Motif ID: Pax5

Z-value: 1.382


Transcription factors associated with Pax5:

Gene SymbolEntrez IDGene Name
Pax5 ENSMUSG00000014030.9 Pax5

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Pax5mm10_v2_chr4_-_44710408_44710418-0.419.3e-02Click!


Activity profile for motif Pax5.

activity profile for motif Pax5


Sorted Z-values histogram for motif Pax5

Sorted Z-values for motif Pax5



Network of associatons between targets according to the STRING database.



First level regulatory network of Pax5

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr3_+_89520152 4.843 ENSMUST00000000811.7
 Kcnn3
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3
chr13_+_83573577 4.601 ENSMUST00000185052.1
 Mef2c
myocyte enhancer factor 2C
chr16_+_45094036 4.352 ENSMUST00000061050.5
 Ccdc80
coiled-coil domain containing 80
chr16_+_45093611 4.235 ENSMUST00000099498.2
 Ccdc80
coiled-coil domain containing 80
chr10_-_110000219 4.005 ENSMUST00000032719.7
 Nav3
neuron navigator 3
chr4_-_64046925 3.898 ENSMUST00000107377.3
 Tnc
tenascin C
chr2_-_162661075 3.672 ENSMUST00000109442.1
ENSMUST00000109445.2
ENSMUST00000109443.1
ENSMUST00000109441.1
 Ptprt



protein tyrosine phosphatase, receptor type, T



chr10_+_127725392 3.644 ENSMUST00000026466.3
 Tac2
tachykinin 2
chr4_-_123664725 3.577 ENSMUST00000147030.1
 Macf1
microtubule-actin crosslinking factor 1
chr3_-_152982240 3.386 ENSMUST00000044278.5
 St6galnac5
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5
chr6_-_18514802 3.326 ENSMUST00000090601.5
 Cttnbp2
cortactin binding protein 2
chr15_-_79164477 3.267 ENSMUST00000040019.4
 Sox10
SRY-box containing gene 10
chr10_-_109764840 3.227 ENSMUST00000163071.1
 Nav3
neuron navigator 3
chr1_-_56972437 3.227 ENSMUST00000042857.7
 Satb2
special AT-rich sequence binding protein 2
chr2_+_91945703 3.100 ENSMUST00000178895.1
 Gm9821
predicted gene 9821
chr5_+_89027959 2.993 ENSMUST00000130041.1
 Slc4a4
solute carrier family 4 (anion exchanger), member 4
chr14_+_45219993 2.967 ENSMUST00000146150.1
 Gpr137c
G protein-coupled receptor 137C
chr7_-_79386943 2.926 ENSMUST00000053718.8
ENSMUST00000179243.1
 Rlbp1

retinaldehyde binding protein 1

chr13_+_109632760 2.841 ENSMUST00000135275.1
 Pde4d
phosphodiesterase 4D, cAMP specific
chr7_-_118243564 2.792 ENSMUST00000179047.1
ENSMUST00000032891.8
 Smg1

SMG1 homolog, phosphatidylinositol 3-kinase-related kinase (C. elegans)


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 338 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 8.0 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.6 7.3 GO:0070842 aggresome assembly(GO:0070842)
1.1 6.7 GO:0010624 regulation of Schwann cell proliferation(GO:0010624)
0.1 5.9 GO:0010811 positive regulation of cell-substrate adhesion(GO:0010811)
0.2 5.7 GO:0007616 long-term memory(GO:0007616)
1.7 5.1 GO:0007521 muscle cell fate determination(GO:0007521)
0.3 5.1 GO:0015701 bicarbonate transport(GO:0015701)
0.0 4.3 GO:0051017 actin filament bundle assembly(GO:0051017) actin filament bundle organization(GO:0061572)
1.0 4.0 GO:0014012 peripheral nervous system axon regeneration(GO:0014012)
0.9 3.6 GO:0007217 tachykinin receptor signaling pathway(GO:0007217)
0.4 3.6 GO:0006620 posttranslational protein targeting to membrane(GO:0006620)
0.1 3.6 GO:0045600 positive regulation of fat cell differentiation(GO:0045600)
0.9 3.5 GO:0099566 regulation of postsynaptic cytosolic calcium ion concentration(GO:0099566)
0.3 3.3 GO:0045161 neuronal ion channel clustering(GO:0045161)
0.2 3.3 GO:0046548 retinal rod cell development(GO:0046548)
0.2 3.3 GO:0009312 oligosaccharide biosynthetic process(GO:0009312)
0.1 3.3 GO:0015807 L-amino acid transport(GO:0015807)
0.2 3.2 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
0.0 3.2 GO:1903955 positive regulation of protein targeting to mitochondrion(GO:1903955)
0.2 3.1 GO:0030033 microvillus assembly(GO:0030033)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 137 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 20.9 GO:0045211 postsynaptic membrane(GO:0045211)
0.0 14.1 GO:0005887 integral component of plasma membrane(GO:0005887)
0.8 12.5 GO:0005614 interstitial matrix(GO:0005614)
0.0 9.2 GO:0060076 excitatory synapse(GO:0060076)
0.1 7.7 GO:0031594 neuromuscular junction(GO:0031594)
0.2 4.8 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.3 4.2 GO:0043083 synaptic cleft(GO:0043083)
0.1 4.0 GO:0005871 kinesin complex(GO:0005871)
0.1 3.6 GO:0031672 A band(GO:0031672)
0.0 3.6 GO:0043197 dendritic spine(GO:0043197) neuron spine(GO:0044309)
0.0 3.6 GO:0008021 synaptic vesicle(GO:0008021)
0.1 3.5 GO:0033268 node of Ranvier(GO:0033268)
0.9 3.4 GO:0097450 astrocyte end-foot(GO:0097450)
0.1 3.4 GO:0002102 podosome(GO:0002102)
0.1 3.3 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.1 3.1 GO:0071339 MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339)
0.4 3.0 GO:0031315 extrinsic component of mitochondrial outer membrane(GO:0031315)
0.5 2.8 GO:0044308 axonal spine(GO:0044308)
0.0 2.8 GO:0030016 myofibril(GO:0030016)
0.1 2.7 GO:0030673 axolemma(GO:0030673)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 210 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 8.6 GO:0001968 fibronectin binding(GO:0001968)
0.4 6.4 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.8 6.3 GO:0099583 neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration(GO:0099583)
0.2 4.9 GO:0004385 guanylate kinase activity(GO:0004385)
1.2 4.8 GO:0016286 small conductance calcium-activated potassium channel activity(GO:0016286)
0.0 4.7 GO:0017124 SH3 domain binding(GO:0017124)
0.0 4.7 GO:0016887 ATPase activity(GO:0016887)
0.3 4.6 GO:0003680 AT DNA binding(GO:0003680)
0.6 3.9 GO:0045545 syndecan binding(GO:0045545)
0.3 3.7 GO:0070097 delta-catenin binding(GO:0070097)
0.1 3.7 GO:0050840 extracellular matrix binding(GO:0050840)
0.1 3.5 GO:0005249 voltage-gated potassium channel activity(GO:0005249)
0.5 3.3 GO:0001665 alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity(GO:0001665)
0.4 3.3 GO:0005519 cytoskeletal regulatory protein binding(GO:0005519)
0.1 3.2 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0 3.1 GO:0003777 microtubule motor activity(GO:0003777)
0.1 3.0 GO:0046875 ephrin receptor binding(GO:0046875)
0.0 3.0 GO:0005516 calmodulin binding(GO:0005516)
1.0 2.9 GO:0003989 acetyl-CoA carboxylase activity(GO:0003989)
0.5 2.9 GO:0019841 retinol binding(GO:0019841)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 47 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 10.6 PID_REELIN_PATHWAY Reelin signaling pathway
0.1 5.5 PID_MAPK_TRK_PATHWAY Trk receptor signaling mediated by the MAPK pathway
0.1 4.2 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.1 4.0 PID_CDC42_REG_PATHWAY Regulation of CDC42 activity
0.1 4.0 PID_ARF6_TRAFFICKING_PATHWAY Arf6 trafficking events
0.1 3.7 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.1 3.6 PID_EPHB_FWD_PATHWAY EPHB forward signaling
0.1 3.4 PID_SYNDECAN_4_PATHWAY Syndecan-4-mediated signaling events
0.1 3.3 PID_AJDISS_2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.1 2.7 PID_NCADHERIN_PATHWAY N-cadherin signaling events
0.2 2.5 PID_ERBB_NETWORK_PATHWAY ErbB receptor signaling network
0.1 2.2 PID_TRKR_PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.1 1.9 PID_THROMBIN_PAR4_PATHWAY PAR4-mediated thrombin signaling events
0.1 1.5 PID_ERB_GENOMIC_PATHWAY Validated nuclear estrogen receptor beta network
0.0 1.5 PID_RHOA_PATHWAY RhoA signaling pathway
0.1 1.4 PID_A6B1_A6B4_INTEGRIN_PATHWAY a6b1 and a6b4 Integrin signaling
0.0 1.3 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton
0.1 1.2 PID_CIRCADIAN_PATHWAY Circadian rhythm pathway
0.0 1.2 PID_BCR_5PATHWAY BCR signaling pathway
0.0 1.2 PID_AVB3_INTEGRIN_PATHWAY Integrins in angiogenesis

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 75 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 6.0 REACTOME_POTASSIUM_CHANNELS Genes involved in Potassium Channels
0.2 5.9 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.1 5.9 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.2 5.5 REACTOME_UNBLOCKING_OF_NMDA_RECEPTOR_GLUTAMATE_BINDING_AND_ACTIVATION Genes involved in Unblocking of NMDA receptor, glutamate binding and activation
0.2 4.9 REACTOME_INSULIN_SYNTHESIS_AND_PROCESSING Genes involved in Insulin Synthesis and Processing
0.1 4.6 REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.0 3.9 REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS Genes involved in Integrin cell surface interactions
0.0 3.1 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.0 3.0 REACTOME_MEIOTIC_SYNAPSIS Genes involved in Meiotic Synapsis
0.1 2.9 REACTOME_FATTY_ACYL_COA_BIOSYNTHESIS Genes involved in Fatty Acyl-CoA Biosynthesis
0.1 2.6 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.1 2.6 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases
0.1 2.4 REACTOME_BMAL1_CLOCK_NPAS2_ACTIVATES_CIRCADIAN_EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.1 2.2 REACTOME_ACTIVATION_OF_RAC Genes involved in Activation of Rac
0.1 2.2 REACTOME_AMYLOIDS Genes involved in Amyloids
0.1 2.2 REACTOME_SEMA4D_IN_SEMAPHORIN_SIGNALING Genes involved in Sema4D in semaphorin signaling
0.2 2.0 REACTOME_IL_6_SIGNALING Genes involved in Interleukin-6 signaling
0.3 1.9 REACTOME_ACETYLCHOLINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Acetylcholine Neurotransmitter Release Cycle
0.1 1.9 REACTOME_PRE_NOTCH_TRANSCRIPTION_AND_TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation
0.1 1.8 REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX Genes involved in Degradation of the extracellular matrix