Genes involved in Kinesins
0.0 1.0 REACTOME_MRNA_SPLICING_MINOR_PATHWAY Genes involved in mRNA Splicing - Minor Pathway
0.0 1.0 REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT Genes involved in Mitochondrial Protein Import
0.0 0.8 REACTOME_APOPTOSIS_INDUCED_DNA_FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.0 0.8 REACTOME_CHONDROITIN_SULFATE_BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis