Motif ID: Foxp1_Foxj2

Z-value: 2.062

Transcription factors associated with Foxp1_Foxj2:

Gene SymbolEntrez IDGene Name
Foxj2 ENSMUSG00000003154.9 Foxj2
Foxp1 ENSMUSG00000030067.11 Foxp1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Foxj2mm10_v2_chr6_+_122819888_1228199380.911.1e-07Click!
Foxp1mm10_v2_chr6_-_99435345_994353680.682.1e-03Click!


Activity profile for motif Foxp1_Foxj2.

activity profile for motif Foxp1_Foxj2


Sorted Z-values histogram for motif Foxp1_Foxj2

Sorted Z-values for motif Foxp1_Foxj2



Network of associatons between targets according to the STRING database.



First level regulatory network of Foxp1_Foxj2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr8_+_66386292 9.250 ENSMUST00000039540.5
ENSMUST00000110253.2
 March1

membrane-associated ring finger (C3HC4) 1

chr8_-_84773381 8.547 ENSMUST00000109764.1
 Nfix
nuclear factor I/X
chr6_-_148444336 8.258 ENSMUST00000060095.8
ENSMUST00000100772.3
 Tmtc1

transmembrane and tetratricopeptide repeat containing 1

chr16_+_91269759 7.541 ENSMUST00000056882.5
 Olig1
oligodendrocyte transcription factor 1
chr9_-_121495678 7.444 ENSMUST00000035120.4
 Cck
cholecystokinin
chr5_+_122643878 7.301 ENSMUST00000100737.3
ENSMUST00000121489.1
ENSMUST00000031425.8
ENSMUST00000086247.5
 P2rx7



purinergic receptor P2X, ligand-gated ion channel, 7



chr5_+_75152274 7.097 ENSMUST00000000476.8
 Pdgfra
platelet derived growth factor receptor, alpha polypeptide
chr4_-_151108244 7.069 ENSMUST00000131948.1
 Camta1
calmodulin binding transcription activator 1
chr16_-_43979050 6.697 ENSMUST00000165648.1
ENSMUST00000036321.7
 Zdhhc23

zinc finger, DHHC domain containing 23

chr1_+_66386968 6.411 ENSMUST00000145419.1
 Map2
microtubule-associated protein 2
chr4_-_87806296 6.323 ENSMUST00000126353.1
ENSMUST00000149357.1
 Mllt3

myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3

chr15_-_58214882 6.312 ENSMUST00000022986.6
 Fbxo32
F-box protein 32
chr9_-_40455670 6.277 ENSMUST00000165104.1
ENSMUST00000045682.5
 Gramd1b

GRAM domain containing 1B

chr16_-_22439719 6.188 ENSMUST00000079601.6
 Etv5
ets variant gene 5
chr10_+_60106452 5.906 ENSMUST00000165024.2
 Spock2
sparc/osteonectin, cwcv and kazal-like domains proteoglycan 2
chr16_-_22439570 5.808 ENSMUST00000170393.1
 Etv5
ets variant gene 5
chr6_-_58907120 5.713 ENSMUST00000059539.3
 Nap1l5
nucleosome assembly protein 1-like 5
chr15_-_66969616 5.702 ENSMUST00000170903.1
ENSMUST00000166420.1
ENSMUST00000005256.6
ENSMUST00000164070.1
 Ndrg1



N-myc downstream regulated gene 1



chr6_+_135362931 5.576 ENSMUST00000032330.9
 Emp1
epithelial membrane protein 1
chr7_+_110772604 5.400 ENSMUST00000005829.6
 Ampd3
adenosine monophosphate deaminase 3

