Motif ID: Ybx1_Nfya_Nfyb_Nfyc_Cebpz

Z-value: 7.218

Transcription factors associated with Ybx1_Nfya_Nfyb_Nfyc_Cebpz:

Gene SymbolEntrez IDGene Name
Cebpz ENSMUSG00000024081.8 Cebpz
Nfya ENSMUSG00000023994.7 Nfya
Nfyb ENSMUSG00000020248.12 Nfyb
Nfyc ENSMUSG00000032897.11 Nfyc
Ybx1 ENSMUSG00000028639.8 Ybx1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Ybx1mm10_v2_chr4_-_119294520_1192946040.771.9e-04Click!
Nfybmm10_v2_chr10_-_82764088_82764144-0.701.2e-03Click!
Cebpzmm10_v2_chr17_-_78937031_78937074-0.493.7e-02Click!
Nfycmm10_v2_chr4_-_120815703_1208157610.456.2e-02Click!
Nfyamm10_v2_chr17_-_48409729_48409906-0.322.0e-01Click!


Activity profile for motif Ybx1_Nfya_Nfyb_Nfyc_Cebpz.

activity profile for motif Ybx1_Nfya_Nfyb_Nfyc_Cebpz


Sorted Z-values histogram for motif Ybx1_Nfya_Nfyb_Nfyc_Cebpz

Sorted Z-values for motif Ybx1_Nfya_Nfyb_Nfyc_Cebpz



Network of associatons between targets according to the STRING database.



First level regulatory network of Ybx1_Nfya_Nfyb_Nfyc_Cebpz

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_+_124829582 25.617 ENSMUST00000024270.7
 Cdca3
cell division cycle associated 3
chr8_+_83955507 22.273 ENSMUST00000005607.8
 Asf1b
ASF1 anti-silencing function 1 homolog B (S. cerevisiae)
chr16_-_17125106 21.764 ENSMUST00000093336.6
 2610318N02Rik
RIKEN cDNA 2610318N02 gene
chr3_-_89418287 18.237 ENSMUST00000029679.3
 Cks1b
CDC28 protein kinase 1b
chr13_-_23745511 17.490 ENSMUST00000091752.2
 Hist1h3c
histone cluster 1, H3c
chr6_+_124829540 16.878 ENSMUST00000150120.1
 Cdca3
cell division cycle associated 3
chr3_-_8667033 16.820 ENSMUST00000042412.3
 Hey1
hairy/enhancer-of-split related with YRPW motif 1
chr6_+_124830217 16.107 ENSMUST00000131847.1
ENSMUST00000151674.1
 Cdca3

cell division cycle associated 3

chr8_+_57511833 14.814 ENSMUST00000067925.6
 Hmgb2
high mobility group box 2
chr14_+_46760526 14.559 ENSMUST00000067426.4
 Cdkn3
cyclin-dependent kinase inhibitor 3
chrX_+_58030622 14.197 ENSMUST00000088627.4
 Zic3
zinc finger protein of the cerebellum 3
chr2_+_34772089 13.982 ENSMUST00000028222.6
ENSMUST00000100171.2
 Hspa5

heat shock protein 5

chr11_-_87108656 13.881 ENSMUST00000051395.8
 Prr11
proline rich 11
chr14_+_19751257 13.591 ENSMUST00000022340.3
 Nid2
nidogen 2
chr13_-_56252163 12.901 ENSMUST00000058475.4
 Neurog1
neurogenin 1
chr11_+_54902743 12.857 ENSMUST00000082430.3
 Gpx3
glutathione peroxidase 3
chr17_-_24251382 12.286 ENSMUST00000115390.3
 Ccnf
cyclin F
chr11_+_95337012 12.284 ENSMUST00000037502.6
 Fam117a
family with sequence similarity 117, member A
chr16_+_30065333 12.149 ENSMUST00000023171.7
 Hes1
hairy and enhancer of split 1 (Drosophila)
chr7_-_120982260 12.067 ENSMUST00000033169.8
 Cdr2
cerebellar degeneration-related 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 660 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.7 83.8 GO:0034723 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.7 65.1 GO:0006342 chromatin silencing(GO:0006342)
1.7 46.8 GO:0032467 positive regulation of cytokinesis(GO:0032467)
6.8 40.9 GO:0072049 comma-shaped body morphogenesis(GO:0072049)
0.8 33.4 GO:0045737 positive regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045737)
4.2 33.3 GO:0016321 female meiosis chromosome segregation(GO:0016321)
1.3 32.7 GO:0006270 DNA replication initiation(GO:0006270)
1.4 28.2 GO:0043486 histone exchange(GO:0043486)
0.2 28.0 GO:0006457 protein folding(GO:0006457)
1.8 27.7 GO:0007100 mitotic centrosome separation(GO:0007100)
1.3 25.0 GO:0042744 hydrogen peroxide catabolic process(GO:0042744)
3.6 24.9 GO:0031536 positive regulation of exit from mitosis(GO:0031536)
4.0 23.7 GO:0035469 determination of pancreatic left/right asymmetry(GO:0035469)
0.1 22.5 GO:0051301 cell division(GO:0051301)
0.9 22.3 GO:0060236 regulation of mitotic spindle organization(GO:0060236)
1.8 22.0 GO:0030953 astral microtubule organization(GO:0030953)
0.4 21.7 GO:0008156 negative regulation of DNA replication(GO:0008156)
2.1 21.4 GO:0051255 spindle midzone assembly(GO:0051255) mitotic spindle midzone assembly(GO:0051256)
0.3 17.7 GO:0006334 nucleosome assembly(GO:0006334)
1.7 17.4 GO:0010826 negative regulation of centrosome duplication(GO:0010826) negative regulation of centrosome cycle(GO:0046606)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 276 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.8 128.7 GO:0000786 nucleosome(GO:0000786)
0.0 67.7 GO:0005634 nucleus(GO:0005634)
0.6 62.6 GO:0000776 kinetochore(GO:0000776)
0.2 61.5 GO:0016607 nuclear speck(GO:0016607)
0.2 58.8 GO:0000790 nuclear chromatin(GO:0000790)
4.2 54.7 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.1 51.5 GO:0005615 extracellular space(GO:0005615)
0.9 43.7 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
2.2 38.1 GO:0031616 spindle pole centrosome(GO:0031616)
0.0 36.9 GO:0005739 mitochondrion(GO:0005739)
6.7 33.6 GO:0097149 centralspindlin complex(GO:0097149)
0.3 29.9 GO:0005913 cell-cell adherens junction(GO:0005913)
1.2 28.7 GO:0005680 anaphase-promoting complex(GO:0005680)
0.4 28.6 GO:0005643 nuclear pore(GO:0005643)
5.5 27.6 GO:0032133 chromosome passenger complex(GO:0032133)
0.6 27.0 GO:0005657 replication fork(GO:0005657)
1.6 23.9 GO:0042555 MCM complex(GO:0042555)
1.1 22.5 GO:0045120 pronucleus(GO:0045120)
0.3 21.0 GO:0005814 centriole(GO:0005814)
0.2 20.2 GO:0015934 large ribosomal subunit(GO:0015934)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 421 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.5 121.1 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.6 56.0 GO:0051082 unfolded protein binding(GO:0051082)
0.3 41.3 GO:0001047 core promoter binding(GO:0001047)
0.4 34.8 GO:0035326 enhancer binding(GO:0035326)
8.2 32.7 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity(GO:0061575)
0.4 28.4 GO:0051087 chaperone binding(GO:0051087)
0.9 28.1 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.4 27.7 GO:0070491 repressing transcription factor binding(GO:0070491)
0.2 24.7 GO:0003735 structural constituent of ribosome(GO:0003735)
0.5 23.8 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631) ubiquitin-like protein conjugating enzyme activity(GO:0061650)
0.1 23.6 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.1 23.6 GO:0008017 microtubule binding(GO:0008017)
7.8 23.4 GO:0035939 microsatellite binding(GO:0035939)
1.7 23.3 GO:0003688 DNA replication origin binding(GO:0003688)
0.1 23.3 GO:0045296 cadherin binding(GO:0045296)
1.3 22.9 GO:0000400 four-way junction DNA binding(GO:0000400)
2.1 22.8 GO:0008430 selenium binding(GO:0008430)
0.3 22.5 GO:0003777 microtubule motor activity(GO:0003777)
0.3 20.0 GO:0003697 single-stranded DNA binding(GO:0003697)
0.1 19.7 GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 85 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.2 138.2 PID_PLK1_PATHWAY PLK1 signaling events
1.5 55.2 PID_FOXM1_PATHWAY FOXM1 transcription factor network
1.1 51.9 PID_FANCONI_PATHWAY Fanconi anemia pathway
0.7 40.7 PID_HES_HEY_PATHWAY Notch-mediated HES/HEY network
0.4 39.2 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.5 34.9 PID_TELOMERASE_PATHWAY Regulation of Telomerase
0.9 32.6 PID_AURORA_B_PATHWAY Aurora B signaling
1.1 30.5 PID_SMAD2_3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
2.0 28.6 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.3 24.0 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.5 20.4 PID_EPHRINB_REV_PATHWAY Ephrin B reverse signaling
0.3 19.6 PID_CMYB_PATHWAY C-MYB transcription factor network
0.5 17.6 PID_LYMPH_ANGIOGENESIS_PATHWAY VEGFR3 signaling in lymphatic endothelium
0.3 15.0 PID_E2F_PATHWAY E2F transcription factor network
0.6 14.5 PID_MYC_PATHWAY C-MYC pathway
0.7 14.4 PID_ATR_PATHWAY ATR signaling pathway
0.6 13.7 PID_AURORA_A_PATHWAY Aurora A signaling
0.4 13.6 NABA_BASEMENT_MEMBRANES Genes encoding structural components of basement membranes
0.4 11.7 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.3 11.7 PID_IL12_2PATHWAY IL12-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 152 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.5 130.0 REACTOME_RNA_POL_I_PROMOTER_OPENING Genes involved in RNA Polymerase I Promoter Opening
0.9 76.8 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.4 58.1 REACTOME_MRNA_SPLICING Genes involved in mRNA Splicing
2.8 47.7 REACTOME_CYCLIN_A_B1_ASSOCIATED_EVENTS_DURING_G2_M_TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
1.8 44.2 REACTOME_CHOLESTEROL_BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
1.7 43.7 REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
2.7 43.2 REACTOME_ASSOCIATION_OF_LICENSING_FACTORS_WITH_THE_PRE_REPLICATIVE_COMPLEX Genes involved in Association of licensing factors with the pre-replicative complex
0.5 34.9 REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
1.6 34.8 REACTOME_APC_CDC20_MEDIATED_DEGRADATION_OF_NEK2A Genes involved in APC-Cdc20 mediated degradation of Nek2A
2.3 34.7 REACTOME_UNWINDING_OF_DNA Genes involved in Unwinding of DNA
1.9 31.2 REACTOME_APOPTOSIS_INDUCED_DNA_FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
1.1 29.7 REACTOME_KINESINS Genes involved in Kinesins
0.5 23.8 REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT Genes involved in Mitochondrial Protein Import
0.7 23.2 REACTOME_G1_PHASE Genes involved in G1 Phase
0.4 22.8 REACTOME_APC_C_CDH1_MEDIATED_DEGRADATION_OF_CDC20_AND_OTHER_APC_C_CDH1_TARGETED_PROTEINS_IN_LATE_MITOSIS_EARLY_G1 Genes involved in APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
2.5 22.7 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_ATF6_ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.8 22.1 REACTOME_REGULATION_OF_BETA_CELL_DEVELOPMENT Genes involved in Regulation of beta-cell development
1.4 19.9 REACTOME_SYNTHESIS_SECRETION_AND_INACTIVATION_OF_GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.4 19.0 REACTOME_ANTIVIRAL_MECHANISM_BY_IFN_STIMULATED_GENES Genes involved in Antiviral mechanism by IFN-stimulated genes
0.3 18.6 REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production