Motif ID: Hoxa2

Z-value: 1.153


Transcription factors associated with Hoxa2:

Gene SymbolEntrez IDGene Name
Hoxa2 ENSMUSG00000014704.8 Hoxa2



Activity profile for motif Hoxa2.

activity profile for motif Hoxa2


Sorted Z-values histogram for motif Hoxa2

Sorted Z-values for motif Hoxa2



Network of associatons between targets according to the STRING database.



First level regulatory network of Hoxa2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr5_+_139543889 5.671 ENSMUST00000174792.1
ENSMUST00000031523.8
 Uncx

UNC homeobox

chr16_-_23890805 4.780 ENSMUST00000004480.3
 Sst
somatostatin
chr12_+_109747903 3.114 ENSMUST00000183084.1
ENSMUST00000182300.1
 Mirg

miRNA containing gene

chr2_-_117342949 3.097 ENSMUST00000102534.4
 Rasgrp1
RAS guanyl releasing protein 1
chr2_-_117342831 2.925 ENSMUST00000178884.1
 Rasgrp1
RAS guanyl releasing protein 1
chr2_-_117342709 2.724 ENSMUST00000173541.1
ENSMUST00000172901.1
ENSMUST00000173252.1
 Rasgrp1


RAS guanyl releasing protein 1


chr8_-_87959560 2.521 ENSMUST00000109655.2
 Zfp423
zinc finger protein 423
chr8_-_4779513 2.511 ENSMUST00000022945.7
 Shcbp1
Shc SH2-domain binding protein 1
chr13_+_117220584 2.434 ENSMUST00000022242.7
 Emb
embigin
chr14_-_34374617 2.326 ENSMUST00000023826.4
 Sncg
synuclein, gamma
chr7_+_144838590 2.305 ENSMUST00000105898.1
 Fgf3
fibroblast growth factor 3
chrX_-_103483205 2.217 ENSMUST00000127786.2
 Xist
inactive X specific transcripts
chr10_-_92162753 2.204 ENSMUST00000182197.1
 Rmst
rhabdomyosarcoma 2 associated transcript (non-coding RNA)
chr11_-_58801944 2.169 ENSMUST00000094156.4
ENSMUST00000060581.3
 Fam183b

family with sequence similarity 183, member B

chr1_-_133907053 2.015 ENSMUST00000149380.1
ENSMUST00000124051.2
 Optc

opticin

chr9_-_106158109 2.000 ENSMUST00000159809.1
ENSMUST00000162562.1
ENSMUST00000036382.6
ENSMUST00000112543.2
 Glyctk



glycerate kinase



chr4_+_46450892 1.943 ENSMUST00000102926.4
 Anp32b
acidic (leucine-rich) nuclear phosphoprotein 32 family, member B
chr9_+_51621425 1.915 ENSMUST00000089534.4
 Gm7293
predicted gene 7293
chr14_-_61037937 1.900 ENSMUST00000111236.2
 Tnfrsf19
tumor necrosis factor receptor superfamily, member 19
chr5_-_24527276 1.890 ENSMUST00000088311.4
 Gbx1
gastrulation brain homeobox 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 163 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.0 8.7 GO:1902715 positive regulation of interferon-gamma secretion(GO:1902715)
0.8 5.7 GO:0035726 common myeloid progenitor cell proliferation(GO:0035726)
0.8 3.8 GO:0046864 retinol transport(GO:0034633) isoprenoid transport(GO:0046864) terpenoid transport(GO:0046865) alveolar primary septum development(GO:0061143)
0.0 3.8 GO:0016525 negative regulation of angiogenesis(GO:0016525)
1.2 3.5 GO:0001869 regulation of complement activation, lectin pathway(GO:0001868) negative regulation of complement activation, lectin pathway(GO:0001869)
0.0 2.7 GO:0008543 fibroblast growth factor receptor signaling pathway(GO:0008543)
0.1 2.5 GO:0030513 positive regulation of BMP signaling pathway(GO:0030513)
0.5 2.4 GO:0032901 positive regulation of neurotrophin production(GO:0032901)
0.2 2.4 GO:0035873 lactate transport(GO:0015727) lactate transmembrane transport(GO:0035873) plasma membrane lactate transport(GO:0035879)
0.3 2.3 GO:0045876 positive regulation of sister chromatid cohesion(GO:0045876)
0.3 2.3 GO:0030916 otic vesicle formation(GO:0030916) semicircular canal morphogenesis(GO:0048752)
0.7 2.2 GO:0060708 spongiotrophoblast differentiation(GO:0060708)
0.1 2.2 GO:0043486 histone exchange(GO:0043486)
0.5 1.9 GO:0097374 sensory neuron axon guidance(GO:0097374)
0.2 1.9 GO:0009249 protein lipoylation(GO:0009249)
0.2 1.8 GO:2001214 positive regulation of vasculogenesis(GO:2001214)
0.0 1.8 GO:0007052 mitotic spindle organization(GO:0007052)
0.6 1.7 GO:0097401 synaptic vesicle lumen acidification(GO:0097401)
0.3 1.7 GO:0072103 renal system vasculature morphogenesis(GO:0061438) kidney vasculature morphogenesis(GO:0061439) glomerulus vasculature morphogenesis(GO:0072103) glomerular capillary formation(GO:0072104)
0.0 1.7 GO:0009566 fertilization(GO:0009566)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 75 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 4.3 GO:0031262 Ndc80 complex(GO:0031262)
0.4 3.5 GO:0000805 X chromosome(GO:0000805)
0.0 3.2 GO:0070469 respiratory chain(GO:0070469)
0.0 2.7 GO:0001669 acrosomal vesicle(GO:0001669)
0.1 2.4 GO:0097546 ciliary base(GO:0097546)
0.0 2.4 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.1 2.1 GO:0030134 ER to Golgi transport vesicle(GO:0030134)
0.0 2.0 GO:0005776 autophagosome(GO:0005776)
0.3 1.9 GO:0000172 ribonuclease MRP complex(GO:0000172)
0.4 1.8 GO:0031466 Cul5-RING ubiquitin ligase complex(GO:0031466)
0.0 1.8 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.0 1.8 GO:0005643 nuclear pore(GO:0005643)
0.0 1.8 GO:0072562 blood microparticle(GO:0072562)
0.1 1.7 GO:0044300 cerebellar mossy fiber(GO:0044300)
0.1 1.5 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.0 1.5 GO:0034707 chloride channel complex(GO:0034707)
0.4 1.3 GO:0044614 nuclear pore cytoplasmic filaments(GO:0044614)
0.0 1.2 GO:0031307 integral component of mitochondrial outer membrane(GO:0031307)
0.0 1.1 GO:0000788 nuclear nucleosome(GO:0000788)
0.3 1.0 GO:0005584 collagen type I trimer(GO:0005584)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 122 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 9.7 GO:0019992 diacylglycerol binding(GO:0019992)
0.1 3.8 GO:0051183 vitamin transporter activity(GO:0051183)
0.2 3.5 GO:0001848 complement binding(GO:0001848)
0.1 3.1 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.1 2.5 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.1 2.5 GO:0042169 SH2 domain binding(GO:0042169)
0.3 2.4 GO:0048403 brain-derived neurotrophic factor binding(GO:0048403)
0.1 2.4 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0 2.3 GO:0005179 hormone activity(GO:0005179)
0.1 2.1 GO:0043014 alpha-tubulin binding(GO:0043014)
0.0 2.0 GO:0043021 ribonucleoprotein complex binding(GO:0043021)
0.0 2.0 GO:0003735 structural constituent of ribosome(GO:0003735)
0.0 2.0 GO:0042393 histone binding(GO:0042393)
0.6 1.9 GO:0000171 ribonuclease MRP activity(GO:0000171)
0.6 1.7 GO:0005436 sodium:phosphate symporter activity(GO:0005436) sodium:inorganic phosphate symporter activity(GO:0015319)
0.1 1.6 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709)
0.5 1.5 GO:0031750 D3 dopamine receptor binding(GO:0031750)
0.3 1.4 GO:0017108 5'-flap endonuclease activity(GO:0017108)
0.0 1.4 GO:0004864 protein phosphatase inhibitor activity(GO:0004864)
0.0 1.4 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 27 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 8.3 PID_RAS_PATHWAY Regulation of Ras family activation
0.1 3.8 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.0 3.0 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 2.5 PID_PLK1_PATHWAY PLK1 signaling events
0.0 2.0 PID_ERA_GENOMIC_PATHWAY Validated nuclear estrogen receptor alpha network
0.1 1.9 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.0 1.7 PID_NOTCH_PATHWAY Notch signaling pathway
0.0 1.6 NABA_COLLAGENS Genes encoding collagen proteins
0.1 1.3 PID_RANBP2_PATHWAY Sumoylation by RanBP2 regulates transcriptional repression
0.0 1.2 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 1.1 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.0 1.0 PID_IL27_PATHWAY IL27-mediated signaling events
0.0 1.0 PID_MYC_PATHWAY C-MYC pathway
0.0 0.9 PID_SMAD2_3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.0 0.8 PID_P38_ALPHA_BETA_PATHWAY Regulation of p38-alpha and p38-beta
0.0 0.6 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.0 0.5 PID_INTEGRIN_A9B1_PATHWAY Alpha9 beta1 integrin signaling events
0.0 0.5 PID_BARD1_PATHWAY BARD1 signaling events
0.0 0.5 PID_RAC1_PATHWAY RAC1 signaling pathway
0.0 0.5 PID_IL4_2PATHWAY IL4-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 43 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 9.2 REACTOME_RAP1_SIGNALLING Genes involved in Rap1 signalling
0.1 6.0 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.0 5.8 REACTOME_G_ALPHA_I_SIGNALLING_EVENTS Genes involved in G alpha (i) signalling events
0.0 3.8 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT_ATP_SYNTHESIS_BY_CHEMIOSMOTIC_COUPLING_AND_HEAT_PRODUCTION_BY_UNCOUPLING_PROTEINS_ Genes involved in Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
0.4 3.5 REACTOME_INTRINSIC_PATHWAY Genes involved in Intrinsic Pathway
0.1 2.8 REACTOME_PRE_NOTCH_PROCESSING_IN_GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.0 2.6 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.2 2.5 REACTOME_FGFR1_LIGAND_BINDING_AND_ACTIVATION Genes involved in FGFR1 ligand binding and activation
0.0 2.4 REACTOME_RNA_POL_I_PROMOTER_OPENING Genes involved in RNA Polymerase I Promoter Opening
0.1 2.0 REACTOME_SULFUR_AMINO_ACID_METABOLISM Genes involved in Sulfur amino acid metabolism
0.0 1.7 REACTOME_METABOLISM_OF_NON_CODING_RNA Genes involved in Metabolism of non-coding RNA
0.0 1.5 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.1 1.4 REACTOME_REMOVAL_OF_THE_FLAP_INTERMEDIATE_FROM_THE_C_STRAND Genes involved in Removal of the Flap Intermediate from the C-strand
0.1 1.3 REACTOME_METAL_ION_SLC_TRANSPORTERS Genes involved in Metal ion SLC transporters
0.0 1.3 REACTOME_SMAD2_SMAD3_SMAD4_HETEROTRIMER_REGULATES_TRANSCRIPTION Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
0.2 1.2 REACTOME_ENDOGENOUS_STEROLS Genes involved in Endogenous sterols
0.1 1.1 REACTOME_GLUTAMATE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Glutamate Neurotransmitter Release Cycle
0.1 1.0 REACTOME_PLATELET_ADHESION_TO_EXPOSED_COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.1 1.0 REACTOME_POST_CHAPERONIN_TUBULIN_FOLDING_PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.0 1.0 REACTOME_PYRIMIDINE_METABOLISM Genes involved in Pyrimidine metabolism