ISMARA results: AAGUGCU

Project

GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)

Navigation

Downloads

Results for AAGUGCU

Z-value: 0.53

Motif logo

miRNA associated with seed AAGUGCU

Name	miRBASE accession
hsa-miR-302a-3p miRBase	MIMAT0000684
hsa-miR-302b-3p miRBase	MIMAT0000715
hsa-miR-302c-3p.1 miRBase	MIMAT0000717
hsa-miR-302d-3p miRBase	MIMAT0000718
hsa-miR-302e miRBase	MIMAT0005931
hsa-miR-372-3p miRBase	MIMAT0000724
hsa-miR-373-3p miRBase	MIMAT0000726
hsa-miR-520a-3p miRBase	MIMAT0002834
hsa-miR-520b miRBase	MIMAT0002843
hsa-miR-520c-3p miRBase	MIMAT0002846
hsa-miR-520d-3p miRBase	MIMAT0002856
hsa-miR-520e miRBase	MIMAT0002825

Activity profile of AAGUGCU motif

Sorted Z-values of AAGUGCU motif

Top targets:

Search:

Show entries

Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr14_-_60097297 Show fit	8.43	ENST00000395090.1	RTN1 Ensembl NCBI GeneCards UniProt NextProt Show fit	reticulon 1
chr12_-_45269430 Show fit	7.84	ENST00000395487.2	NELL2 Ensembl NCBI GeneCards UniProt NextProt Show fit	NEL-like 2 (chicken)
chr1_-_20812690 Show fit	7.33	ENST00000375078.3	CAMK2N1 Ensembl NCBI GeneCards UniProt NextProt Show fit	calcium/calmodulin-dependent protein kinase II inhibitor 1
chr12_-_16761007 Show fit	5.16	ENST00000354662.1 ENST00000441439.2	LMO3 Ensembl NCBI GeneCards UniProt NextProt Show fit	LIM domain only 3 (rhombotin-like 2)
chrX_+_16737718 Show fit	5.08	ENST00000380155.3	SYAP1 Ensembl NCBI GeneCards UniProt NextProt Show fit	synapse associated protein 1
chr8_+_42752053 Show fit	4.73	ENST00000307602.4	HOOK3 Ensembl NCBI GeneCards UniProt NextProt Show fit	hook microtubule-tethering protein 3
chrX_+_110339439 Show fit	4.49	ENST00000372010.1 ENST00000519681.1 ENST00000372007.5	PAK3 Ensembl NCBI GeneCards UniProt NextProt Show fit	p21 protein (Cdc42/Rac)-activated kinase 3
chr1_+_226411319 Show fit	4.46	ENST00000542034.1 ENST00000366810.5	MIXL1 Ensembl NCBI GeneCards UniProt NextProt Show fit	Mix paired-like homeobox
chr3_-_13009168 Show fit	4.44	ENST00000273221.4	IQSEC1 Ensembl NCBI GeneCards UniProt NextProt Show fit	IQ motif and Sec7 domain 1
chr3_+_43328004 Show fit	4.41	ENST00000454177.1 ENST00000429705.2 ENST00000296088.7 ENST00000437827.1	SNRK Ensembl NCBI GeneCards UniProt NextProt Show fit	SNF related kinase

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of AAGUGCU

View svg image
View png image

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.4	8.4	GO:0032012	regulation of ARF protein signal transduction(GO:0032012)
0.6	7.8	GO:0070050	neuron cellular homeostasis(GO:0070050)
0.9	5.2	GO:2000324	positive regulation of glucocorticoid receptor signaling pathway(GO:2000324)
0.3	5.0	GO:0002347	response to tumor cell(GO:0002347)
1.2	4.7	GO:0022027	interkinetic nuclear migration(GO:0022027)
0.2	4.5	GO:0010763	positive regulation of fibroblast migration(GO:0010763)
0.4	4.2	GO:0014877	response to muscle inactivity involved in regulation of muscle adaptation(GO:0014877) response to denervation involved in regulation of muscle adaptation(GO:0014894)
0.5	4.1	GO:2000766	negative regulation of cytoplasmic translation(GO:2000766)
0.6	3.9	GO:1903818	positive regulation of voltage-gated potassium channel activity(GO:1903818)
0.4	3.9	GO:0045647	negative regulation of erythrocyte differentiation(GO:0045647)

