Motif ID: Irf3

Z-value: 0.906


Transcription factors associated with Irf3:

Gene SymbolEntrez IDGene Name
Irf3 ENSMUSG00000003184.8 Irf3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Irf3mm10_v2_chr7_+_44997648_449977000.455.9e-02Click!


Activity profile for motif Irf3.

activity profile for motif Irf3


Sorted Z-values histogram for motif Irf3

Sorted Z-values for motif Irf3



Network of associatons between targets according to the STRING database.



First level regulatory network of Irf3

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 92 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_+_122147680 1.364 ENSMUST00000102476.4
 B2m
beta-2 microglobulin
chr2_-_105399286 1.353 ENSMUST00000006128.6
 Rcn1
reticulocalbin 1
chr19_+_36409719 1.343 ENSMUST00000062389.5
 Pcgf5
polycomb group ring finger 5
chr8_-_71537402 1.264 ENSMUST00000051672.7
 Bst2
bone marrow stromal cell antigen 2
chr7_-_45136231 1.141 ENSMUST00000124300.1
ENSMUST00000085377.5
 Rpl13a
Flt3l
ribosomal protein L13A
FMS-like tyrosine kinase 3 ligand
chr8_-_80739497 1.004 ENSMUST00000043359.8
 Smarca5
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5
chr2_+_180589245 0.990 ENSMUST00000029087.3
 Ogfr
opioid growth factor receptor
chr3_+_142560108 0.973 ENSMUST00000128609.1
ENSMUST00000029935.7
 Gbp3

guanylate binding protein 3

chr3_+_142560052 0.966 ENSMUST00000106222.2
 Gbp3
guanylate binding protein 3
chr3_+_142560351 0.901 ENSMUST00000106221.1
 Gbp3
guanylate binding protein 3
chr5_+_123252087 0.843 ENSMUST00000121964.1
 Wdr66
WD repeat domain 66
chr3_-_50443603 0.842 ENSMUST00000029297.4
 Slc7a11
solute carrier family 7 (cationic amino acid transporter, y+ system), member 11
chr1_+_37890477 0.762 ENSMUST00000027256.5
 Mrpl30
mitochondrial ribosomal protein L30
chr7_-_15922361 0.740 ENSMUST00000044355.7
 Sepw1
selenoprotein W, muscle 1
chr16_+_35938470 0.732 ENSMUST00000114878.1
 Parp9
poly (ADP-ribose) polymerase family, member 9
chr7_-_100514800 0.718 ENSMUST00000054923.7
 Dnajb13
DnaJ (Hsp40) related, subfamily B, member 13
chr19_+_43752996 0.708 ENSMUST00000026199.7
ENSMUST00000112047.3
ENSMUST00000153295.1
 Cutc


cutC copper transporter homolog (E.coli)


chrX_+_101429555 0.703 ENSMUST00000033673.6
 Nono
non-POU-domain-containing, octamer binding protein
chr11_+_72301613 0.692 ENSMUST00000151440.1
ENSMUST00000146233.1
ENSMUST00000140842.2
 Xaf1


XIAP associated factor 1


chr9_-_35176039 0.669 ENSMUST00000119847.1
ENSMUST00000034539.5
 Dcps

decapping enzyme, scavenger


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 40 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 3.1 GO:0044406 adhesion of symbiont to host(GO:0044406)
0.1 2.2 GO:0019884 antigen processing and presentation of exogenous antigen(GO:0019884)
0.4 1.7 GO:0034759 regulation of iron ion transport(GO:0034756) regulation of iron ion transmembrane transport(GO:0034759)
0.3 1.3 GO:1901252 regulation of intracellular transport of viral material(GO:1901252)
0.4 1.1 GO:0090289 regulation of osteoclast proliferation(GO:0090289)
0.1 1.1 GO:0060330 regulation of response to interferon-gamma(GO:0060330)
0.0 1.1 GO:0035456 response to interferon-beta(GO:0035456)
0.1 1.0 GO:0016584 nucleosome positioning(GO:0016584)
0.2 0.9 GO:0046967 cytosol to ER transport(GO:0046967)
0.1 0.8 GO:0089711 L-glutamate transmembrane transport(GO:0089711)
0.1 0.7 GO:0045218 zonula adherens maintenance(GO:0045218)
0.1 0.7 GO:1903377 negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903377)
0.1 0.7 GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA(GO:0000290)
0.0 0.7 GO:0055070 copper ion homeostasis(GO:0055070)
0.0 0.7 GO:0048268 clathrin coat assembly(GO:0048268)
0.0 0.7 GO:0035082 axoneme assembly(GO:0035082)
0.6 0.6 GO:1904959 regulation of electron carrier activity(GO:1904732) regulation of cytochrome-c oxidase activity(GO:1904959)
0.2 0.6 GO:0006059 hexitol metabolic process(GO:0006059) alditol biosynthetic process(GO:0019401)
0.1 0.6 GO:0090086 negative regulation of protein deubiquitination(GO:0090086)
0.1 0.6 GO:0035547 interferon-beta secretion(GO:0035546) regulation of interferon-beta secretion(GO:0035547) positive regulation of interferon-beta secretion(GO:0035549)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 29 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 3.1 GO:0020005 symbiont-containing vacuole membrane(GO:0020005)
0.2 1.7 GO:1990712 HFE-transferrin receptor complex(GO:1990712)
0.0 1.3 GO:0031519 PcG protein complex(GO:0031519)
0.0 1.3 GO:0031225 anchored component of membrane(GO:0031225)
0.2 1.1 GO:0097452 GAIT complex(GO:0097452)
0.0 1.1 GO:0072562 blood microparticle(GO:0072562)
0.3 1.0 GO:0008537 proteasome activator complex(GO:0008537)
0.1 1.0 GO:0005677 chromatin silencing complex(GO:0005677)
0.1 0.9 GO:0042825 TAP complex(GO:0042825)
0.0 0.8 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.2 0.7 GO:0099631 postsynaptic endocytic zone cytoplasmic component(GO:0099631)
0.1 0.7 GO:0042382 paraspeckles(GO:0042382)
0.1 0.7 GO:0005915 zonula adherens(GO:0005915)
0.2 0.6 GO:0097454 Schwann cell microvillus(GO:0097454)
0.1 0.6 GO:1990111 spermatoproteasome complex(GO:1990111)
0.1 0.6 GO:0071797 LUBAC complex(GO:0071797)
0.1 0.6 GO:0019773 proteasome core complex, alpha-subunit complex(GO:0019773)
0.1 0.5 GO:0005638 lamin filament(GO:0005638)
0.0 0.5 GO:0031083 BLOC-1 complex(GO:0031083)
0.0 0.4 GO:0000788 nuclear nucleosome(GO:0000788)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 28 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 1.6 GO:0061133 endopeptidase activator activity(GO:0061133)
0.1 1.4 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.1 1.4 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.0 1.4 GO:0031491 nucleosome binding(GO:0031491)
0.1 1.3 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.1 1.2 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.0 1.1 GO:0030971 receptor tyrosine kinase binding(GO:0030971)
0.2 0.9 GO:0015433 peptide antigen-transporting ATPase activity(GO:0015433) tapasin binding(GO:0046980)
0.2 0.8 GO:0000099 sulfur amino acid transmembrane transporter activity(GO:0000099)
0.1 0.7 GO:0000340 RNA 7-methylguanosine cap binding(GO:0000340)
0.1 0.7 GO:0032050 clathrin heavy chain binding(GO:0032050)
0.1 0.7 GO:0070097 delta-catenin binding(GO:0070097)
0.0 0.7 GO:0005507 copper ion binding(GO:0005507)
0.1 0.6 GO:0004032 alditol:NADP+ 1-oxidoreductase activity(GO:0004032)
0.1 0.6 GO:0016531 copper chaperone activity(GO:0016531)
0.0 0.6 GO:0015036 disulfide oxidoreductase activity(GO:0015036)
0.1 0.5 GO:0043023 ribosomal large subunit binding(GO:0043023)
0.0 0.5 GO:0005159 insulin-like growth factor receptor binding(GO:0005159)
0.0 0.5 GO:0043015 gamma-tubulin binding(GO:0043015)
0.1 0.4 GO:0008109 N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109)

Gene overrepresentation in C2:CP category:

Showing 1 to 6 of 6 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.8 PID_NFAT_TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.0 1.9 PID_IL12_2PATHWAY IL12-mediated signaling events
0.0 0.7 PID_CIRCADIAN_PATHWAY Circadian rhythm pathway
0.0 0.7 PID_ARF_3PATHWAY Arf1 pathway
0.0 0.7 PID_ECADHERIN_STABILIZATION_PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.0 0.6 PID_AURORA_B_PATHWAY Aurora B signaling

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 13 of 13 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.8 REACTOME_CROSS_PRESENTATION_OF_SOLUBLE_EXOGENOUS_ANTIGENS_ENDOSOMES Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)
0.5 1.4 REACTOME_ENDOSOMAL_VACUOLAR_PATHWAY Genes involved in Endosomal/Vacuolar pathway
0.1 1.2 REACTOME_ANTIGEN_PRESENTATION_FOLDING_ASSEMBLY_AND_PEPTIDE_LOADING_OF_CLASS_I_MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.0 1.1 REACTOME_PEPTIDE_CHAIN_ELONGATION Genes involved in Peptide chain elongation
0.0 1.0 REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.0 0.8 REACTOME_BASIGIN_INTERACTIONS Genes involved in Basigin interactions
0.1 0.7 REACTOME_MRNA_DECAY_BY_3_TO_5_EXORIBONUCLEASE Genes involved in mRNA Decay by 3' to 5' Exoribonuclease
0.0 0.7 REACTOME_TRAF3_DEPENDENT_IRF_ACTIVATION_PATHWAY Genes involved in TRAF3-dependent IRF activation pathway
0.0 0.7 REACTOME_GAP_JUNCTION_DEGRADATION Genes involved in Gap junction degradation
0.0 0.6 REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT Genes involved in Mitochondrial Protein Import
0.0 0.5 REACTOME_REGULATION_OF_IFNG_SIGNALING Genes involved in Regulation of IFNG signaling
0.0 0.4 REACTOME_RNA_POL_I_PROMOTER_OPENING Genes involved in RNA Polymerase I Promoter Opening
0.0 0.3 REACTOME_RIP_MEDIATED_NFKB_ACTIVATION_VIA_DAI Genes involved in RIP-mediated NFkB activation via DAI