Motif ID: Irf3
Z-value: 0.906
Transcription factors associated with Irf3:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Irf3 | ENSMUSG00000003184.8 | Irf3 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Irf3 | mm10_v2_chr7_+_44997648_44997700 | 0.45 | 5.9e-02 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 0.6 | GO:1904959 | regulation of electron carrier activity(GO:1904732) regulation of cytochrome-c oxidase activity(GO:1904959) |
| 0.4 | 1.7 | GO:0034759 | regulation of iron ion transport(GO:0034756) regulation of iron ion transmembrane transport(GO:0034759) |
| 0.4 | 1.1 | GO:0090289 | regulation of osteoclast proliferation(GO:0090289) |
| 0.3 | 1.3 | GO:1901252 | regulation of intracellular transport of viral material(GO:1901252) |
| 0.2 | 0.9 | GO:0046967 | cytosol to ER transport(GO:0046967) |
| 0.2 | 0.6 | GO:0006059 | hexitol metabolic process(GO:0006059) alditol biosynthetic process(GO:0019401) |
| 0.2 | 3.1 | GO:0044406 | adhesion of symbiont to host(GO:0044406) |
| 0.2 | 0.5 | GO:0010533 | regulation of activation of Janus kinase activity(GO:0010533) |
| 0.1 | 0.3 | GO:0019885 | antigen processing and presentation of endogenous peptide antigen via MHC class I(GO:0019885) |
| 0.1 | 1.0 | GO:0016584 | nucleosome positioning(GO:0016584) |
| 0.1 | 0.6 | GO:0090086 | negative regulation of protein deubiquitination(GO:0090086) |
| 0.1 | 1.1 | GO:0060330 | regulation of response to interferon-gamma(GO:0060330) |
| 0.1 | 0.5 | GO:1902626 | assembly of large subunit precursor of preribosome(GO:1902626) |
| 0.1 | 0.6 | GO:0035547 | interferon-beta secretion(GO:0035546) regulation of interferon-beta secretion(GO:0035547) positive regulation of interferon-beta secretion(GO:0035549) |
| 0.1 | 0.7 | GO:0045218 | zonula adherens maintenance(GO:0045218) |
| 0.1 | 0.4 | GO:1902340 | telomeric heterochromatin assembly(GO:0031509) negative regulation of chromosome condensation(GO:1902340) |
| 0.1 | 0.7 | GO:1903377 | negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903377) |
| 0.1 | 2.2 | GO:0019884 | antigen processing and presentation of exogenous antigen(GO:0019884) |
| 0.1 | 0.6 | GO:1990504 | dense core granule exocytosis(GO:1990504) |
| 0.1 | 0.6 | GO:0097039 | protein linear polyubiquitination(GO:0097039) |
| 0.1 | 0.8 | GO:0089711 | L-glutamate transmembrane transport(GO:0089711) |
| 0.1 | 0.2 | GO:0001580 | detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580) |
| 0.1 | 0.4 | GO:0036438 | maintenance of lens transparency(GO:0036438) |
| 0.1 | 0.7 | GO:0000290 | deadenylation-dependent decapping of nuclear-transcribed mRNA(GO:0000290) |
| 0.1 | 0.3 | GO:0034421 | post-translational protein acetylation(GO:0034421) |
| 0.1 | 0.4 | GO:0032929 | negative regulation of superoxide anion generation(GO:0032929) |
| 0.1 | 0.4 | GO:0043569 | negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569) |
| 0.0 | 0.3 | GO:0060340 | positive regulation of type I interferon-mediated signaling pathway(GO:0060340) |
| 0.0 | 0.2 | GO:0070212 | protein poly-ADP-ribosylation(GO:0070212) |
| 0.0 | 0.7 | GO:0055070 | copper ion homeostasis(GO:0055070) |
| 0.0 | 0.3 | GO:0045629 | negative regulation of T-helper 2 cell differentiation(GO:0045629) |
| 0.0 | 1.1 | GO:0035456 | response to interferon-beta(GO:0035456) |
| 0.0 | 0.0 | GO:0002589 | regulation of antigen processing and presentation of peptide antigen via MHC class I(GO:0002589) |
| 0.0 | 0.7 | GO:0048268 | clathrin coat assembly(GO:0048268) |
| 0.0 | 0.5 | GO:0099517 | anterograde synaptic vesicle transport(GO:0048490) synaptic vesicle cytoskeletal transport(GO:0099514) synaptic vesicle transport along microtubule(GO:0099517) |
| 0.0 | 0.3 | GO:0035455 | response to interferon-alpha(GO:0035455) |
| 0.0 | 0.3 | GO:0000920 | cell separation after cytokinesis(GO:0000920) |
| 0.0 | 0.3 | GO:0008535 | respiratory chain complex IV assembly(GO:0008535) |
| 0.0 | 0.7 | GO:0035082 | axoneme assembly(GO:0035082) |
| 0.0 | 0.3 | GO:1902236 | negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway(GO:1902236) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 1.0 | GO:0008537 | proteasome activator complex(GO:0008537) |
| 0.3 | 3.1 | GO:0020005 | symbiont-containing vacuole membrane(GO:0020005) |
| 0.2 | 0.7 | GO:0099631 | postsynaptic endocytic zone cytoplasmic component(GO:0099631) |
| 0.2 | 0.2 | GO:0020003 | symbiont-containing vacuole(GO:0020003) |
| 0.2 | 1.7 | GO:1990712 | HFE-transferrin receptor complex(GO:1990712) |
| 0.2 | 1.1 | GO:0097452 | GAIT complex(GO:0097452) |
| 0.2 | 0.6 | GO:0097454 | Schwann cell microvillus(GO:0097454) |
| 0.1 | 0.6 | GO:1990111 | spermatoproteasome complex(GO:1990111) |
| 0.1 | 0.6 | GO:0071797 | LUBAC complex(GO:0071797) |
| 0.1 | 0.9 | GO:0042825 | TAP complex(GO:0042825) |
| 0.1 | 0.3 | GO:0097233 | lamellar body membrane(GO:0097232) alveolar lamellar body membrane(GO:0097233) |
| 0.1 | 1.0 | GO:0005677 | chromatin silencing complex(GO:0005677) |
| 0.1 | 0.7 | GO:0042382 | paraspeckles(GO:0042382) |
| 0.1 | 0.2 | GO:0038045 | large latent transforming growth factor-beta complex(GO:0038045) |
| 0.1 | 0.5 | GO:0005638 | lamin filament(GO:0005638) |
| 0.1 | 0.6 | GO:0019773 | proteasome core complex, alpha-subunit complex(GO:0019773) |
| 0.1 | 0.7 | GO:0005915 | zonula adherens(GO:0005915) |
| 0.1 | 0.3 | GO:0000839 | Hrd1p ubiquitin ligase ERAD-L complex(GO:0000839) |
| 0.0 | 0.5 | GO:0031083 | BLOC-1 complex(GO:0031083) |
| 0.0 | 0.2 | GO:0071012 | catalytic step 1 spliceosome(GO:0071012) |
| 0.0 | 0.3 | GO:0031618 | nuclear pericentric heterochromatin(GO:0031618) |
| 0.0 | 1.3 | GO:0031519 | PcG protein complex(GO:0031519) |
| 0.0 | 0.2 | GO:0017101 | aminoacyl-tRNA synthetase multienzyme complex(GO:0017101) |
| 0.0 | 0.8 | GO:0000315 | organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762) |
| 0.0 | 0.4 | GO:0000788 | nuclear nucleosome(GO:0000788) |
| 0.0 | 1.1 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.0 | 0.1 | GO:0031465 | Cul4B-RING E3 ubiquitin ligase complex(GO:0031465) |
| 0.0 | 0.3 | GO:0070069 | cytochrome complex(GO:0070069) |
| 0.0 | 1.3 | GO:0031225 | anchored component of membrane(GO:0031225) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 0.9 | GO:0015433 | peptide antigen-transporting ATPase activity(GO:0015433) tapasin binding(GO:0046980) |
| 0.2 | 0.8 | GO:0000099 | sulfur amino acid transmembrane transporter activity(GO:0000099) |
| 0.2 | 1.6 | GO:0061133 | endopeptidase activator activity(GO:0061133) |
| 0.1 | 0.4 | GO:0008109 | N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109) |
| 0.1 | 0.6 | GO:0004032 | alditol:NADP+ 1-oxidoreductase activity(GO:0004032) |
| 0.1 | 1.3 | GO:0008191 | metalloendopeptidase inhibitor activity(GO:0008191) |
| 0.1 | 0.3 | GO:0003692 | left-handed Z-DNA binding(GO:0003692) |
| 0.1 | 0.6 | GO:0016531 | copper chaperone activity(GO:0016531) |
| 0.1 | 1.4 | GO:0003950 | NAD+ ADP-ribosyltransferase activity(GO:0003950) |
| 0.1 | 0.7 | GO:0000340 | RNA 7-methylguanosine cap binding(GO:0000340) |
| 0.1 | 1.4 | GO:0070006 | metalloaminopeptidase activity(GO:0070006) |
| 0.1 | 0.7 | GO:0032050 | clathrin heavy chain binding(GO:0032050) |
| 0.1 | 0.2 | GO:0050436 | microfibril binding(GO:0050436) |
| 0.1 | 1.2 | GO:0004298 | threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003) |
| 0.1 | 0.3 | GO:0004468 | lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468) |
| 0.1 | 0.5 | GO:0043023 | ribosomal large subunit binding(GO:0043023) |
| 0.1 | 0.7 | GO:0070097 | delta-catenin binding(GO:0070097) |
| 0.0 | 0.4 | GO:0003993 | acid phosphatase activity(GO:0003993) |
| 0.0 | 0.3 | GO:0039706 | co-receptor binding(GO:0039706) |
| 0.0 | 0.5 | GO:0005159 | insulin-like growth factor receptor binding(GO:0005159) |
| 0.0 | 0.2 | GO:0051434 | BH3 domain binding(GO:0051434) |
| 0.0 | 0.6 | GO:0015036 | disulfide oxidoreductase activity(GO:0015036) |
| 0.0 | 1.1 | GO:0030971 | receptor tyrosine kinase binding(GO:0030971) |
| 0.0 | 1.4 | GO:0031491 | nucleosome binding(GO:0031491) |
| 0.0 | 0.7 | GO:0005507 | copper ion binding(GO:0005507) |
| 0.0 | 0.3 | GO:1904264 | ubiquitin protein ligase activity involved in ERAD pathway(GO:1904264) |
| 0.0 | 0.3 | GO:0004129 | cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676) |
| 0.0 | 0.5 | GO:0043015 | gamma-tubulin binding(GO:0043015) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.8 | PID_NFAT_TFPATHWAY | Calcineurin-regulated NFAT-dependent transcription in lymphocytes |
| 0.0 | 0.7 | PID_CIRCADIAN_PATHWAY | Circadian rhythm pathway |
| 0.0 | 1.9 | PID_IL12_2PATHWAY | IL12-mediated signaling events |
| 0.0 | 0.7 | PID_ARF_3PATHWAY | Arf1 pathway |
| 0.0 | 0.6 | PID_AURORA_B_PATHWAY | Aurora B signaling |
| 0.0 | 0.7 | PID_ECADHERIN_STABILIZATION_PATHWAY | Stabilization and expansion of the E-cadherin adherens junction |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 1.4 | REACTOME_ENDOSOMAL_VACUOLAR_PATHWAY | Genes involved in Endosomal/Vacuolar pathway |
| 0.1 | 1.2 | REACTOME_ANTIGEN_PRESENTATION_FOLDING_ASSEMBLY_AND_PEPTIDE_LOADING_OF_CLASS_I_MHC | Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC |
| 0.1 | 0.7 | REACTOME_MRNA_DECAY_BY_3_TO_5_EXORIBONUCLEASE | Genes involved in mRNA Decay by 3' to 5' Exoribonuclease |
| 0.1 | 2.8 | REACTOME_CROSS_PRESENTATION_OF_SOLUBLE_EXOGENOUS_ANTIGENS_ENDOSOMES | Genes involved in Cross-presentation of soluble exogenous antigens (endosomes) |
| 0.0 | 0.5 | REACTOME_REGULATION_OF_IFNG_SIGNALING | Genes involved in Regulation of IFNG signaling |
| 0.0 | 0.7 | REACTOME_TRAF3_DEPENDENT_IRF_ACTIVATION_PATHWAY | Genes involved in TRAF3-dependent IRF activation pathway |
| 0.0 | 0.7 | REACTOME_GAP_JUNCTION_DEGRADATION | Genes involved in Gap junction degradation |
| 0.0 | 0.8 | REACTOME_BASIGIN_INTERACTIONS | Genes involved in Basigin interactions |
| 0.0 | 0.4 | REACTOME_RNA_POL_I_PROMOTER_OPENING | Genes involved in RNA Polymerase I Promoter Opening |
| 0.0 | 1.0 | REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE | Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere |
| 0.0 | 0.3 | REACTOME_RIP_MEDIATED_NFKB_ACTIVATION_VIA_DAI | Genes involved in RIP-mediated NFkB activation via DAI |
| 0.0 | 0.6 | REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT | Genes involved in Mitochondrial Protein Import |
| 0.0 | 1.1 | REACTOME_PEPTIDE_CHAIN_ELONGATION | Genes involved in Peptide chain elongation |
