Motif ID: Irx5

Z-value: 0.521


Transcription factors associated with Irx5:

Gene SymbolEntrez IDGene Name
Irx5 ENSMUSG00000031737.10 Irx5

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Irx5mm10_v2_chr8_+_92357787_923578010.522.6e-02Click!


Activity profile for motif Irx5.

activity profile for motif Irx5


Sorted Z-values histogram for motif Irx5

Sorted Z-values for motif Irx5



Network of associatons between targets according to the STRING database.



First level regulatory network of Irx5

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 62 entries
PromoterScoreRefseqGene SymbolGene Name
chr12_+_55598917 1.633 ENSMUST00000051857.3
 Insm2
insulinoma-associated 2
chr5_+_139543889 1.179 ENSMUST00000174792.1
ENSMUST00000031523.8
 Uncx

UNC homeobox

chr2_-_79908428 1.148 ENSMUST00000102652.3
ENSMUST00000102651.3
 Pde1a

phosphodiesterase 1A, calmodulin-dependent

chr16_+_30065333 1.125 ENSMUST00000023171.7
 Hes1
hairy and enhancer of split 1 (Drosophila)
chr7_-_114927726 1.058 ENSMUST00000059737.2
 Gm6816
predicted gene 6816
chr2_-_79908389 0.876 ENSMUST00000090756.4
 Pde1a
phosphodiesterase 1A, calmodulin-dependent
chr6_+_50110837 0.732 ENSMUST00000167628.1
 Mpp6
membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6)
chr10_+_97565436 0.725 ENSMUST00000038160.4
 Lum
lumican
chr10_+_3872667 0.712 ENSMUST00000136671.1
ENSMUST00000042438.6
 Plekhg1

pleckstrin homology domain containing, family G (with RhoGef domain) member 1

chr9_-_78378725 0.654 ENSMUST00000034900.7
 Ooep
oocyte expressed protein
chr2_+_25180737 0.626 ENSMUST00000104999.2
 Nrarp
Notch-regulated ankyrin repeat protein
chr10_+_11609256 0.615 ENSMUST00000052902.7
 Gm9797
predicted pseudogene 9797
chr10_-_99759658 0.517 ENSMUST00000056085.4
 Csl
citrate synthase like
chr8_+_85171322 0.514 ENSMUST00000076896.5
 Gm6531
predicted gene 6531
chr17_+_50698525 0.501 ENSMUST00000061681.7
 Gm7334
predicted gene 7334
chr5_+_48242549 0.427 ENSMUST00000172493.1
 Slit2
slit homolog 2 (Drosophila)
chr12_-_108893197 0.415 ENSMUST00000161154.1
ENSMUST00000161410.1
 Wars

tryptophanyl-tRNA synthetase

chr1_-_78968079 0.398 ENSMUST00000049117.5
 Gm5830
predicted pseudogene 5830
chr3_+_95124476 0.384 ENSMUST00000131597.1
ENSMUST00000005769.6
ENSMUST00000107227.1
 Tmod4


tropomodulin 4


chr2_-_85035487 0.379 ENSMUST00000028465.7
 P2rx3
purinergic receptor P2X, ligand-gated ion channel, 3

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 19 of 19 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.0 GO:0046069 cGMP catabolic process(GO:0046069)
0.1 1.2 GO:0035726 common myeloid progenitor cell proliferation(GO:0035726)
0.4 1.1 GO:0021557 oculomotor nerve development(GO:0021557)
0.2 0.7 GO:0032914 positive regulation of transforming growth factor beta1 production(GO:0032914)
0.0 0.7 GO:0007566 embryo implantation(GO:0007566)
0.1 0.6 GO:0014807 regulation of somitogenesis(GO:0014807)
0.1 0.4 GO:0021972 corticospinal neuron axon guidance through spinal cord(GO:0021972) positive regulation of negative chemotaxis(GO:0050924) induction of negative chemotaxis(GO:0050929) negative regulation of mononuclear cell migration(GO:0071676) negative regulation of retinal ganglion cell axon guidance(GO:0090260)
0.1 0.4 GO:0006436 tryptophanyl-tRNA aminoacylation(GO:0006436)
0.1 0.4 GO:1904058 positive regulation of sensory perception of pain(GO:1904058)
0.1 0.4 GO:0051694 pointed-end actin filament capping(GO:0051694)
0.1 0.3 GO:0015803 branched-chain amino acid transport(GO:0015803) leucine transport(GO:0015820)
0.0 0.2 GO:0090666 scaRNA localization to Cajal body(GO:0090666)
0.0 0.2 GO:0010890 positive regulation of sequestering of triglyceride(GO:0010890)
0.0 0.2 GO:1903553 positive regulation of extracellular exosome assembly(GO:1903553)
0.0 0.2 GO:1901621 negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning(GO:1901621)
0.0 0.1 GO:0002430 complement receptor mediated signaling pathway(GO:0002430) GPI anchor release(GO:0006507)
0.0 0.1 GO:1990927 negative regulation of membrane invagination(GO:1905154) calcium ion regulated lysosome exocytosis(GO:1990927)
0.0 0.1 GO:1902897 regulation of postsynaptic density protein 95 clustering(GO:1902897)
0.0 0.1 GO:0070829 heterochromatin maintenance(GO:0070829)

Gene overrepresentation in cellular_component category:

Showing 1 to 8 of 8 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.1 GO:0016363 nuclear matrix(GO:0016363)
0.1 0.7 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.0 0.4 GO:0031080 nuclear pore outer ring(GO:0031080)
0.0 0.4 GO:0031229 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229)
0.0 0.4 GO:0005865 striated muscle thin filament(GO:0005865)
0.1 0.3 GO:0070876 SOSS complex(GO:0070876)
0.0 0.3 GO:0001520 outer dense fiber(GO:0001520)
0.0 0.3 GO:0005838 proteasome regulatory particle(GO:0005838)

Gene overrepresentation in molecular_function category:

Showing 1 to 15 of 15 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 2.0 GO:0048101 calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117) calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101)
0.0 1.1 GO:0008432 JUN kinase binding(GO:0008432)
0.0 0.7 GO:0004385 guanylate kinase activity(GO:0004385)
0.0 0.7 GO:0005518 collagen binding(GO:0005518)
0.1 0.4 GO:0004830 tryptophan-tRNA ligase activity(GO:0004830)
0.1 0.4 GO:0035381 extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381)
0.1 0.4 GO:0048495 GTPase inhibitor activity(GO:0005095) Roundabout binding(GO:0048495)
0.0 0.4 GO:0005523 tropomyosin binding(GO:0005523)
0.0 0.3 GO:0016780 phosphotransferase activity, for other substituted phosphate groups(GO:0016780)
0.1 0.2 GO:0000253 3-keto sterol reductase activity(GO:0000253)
0.0 0.2 GO:0045545 syndecan binding(GO:0045545)
0.0 0.2 GO:0070034 telomerase RNA binding(GO:0070034)
0.0 0.1 GO:0004489 methylenetetrahydrofolate reductase (NAD(P)H) activity(GO:0004489)
0.0 0.1 GO:0004322 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.0 0.1 GO:0004630 phospholipase D activity(GO:0004630)

Gene overrepresentation in C2:CP category:

Showing 1 to 5 of 5 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.1 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.0 0.7 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.0 0.4 PID_GLYPICAN_1PATHWAY Glypican 1 network
0.0 0.2 PID_IL5_PATHWAY IL5-mediated signaling events
0.0 0.1 PID_THROMBIN_PAR4_PATHWAY PAR4-mediated thrombin signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 8 of 8 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.0 REACTOME_CGMP_EFFECTS Genes involved in cGMP effects
0.0 1.1 REACTOME_REGULATION_OF_BETA_CELL_DEVELOPMENT Genes involved in Regulation of beta-cell development
0.1 0.7 REACTOME_KERATAN_SULFATE_DEGRADATION Genes involved in Keratan sulfate degradation
0.0 0.4 REACTOME_ACTIVATION_OF_RAC Genes involved in Activation of Rac
0.0 0.4 REACTOME_CYTOSOLIC_TRNA_AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.0 0.4 REACTOME_REGULATION_OF_GLUCOKINASE_BY_GLUCOKINASE_REGULATORY_PROTEIN Genes involved in Regulation of Glucokinase by Glucokinase Regulatory Protein
0.0 0.3 REACTOME_BASIGIN_INTERACTIONS Genes involved in Basigin interactions
0.0 0.3 REACTOME_SYNTHESIS_OF_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)