Motif ID: Nkx2-4

Z-value: 0.532


Transcription factors associated with Nkx2-4:

Gene SymbolEntrez IDGene Name
Nkx2-4 ENSMUSG00000054160.2 Nkx2-4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nkx2-4mm10_v2_chr2_-_147085445_1470854830.155.4e-01Click!


Activity profile for motif Nkx2-4.

activity profile for motif Nkx2-4


Sorted Z-values histogram for motif Nkx2-4

Sorted Z-values for motif Nkx2-4



Network of associatons between targets according to the STRING database.



First level regulatory network of Nkx2-4

PNG image of the network

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Top targets:


Showing 1 to 20 of 81 entries
PromoterScoreRefseqGene SymbolGene Name
chr10_+_4611971 1.614 ENSMUST00000105590.1
ENSMUST00000067086.7
 Esr1

estrogen receptor 1 (alpha)

chr13_-_66852017 1.412 ENSMUST00000059329.6
 Gm17449
predicted gene, 17449
chr13_+_65512678 1.268 ENSMUST00000081471.2
 Gm10139
predicted gene 10139
chr1_+_178798438 0.918 ENSMUST00000160789.1
 Kif26b
kinesin family member 26B
chr15_-_26895049 0.745 ENSMUST00000059204.9
 Fbxl7
F-box and leucine-rich repeat protein 7
chr7_-_115824699 0.731 ENSMUST00000169129.1
 Sox6
SRY-box containing gene 6
chr15_+_99055164 0.716 ENSMUST00000047104.7
ENSMUST00000024249.3
 Prph

peripherin

chr12_-_91746020 0.612 ENSMUST00000166967.1
 Ston2
stonin 2
chr14_+_48446128 0.605 ENSMUST00000124720.1
 Tmem260
transmembrane protein 260
chr8_+_45628176 0.588 ENSMUST00000130850.1
 Sorbs2
sorbin and SH3 domain containing 2
chr2_-_27507656 0.575 ENSMUST00000154316.1
 Brd3
bromodomain containing 3
chr3_+_88629499 0.550 ENSMUST00000175745.1
 Arhgef2
rho/rac guanine nucleotide exchange factor (GEF) 2
chr6_+_30568367 0.540 ENSMUST00000049251.5
 Cpa4
carboxypeptidase A4
chr13_+_108316395 0.539 ENSMUST00000171178.1
 Depdc1b
DEP domain containing 1B
chr11_+_98863610 0.525 ENSMUST00000142414.1
ENSMUST00000037480.8
 Wipf2

WAS/WASL interacting protein family, member 2

chr5_+_32136458 0.495 ENSMUST00000031017.9
 Fosl2
fos-like antigen 2
chr8_+_45627946 0.460 ENSMUST00000145458.1
 Sorbs2
sorbin and SH3 domain containing 2
chr7_-_132813095 0.455 ENSMUST00000106165.1
 Fam53b
family with sequence similarity 53, member B
chr2_-_93046053 0.434 ENSMUST00000111272.1
ENSMUST00000178666.1
ENSMUST00000147339.1
 Prdm11


PR domain containing 11


chr2_+_25180737 0.431 ENSMUST00000104999.2
 Nrarp
Notch-regulated ankyrin repeat protein

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 32 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 1.6 GO:0060745 mammary gland branching involved in pregnancy(GO:0060745)
0.0 1.1 GO:0003301 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.3 0.9 GO:0072092 ureteric bud invasion(GO:0072092)
0.1 0.7 GO:2000741 positive regulation of mesenchymal stem cell differentiation(GO:2000741)
0.0 0.7 GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146)
0.0 0.7 GO:0045104 intermediate filament cytoskeleton organization(GO:0045104)
0.1 0.6 GO:0071802 negative regulation of podosome assembly(GO:0071802)
0.0 0.6 GO:0048488 synaptic vesicle endocytosis(GO:0048488)
0.0 0.5 GO:0003334 keratinocyte development(GO:0003334)
0.1 0.4 GO:0090669 snoRNA guided rRNA pseudouridine synthesis(GO:0000454) telomerase RNA stabilization(GO:0090669)
0.0 0.4 GO:0014807 regulation of somitogenesis(GO:0014807)
0.0 0.4 GO:0071455 cellular response to hyperoxia(GO:0071455)
0.0 0.4 GO:0048934 peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
0.1 0.3 GO:1904975 response to bleomycin(GO:1904975) cellular response to bleomycin(GO:1904976)
0.0 0.3 GO:0044804 nucleophagy(GO:0044804)
0.1 0.2 GO:0051902 negative regulation of mitochondrial depolarization(GO:0051902) negative regulation of membrane depolarization(GO:1904180)
0.0 0.2 GO:0006177 GMP biosynthetic process(GO:0006177)
0.0 0.2 GO:0001661 conditioned taste aversion(GO:0001661) amygdala development(GO:0021764)
0.0 0.2 GO:0051182 coenzyme transport(GO:0051182)
0.0 0.2 GO:0001675 acrosome assembly(GO:0001675)

Gene overrepresentation in cellular_component category:

Showing 1 to 9 of 9 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 1.6 GO:0097550 transcriptional preinitiation complex(GO:0097550)
0.0 0.9 GO:0005871 kinesin complex(GO:0005871)
0.2 0.7 GO:0044299 C-fiber(GO:0044299)
0.0 0.4 GO:0005732 small nucleolar ribonucleoprotein complex(GO:0005732)
0.0 0.3 GO:0031616 spindle pole centrosome(GO:0031616)
0.1 0.2 GO:0034457 Mpp10 complex(GO:0034457)
0.0 0.2 GO:0002080 acrosomal membrane(GO:0002080)
0.0 0.2 GO:0012507 ER to Golgi transport vesicle membrane(GO:0012507)
0.0 0.1 GO:0042406 extrinsic component of endoplasmic reticulum membrane(GO:0042406)

Gene overrepresentation in molecular_function category:

Showing 1 to 15 of 15 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 1.6 GO:0031798 type 1 metabotropic glutamate receptor binding(GO:0031798) RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding(GO:0038052)
0.0 0.9 GO:0003777 microtubule motor activity(GO:0003777)
0.0 0.6 GO:0070577 lysine-acetylated histone binding(GO:0070577)
0.0 0.6 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0 0.5 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.0 0.4 GO:0070034 telomerase RNA binding(GO:0070034)
0.0 0.4 GO:0035497 cAMP response element binding(GO:0035497)
0.0 0.4 GO:0001223 transcription coactivator binding(GO:0001223)
0.1 0.2 GO:0043758 acetate-CoA ligase (ADP-forming) activity(GO:0043758)
0.1 0.2 GO:0030519 snoRNP binding(GO:0030519)
0.0 0.2 GO:0003938 IMP dehydrogenase activity(GO:0003938)
0.0 0.2 GO:0051185 coenzyme transporter activity(GO:0051185)
0.0 0.2 GO:0071253 connexin binding(GO:0071253)
0.0 0.1 GO:0044020 protein-arginine omega-N monomethyltransferase activity(GO:0035241) histone methyltransferase activity (H4-R3 specific)(GO:0044020)
0.0 0.1 GO:0045028 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled adenosine receptor activity(GO:0001609) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)

Gene overrepresentation in C2:CP category:

Showing 1 to 5 of 5 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.9 PID_ER_NONGENOMIC_PATHWAY Plasma membrane estrogen receptor signaling
0.0 1.0 PID_RHOA_REG_PATHWAY Regulation of RhoA activity
0.0 0.5 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 0.4 PID_HDAC_CLASSIII_PATHWAY Signaling events mediated by HDAC Class III
0.0 0.3 PID_CIRCADIAN_PATHWAY Circadian rhythm pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 8 of 8 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.6 REACTOME_NUCLEAR_SIGNALING_BY_ERBB4 Genes involved in Nuclear signaling by ERBB4
0.0 1.0 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.0 0.3 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_EARLY_ENDOSOME_MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane
0.0 0.2 REACTOME_P130CAS_LINKAGE_TO_MAPK_SIGNALING_FOR_INTEGRINS Genes involved in p130Cas linkage to MAPK signaling for integrins
0.0 0.2 REACTOME_PURINE_RIBONUCLEOSIDE_MONOPHOSPHATE_BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.0 0.2 REACTOME_ALPHA_LINOLENIC_ACID_ALA_METABOLISM Genes involved in alpha-linolenic acid (ALA) metabolism
0.0 0.1 REACTOME_CREATION_OF_C4_AND_C2_ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.0 0.1 REACTOME_REGULATION_OF_INSULIN_SECRETION_BY_ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine