Motif ID: Stat6

Z-value: 0.854


Transcription factors associated with Stat6:

Gene SymbolEntrez IDGene Name
Stat6 ENSMUSG00000002147.12 Stat6

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Stat6mm10_v2_chr10_+_127642975_127643034-0.272.7e-01Click!


Activity profile for motif Stat6.

activity profile for motif Stat6


Sorted Z-values histogram for motif Stat6

Sorted Z-values for motif Stat6



Network of associatons between targets according to the STRING database.



First level regulatory network of Stat6

PNG image of the network

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Top targets:


Showing 1 to 20 of 152 entries
PromoterScoreRefseqGene SymbolGene Name
chr3_+_102010138 3.250 ENSMUST00000066187.4
 Nhlh2
nescient helix loop helix 2
chr14_-_21989475 3.052 ENSMUST00000043409.7
 Zfp503
zinc finger protein 503
chr16_-_23890805 2.188 ENSMUST00000004480.3
 Sst
somatostatin
chr5_-_106574706 2.183 ENSMUST00000131029.1
ENSMUST00000124394.2
 RP24-421H18.1

RP24-421H18.1

chr5_+_139543889 2.155 ENSMUST00000174792.1
ENSMUST00000031523.8
 Uncx

UNC homeobox

chr17_+_29090969 1.951 ENSMUST00000119901.1
 Cdkn1a
cyclin-dependent kinase inhibitor 1A (P21)
chr18_+_50053282 1.875 ENSMUST00000148159.2
 Tnfaip8
tumor necrosis factor, alpha-induced protein 8
chr10_+_97479470 1.765 ENSMUST00000105287.3
 Dcn
decorin
chr3_+_67892189 1.512 ENSMUST00000063263.3
 Iqcj
IQ motif containing J
chr17_-_89910449 1.476 ENSMUST00000086423.4
 Gm10184
predicted pseudogene 10184
chr7_-_126800354 1.315 ENSMUST00000106348.1
 Aldoa
aldolase A, fructose-bisphosphate
chr19_+_12846773 1.278 ENSMUST00000164001.1
 Gm5244
predicted pseudogene 5244
chr7_-_70366735 1.154 ENSMUST00000089565.5
 Nr2f2
nuclear receptor subfamily 2, group F, member 2
chr9_-_70421533 1.129 ENSMUST00000034742.6
 Ccnb2
cyclin B2
chr1_+_146497614 1.093 ENSMUST00000132847.1
ENSMUST00000166814.1
 Brinp3

bone morphogenetic protein/retinoic acid inducible neural specific 3

chr7_-_90129339 1.078 ENSMUST00000181189.1
 2310010J17Rik
RIKEN cDNA 2310010J17 gene
chr1_-_144177259 1.031 ENSMUST00000111941.1
ENSMUST00000052375.1
 Rgs13

regulator of G-protein signaling 13

chr4_-_116708312 1.019 ENSMUST00000030453.4
 Mmachc
methylmalonic aciduria cblC type, with homocystinuria
chr14_-_65425453 0.919 ENSMUST00000059339.5
 Pnoc
prepronociceptin
chr7_-_127286385 0.891 ENSMUST00000172206.2
 Gm17511
predicted gene, 17511

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 64 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.2 GO:0007617 mating behavior(GO:0007617) multi-organism reproductive behavior(GO:0044705)
1.0 3.1 GO:0070315 G1 to G0 transition involved in cell differentiation(GO:0070315)
0.3 2.2 GO:0035726 common myeloid progenitor cell proliferation(GO:0035726)
0.2 2.1 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.2 2.0 GO:0071493 cellular response to UV-B(GO:0071493)
0.0 1.9 GO:0050830 defense response to Gram-positive bacterium(GO:0050830)
0.3 1.8 GO:1900747 negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747)
0.0 1.7 GO:0071300 cellular response to retinoic acid(GO:0071300)
0.1 1.6 GO:0045722 positive regulation of gluconeogenesis(GO:0045722)
0.2 1.4 GO:0015842 aminergic neurotransmitter loading into synaptic vesicle(GO:0015842)
0.2 1.2 GO:0060849 regulation of transcription involved in lymphatic endothelial cell fate commitment(GO:0060849)
0.0 1.1 GO:0043029 T cell homeostasis(GO:0043029)
0.2 1.0 GO:0042364 water-soluble vitamin biosynthetic process(GO:0042364)
0.0 1.0 GO:0045744 negative regulation of G-protein coupled receptor protein signaling pathway(GO:0045744)
0.0 0.9 GO:0007218 neuropeptide signaling pathway(GO:0007218)
0.0 0.8 GO:0030903 notochord development(GO:0030903)
0.0 0.8 GO:0018345 protein palmitoylation(GO:0018345)
0.0 0.8 GO:0001937 negative regulation of endothelial cell proliferation(GO:0001937)
0.2 0.7 GO:2000383 regulation of ectoderm development(GO:2000383) negative regulation of ectoderm development(GO:2000384)
0.2 0.7 GO:1900740 regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900739) positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900740)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 25 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.1 GO:0035686 sperm fibrous sheath(GO:0035686)
0.7 2.0 GO:0070557 PCNA-p21 complex(GO:0070557)
0.1 1.8 GO:0098644 complex of collagen trimers(GO:0098644)
0.0 1.1 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.2 0.8 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.0 0.8 GO:0000314 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.1 0.7 GO:0045298 tubulin complex(GO:0045298)
0.0 0.7 GO:0044300 cerebellar mossy fiber(GO:0044300)
0.0 0.7 GO:0043209 myelin sheath(GO:0043209)
0.0 0.7 GO:0000313 organellar ribosome(GO:0000313) mitochondrial ribosome(GO:0005761)
0.1 0.6 GO:0042825 TAP complex(GO:0042825)
0.0 0.6 GO:0031932 TORC2 complex(GO:0031932)
0.0 0.6 GO:0045239 tricarboxylic acid cycle enzyme complex(GO:0045239)
0.0 0.6 GO:0005637 nuclear inner membrane(GO:0005637)
0.0 0.6 GO:0005801 cis-Golgi network(GO:0005801)
0.1 0.5 GO:0030891 VCB complex(GO:0030891)
0.1 0.5 GO:0046696 lipopolysaccharide receptor complex(GO:0046696)
0.1 0.4 GO:1990111 spermatoproteasome complex(GO:1990111)
0.0 0.4 GO:0070971 endoplasmic reticulum exit site(GO:0070971)
0.1 0.3 GO:0044299 C-fiber(GO:0044299)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 38 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.1 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.0 2.6 GO:0050840 extracellular matrix binding(GO:0050840)
0.0 2.2 GO:0005179 hormone activity(GO:0005179)
0.3 2.1 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.7 2.0 GO:0019912 cyclin-dependent protein kinase activating kinase activity(GO:0019912)
0.0 1.9 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.0 1.6 GO:0004864 protein phosphatase inhibitor activity(GO:0004864)
0.4 1.4 GO:0036468 aromatic-L-amino-acid decarboxylase activity(GO:0004058) L-dopa decarboxylase activity(GO:0036468)
0.1 1.2 GO:0001972 retinoic acid binding(GO:0001972)
0.1 1.0 GO:0031419 cobalamin binding(GO:0031419)
0.1 0.9 GO:0001515 opioid peptide activity(GO:0001515)
0.0 0.8 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.1 0.7 GO:0000340 RNA 7-methylguanosine cap binding(GO:0000340)
0.1 0.7 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.0 0.7 GO:0004697 protein kinase C activity(GO:0004697)
0.2 0.6 GO:0015433 peptide antigen-transporting ATPase activity(GO:0015433) tapasin binding(GO:0046980)
0.1 0.6 GO:0070180 large ribosomal subunit rRNA binding(GO:0070180)
0.1 0.6 GO:0030550 acetylcholine receptor inhibitor activity(GO:0030550)
0.0 0.6 GO:0055106 ubiquitin-protein transferase regulator activity(GO:0055106)
0.0 0.6 GO:0070717 poly-purine tract binding(GO:0070717)

Gene overrepresentation in C2:CP category:

Showing 1 to 11 of 11 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.1 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 2.1 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.2 2.0 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.0 1.2 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.0 1.1 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.0 1.0 PID_BCR_5PATHWAY BCR signaling pathway
0.0 0.7 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 0.7 PID_PLK1_PATHWAY PLK1 signaling events
0.0 0.5 PID_HIF1A_PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.0 0.5 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling
0.0 0.3 PID_SYNDECAN_2_PATHWAY Syndecan-2-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 20 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.4 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.0 2.1 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.1 2.0 REACTOME_AKT_PHOSPHORYLATES_TARGETS_IN_THE_CYTOSOL Genes involved in AKT phosphorylates targets in the cytosol
0.1 1.8 REACTOME_CS_DS_DEGRADATION Genes involved in CS/DS degradation
0.1 1.4 REACTOME_AMINE_DERIVED_HORMONES Genes involved in Amine-derived hormones
0.1 1.1 REACTOME_CYCLIN_A_B1_ASSOCIATED_EVENTS_DURING_G2_M_TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.0 1.1 REACTOME_FORMATION_OF_THE_TERNARY_COMPLEX_AND_SUBSEQUENTLY_THE_43S_COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.0 1.0 REACTOME_VIF_MEDIATED_DEGRADATION_OF_APOBEC3G Genes involved in Vif-mediated degradation of APOBEC3G
0.0 1.0 REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.0 0.8 REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ Genes involved in Response to elevated platelet cytosolic Ca2+
0.1 0.7 REACTOME_MRNA_DECAY_BY_3_TO_5_EXORIBONUCLEASE Genes involved in mRNA Decay by 3' to 5' Exoribonuclease
0.0 0.7 REACTOME_ACTIVATION_OF_BH3_ONLY_PROTEINS Genes involved in Activation of BH3-only proteins
0.0 0.6 REACTOME_ANTIGEN_PRESENTATION_FOLDING_ASSEMBLY_AND_PEPTIDE_LOADING_OF_CLASS_I_MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.1 0.5 REACTOME_IKK_COMPLEX_RECRUITMENT_MEDIATED_BY_RIP1 Genes involved in IKK complex recruitment mediated by RIP1
0.0 0.5 REACTOME_OXYGEN_DEPENDENT_PROLINE_HYDROXYLATION_OF_HYPOXIA_INDUCIBLE_FACTOR_ALPHA Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.0 0.3 REACTOME_HS_GAG_DEGRADATION Genes involved in HS-GAG degradation
0.0 0.2 REACTOME_GAP_JUNCTION_ASSEMBLY Genes involved in Gap junction assembly
0.0 0.2 REACTOME_NEF_MEDIATED_DOWNREGULATION_OF_MHC_CLASS_I_COMPLEX_CELL_SURFACE_EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.0 0.2 REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.0 0.1 REACTOME_SYNTHESIS_OF_PE Genes involved in Synthesis of PE