Motif ID: Nr2c1

Z-value: 0.694


Transcription factors associated with Nr2c1:

Gene SymbolEntrez IDGene Name
Nr2c1 ENSMUSG00000005897.8 Nr2c1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nr2c1mm10_v2_chr10_+_94147982_941480230.107.0e-01Click!


Activity profile for motif Nr2c1.

activity profile for motif Nr2c1


Sorted Z-values histogram for motif Nr2c1

Sorted Z-values for motif Nr2c1



Network of associatons between targets according to the STRING database.



First level regulatory network of Nr2c1

PNG image of the network

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Top targets:


Showing 1 to 20 of 103 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_-_46991842 2.127 ENSMUST00000107749.2
 Gabbr2
gamma-aminobutyric acid (GABA) B receptor, 2
chr9_-_29411736 2.091 ENSMUST00000115236.1
 Ntm
neurotrimin
chr15_+_80091320 2.064 ENSMUST00000009728.6
ENSMUST00000009727.5
 Syngr1

synaptogyrin 1

chr9_-_29412204 1.961 ENSMUST00000115237.1
 Ntm
neurotrimin
chr10_-_86498836 1.785 ENSMUST00000120638.1
 Syn3
synapsin III
chr10_+_58813359 1.756 ENSMUST00000135526.2
ENSMUST00000153031.1
 Sh3rf3

SH3 domain containing ring finger 3

chr1_-_155417283 1.723 ENSMUST00000027741.5
 Xpr1
xenotropic and polytropic retrovirus receptor 1
chr12_-_83487708 1.421 ENSMUST00000177959.1
ENSMUST00000178756.1
 Dpf3

D4, zinc and double PHD fingers, family 3

chr7_+_110768169 1.360 ENSMUST00000170374.1
 Ampd3
adenosine monophosphate deaminase 3
chr6_-_142964404 1.274 ENSMUST00000032421.3
 St8sia1
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1
chr6_+_22875496 1.267 ENSMUST00000090568.3
 Ptprz1
protein tyrosine phosphatase, receptor type Z, polypeptide 1
chr9_-_21037775 1.234 ENSMUST00000180870.1
 Gm26592
predicted gene, 26592
chr5_+_117120120 1.211 ENSMUST00000111978.1
 Taok3
TAO kinase 3
chr1_-_58586191 1.186 ENSMUST00000038372.7
ENSMUST00000097724.3
ENSMUST00000161000.1
ENSMUST00000161600.1
 Fam126b



family with sequence similarity 126, member B



chr11_+_75193783 1.160 ENSMUST00000102514.3
 Rtn4rl1
reticulon 4 receptor-like 1
chr2_-_29253001 1.108 ENSMUST00000071201.4
 Ntng2
netrin G2
chr16_-_44139630 1.078 ENSMUST00000137557.1
ENSMUST00000147025.1
 Atp6v1a

ATPase, H+ transporting, lysosomal V1 subunit A

chr11_-_26210553 1.038 ENSMUST00000101447.3
 5730522E02Rik
RIKEN cDNA 5730522E02 gene
chr11_-_76577701 1.004 ENSMUST00000176179.1
 Abr
active BCR-related gene
chr7_+_46397648 0.965 ENSMUST00000160433.1
 Kcnc1
potassium voltage gated channel, Shaw-related subfamily, member 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 41 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 4.5 GO:0010977 negative regulation of neuron projection development(GO:0010977)
0.0 2.2 GO:0099643 neurotransmitter secretion(GO:0007269) signal release from synapse(GO:0099643)
0.1 2.1 GO:0048172 regulation of short-term neuronal synaptic plasticity(GO:0048172)
0.1 2.1 GO:0007214 gamma-aminobutyric acid signaling pathway(GO:0007214)
0.6 1.8 GO:0071929 alpha-tubulin acetylation(GO:0071929)
0.3 1.7 GO:0030643 cellular phosphate ion homeostasis(GO:0030643) phosphate ion transmembrane transport(GO:0035435) cellular trivalent inorganic anion homeostasis(GO:0072502)
0.1 1.5 GO:0036295 cellular response to increased oxygen levels(GO:0036295)
0.2 1.4 GO:0032264 IMP salvage(GO:0032264)
0.0 1.4 GO:0034605 cellular response to heat(GO:0034605)
0.4 1.3 GO:1900149 positive regulation of Schwann cell migration(GO:1900149)
0.1 1.2 GO:0007095 mitotic G2 DNA damage checkpoint(GO:0007095)
0.2 1.0 GO:0043314 negative regulation of neutrophil degranulation(GO:0043314) negative regulation of blood vessel remodeling(GO:0060313)
0.1 1.0 GO:1903818 positive regulation of voltage-gated potassium channel activity(GO:1903818)
0.1 1.0 GO:0048681 negative regulation of axon regeneration(GO:0048681)
0.1 0.7 GO:0010724 regulation of definitive erythrocyte differentiation(GO:0010724)
0.0 0.7 GO:0001553 luteinization(GO:0001553)
0.2 0.6 GO:0070973 COPI-coated vesicle budding(GO:0035964) protein localization to endoplasmic reticulum exit site(GO:0070973)
0.1 0.6 GO:0014874 response to stimulus involved in regulation of muscle adaptation(GO:0014874)
0.0 0.6 GO:2001240 negative regulation of signal transduction in absence of ligand(GO:1901099) negative regulation of extrinsic apoptotic signaling pathway in absence of ligand(GO:2001240)
0.1 0.5 GO:0006646 phosphatidylethanolamine biosynthetic process(GO:0006646)

Gene overrepresentation in cellular_component category:

Showing 1 to 19 of 19 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.6 GO:0030672 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.0 4.1 GO:0031225 anchored component of membrane(GO:0031225)
0.1 2.3 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.4 2.1 GO:0038039 G-protein coupled receptor heterodimeric complex(GO:0038039)
0.2 1.8 GO:0097427 microtubule bundle(GO:0097427)
0.2 1.5 GO:0033180 proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.1 1.4 GO:0071565 nBAF complex(GO:0071565)
0.4 1.3 GO:0072534 perineuronal net(GO:0072534)
0.0 1.0 GO:0030673 axolemma(GO:0030673)
0.0 0.8 GO:0016328 lateral plasma membrane(GO:0016328)
0.0 0.6 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.0 0.6 GO:0016235 aggresome(GO:0016235)
0.0 0.6 GO:0016529 sarcoplasmic reticulum(GO:0016529)
0.0 0.5 GO:0032279 asymmetric synapse(GO:0032279)
0.0 0.4 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.0 0.3 GO:0030127 COPII vesicle coat(GO:0030127)
0.0 0.2 GO:0000308 cytoplasmic cyclin-dependent protein kinase holoenzyme complex(GO:0000308)
0.0 0.2 GO:0036396 MIS complex(GO:0036396) mRNA editing complex(GO:0045293)
0.0 0.1 GO:0031415 NatA complex(GO:0031415)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 26 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 2.1 GO:0004965 G-protein coupled GABA receptor activity(GO:0004965)
0.3 1.8 GO:0004468 lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468)
0.6 1.7 GO:0000822 inositol hexakisphosphate binding(GO:0000822)
0.1 1.5 GO:0046961 proton-transporting ATPase activity, rotational mechanism(GO:0046961)
0.2 1.4 GO:0003876 AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.2 1.3 GO:0003828 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)
0.0 1.3 GO:0017134 fibroblast growth factor binding(GO:0017134)
0.1 1.2 GO:0035374 chondroitin sulfate binding(GO:0035374)
0.1 1.2 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.1 1.0 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.2 0.7 GO:0070139 ubiquitin-like protein-specific endopeptidase activity(GO:0070137) SUMO-specific endopeptidase activity(GO:0070139)
0.0 0.6 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.2 0.5 GO:0052658 inositol-1,4,5-trisphosphate 5-phosphatase activity(GO:0052658)
0.1 0.5 GO:0004103 choline kinase activity(GO:0004103)
0.0 0.5 GO:0005225 volume-sensitive anion channel activity(GO:0005225)
0.0 0.5 GO:0034237 protein kinase A regulatory subunit binding(GO:0034237)
0.1 0.4 GO:0016907 G-protein coupled acetylcholine receptor activity(GO:0016907)
0.0 0.4 GO:0050811 GABA receptor binding(GO:0050811)
0.1 0.3 GO:0043183 vascular endothelial growth factor receptor 1 binding(GO:0043183)
0.0 0.3 GO:0004652 polynucleotide adenylyltransferase activity(GO:0004652)

Gene overrepresentation in C2:CP category:

Showing 1 to 5 of 5 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.2 PID_P38_MKK3_6PATHWAY p38 MAPK signaling pathway
0.0 1.1 NABA_BASEMENT_MEMBRANES Genes encoding structural components of basement membranes
0.0 1.0 PID_RAC1_REG_PATHWAY Regulation of RAC1 activity
0.0 0.6 PID_ARF_3PATHWAY Arf1 pathway
0.0 0.3 PID_VEGF_VEGFR_PATHWAY VEGF and VEGFR signaling network

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 13 of 13 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 2.5 REACTOME_DOPAMINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Dopamine Neurotransmitter Release Cycle
0.2 2.1 REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.1 1.5 REACTOME_INSULIN_RECEPTOR_RECYCLING Genes involved in Insulin receptor recycling
0.1 1.4 REACTOME_PURINE_SALVAGE Genes involved in Purine salvage
0.0 1.0 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.0 1.0 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.1 0.6 REACTOME_COPI_MEDIATED_TRANSPORT Genes involved in COPI Mediated Transport
0.0 0.6 REACTOME_REGULATION_OF_AMPK_ACTIVITY_VIA_LKB1 Genes involved in Regulation of AMPK activity via LKB1
0.1 0.5 REACTOME_REGULATION_OF_INSULIN_SECRETION_BY_ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.0 0.5 REACTOME_SYNTHESIS_OF_PE Genes involved in Synthesis of PE
0.0 0.5 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_PLASMA_MEMBRANE Genes involved in Synthesis of PIPs at the plasma membrane
0.0 0.3 REACTOME_VEGF_LIGAND_RECEPTOR_INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.0 0.2 REACTOME_ACTIVATION_OF_RAC Genes involved in Activation of Rac