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 390 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.6 13.2 GO:0048133 germ-line stem cell division(GO:0042078) male germ-line stem cell asymmetric division(GO:0048133) germline stem cell asymmetric division(GO:0098728)
0.3 12.8 GO:0006376 mRNA splice site selection(GO:0006376)
1.1 11.9 GO:0042572 retinol metabolic process(GO:0042572)
0.1 11.7 GO:0050885 neuromuscular process controlling balance(GO:0050885)
0.6 11.4 GO:0002495 antigen processing and presentation of peptide antigen via MHC class II(GO:0002495)
0.4 10.9 GO:0022401 desensitization of G-protein coupled receptor protein signaling pathway(GO:0002029) negative adaptation of signaling pathway(GO:0022401)
0.8 10.7 GO:0016191 synaptic vesicle uncoating(GO:0016191)
0.7 10.5 GO:2000096 positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096)
1.3 10.4 GO:0060137 maternal process involved in parturition(GO:0060137)
0.8 10.4 GO:0070842 aggresome assembly(GO:0070842)
0.6 10.1 GO:0021684 cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
0.1 10.1 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.9 9.8 GO:0010650 positive regulation of cell communication by electrical coupling(GO:0010650) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.9 7.5 GO:2000301 negative regulation of synaptic vesicle exocytosis(GO:2000301)
2.4 7.3 GO:0032650 regulation of interleukin-1 alpha production(GO:0032650) positive regulation of interleukin-1 alpha production(GO:0032730) interleukin-1 alpha secretion(GO:0050703) regulation of bleb assembly(GO:1904170)
0.8 7.3 GO:0051901 positive regulation of mitochondrial depolarization(GO:0051901)
2.4 7.1 GO:0043379 memory T cell differentiation(GO:0043379)
2.3 6.9 GO:0035790 platelet-derived growth factor receptor-alpha signaling pathway(GO:0035790)
0.7 6.6 GO:0036371 protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371)
0.9 6.4 GO:0035826 rubidium ion transport(GO:0035826) cellular hypotonic response(GO:0071476)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 156 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 30.2 GO:0014069 postsynaptic density(GO:0014069)
0.0 24.8 GO:0005887 integral component of plasma membrane(GO:0005887)
0.6 18.9 GO:0043194 axon initial segment(GO:0043194)
0.1 16.5 GO:0005802 trans-Golgi network(GO:0005802)
0.5 15.0 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.1 12.8 GO:0000139 Golgi membrane(GO:0000139)
0.6 9.5 GO:0031229 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229)
0.0 9.2 GO:0098852 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.2 8.8 GO:0008023 transcription elongation factor complex(GO:0008023)
0.1 8.0 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.1 7.5 GO:0031941 filamentous actin(GO:0031941)
0.0 7.2 GO:0005874 microtubule(GO:0005874)
0.2 6.6 GO:0031430 M band(GO:0031430)
0.7 6.4 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
0.2 6.4 GO:0035861 site of double-strand break(GO:0035861)
0.1 6.4 GO:0016323 basolateral plasma membrane(GO:0016323)
0.5 5.9 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.0 5.7 GO:0045211 postsynaptic membrane(GO:0045211)
0.3 5.6 GO:0071564 npBAF complex(GO:0071564)
0.1 5.4 GO:0080008 Cul4-RING E3 ubiquitin ligase complex(GO:0080008)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 256 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 20.1 GO:0030507 spectrin binding(GO:0030507)
0.2 13.1 GO:0036002 pre-mRNA binding(GO:0036002)
1.8 12.3 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.4 12.1 GO:0017075 syntaxin-1 binding(GO:0017075)
0.1 11.5 GO:0017124 SH3 domain binding(GO:0017124)
0.3 10.0 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.1 9.6 GO:0017137 Rab GTPase binding(GO:0017137)
0.4 9.3 GO:0042287 MHC protein binding(GO:0042287)
0.0 9.2 GO:0008017 microtubule binding(GO:0008017)
0.2 8.6 GO:0043015 gamma-tubulin binding(GO:0043015)
0.0 8.2 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
0.2 8.1 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.3 7.9 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.3 7.5 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
1.2 7.3 GO:0035381 extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381)
2.4 7.1 GO:0030549 acetylcholine receptor activator activity(GO:0030549)
1.4 7.1 GO:0038085 vascular endothelial growth factor binding(GO:0038085)
0.9 6.4 GO:0015379 potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820)
0.8 6.4 GO:0005519 cytoskeletal regulatory protein binding(GO:0005519)
0.6 6.3 GO:0008526 phosphatidylinositol transporter activity(GO:0008526)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 68 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 15.1 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.2 12.3 PID_FOXO_PATHWAY FoxO family signaling
0.4 11.4 PID_IL12_STAT4_PATHWAY IL12 signaling mediated by STAT4
0.2 10.4 PID_LKB1_PATHWAY LKB1 signaling events
0.3 9.0 PID_ARF6_DOWNSTREAM_PATHWAY Arf6 downstream pathway
0.2 7.7 PID_RHOA_PATHWAY RhoA signaling pathway
0.3 7.6 ST_G_ALPHA_S_PATHWAY G alpha s Pathway
0.4 7.4 PID_PDGFRA_PATHWAY PDGFR-alpha signaling pathway
0.2 7.3 PID_IL3_PATHWAY IL3-mediated signaling events
0.2 6.4 PID_IL6_7_PATHWAY IL6-mediated signaling events
0.0 6.1 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 5.6 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression
0.1 5.4 PID_CD8_TCR_PATHWAY TCR signaling in naïve CD8+ T cells
0.1 5.2 PID_AR_TF_PATHWAY Regulation of Androgen receptor activity
0.1 5.0 PID_CDC42_REG_PATHWAY Regulation of CDC42 activity
0.2 4.5 PID_EPO_PATHWAY EPO signaling pathway
0.2 4.3 PID_CIRCADIAN_PATHWAY Circadian rhythm pathway
0.2 3.9 PID_ECADHERIN_KERATINOCYTE_PATHWAY E-cadherin signaling in keratinocytes
0.1 3.7 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 3.7 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 96 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 10.9 REACTOME_LYSOSOME_VESICLE_BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
0.3 9.8 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
1.4 9.5 REACTOME_THE_NLRP3_INFLAMMASOME Genes involved in The NLRP3 inflammasome
0.1 8.9 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.4 8.3 REACTOME_PKA_MEDIATED_PHOSPHORYLATION_OF_CREB Genes involved in PKA-mediated phosphorylation of CREB
0.8 7.8 REACTOME_ACETYLCHOLINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Acetylcholine Neurotransmitter Release Cycle
0.1 7.7 REACTOME_L1CAM_INTERACTIONS Genes involved in L1CAM interactions
0.3 7.3 REACTOME_GROWTH_HORMONE_RECEPTOR_SIGNALING Genes involved in Growth hormone receptor signaling
0.4 6.7 REACTOME_ACTIVATION_OF_THE_AP1_FAMILY_OF_TRANSCRIPTION_FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.3 6.3 REACTOME_CRMPS_IN_SEMA3A_SIGNALING Genes involved in CRMPs in Sema3A signaling
0.3 5.4 REACTOME_SPRY_REGULATION_OF_FGF_SIGNALING Genes involved in Spry regulation of FGF signaling
0.3 5.4 REACTOME_PURINE_SALVAGE Genes involved in Purine salvage
0.4 5.1 REACTOME_REGULATION_OF_RHEB_GTPASE_ACTIVITY_BY_AMPK Genes involved in Regulation of Rheb GTPase activity by AMPK
0.4 4.9 REACTOME_IL_7_SIGNALING Genes involved in Interleukin-7 signaling
0.5 4.7 REACTOME_PHOSPHORYLATION_OF_CD3_AND_TCR_ZETA_CHAINS Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.6 4.6 REACTOME_TRANSPORT_OF_ORGANIC_ANIONS Genes involved in Transport of organic anions
0.1 4.5 REACTOME_BMAL1_CLOCK_NPAS2_ACTIVATES_CIRCADIAN_EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.1 4.5 REACTOME_MHC_CLASS_II_ANTIGEN_PRESENTATION Genes involved in MHC class II antigen presentation
0.2 4.2 REACTOME_EGFR_DOWNREGULATION Genes involved in EGFR downregulation
0.1 4.1 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions