Motif ID: Nr2e1

Z-value: 0.386


Transcription factors associated with Nr2e1:

Gene SymbolEntrez IDGene Name
Nr2e1 ENSMUSG00000019803.5 Nr2e1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nr2e1mm10_v2_chr10_-_42583628_425836390.662.7e-03Click!


Activity profile for motif Nr2e1.

activity profile for motif Nr2e1


Sorted Z-values histogram for motif Nr2e1

Sorted Z-values for motif Nr2e1



Network of associatons between targets according to the STRING database.



First level regulatory network of Nr2e1

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr8_-_61902669 0.794 ENSMUST00000121785.1
ENSMUST00000034057.7
 Palld

palladin, cytoskeletal associated protein

chr8_+_36489191 0.588 ENSMUST00000171777.1
 6430573F11Rik
RIKEN cDNA 6430573F11 gene
chr4_+_32238950 0.529 ENSMUST00000037416.6
 Bach2
BTB and CNC homology 2
chr7_+_131542867 0.476 ENSMUST00000046093.5
 Hmx3
H6 homeobox 3
chr14_+_32028989 0.474 ENSMUST00000022460.4
 Galnt15
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 15
chrX_-_95658379 0.461 ENSMUST00000119640.1
 Zc4h2
zinc finger, C4H2 domain containing
chrX_-_95658392 0.459 ENSMUST00000120620.1
 Zc4h2
zinc finger, C4H2 domain containing
chr15_-_10485385 0.440 ENSMUST00000168690.1
 Brix1
BRX1, biogenesis of ribosomes, homolog (S. cerevisiae)
chr7_+_114768736 0.416 ENSMUST00000117543.1
 Insc
inscuteable homolog (Drosophila)
chrX_-_95658416 0.378 ENSMUST00000044382.6
 Zc4h2
zinc finger, C4H2 domain containing
chr1_-_53785214 0.363 ENSMUST00000027263.7
 Stk17b
serine/threonine kinase 17b (apoptosis-inducing)
chr10_-_61784014 0.338 ENSMUST00000020283.4
 H2afy2
H2A histone family, member Y2
chr9_-_71163224 0.336 ENSMUST00000074465.2
 Aqp9
aquaporin 9
chr4_-_35845204 0.335 ENSMUST00000164772.1
ENSMUST00000065173.2
 Lingo2

leucine rich repeat and Ig domain containing 2

chr4_-_63403330 0.318 ENSMUST00000035724.4
 Akna
AT-hook transcription factor
chr6_-_126939524 0.289 ENSMUST00000144954.1
ENSMUST00000112221.1
ENSMUST00000112220.1
 Rad51ap1


RAD51 associated protein 1


chr5_-_88527841 0.283 ENSMUST00000087033.3
 Igj
immunoglobulin joining chain
chr15_-_10485890 0.238 ENSMUST00000169050.1
ENSMUST00000022855.5
 Brix1

BRX1, biogenesis of ribosomes, homolog (S. cerevisiae)

chr3_+_14578609 0.234 ENSMUST00000029069.6
ENSMUST00000165922.2
 E2f5

E2F transcription factor 5

chr14_-_54517353 0.222 ENSMUST00000023873.5
 Prmt5
protein arginine N-methyltransferase 5
chr7_+_78895903 0.214 ENSMUST00000107425.1
ENSMUST00000107421.1
ENSMUST00000107423.1
 Aen


apoptosis enhancing nuclease


chrX_-_143827391 0.211 ENSMUST00000087316.5
 Capn6
calpain 6
chr15_+_10486008 0.207 ENSMUST00000022856.8
ENSMUST00000100775.3
ENSMUST00000169519.1
 Rad1


RAD1 homolog (S. pombe)


chr18_+_36793918 0.206 ENSMUST00000001419.8
 Zmat2
zinc finger, matrin type 2
chr12_+_111166536 0.132 ENSMUST00000060274.6
 Traf3
TNF receptor-associated factor 3
chr15_+_41830921 0.132 ENSMUST00000166917.1
 Oxr1
oxidation resistance 1
chr12_+_111166349 0.115 ENSMUST00000117269.1
 Traf3
TNF receptor-associated factor 3
chr15_-_97705787 0.110 ENSMUST00000023104.5
 Rpap3
RNA polymerase II associated protein 3
chr6_+_126939957 0.109 ENSMUST00000032497.3
 D6Wsu163e
DNA segment, Chr 6, Wayne State University 163, expressed
chr4_-_119415494 0.088 ENSMUST00000063642.2
 Ccdc30
coiled-coil domain containing 30
chr17_+_32685655 0.086 ENSMUST00000008801.6
 Cyp4f15
cytochrome P450, family 4, subfamily f, polypeptide 15
chr12_+_111166413 0.072 ENSMUST00000021706.4
 Traf3
TNF receptor-associated factor 3
chr10_+_18469958 0.068 ENSMUST00000162891.1
ENSMUST00000100054.3
 Nhsl1

NHS-like 1

chr17_+_32685610 0.060 ENSMUST00000168171.1
 Cyp4f15
cytochrome P450, family 4, subfamily f, polypeptide 15
chr7_-_80405425 0.044 ENSMUST00000107362.3
ENSMUST00000135306.1
 Furin

furin (paired basic amino acid cleaving enzyme)

chr17_+_33919332 0.040 ENSMUST00000025161.7
 Tapbp
TAP binding protein
chrM_+_7005 0.035 ENSMUST00000082405.1
 mt-Co2
mitochondrially encoded cytochrome c oxidase II
chr12_-_87147883 0.035 ENSMUST00000037788.4
 Pomt2
protein-O-mannosyltransferase 2
chr12_+_111166485 0.029 ENSMUST00000139162.1
 Traf3
TNF receptor-associated factor 3

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:2000271 positive regulation of fibroblast apoptotic process(GO:2000271)
0.1 0.3 GO:1901837 negative regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter(GO:1901837)
0.1 0.6 GO:0002098 tRNA wobble uridine modification(GO:0002098)
0.0 0.3 GO:0032782 bile acid secretion(GO:0032782)
0.0 0.2 GO:0043985 histone H4-R3 methylation(GO:0043985)
0.0 0.8 GO:0071803 keratinocyte development(GO:0003334) positive regulation of podosome assembly(GO:0071803)
0.0 0.3 GO:0008063 Toll signaling pathway(GO:0008063)
0.0 0.2 GO:0033313 meiotic cell cycle checkpoint(GO:0033313)
0.0 0.7 GO:0000027 ribosomal large subunit assembly(GO:0000027)
0.0 0.3 GO:0036297 interstrand cross-link repair(GO:0036297)
0.0 0.0 GO:0090472 dibasic protein processing(GO:0090472)
0.0 0.1 GO:1902083 negative regulation of peptidyl-cysteine S-nitrosylation(GO:1902083)
0.0 0.5 GO:0060135 maternal process involved in female pregnancy(GO:0060135)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 GO:0001740 Barr body(GO:0001740)
0.0 0.2 GO:0030896 checkpoint clamp complex(GO:0030896)
0.0 0.3 GO:0035631 CD40 receptor complex(GO:0035631)
0.0 0.2 GO:0034709 methylosome(GO:0034709)
0.0 0.8 GO:0002102 podosome(GO:0002102)
0.0 0.1 GO:0097255 R2TP complex(GO:0097255)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 GO:0016300 tRNA (uracil) methyltransferase activity(GO:0016300)
0.1 0.3 GO:0015254 glycerol channel activity(GO:0015254)
0.1 0.2 GO:0035243 protein-arginine omega-N symmetric methyltransferase activity(GO:0035243)
0.1 0.5 GO:0001206 transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206)
0.1 0.2 GO:0008853 exodeoxyribonuclease III activity(GO:0008853)
0.0 0.3 GO:0031996 thioesterase binding(GO:0031996)
0.0 0.5 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.0 0.2 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 REACTOME_PASSIVE_TRANSPORT_BY_AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.0 0.3 REACTOME_ACTIVATION_OF_IRF3_IRF7_MEDIATED_BY_TBK1_IKK_EPSILON Genes involved in Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon