Motif ID: Zbtb16

Z-value: 1.542


Transcription factors associated with Zbtb16:

Gene SymbolEntrez IDGene Name
Zbtb16 ENSMUSG00000066687.4 Zbtb16

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Zbtb16mm10_v2_chr9_-_48835932_48835962-0.691.6e-03Click!


Activity profile for motif Zbtb16.

activity profile for motif Zbtb16


Sorted Z-values histogram for motif Zbtb16

Sorted Z-values for motif Zbtb16



Network of associatons between targets according to the STRING database.



First level regulatory network of Zbtb16

PNG image of the network

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Top targets:


Showing 1 to 20 of 195 entries
PromoterScoreRefseqGene SymbolGene Name
chrY_+_90785442 6.871 ENSMUST00000177591.1
ENSMUST00000177671.1
ENSMUST00000179077.1
 Erdr1


erythroid differentiation regulator 1


chrX_+_170010744 6.271 ENSMUST00000178789.1
 Gm21887
predicted gene, 21887
chr1_+_107511489 4.492 ENSMUST00000064916.2
 Serpinb2
serine (or cysteine) peptidase inhibitor, clade B, member 2
chr1_+_107511416 4.455 ENSMUST00000009356.4
 Serpinb2
serine (or cysteine) peptidase inhibitor, clade B, member 2
chr9_-_79977782 3.947 ENSMUST00000093811.4
 Filip1
filamin A interacting protein 1
chr4_+_44300876 3.536 ENSMUST00000045607.5
 Melk
maternal embryonic leucine zipper kinase
chr17_-_26099257 2.854 ENSMUST00000053575.3
 Gm8186
predicted gene 8186
chr3_-_157925056 2.664 ENSMUST00000118539.1
 Cth
cystathionase (cystathionine gamma-lyase)
chr4_-_117178726 2.582 ENSMUST00000153953.1
ENSMUST00000106436.1
 Kif2c

kinesin family member 2C

chrX_+_170009892 2.576 ENSMUST00000180251.1
 Gm21887
predicted gene, 21887
chr9_-_69451035 2.512 ENSMUST00000071565.5
 Gm4978
predicted gene 4978
chr3_+_116878227 2.405 ENSMUST00000040260.6
 Frrs1
ferric-chelate reductase 1
chr19_-_30175414 2.295 ENSMUST00000025778.7
 Gldc
glycine decarboxylase
chr17_+_46496753 2.239 ENSMUST00000046497.6
 Dnph1
2'-deoxynucleoside 5'-phosphate N-hydrolase 1
chr10_+_75589363 2.187 ENSMUST00000072217.2
 Ggt5
gamma-glutamyltransferase 5
chr5_-_149051300 2.181 ENSMUST00000110505.1
 Hmgb1
high mobility group box 1
chr5_+_110330697 2.140 ENSMUST00000112481.1
 Pole
polymerase (DNA directed), epsilon
chr19_+_53140430 2.133 ENSMUST00000111741.2
 Add3
adducin 3 (gamma)
chr1_-_150465563 2.110 ENSMUST00000164600.1
ENSMUST00000111902.2
ENSMUST00000111901.2
ENSMUST00000006171.9
 Prg4



proteoglycan 4 (megakaryocyte stimulating factor, articular superficial zone protein)



chr10_+_22360552 2.050 ENSMUST00000182677.1
 Raet1d
retinoic acid early transcript delta

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 91 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 8.9 GO:0010466 negative regulation of peptidase activity(GO:0010466)
0.1 8.8 GO:0035019 somatic stem cell population maintenance(GO:0035019)
0.1 3.5 GO:0008631 intrinsic apoptotic signaling pathway in response to oxidative stress(GO:0008631)
0.9 2.7 GO:0019343 cysteine biosynthetic process via cystathionine(GO:0019343) cysteine biosynthetic process(GO:0019344)
0.5 2.6 GO:0030951 establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951)
0.8 2.3 GO:0006546 glycine catabolic process(GO:0006546) glycine decarboxylation via glycine cleavage system(GO:0019464)
0.7 2.2 GO:0045819 plasmacytoid dendritic cell activation(GO:0002270) positive regulation of glycogen catabolic process(GO:0045819)
0.5 2.2 GO:0006751 glutathione catabolic process(GO:0006751)
0.2 2.2 GO:0009162 deoxyribonucleoside monophosphate metabolic process(GO:0009162)
0.7 2.1 GO:0045004 DNA replication proofreading(GO:0045004)
0.5 2.1 GO:0045409 negative regulation of interleukin-6 biosynthetic process(GO:0045409)
0.6 1.8 GO:0086053 AV node cell to bundle of His cell communication by electrical coupling(GO:0086053)
0.6 1.8 GO:0043988 histone H3-S28 phosphorylation(GO:0043988)
0.1 1.7 GO:0001913 T cell mediated cytotoxicity(GO:0001913)
0.3 1.6 GO:0051461 regulation of corticotropin secretion(GO:0051459) positive regulation of corticotropin secretion(GO:0051461)
0.2 1.6 GO:0006729 tetrahydrobiopterin biosynthetic process(GO:0006729) tetrahydrobiopterin metabolic process(GO:0046146)
0.2 1.6 GO:0006561 proline biosynthetic process(GO:0006561)
0.1 1.5 GO:0031119 tRNA pseudouridine synthesis(GO:0031119)
0.1 1.5 GO:0006228 UTP biosynthetic process(GO:0006228)
0.1 1.5 GO:0044872 lipoprotein transport(GO:0042953) lipoprotein localization(GO:0044872)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 55 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.6 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.0 3.1 GO:0005938 cell cortex(GO:0005938)
0.0 2.9 GO:1990204 oxidoreductase complex(GO:1990204)
0.0 2.7 GO:0005643 nuclear pore(GO:0005643)
0.1 2.6 GO:0035371 microtubule plus-end(GO:0035371)
0.0 2.4 GO:0005882 intermediate filament(GO:0005882)
0.1 2.3 GO:0000314 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.5 2.1 GO:0089717 spanning component of plasma membrane(GO:0044214) spanning component of membrane(GO:0089717)
0.4 2.1 GO:0008622 epsilon DNA polymerase complex(GO:0008622)
0.0 2.1 GO:0000794 condensed nuclear chromosome(GO:0000794)
0.3 1.9 GO:0005663 DNA replication factor C complex(GO:0005663)
0.6 1.8 GO:0071001 U4/U6 snRNP(GO:0071001)
0.4 1.8 GO:0032133 chromosome passenger complex(GO:0032133)
0.1 1.8 GO:0005922 connexon complex(GO:0005922)
0.1 1.8 GO:0071010 prespliceosome(GO:0071010)
0.4 1.6 GO:0017071 intracellular cyclic nucleotide activated cation channel complex(GO:0017071)
0.0 1.4 GO:0035869 ciliary transition zone(GO:0035869)
0.2 1.3 GO:0030870 Mre11 complex(GO:0030870)
0.1 1.3 GO:0016460 myosin II complex(GO:0016460)
0.1 1.2 GO:0031618 nuclear pericentric heterochromatin(GO:0031618)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 76 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 8.9 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 4.7 GO:0003735 structural constituent of ribosome(GO:0003735)
0.1 3.1 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.3 2.7 GO:0016846 carbon-sulfur lyase activity(GO:0016846)
0.2 2.6 GO:0051010 microtubule plus-end binding(GO:0051010)
0.5 2.4 GO:0000293 ferric-chelate reductase activity(GO:0000293)
0.1 2.3 GO:0016594 glycine binding(GO:0016594)
0.7 2.2 GO:0000402 open form four-way junction DNA binding(GO:0000401) crossed form four-way junction DNA binding(GO:0000402)
0.3 2.2 GO:0008242 omega peptidase activity(GO:0008242)
0.1 2.2 GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds(GO:0016799)
0.7 2.1 GO:0008310 single-stranded DNA 3'-5' exodeoxyribonuclease activity(GO:0008310)
0.1 2.1 GO:0030247 pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
0.1 2.1 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.2 1.9 GO:0003689 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.0 1.9 GO:0005080 protein kinase C binding(GO:0005080)
0.6 1.8 GO:0086077 gap junction channel activity involved in AV node cell-bundle of His cell electrical coupling(GO:0086077)
0.4 1.8 GO:0035174 histone serine kinase activity(GO:0035174)
0.0 1.8 GO:0003755 peptidyl-prolyl cis-trans isomerase activity(GO:0003755)
0.2 1.7 GO:0046703 natural killer cell lectin-like receptor binding(GO:0046703)
0.4 1.6 GO:0004735 pyrroline-5-carboxylate reductase activity(GO:0004735)

Gene overrepresentation in C2:CP category:

Showing 1 to 16 of 16 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 8.9 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 4.4 PID_AURORA_B_PATHWAY Aurora B signaling
0.1 2.8 PID_SMAD2_3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.1 2.2 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling
0.1 2.1 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.0 1.8 PID_FAS_PATHWAY FAS (CD95) signaling pathway
0.1 1.5 PID_ARF6_DOWNSTREAM_PATHWAY Arf6 downstream pathway
0.0 1.3 PID_BARD1_PATHWAY BARD1 signaling events
0.0 1.1 PID_P53_REGULATION_PATHWAY p53 pathway
0.0 1.0 ST_P38_MAPK_PATHWAY p38 MAPK Pathway
0.0 0.9 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.0 0.7 PID_RAC1_PATHWAY RAC1 signaling pathway
0.1 0.6 SA_FAS_SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
0.0 0.6 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 0.4 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.0 0.3 PID_AURORA_A_PATHWAY Aurora A signaling

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 30 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 8.5 REACTOME_HEMOSTASIS Genes involved in Hemostasis
0.0 3.6 REACTOME_PEPTIDE_CHAIN_ELONGATION Genes involved in Peptide chain elongation
0.1 2.7 REACTOME_SULFUR_AMINO_ACID_METABOLISM Genes involved in Sulfur amino acid metabolism
0.1 2.6 REACTOME_KINESINS Genes involved in Kinesins
0.2 2.5 REACTOME_APOPTOSIS_INDUCED_DNA_FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.1 2.2 REACTOME_GLUTATHIONE_CONJUGATION Genes involved in Glutathione conjugation
0.0 2.2 REACTOME_APC_C_CDH1_MEDIATED_DEGRADATION_OF_CDC20_AND_OTHER_APC_C_CDH1_TARGETED_PROTEINS_IN_LATE_MITOSIS_EARLY_G1 Genes involved in APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
0.0 2.2 REACTOME_ANTIVIRAL_MECHANISM_BY_IFN_STIMULATED_GENES Genes involved in Antiviral mechanism by IFN-stimulated genes
0.1 2.1 REACTOME_REPAIR_SYNTHESIS_FOR_GAP_FILLING_BY_DNA_POL_IN_TC_NER Genes involved in Repair synthesis for gap-filling by DNA polymerase in TC-NER
0.2 1.8 REACTOME_GAP_JUNCTION_ASSEMBLY Genes involved in Gap junction assembly
0.0 1.8 REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT Genes involved in Mitochondrial Protein Import
0.1 1.5 REACTOME_SYNTHESIS_AND_INTERCONVERSION_OF_NUCLEOTIDE_DI_AND_TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.1 1.3 REACTOME_HOMOLOGOUS_RECOMBINATION_REPAIR_OF_REPLICATION_INDEPENDENT_DOUBLE_STRAND_BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.1 1.1 REACTOME_FORMATION_OF_ATP_BY_CHEMIOSMOTIC_COUPLING Genes involved in Formation of ATP by chemiosmotic coupling
0.0 1.1 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT Genes involved in Respiratory electron transport
0.0 1.0 REACTOME_STRIATED_MUSCLE_CONTRACTION Genes involved in Striated Muscle Contraction
0.1 0.7 REACTOME_RECEPTOR_LIGAND_BINDING_INITIATES_THE_SECOND_PROTEOLYTIC_CLEAVAGE_OF_NOTCH_RECEPTOR Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.0 0.7 REACTOME_DEADENYLATION_OF_MRNA Genes involved in Deadenylation of mRNA
0.0 0.7 REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.1 0.6 REACTOME_BASE_FREE_SUGAR_PHOSPHATE_REMOVAL_VIA_THE_SINGLE_NUCLEOTIDE_REPLACEMENT_PATHWAY Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway