Motif ID: Irx5

Z-value: 0.521


Transcription factors associated with Irx5:

Gene SymbolEntrez IDGene Name
Irx5 ENSMUSG00000031737.10 Irx5

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Irx5mm10_v2_chr8_+_92357787_923578010.522.6e-02Click!


Activity profile for motif Irx5.

activity profile for motif Irx5


Sorted Z-values histogram for motif Irx5

Sorted Z-values for motif Irx5



Network of associatons between targets according to the STRING database.



First level regulatory network of Irx5

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr12_+_55598917 1.633 ENSMUST00000051857.3
 Insm2
insulinoma-associated 2
chr5_+_139543889 1.179 ENSMUST00000174792.1
ENSMUST00000031523.8
 Uncx

UNC homeobox

chr2_-_79908428 1.148 ENSMUST00000102652.3
ENSMUST00000102651.3
 Pde1a

phosphodiesterase 1A, calmodulin-dependent

chr16_+_30065333 1.125 ENSMUST00000023171.7
 Hes1
hairy and enhancer of split 1 (Drosophila)
chr7_-_114927726 1.058 ENSMUST00000059737.2
 Gm6816
predicted gene 6816
chr2_-_79908389 0.876 ENSMUST00000090756.4
 Pde1a
phosphodiesterase 1A, calmodulin-dependent
chr6_+_50110837 0.732 ENSMUST00000167628.1
 Mpp6
membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6)
chr10_+_97565436 0.725 ENSMUST00000038160.4
 Lum
lumican
chr10_+_3872667 0.712 ENSMUST00000136671.1
ENSMUST00000042438.6
 Plekhg1

pleckstrin homology domain containing, family G (with RhoGef domain) member 1

chr9_-_78378725 0.654 ENSMUST00000034900.7
 Ooep
oocyte expressed protein
chr2_+_25180737 0.626 ENSMUST00000104999.2
 Nrarp
Notch-regulated ankyrin repeat protein
chr10_+_11609256 0.615 ENSMUST00000052902.7
 Gm9797
predicted pseudogene 9797
chr10_-_99759658 0.517 ENSMUST00000056085.4
 Csl
citrate synthase like
chr8_+_85171322 0.514 ENSMUST00000076896.5
 Gm6531
predicted gene 6531
chr17_+_50698525 0.501 ENSMUST00000061681.7
 Gm7334
predicted gene 7334
chr5_+_48242549 0.427 ENSMUST00000172493.1
 Slit2
slit homolog 2 (Drosophila)
chr12_-_108893197 0.415 ENSMUST00000161154.1
ENSMUST00000161410.1
 Wars

tryptophanyl-tRNA synthetase

chr1_-_78968079 0.398 ENSMUST00000049117.5
 Gm5830
predicted pseudogene 5830
chr3_+_95124476 0.384 ENSMUST00000131597.1
ENSMUST00000005769.6
ENSMUST00000107227.1
 Tmod4


tropomodulin 4


chr2_-_85035487 0.379 ENSMUST00000028465.7
 P2rx3
purinergic receptor P2X, ligand-gated ion channel, 3
chr2_+_152427639 0.379 ENSMUST00000128737.1
 6820408C15Rik
RIKEN cDNA 6820408C15 gene
chr10_+_88146992 0.372 ENSMUST00000052355.7
 Nup37
nucleoporin 37
chr2_-_101621033 0.363 ENSMUST00000090513.4
 B230118H07Rik
RIKEN cDNA B230118H07 gene
chr5_-_88675190 0.345 ENSMUST00000133532.1
ENSMUST00000150438.1
 Grsf1

G-rich RNA sequence binding factor 1

chr19_-_8713862 0.344 ENSMUST00000010239.4
 Slc3a2
solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2
chr10_+_79960145 0.342 ENSMUST00000045247.7
 Wdr18
WD repeat domain 18
chr4_-_59783800 0.313 ENSMUST00000107526.1
ENSMUST00000095063.4
 Inip

INTS3 and NABP interacting protein

chr11_-_68927049 0.302 ENSMUST00000038932.7
 Odf4
outer dense fiber of sperm tails 4
chr4_-_43653560 0.295 ENSMUST00000107870.2
 Spag8
sperm associated antigen 8
chr10_-_13868779 0.289 ENSMUST00000105534.3
 Aig1
androgen-induced 1
chr3_+_124321031 0.286 ENSMUST00000058994.4
 Tram1l1
translocation associated membrane protein 1-like 1
chr14_-_14120904 0.286 ENSMUST00000022256.3
 Psmd6
proteasome (prosome, macropain) 26S subunit, non-ATPase, 6
chr17_-_87025353 0.280 ENSMUST00000024957.6
 Pigf
phosphatidylinositol glycan anchor biosynthesis, class F
chr16_-_56024628 0.253 ENSMUST00000119981.1
ENSMUST00000096021.3
 Pcnp

PEST proteolytic signal containing nuclear protein

chr8_-_107263248 0.246 ENSMUST00000080443.6
 Rps18-ps3
ribosomal protein S18, pseudogene 3
chr11_-_69579320 0.243 ENSMUST00000048139.5
 Wrap53
WD repeat containing, antisense to Trp53
chr1_+_165301863 0.232 ENSMUST00000178700.1
 Gpr161
G protein-coupled receptor 161
chr1_-_169969143 0.211 ENSMUST00000027989.6
ENSMUST00000111353.3
 Hsd17b7

hydroxysteroid (17-beta) dehydrogenase 7

chr4_+_6365650 0.209 ENSMUST00000029912.4
ENSMUST00000103008.5
ENSMUST00000175769.1
ENSMUST00000108374.1
ENSMUST00000140830.1
 Sdcbp




syndecan binding protein




chr4_-_49521036 0.199 ENSMUST00000057829.3
 Mrpl50
mitochondrial ribosomal protein L50
chr17_+_7925990 0.198 ENSMUST00000036370.7
 Tagap
T cell activation Rho GTPase activating protein
chr16_+_33185045 0.183 ENSMUST00000039733.8
 Osbpl11
oxysterol binding protein-like 11
chr17_+_87025550 0.145 ENSMUST00000024959.3
ENSMUST00000160269.1
 Cript

cysteine-rich PDZ-binding protein

chr13_+_24943144 0.138 ENSMUST00000021773.5
 Gpld1
glycosylphosphatidylinositol specific phospholipase D1
chr11_-_69395333 0.137 ENSMUST00000108660.1
ENSMUST00000051620.4
 Cyb5d1

cytochrome b5 domain containing 1

chr2_+_104027721 0.112 ENSMUST00000028603.3
 Fbxo3
F-box protein 3
chr4_-_43653542 0.106 ENSMUST00000084646.4
 Spag8
sperm associated antigen 8
chr14_+_48446340 0.105 ENSMUST00000111735.2
 Tmem260
transmembrane protein 260
chr14_+_48120841 0.099 ENSMUST00000073150.4
 Peli2
pellino 2
chr3_-_88762244 0.087 ENSMUST00000183267.1
 Syt11
synaptotagmin XI
chr3_+_19957037 0.083 ENSMUST00000091309.5
ENSMUST00000108329.1
ENSMUST00000003714.6
 Cp


ceruloplasmin


chr11_+_69395647 0.074 ENSMUST00000144531.1
 Lsmd1
LSM domain containing 1
chr14_-_19977249 0.062 ENSMUST00000160013.1
 Gng2
guanine nucleotide binding protein (G protein), gamma 2
chr4_+_148039097 0.054 ENSMUST00000141283.1
 Mthfr
5,10-methylenetetrahydrofolate reductase
chr2_-_73625731 0.043 ENSMUST00000070579.6
 Chn1
chimerin (chimaerin) 1
chr18_+_76944384 0.040 ENSMUST00000156454.1
ENSMUST00000150990.1
ENSMUST00000026485.7
ENSMUST00000148955.1
 Hdhd2



haloacid dehalogenase-like hydrolase domain containing 2



chr14_-_19977151 0.036 ENSMUST00000055100.7
ENSMUST00000162425.1
 Gng2

guanine nucleotide binding protein (G protein), gamma 2

chr7_-_98112618 0.036 ENSMUST00000153657.1
 Myo7a
myosin VIIA
chr14_-_19977040 0.035 ENSMUST00000159028.1
 Gng2
guanine nucleotide binding protein (G protein), gamma 2
chr7_-_142576492 0.030 ENSMUST00000140716.1
 H19
H19 fetal liver mRNA
chr2_+_104027823 0.012 ENSMUST00000111135.1
ENSMUST00000111136.1
ENSMUST00000102565.3
 Fbxo3


F-box protein 3


chr6_+_121183667 0.002 ENSMUST00000118234.1
ENSMUST00000088561.3
ENSMUST00000137432.1
ENSMUST00000120066.1
 Pex26



peroxisomal biogenesis factor 26




Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.1 GO:0021557 oculomotor nerve development(GO:0021557)
0.2 0.7 GO:0032914 positive regulation of transforming growth factor beta1 production(GO:0032914)
0.1 1.2 GO:0035726 common myeloid progenitor cell proliferation(GO:0035726)
0.1 0.4 GO:0021972 corticospinal neuron axon guidance through spinal cord(GO:0021972) positive regulation of negative chemotaxis(GO:0050924) induction of negative chemotaxis(GO:0050929) negative regulation of mononuclear cell migration(GO:0071676) negative regulation of retinal ganglion cell axon guidance(GO:0090260)
0.1 0.4 GO:0006436 tryptophanyl-tRNA aminoacylation(GO:0006436)
0.1 0.4 GO:1904058 positive regulation of sensory perception of pain(GO:1904058)
0.1 2.0 GO:0046069 cGMP catabolic process(GO:0046069)
0.1 0.3 GO:0015803 branched-chain amino acid transport(GO:0015803) leucine transport(GO:0015820)
0.1 0.4 GO:0051694 pointed-end actin filament capping(GO:0051694)
0.1 0.6 GO:0014807 regulation of somitogenesis(GO:0014807)
0.0 0.2 GO:0090666 scaRNA localization to Cajal body(GO:0090666)
0.0 0.1 GO:0002430 complement receptor mediated signaling pathway(GO:0002430) GPI anchor release(GO:0006507)
0.0 0.2 GO:0010890 positive regulation of sequestering of triglyceride(GO:0010890)
0.0 0.2 GO:1903553 positive regulation of extracellular exosome assembly(GO:1903553)
0.0 0.1 GO:1990927 negative regulation of membrane invagination(GO:1905154) calcium ion regulated lysosome exocytosis(GO:1990927)
0.0 0.1 GO:1902897 regulation of postsynaptic density protein 95 clustering(GO:1902897)
0.0 0.2 GO:1901621 negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning(GO:1901621)
0.0 0.1 GO:0070829 heterochromatin maintenance(GO:0070829)
0.0 0.7 GO:0007566 embryo implantation(GO:0007566)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0070876 SOSS complex(GO:0070876)
0.1 0.7 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.0 0.3 GO:0001520 outer dense fiber(GO:0001520)
0.0 0.4 GO:0031080 nuclear pore outer ring(GO:0031080)
0.0 0.4 GO:0031229 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229)
0.0 0.4 GO:0005865 striated muscle thin filament(GO:0005865)
0.0 0.3 GO:0005838 proteasome regulatory particle(GO:0005838)
0.0 1.1 GO:0016363 nuclear matrix(GO:0016363)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 2.0 GO:0048101 calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117) calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101)
0.1 0.4 GO:0004830 tryptophan-tRNA ligase activity(GO:0004830)
0.1 0.2 GO:0000253 3-keto sterol reductase activity(GO:0000253)
0.1 0.4 GO:0035381 extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381)
0.1 0.4 GO:0048495 GTPase inhibitor activity(GO:0005095) Roundabout binding(GO:0048495)
0.0 0.4 GO:0005523 tropomyosin binding(GO:0005523)
0.0 1.1 GO:0008432 JUN kinase binding(GO:0008432)
0.0 0.2 GO:0045545 syndecan binding(GO:0045545)
0.0 0.7 GO:0004385 guanylate kinase activity(GO:0004385)
0.0 0.1 GO:0004489 methylenetetrahydrofolate reductase (NAD(P)H) activity(GO:0004489)
0.0 0.1 GO:0004322 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.0 0.1 GO:0004630 phospholipase D activity(GO:0004630)
0.0 0.2 GO:0070034 telomerase RNA binding(GO:0070034)
0.0 0.3 GO:0016780 phosphotransferase activity, for other substituted phosphate groups(GO:0016780)
0.0 0.7 GO:0005518 collagen binding(GO:0005518)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.1 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.0 0.7 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.0 0.4 PID_GLYPICAN_1PATHWAY Glypican 1 network
0.0 0.2 PID_IL5_PATHWAY IL5-mediated signaling events
0.0 0.1 PID_THROMBIN_PAR4_PATHWAY PAR4-mediated thrombin signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.0 REACTOME_CGMP_EFFECTS Genes involved in cGMP effects
0.1 0.7 REACTOME_KERATAN_SULFATE_DEGRADATION Genes involved in Keratan sulfate degradation
0.0 1.1 REACTOME_REGULATION_OF_BETA_CELL_DEVELOPMENT Genes involved in Regulation of beta-cell development
0.0 0.4 REACTOME_ACTIVATION_OF_RAC Genes involved in Activation of Rac
0.0 0.4 REACTOME_CYTOSOLIC_TRNA_AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.0 0.4 REACTOME_REGULATION_OF_GLUCOKINASE_BY_GLUCOKINASE_REGULATORY_PROTEIN Genes involved in Regulation of Glucokinase by Glucokinase Regulatory Protein
0.0 0.3 REACTOME_BASIGIN_INTERACTIONS Genes involved in Basigin interactions
0.0 0.3 REACTOME_SYNTHESIS_OF_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)