Motif ID: Nkx2-6

Z-value: 0.225


Transcription factors associated with Nkx2-6:

Gene SymbolEntrez IDGene Name
Nkx2-6 ENSMUSG00000044186.9 Nkx2-6



Activity profile for motif Nkx2-6.

activity profile for motif Nkx2-6


Sorted Z-values histogram for motif Nkx2-6

Sorted Z-values for motif Nkx2-6



Network of associatons between targets according to the STRING database.



First level regulatory network of Nkx2-6

PNG image of the network

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Top targets:


Showing 1 to 18 of 18 entries
PromoterScoreRefseqGene SymbolGene Name
chr7_-_116237767 0.393 ENSMUST00000182834.1
 Plekha7
pleckstrin homology domain containing, family A member 7
chr7_-_116031047 0.359 ENSMUST00000106612.1
 Sox6
SRY-box containing gene 6
chr10_+_52358767 0.334 ENSMUST00000180473.1
 Gm26741
predicted gene, 26741
chr4_-_109665249 0.212 ENSMUST00000063531.4
 Cdkn2c
cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
chr1_-_156034826 0.194 ENSMUST00000141878.1
ENSMUST00000123705.1
 Tor1aip1

torsin A interacting protein 1

chr5_+_110330697 0.177 ENSMUST00000112481.1
 Pole
polymerase (DNA directed), epsilon
chr1_-_156034800 0.171 ENSMUST00000169241.1
 Tor1aip1
torsin A interacting protein 1
chr15_-_78773452 0.169 ENSMUST00000018313.5
 Mfng
MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
chr3_+_87525572 0.154 ENSMUST00000170036.1
ENSMUST00000117293.1
 Etv3

ets variant gene 3

chr1_+_156035392 0.153 ENSMUST00000111757.3
 Tor1aip2
torsin A interacting protein 2
chr4_+_62619515 0.148 ENSMUST00000084521.4
ENSMUST00000107424.1
 Rgs3

regulator of G-protein signaling 3

chr2_+_3114220 0.116 ENSMUST00000072955.5
 Fam171a1
family with sequence similarity 171, member A1
chr2_-_121456693 0.105 ENSMUST00000110613.2
ENSMUST00000056312.3
 Serinc4

serine incorporator 4

chr4_-_91399984 0.067 ENSMUST00000102799.3
 Elavl2
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)
chr14_+_54360826 0.066 ENSMUST00000000985.5
 Oxa1l
oxidase assembly 1-like
chr3_+_62419668 0.056 ENSMUST00000161057.1
 Arhgef26
Rho guanine nucleotide exchange factor (GEF) 26
chr17_-_45599603 0.025 ENSMUST00000171847.1
ENSMUST00000166633.1
ENSMUST00000169729.1
 Slc29a1


solute carrier family 29 (nucleoside transporters), member 1


chr19_+_8802486 0.020 ENSMUST00000172175.1
 Zbtb3
zinc finger and BTB domain containing 3

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 8 of 8 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 0.4 GO:0045218 zonula adherens maintenance(GO:0045218)
0.0 0.4 GO:0071763 nuclear membrane organization(GO:0071763)
0.0 0.4 GO:2000741 positive regulation of mesenchymal stem cell differentiation(GO:2000741)
0.1 0.2 GO:0045004 DNA replication proofreading(GO:0045004)
0.0 0.2 GO:0002315 marginal zone B cell differentiation(GO:0002315)
0.0 0.2 GO:0097011 cellular response to granulocyte macrophage colony-stimulating factor stimulus(GO:0097011)
0.0 0.2 GO:0090435 protein localization to nuclear envelope(GO:0090435)
0.0 0.1 GO:0033615 mitochondrial proton-transporting ATP synthase complex assembly(GO:0033615)

Gene overrepresentation in cellular_component category:

Showing 1 to 3 of 3 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.4 GO:0005915 zonula adherens(GO:0005915)
0.0 0.2 GO:0008622 epsilon DNA polymerase complex(GO:0008622)
0.0 0.2 GO:0090571 RNA polymerase II transcription repressor complex(GO:0090571)

Gene overrepresentation in molecular_function category:

Showing 1 to 6 of 6 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.4 GO:0070097 delta-catenin binding(GO:0070097)
0.0 0.4 GO:0005521 lamin binding(GO:0005521)
0.1 0.2 GO:0008310 single-stranded DNA 3'-5' exodeoxyribonuclease activity(GO:0008310)
0.1 0.2 GO:0033829 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
0.0 0.2 GO:0017151 DEAD/H-box RNA helicase binding(GO:0017151)
0.0 0.2 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 1 of 1 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.2 REACTOME_REPAIR_SYNTHESIS_FOR_GAP_FILLING_BY_DNA_POL_IN_TC_NER Genes involved in Repair synthesis for gap-filling by DNA polymerase in TC-NER