Showing 1 to 10 of 182 entries

Gene overrepresentation in cellular_component category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.0	9.1	GO:0099572	postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572)
0.0	7.1	GO:0030176	integral component of endoplasmic reticulum membrane(GO:0030176)
1.7	7.0	GO:0070695	FHF complex(GO:0070695)
0.0	6.3	GO:0015629	actin cytoskeleton(GO:0015629)
0.0	4.8	GO:0031225	anchored component of membrane(GO:0031225)
0.4	4.4	GO:0016602	CCAAT-binding factor complex(GO:0016602)
0.1	4.3	GO:0031463	Cul3-RING ubiquitin ligase complex(GO:0031463)
0.2	4.1	GO:1990124	messenger ribonucleoprotein complex(GO:1990124)
0.0	4.1	GO:0005758	mitochondrial intermembrane space(GO:0005758)
0.0	4.1	GO:0000777	condensed chromosome kinetochore(GO:0000777)

Showing 1 to 10 of 75 entries

Gene overrepresentation in molecular_function category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	16.3	GO:0001227	transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.0	9.1	GO:0004842	ubiquitin-protein transferase activity(GO:0004842)
0.0	8.8	GO:0001071	nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700)
0.3	8.4	GO:0005086	ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.0	7.7	GO:0001077	transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
1.2	7.3	GO:0010858	calcium-dependent protein kinase regulator activity(GO:0010858)
0.3	5.5	GO:0045295	gamma-catenin binding(GO:0045295)
0.3	5.2	GO:0035925	mRNA 3'-UTR AU-rich region binding(GO:0035925)
0.2	4.7	GO:0051959	dynein light intermediate chain binding(GO:0051959)
0.0	4.7	GO:0005096	GTPase activator activity(GO:0005096)

Showing 1 to 10 of 110 entries

Gene overrepresentation in C2:CP category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	8.2	PID AR TF PATHWAY	Regulation of Androgen receptor activity
0.1	7.1	SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES	Genes related to regulation of the actin cytoskeleton
0.0	6.2	NABA ECM GLYCOPROTEINS	Genes encoding structural ECM glycoproteins
0.1	4.9	PID NETRIN PATHWAY	Netrin-mediated signaling events
0.1	4.4	PID ARF6 PATHWAY	Arf6 signaling events
0.1	3.7	PID AURORA A PATHWAY	Aurora A signaling
0.1	3.5	ST MYOCYTE AD PATHWAY	Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.0	3.5	PID CD8 TCR PATHWAY	TCR signaling in naïve CD8+ T cells
0.1	3.1	PID IL3 PATHWAY	IL3-mediated signaling events
0.1	3.1	PID FGF PATHWAY	FGF signaling pathway

Showing 1 to 10 of 42 entries

Gene overrepresentation in C2:CP:REACTOME category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	5.1	REACTOME VOLTAGE GATED POTASSIUM CHANNELS	Genes involved in Voltage gated Potassium channels
0.1	4.7	REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION	Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.3	4.4	REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA	Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.1	4.3	REACTOME NRAGE SIGNALS DEATH THROUGH JNK	Genes involved in NRAGE signals death through JNK
0.1	3.8	REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS	Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.2	3.3	REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE	Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
0.1	3.3	REACTOME NITRIC OXIDE STIMULATES GUANYLATE CYCLASE	Genes involved in Nitric oxide stimulates guanylate cyclase
0.1	3.1	REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS	Genes involved in Facilitative Na+-independent glucose transporters
0.2	3.0	REACTOME THE NLRP3 INFLAMMASOME	Genes involved in The NLRP3 inflammasome
0.0	2.9	REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY	Genes involved in Nuclear Receptor transcription pathway

Showing 1 to 10 of 47 entries

Results for AAGUGCU

Z-value: 0.53

Motif logo

miRNA associated with seed AAGUGCU

Activity profile of AAGUGCU motif

Sorted Z-values of AAGUGCU motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of AAGUGCU

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: