Motif ID: Foxa3

Z-value: 0.955


Transcription factors associated with Foxa3:

Gene SymbolEntrez IDGene Name
Foxa3 ENSMUSG00000040891.5 Foxa3



Activity profile for motif Foxa3.

activity profile for motif Foxa3


Sorted Z-values histogram for motif Foxa3

Sorted Z-values for motif Foxa3



Network of associatons between targets according to the STRING database.



First level regulatory network of Foxa3

PNG image of the network

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Top targets:


Showing 1 to 20 of 154 entries
PromoterScoreRefseqGene SymbolGene Name
chr9_+_53850243 4.856 ENSMUST00000048485.5
 Sln
sarcolipin
chr16_+_91269759 3.947 ENSMUST00000056882.5
 Olig1
oligodendrocyte transcription factor 1
chr7_-_103813913 3.000 ENSMUST00000098192.3
 Hbb-bt
hemoglobin, beta adult t chain
chr1_+_17145357 2.612 ENSMUST00000026879.7
 Gdap1
ganglioside-induced differentiation-associated-protein 1
chr7_-_103827922 2.230 ENSMUST00000023934.6
ENSMUST00000153218.1
 Hbb-bs

hemoglobin, beta adult s chain

chr10_+_60106452 2.164 ENSMUST00000165024.2
 Spock2
sparc/osteonectin, cwcv and kazal-like domains proteoglycan 2
chr4_+_42916647 2.051 ENSMUST00000132173.1
ENSMUST00000107975.1
 N28178

expressed sequence N28178

chr4_+_102430047 1.902 ENSMUST00000172616.1
 Pde4b
phosphodiesterase 4B, cAMP specific
chr18_+_67133713 1.877 ENSMUST00000076605.7
 Gnal
guanine nucleotide binding protein, alpha stimulating, olfactory type
chr13_+_16011851 1.874 ENSMUST00000042603.6
 Inhba
inhibin beta-A
chr19_+_26623419 1.703 ENSMUST00000176584.1
 Smarca2
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
chr11_-_26210553 1.702 ENSMUST00000101447.3
 5730522E02Rik
RIKEN cDNA 5730522E02 gene
chr17_+_70522083 1.700 ENSMUST00000148486.1
ENSMUST00000133717.1
 Dlgap1

discs, large (Drosophila) homolog-associated protein 1

chr8_-_84773381 1.628 ENSMUST00000109764.1
 Nfix
nuclear factor I/X
chr5_-_103211251 1.594 ENSMUST00000060871.5
ENSMUST00000112846.1
ENSMUST00000170792.1
ENSMUST00000112847.2
 Mapk10



mitogen-activated protein kinase 10



chr4_+_42922253 1.579 ENSMUST00000139100.1
 N28178
expressed sequence N28178
chr4_-_116405986 1.520 ENSMUST00000123072.1
ENSMUST00000144281.1
 Mast2

microtubule associated serine/threonine kinase 2

chr13_+_23934434 1.443 ENSMUST00000072391.1
 Hist1h2aa
histone cluster 1, H2aa
chr2_+_140395309 1.419 ENSMUST00000110067.1
ENSMUST00000110064.1
ENSMUST00000110063.1
ENSMUST00000110062.1
ENSMUST00000078027.5
ENSMUST00000043836.7
 Macrod2





MACRO domain containing 2





chr3_+_68584154 1.417 ENSMUST00000182997.1
 Schip1
schwannomin interacting protein 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 69 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.2 4.9 GO:1901894 regulation of calcium-transporting ATPase activity(GO:1901894)
0.2 2.9 GO:0070842 aggresome assembly(GO:0070842)
0.1 2.6 GO:0008053 mitochondrial fusion(GO:0008053)
0.0 2.5 GO:0034605 cellular response to heat(GO:0034605)
0.3 2.3 GO:0071420 cellular response to histamine(GO:0071420)
0.2 2.2 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.4 1.9 GO:0042636 negative regulation of hair cycle(GO:0042636) progesterone secretion(GO:0042701) negative regulation of hair follicle development(GO:0051799) positive regulation of ovulation(GO:0060279)
0.3 1.9 GO:0009405 pathogenesis(GO:0009405)
0.1 1.9 GO:1901898 negative regulation of relaxation of cardiac muscle(GO:1901898)
0.2 1.7 GO:0035887 aortic smooth muscle cell differentiation(GO:0035887)
0.1 1.7 GO:2000096 positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096)
0.3 1.6 GO:0007258 JUN phosphorylation(GO:0007258)
0.2 1.6 GO:1904217 regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity(GO:1904217) positive regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity(GO:1904219) regulation of serine C-palmitoyltransferase activity(GO:1904220) positive regulation of serine C-palmitoyltransferase activity(GO:1904222)
0.1 1.6 GO:0021684 cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
0.2 1.5 GO:0045075 interleukin-12 biosynthetic process(GO:0042090) regulation of interleukin-12 biosynthetic process(GO:0045075)
0.4 1.4 GO:0051725 protein de-ADP-ribosylation(GO:0051725)
0.1 1.4 GO:0001553 luteinization(GO:0001553)
0.0 1.3 GO:0006376 mRNA splice site selection(GO:0006376)
0.0 1.3 GO:0050919 negative chemotaxis(GO:0050919)
0.4 1.2 GO:0002182 cytoplasmic translational elongation(GO:0002182) regulation of cytoplasmic translational elongation(GO:1900247) negative regulation of cytoplasmic translational elongation(GO:1900248)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 34 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.3 5.2 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.2 4.9 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.0 4.9 GO:0045211 postsynaptic membrane(GO:0045211)
0.1 2.6 GO:0031307 integral component of mitochondrial outer membrane(GO:0031307)
0.1 2.5 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.2 2.3 GO:1902711 GABA-A receptor complex(GO:1902711)
0.6 1.9 GO:0043512 inhibin A complex(GO:0043512)
0.1 1.9 GO:0000930 gamma-tubulin complex(GO:0000930)
0.1 1.7 GO:0071564 npBAF complex(GO:0071564)
0.0 1.7 GO:0008023 transcription elongation factor complex(GO:0008023)
0.0 1.6 GO:0043204 perikaryon(GO:0043204)
0.1 1.2 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.0 1.2 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.1 1.1 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.1 1.0 GO:0060293 P granule(GO:0043186) pole plasm(GO:0045495) germ plasm(GO:0060293)
0.1 0.9 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.2 0.7 GO:0043259 laminin-1 complex(GO:0005606) laminin-10 complex(GO:0043259)
0.1 0.7 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.1 0.6 GO:0097433 dense body(GO:0097433)
0.0 0.6 GO:0071437 invadopodium(GO:0071437)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 48 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.3 5.2 GO:0031721 haptoglobin binding(GO:0031720) hemoglobin alpha binding(GO:0031721)
0.0 2.8 GO:0008017 microtubule binding(GO:0008017)
0.1 2.6 GO:0004364 glutathione transferase activity(GO:0004364)
0.0 2.4 GO:0050840 extracellular matrix binding(GO:0050840)
0.1 2.3 GO:0004890 GABA-A receptor activity(GO:0004890)
0.0 2.3 GO:0005516 calmodulin binding(GO:0005516)
0.3 1.9 GO:0070699 type II activin receptor binding(GO:0070699)
0.1 1.9 GO:0031683 G-protein beta/gamma-subunit complex binding(GO:0031683)
0.1 1.9 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0 1.7 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
0.4 1.6 GO:0016909 JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.1 1.4 GO:0022889 L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889)
0.0 1.4 GO:0019213 deacetylase activity(GO:0019213)
0.0 1.3 GO:0036002 pre-mRNA binding(GO:0036002)
0.1 1.2 GO:0001158 enhancer sequence-specific DNA binding(GO:0001158)
0.1 1.2 GO:0035925 mRNA 3'-UTR AU-rich region binding(GO:0035925)
0.0 1.1 GO:0048365 Rac GTPase binding(GO:0048365)
0.2 0.9 GO:0047275 glucosaminylgalactosylglucosylceramide beta-galactosyltransferase activity(GO:0047275)
0.1 0.9 GO:0022848 acetylcholine-gated cation channel activity(GO:0022848)
0.0 0.9 GO:0050699 WW domain binding(GO:0050699)

Gene overrepresentation in C2:CP category:

Showing 1 to 19 of 19 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.6 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 2.0 PID_TRKR_PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.1 1.9 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.0 1.9 PID_ALK1_PATHWAY ALK1 signaling events
0.0 1.8 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 1.7 PID_AR_TF_PATHWAY Regulation of Androgen receptor activity
0.0 1.6 ST_GRANULE_CELL_SURVIVAL_PATHWAY Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway.
0.0 1.1 PID_RAC1_REG_PATHWAY Regulation of RAC1 activity
0.0 1.0 PID_AURORA_A_PATHWAY Aurora A signaling
0.0 0.9 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.0 0.9 PID_IL6_7_PATHWAY IL6-mediated signaling events
0.1 0.7 PID_INTEGRIN4_PATHWAY Alpha6 beta4 integrin-ligand interactions
0.0 0.7 PID_IL3_PATHWAY IL3-mediated signaling events
0.0 0.7 PID_REG_GR_PATHWAY Glucocorticoid receptor regulatory network
0.0 0.6 PID_S1P_S1P4_PATHWAY S1P4 pathway
0.0 0.6 ST_ERK1_ERK2_MAPK_PATHWAY ERK1/ERK2 MAPK Pathway
0.0 0.5 PID_ECADHERIN_STABILIZATION_PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.0 0.4 PID_IL12_STAT4_PATHWAY IL12 signaling mediated by STAT4
0.0 0.4 PID_IGF1_PATHWAY IGF1 pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 17 of 17 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.0 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.1 2.3 REACTOME_GABA_A_RECEPTOR_ACTIVATION Genes involved in GABA A receptor activation
0.5 1.9 REACTOME_GLYCOPROTEIN_HORMONES Genes involved in Glycoprotein hormones
0.4 1.9 REACTOME_OLFACTORY_SIGNALING_PATHWAY Genes involved in Olfactory Signaling Pathway
0.1 1.6 REACTOME_ACTIVATION_OF_THE_AP1_FAMILY_OF_TRANSCRIPTION_FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.1 0.9 REACTOME_PRESYNAPTIC_NICOTINIC_ACETYLCHOLINE_RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors
0.0 0.9 REACTOME_BRANCHED_CHAIN_AMINO_ACID_CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.1 0.8 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_EARLY_ENDOSOME_MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane
0.0 0.6 REACTOME_G_PROTEIN_ACTIVATION Genes involved in G-protein activation
0.0 0.5 REACTOME_SIGNALING_BY_NOTCH4 Genes involved in Signaling by NOTCH4
0.0 0.5 REACTOME_SIGNALING_BY_FGFR1_FUSION_MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.0 0.5 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.1 0.4 REACTOME_DOWNSTREAM_SIGNAL_TRANSDUCTION Genes involved in Downstream signal transduction
0.0 0.4 REACTOME_APOPTOSIS_INDUCED_DNA_FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.0 0.4 REACTOME_RNA_POL_III_CHAIN_ELONGATION Genes involved in RNA Polymerase III Chain Elongation
0.0 0.2 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_ATF6_ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.0 0.2 REACTOME_REGULATION_OF_PYRUVATE_DEHYDROGENASE_PDH_COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex