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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)

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Results for ACUGCAU

Z-value: 1.04

Motif logo

logo of

miRNA associated with seed ACUGCAU

NamemiRBASE accession
hsa-miR-217
MIMAT0000274
hsa-miR-6807-3p
MIMAT0027515

Activity profile of ACUGCAU motif

Sorted Z-values of ACUGCAU motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr12_-_109125285 9.73 ENST00000552871.1
ENST00000261401.3
CORO1C
coronin, actin binding protein, 1C
chr9_+_112810878 7.50 ENST00000434623.2
ENST00000374525.1
AKAP2
A kinase (PRKA) anchor protein 2
chr10_-_27443155 7.19 ENST00000427324.1
ENST00000326799.3
YME1L1
YME1-like 1 ATPase
chr9_+_112542572 6.79 ENST00000374530.3
PALM2-AKAP2
PALM2-AKAP2 readthrough
chr9_+_110045537 6.32 ENST00000358015.3
RAD23B
RAD23 homolog B (S. cerevisiae)
chr12_-_31479045 6.28 ENST00000539409.1
ENST00000395766.1
FAM60A
family with sequence similarity 60, member A
chr8_-_103876965 6.13 ENST00000337198.5
AZIN1
antizyme inhibitor 1
chr10_+_54074033 5.55 ENST00000373970.3
DKK1
dickkopf WNT signaling pathway inhibitor 1
chr2_+_235860616 5.43 ENST00000392011.2
SH3BP4
SH3-domain binding protein 4
chr15_-_101792137 5.33 ENST00000254190.3
CHSY1
chondroitin sulfate synthase 1
chr15_+_57210818 4.99 ENST00000438423.2
ENST00000267811.5
ENST00000452095.2
ENST00000559609.1
ENST00000333725.5
TCF12
transcription factor 12
chr1_-_225840747 4.83 ENST00000366843.2
ENST00000366844.3
ENAH
enabled homolog (Drosophila)
chr20_+_43514315 4.75 ENST00000353703.4
YWHAB
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta
chr12_+_69004619 4.54 ENST00000250559.9
ENST00000393436.5
ENST00000425247.2
ENST00000489473.2
ENST00000422358.2
ENST00000541167.1
ENST00000538283.1
ENST00000341355.5
ENST00000537460.1
ENST00000450214.2
ENST00000545270.1
ENST00000538980.1
ENST00000542018.1
ENST00000543393.1
RAP1B
RAP1B, member of RAS oncogene family
chr4_-_76598296 4.31 ENST00000395719.3
G3BP2
GTPase activating protein (SH3 domain) binding protein 2
chr1_-_70671216 4.27 ENST00000370952.3
LRRC40
leucine rich repeat containing 40
chr4_-_69215699 4.09 ENST00000510746.1
ENST00000344157.4
ENST00000355665.3
YTHDC1
YTH domain containing 1
chr6_-_99797522 3.92 ENST00000389677.5
FAXC
failed axon connections homolog (Drosophila)
chr12_-_92539614 3.74 ENST00000256015.3
BTG1
B-cell translocation gene 1, anti-proliferative
chr3_-_160283348 3.72 ENST00000334256.4
KPNA4
karyopherin alpha 4 (importin alpha 3)
chr2_+_99953816 3.60 ENST00000289371.6
EIF5B
eukaryotic translation initiation factor 5B
chr10_-_5855350 3.55 ENST00000456041.1
ENST00000380181.3
ENST00000418688.1
ENST00000380132.4
ENST00000609712.1
ENST00000380191.4
GDI2
GDP dissociation inhibitor 2
chr10_-_98346801 3.54 ENST00000371142.4
TM9SF3
transmembrane 9 superfamily member 3
chr5_-_133304473 3.50 ENST00000231512.3
C5orf15
chromosome 5 open reading frame 15
chr3_-_79068594 3.28 ENST00000436010.2
ROBO1
roundabout, axon guidance receptor, homolog 1 (Drosophila)
chr19_+_41768401 3.25 ENST00000352456.3
ENST00000595018.1
ENST00000597725.1
HNRNPUL1
heterogeneous nuclear ribonucleoprotein U-like 1
chr9_+_33025209 3.09 ENST00000330899.4
ENST00000544625.1
DNAJA1
DnaJ (Hsp40) homolog, subfamily A, member 1
chr8_+_98656336 3.02 ENST00000336273.3
MTDH
metadherin
chr17_-_60142609 3.02 ENST00000397786.2
MED13
mediator complex subunit 13
chr5_-_137911049 2.80 ENST00000297185.3
HSPA9
heat shock 70kDa protein 9 (mortalin)
chr6_+_111195973 2.76 ENST00000368885.3
ENST00000368882.3
ENST00000451850.2
ENST00000368877.5
AMD1
adenosylmethionine decarboxylase 1
chr12_+_104359576 2.70 ENST00000392872.3
ENST00000436021.2
TDG
thymine-DNA glycosylase
chr16_-_66785699 2.65 ENST00000258198.2
DYNC1LI2
dynein, cytoplasmic 1, light intermediate chain 2
chr6_+_64281906 2.52 ENST00000370651.3
PTP4A1
protein tyrosine phosphatase type IVA, member 1
chr5_+_112312416 2.48 ENST00000389063.2
DCP2
decapping mRNA 2
chr3_+_155588300 2.41 ENST00000496455.2
GMPS
guanine monphosphate synthase
chr17_+_30677136 2.23 ENST00000394670.4
ENST00000321233.6
ENST00000394673.2
ENST00000341711.6
ENST00000579634.1
ENST00000580759.1
ENST00000342555.6
ENST00000577908.1
ENST00000394679.5
ENST00000582165.1
ZNF207
zinc finger protein 207
chr7_-_26240357 2.18 ENST00000354667.4
ENST00000356674.7
HNRNPA2B1
heterogeneous nuclear ribonucleoprotein A2/B1
chr1_-_244615425 2.16 ENST00000366535.3
ADSS
adenylosuccinate synthase
chr3_+_180630090 2.12 ENST00000357559.4
ENST00000305586.7
FXR1
fragile X mental retardation, autosomal homolog 1
chr1_+_93544791 2.04 ENST00000545708.1
ENST00000540243.1
ENST00000370298.4
MTF2
metal response element binding transcription factor 2
chr18_-_18691739 1.99 ENST00000399799.2
ROCK1
Rho-associated, coiled-coil containing protein kinase 1
chr17_+_60536002 1.97 ENST00000582809.1
TLK2
tousled-like kinase 2
chr6_+_119215308 1.94 ENST00000229595.5
ASF1A
anti-silencing function 1A histone chaperone
chr12_-_76478686 1.93 ENST00000261182.8
NAP1L1
nucleosome assembly protein 1-like 1
chr15_+_41709302 1.86 ENST00000389629.4
RTF1
Rtf1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)
chr17_-_18266797 1.84 ENST00000316694.3
ENST00000539052.1
SHMT1
serine hydroxymethyltransferase 1 (soluble)
chr5_+_151151471 1.73 ENST00000394123.3
ENST00000543466.1
G3BP1
GTPase activating protein (SH3 domain) binding protein 1
chr5_-_127873659 1.72 ENST00000262464.4
FBN2
fibrillin 2
chr10_+_89622870 1.69 ENST00000371953.3
PTEN
phosphatase and tensin homolog
chr12_+_123237321 1.68 ENST00000280557.6
ENST00000455982.2
DENR
density-regulated protein
chr9_-_95055956 1.68 ENST00000375629.3
ENST00000447699.2
ENST00000375643.3
ENST00000395554.3
IARS
isoleucyl-tRNA synthetase
chr17_+_30264014 1.64 ENST00000322652.5
ENST00000580398.1
SUZ12
SUZ12 polycomb repressive complex 2 subunit
chr2_+_228336849 1.57 ENST00000409979.2
ENST00000310078.8
AGFG1
ArfGAP with FG repeats 1
chr2_+_28974668 1.57 ENST00000296122.6
ENST00000395366.2
PPP1CB
protein phosphatase 1, catalytic subunit, beta isozyme
chr1_+_27022485 1.52 ENST00000324856.7
ARID1A
AT rich interactive domain 1A (SWI-like)
chrX_-_134049262 1.52 ENST00000370783.3
MOSPD1
motile sperm domain containing 1
chr1_-_35658736 1.46 ENST00000357214.5
SFPQ
splicing factor proline/glutamine-rich
chr9_-_74980113 1.45 ENST00000376962.5
ENST00000376960.4
ENST00000237937.3
ZFAND5
zinc finger, AN1-type domain 5
chr16_+_16043406 1.44 ENST00000399410.3
ENST00000399408.2
ENST00000346370.5
ENST00000351154.5
ENST00000345148.5
ENST00000349029.5
ABCC1
ATP-binding cassette, sub-family C (CFTR/MRP), member 1
chr9_-_15510989 1.42 ENST00000380715.1
ENST00000380716.4
ENST00000380738.4
ENST00000380733.4
PSIP1
PC4 and SFRS1 interacting protein 1
chr4_+_77870856 1.41 ENST00000264893.6
ENST00000502584.1
ENST00000510641.1
SEPT11
septin 11
chr11_+_125462690 1.41 ENST00000392708.4
ENST00000529196.1
ENST00000531491.1
STT3A
STT3A, subunit of the oligosaccharyltransferase complex (catalytic)
chr5_+_61602055 1.40 ENST00000381103.2
KIF2A
kinesin heavy chain member 2A
chr14_+_100705322 1.39 ENST00000262238.4
YY1
YY1 transcription factor
chr13_+_50656307 1.38 ENST00000378180.4
DLEU1
deleted in lymphocytic leukemia 1 (non-protein coding)
chr7_-_41742697 1.38 ENST00000242208.4
INHBA
inhibin, beta A
chr2_+_109335929 1.37 ENST00000283195.6
RANBP2
RAN binding protein 2
chr12_+_67663056 1.34 ENST00000545606.1
CAND1
cullin-associated and neddylation-dissociated 1
chr2_+_169312350 1.33 ENST00000305747.6
CERS6
ceramide synthase 6
chr2_+_181845298 1.33 ENST00000410062.4
UBE2E3
ubiquitin-conjugating enzyme E2E 3
chr10_-_88281494 1.29 ENST00000298767.5
WAPAL
wings apart-like homolog (Drosophila)
chr3_+_113465866 1.27 ENST00000273398.3
ENST00000538620.1
ENST00000496747.1
ENST00000475322.1
ATP6V1A
ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A
chr1_-_244013384 1.27 ENST00000366539.1
AKT3
v-akt murine thymoma viral oncogene homolog 3
chr6_-_79944336 1.19 ENST00000344726.5
ENST00000275036.7
HMGN3
high mobility group nucleosomal binding domain 3
chr11_-_85780086 1.14 ENST00000532317.1
ENST00000528256.1
ENST00000526033.1
PICALM
phosphatidylinositol binding clathrin assembly protein
chr3_+_40351169 1.05 ENST00000232905.3
EIF1B
eukaryotic translation initiation factor 1B
chr16_+_81069433 1.05 ENST00000299575.4
ATMIN
ATM interactor
chr15_+_44829255 1.02 ENST00000261868.5
ENST00000424492.3
EIF3J
eukaryotic translation initiation factor 3, subunit J
chr20_+_62496596 1.02 ENST00000369927.4
ENST00000346249.4
ENST00000348257.5
ENST00000352482.4
ENST00000351424.4
ENST00000217121.5
ENST00000358548.4
TPD52L2
tumor protein D52-like 2
chrX_-_131352152 1.00 ENST00000342983.2
RAP2C
RAP2C, member of RAS oncogene family
chr16_+_12995468 0.96 ENST00000424107.3
ENST00000558583.1
ENST00000558318.1
SHISA9
shisa family member 9
chr19_-_47616992 0.95 ENST00000253048.5
ZC3H4
zinc finger CCCH-type containing 4
chr12_-_25403737 0.95 ENST00000256078.4
ENST00000556131.1
ENST00000311936.3
ENST00000557334.1
KRAS
Kirsten rat sarcoma viral oncogene homolog
chr3_+_173116225 0.86 ENST00000457714.1
NLGN1
neuroligin 1
chr2_+_9346892 0.84 ENST00000281419.3
ENST00000315273.4
ASAP2
ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
chr11_-_67980744 0.84 ENST00000401547.2
ENST00000453170.1
ENST00000304363.4
SUV420H1
suppressor of variegation 4-20 homolog 1 (Drosophila)
chr12_+_104850740 0.76 ENST00000547956.1
ENST00000549260.1
ENST00000303694.5
CHST11
carbohydrate (chondroitin 4) sulfotransferase 11
chr5_-_78809950 0.75 ENST00000334082.6
HOMER1
homer homolog 1 (Drosophila)
chr10_+_114709999 0.73 ENST00000355995.4
ENST00000545257.1
ENST00000543371.1
ENST00000536810.1
ENST00000355717.4
ENST00000538897.1
ENST00000534894.1
TCF7L2
transcription factor 7-like 2 (T-cell specific, HMG-box)
chr3_+_11314099 0.68 ENST00000446450.2
ENST00000354956.5
ENST00000354449.3
ENST00000419112.1
ATG7
autophagy related 7
chr4_-_66536057 0.63 ENST00000273854.3
EPHA5
EPH receptor A5
chr15_-_42264702 0.62 ENST00000220325.4
EHD4
EH-domain containing 4
chr10_-_121356007 0.61 ENST00000369093.2
ENST00000436547.2
TIAL1
TIA1 cytotoxic granule-associated RNA binding protein-like 1
chr2_+_178077477 0.58 ENST00000411529.2
ENST00000435711.1
HNRNPA3
heterogeneous nuclear ribonucleoprotein A3
chr10_+_11206925 0.56 ENST00000354440.2
ENST00000315874.4
ENST00000427450.1
CELF2
CUGBP, Elav-like family member 2
chr20_+_1099233 0.56 ENST00000246015.4
ENST00000335877.6
ENST00000438768.2
PSMF1
proteasome (prosome, macropain) inhibitor subunit 1 (PI31)
chr8_-_74884511 0.55 ENST00000518127.1
TCEB1
transcription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C)
chr6_+_26199737 0.53 ENST00000359985.1
HIST1H2BF
histone cluster 1, H2bf
chr1_-_38325256 0.52 ENST00000373036.4
MTF1
metal-regulatory transcription factor 1
chr6_+_163835669 0.49 ENST00000453779.2
ENST00000275262.7
ENST00000392127.2
ENST00000361752.3
QKI
QKI, KH domain containing, RNA binding
chr2_-_24149977 0.44 ENST00000238789.5
ATAD2B
ATPase family, AAA domain containing 2B
chr3_+_30648066 0.41 ENST00000359013.4
TGFBR2
transforming growth factor, beta receptor II (70/80kDa)
chr7_-_83824169 0.40 ENST00000265362.4
SEMA3A
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
chr8_+_104831472 0.40 ENST00000262231.10
ENST00000507740.1
RIMS2
regulating synaptic membrane exocytosis 2
chr14_+_29234870 0.38 ENST00000382535.3
FOXG1
forkhead box G1
chr7_-_26578407 0.38 ENST00000242109.3
KIAA0087
KIAA0087
chr1_+_25071848 0.37 ENST00000374379.4
CLIC4
chloride intracellular channel 4
chr1_+_229406847 0.32 ENST00000366690.4
RAB4A
RAB4A, member RAS oncogene family
chr1_+_109234907 0.31 ENST00000370025.4
ENST00000370022.5
ENST00000370021.1
PRPF38B
pre-mRNA processing factor 38B
chr15_-_83621435 0.30 ENST00000450735.2
ENST00000426485.1
ENST00000399166.2
ENST00000304231.8
HOMER2
homer homolog 2 (Drosophila)
chr10_+_111967345 0.30 ENST00000332674.5
ENST00000453116.1
MXI1
MAX interactor 1, dimerization protein
chr6_-_52926539 0.28 ENST00000350082.5
ENST00000356971.3
ICK
intestinal cell (MAK-like) kinase
chr10_+_43633914 0.26 ENST00000374466.3
ENST00000374464.1
CSGALNACT2
chondroitin sulfate N-acetylgalactosaminyltransferase 2
chr8_+_38614807 0.25 ENST00000330691.6
ENST00000348567.4
TACC1
transforming, acidic coiled-coil containing protein 1
chr13_+_33160553 0.21 ENST00000315596.10
PDS5B
PDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae)
chr4_+_57774042 0.20 ENST00000309042.7
REST
RE1-silencing transcription factor
chrX_+_12993202 0.19 ENST00000451311.2
ENST00000380636.1
TMSB4X
thymosin beta 4, X-linked
chr20_-_44991813 0.18 ENST00000372227.1
SLC35C2
solute carrier family 35 (GDP-fucose transporter), member C2
chr3_-_48342795 0.11 ENST00000452211.1
ENST00000447724.1
ENST00000415053.1
ENST00000425930.1
ENST00000421967.1
ENST00000426723.1
ENST00000450160.1
ENST00000456495.1
ENST00000435684.1
ENST00000447314.1
ENST00000415644.1
ENST00000442597.1
NME6
NME/NM23 nucleoside diphosphate kinase 6
chr1_-_24306798 0.10 ENST00000374452.5
ENST00000492112.2
ENST00000343255.5
ENST00000344989.6
SRSF10
serine/arginine-rich splicing factor 10
chr8_-_29940628 0.10 ENST00000545648.1
ENST00000256255.6
TMEM66
transmembrane protein 66
chr1_-_169455169 0.10 ENST00000367804.4
ENST00000236137.5
SLC19A2
solute carrier family 19 (thiamine transporter), member 2
chr5_-_168006591 0.07 ENST00000239231.6
PANK3
pantothenate kinase 3
chr16_+_68771128 0.06 ENST00000261769.5
ENST00000422392.2
CDH1
cadherin 1, type 1, E-cadherin (epithelial)
chr3_-_164913777 0.05 ENST00000475390.1
SLITRK3
SLIT and NTRK-like family, member 3
chr12_+_62654119 0.05 ENST00000353364.3
ENST00000549523.1
ENST00000280377.5
USP15
ubiquitin specific peptidase 15
chrX_+_9983602 0.01 ENST00000380861.4
WWC3
WWC family member 3

Network of associatons between targets according to the STRING database.

First level regulatory network of ACUGCAU

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.8 5.5 GO:0090244 negative regulation of Wnt signaling pathway involved in heart development(GO:0003308) negative regulation of cell fate specification(GO:0009996) Wnt signaling pathway involved in somitogenesis(GO:0090244)
1.5 6.1 GO:0033387 putrescine biosynthetic process from ornithine(GO:0033387)
1.2 7.2 GO:0035694 mitochondrial protein catabolic process(GO:0035694)
1.1 3.3 GO:0021836 cerebral cortex tangential migration using cell-cell interactions(GO:0021823) postnatal olfactory bulb interneuron migration(GO:0021827) chemorepulsion involved in postnatal olfactory bulb interneuron migration(GO:0021836) regulation of negative chemotaxis(GO:0050923)
0.9 2.8 GO:0006597 spermine biosynthetic process(GO:0006597)
0.9 9.2 GO:0044387 negative regulation of protein kinase activity by regulation of protein phosphorylation(GO:0044387)
0.7 2.2 GO:0044208 'de novo' AMP biosynthetic process(GO:0044208)
0.7 2.7 GO:1902544 oxidative DNA demethylation(GO:0035511) regulation of DNA N-glycosylase activity(GO:1902544)
0.7 2.0 GO:0003383 apical constriction(GO:0003383)
0.6 1.8 GO:1904482 response to tetrahydrofolate(GO:1904481) cellular response to tetrahydrofolate(GO:1904482)
0.6 1.7 GO:0002188 translation reinitiation(GO:0002188)
0.6 1.7 GO:0006428 isoleucyl-tRNA aminoacylation(GO:0006428)
0.5 1.5 GO:0045876 positive regulation of sister chromatid cohesion(GO:0045876)
0.5 1.4 GO:0060279 negative regulation of B cell differentiation(GO:0045578) regulation of ovulation(GO:0060278) positive regulation of ovulation(GO:0060279)
0.5 1.4 GO:0090526 regulation of gluconeogenesis involved in cellular glucose homeostasis(GO:0090526)
0.4 2.2 GO:0044806 G-quadruplex DNA unwinding(GO:0044806)
0.4 1.7 GO:1903984 positive regulation of TRAIL-activated apoptotic signaling pathway(GO:1903984)
0.4 2.4 GO:0006177 GMP biosynthetic process(GO:0006177)
0.4 3.1 GO:1903748 negative regulation of establishment of protein localization to mitochondrion(GO:1903748)
0.4 2.5 GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA(GO:0000290)
0.4 2.8 GO:1902037 negative regulation of hematopoietic stem cell differentiation(GO:1902037)
0.3 2.0 GO:0061087 negative regulation of histone H3-K27 methylation(GO:0061086) positive regulation of histone H3-K27 methylation(GO:0061087)
0.3 3.7 GO:2000271 positive regulation of fibroblast apoptotic process(GO:2000271)
0.3 1.5 GO:0003408 optic cup formation involved in camera-type eye development(GO:0003408)
0.3 5.5 GO:0032486 Rap protein signal transduction(GO:0032486)
0.3 0.9 GO:0098923 retrograde trans-synaptic signaling by soluble gas(GO:0098923) trans-synaptic signaling by soluble gas(GO:0099543) trans-synaptic signaling by trans-synaptic complex(GO:0099545)
0.3 4.5 GO:0007253 cytoplasmic sequestering of NF-kappaB(GO:0007253)
0.3 0.8 GO:0007206 phospholipase C-activating G-protein coupled glutamate receptor signaling pathway(GO:0007206)
0.2 1.4 GO:0035672 oligopeptide transmembrane transport(GO:0035672)
0.2 2.4 GO:0031936 negative regulation of chromatin silencing(GO:0031936)
0.2 0.7 GO:1901859 late nucleophagy(GO:0044805) negative regulation of mitochondrial DNA replication(GO:0090298) negative regulation of mitochondrial DNA metabolic process(GO:1901859) single-organism membrane invagination(GO:1902534)
0.2 5.3 GO:0045880 positive regulation of smoothened signaling pathway(GO:0045880)
0.2 2.0 GO:0001672 regulation of chromatin assembly or disassembly(GO:0001672)
0.2 6.3 GO:0000717 nucleotide-excision repair, DNA duplex unwinding(GO:0000717)
0.2 1.7 GO:0035583 sequestering of TGFbeta in extracellular matrix(GO:0035583)
0.2 0.9 GO:0035900 response to isolation stress(GO:0035900)
0.2 0.7 GO:0010908 regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010908) positive regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010909) canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition(GO:0044334) positive regulation of proteoglycan biosynthetic process(GO:1902730)
0.2 1.6 GO:0001675 acrosome assembly(GO:0001675)
0.2 1.1 GO:1902963 regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902962) negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902963)
0.2 6.2 GO:0006376 mRNA splice site selection(GO:0006376)
0.2 1.9 GO:0001711 endodermal cell fate commitment(GO:0001711) histone H3-K4 trimethylation(GO:0080182)
0.1 1.3 GO:0010265 SCF complex assembly(GO:0010265)
0.1 0.4 GO:0002663 B cell tolerance induction(GO:0002514) regulation of B cell tolerance induction(GO:0002661) positive regulation of B cell tolerance induction(GO:0002663)
0.1 4.7 GO:0043090 amino acid import(GO:0043090)
0.1 3.7 GO:0019054 modulation by virus of host process(GO:0019054)
0.1 1.6 GO:0005981 regulation of glycogen catabolic process(GO:0005981)
0.1 4.7 GO:0051220 cytoplasmic sequestering of protein(GO:0051220)
0.1 1.4 GO:0010225 response to UV-C(GO:0010225)
0.1 1.0 GO:0048172 regulation of short-term neuronal synaptic plasticity(GO:0048172)
0.1 2.1 GO:0060148 positive regulation of posttranscriptional gene silencing(GO:0060148) positive regulation of gene silencing by miRNA(GO:2000637)
0.1 0.4 GO:0048880 sensory system development(GO:0048880)
0.1 1.3 GO:0045793 positive regulation of cell size(GO:0045793)
0.1 1.3 GO:0036295 cellular response to increased oxygen levels(GO:0036295)
0.1 3.0 GO:2000272 negative regulation of receptor activity(GO:2000272)
0.1 2.7 GO:0051642 centrosome localization(GO:0051642)
0.1 0.3 GO:0035720 intraciliary anterograde transport(GO:0035720)
0.1 0.2 GO:2000705 dense core granule biogenesis(GO:0061110) regulation of dense core granule biogenesis(GO:2000705)
0.1 0.3 GO:0050653 chondroitin sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0050653)
0.1 0.8 GO:0036342 post-anal tail morphogenesis(GO:0036342)
0.1 2.2 GO:0007094 mitotic spindle assembly checkpoint(GO:0007094) spindle assembly checkpoint(GO:0071173)
0.0 0.5 GO:0061158 3'-UTR-mediated mRNA destabilization(GO:0061158)
0.0 1.0 GO:1902857 positive regulation of nonmotile primary cilium assembly(GO:1902857)
0.0 0.3 GO:0032482 Rab protein signal transduction(GO:0032482)
0.0 4.6 GO:0006446 regulation of translational initiation(GO:0006446)
0.0 0.4 GO:0098814 spontaneous neurotransmitter secretion(GO:0061669) spontaneous synaptic transmission(GO:0098814)
0.0 1.3 GO:0070534 protein K63-linked ubiquitination(GO:0070534)
0.0 2.5 GO:0031663 lipopolysaccharide-mediated signaling pathway(GO:0031663)
0.0 4.3 GO:1902036 regulation of hematopoietic stem cell differentiation(GO:1902036)
0.0 1.6 GO:0016574 histone ubiquitination(GO:0016574)
0.0 0.6 GO:0032793 positive regulation of CREB transcription factor activity(GO:0032793)
0.0 0.3 GO:0048875 chemical homeostasis within a tissue(GO:0048875)
0.0 0.1 GO:0071934 thiamine transport(GO:0015888) thiamine transmembrane transport(GO:0071934)
0.0 1.7 GO:0032508 DNA duplex unwinding(GO:0032508)
0.0 0.4 GO:0001886 endothelial cell morphogenesis(GO:0001886) retina vasculature morphogenesis in camera-type eye(GO:0061299)
0.0 0.6 GO:0006907 pinocytosis(GO:0006907)
0.0 1.5 GO:0048008 fibroblast migration(GO:0010761) platelet-derived growth factor receptor signaling pathway(GO:0048008)
0.0 1.4 GO:0018279 protein N-linked glycosylation via asparagine(GO:0018279)
0.0 1.3 GO:0046513 ceramide biosynthetic process(GO:0046513)
0.0 2.5 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
0.0 0.2 GO:0036066 protein O-linked fucosylation(GO:0036066)
0.0 5.1 GO:0030336 negative regulation of cell migration(GO:0030336)
0.0 1.4 GO:0090307 mitotic spindle assembly(GO:0090307)
0.0 3.4 GO:0008360 regulation of cell shape(GO:0008360)
0.0 1.2 GO:0061178 regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0061178)
0.0 0.6 GO:0017145 stem cell division(GO:0017145)
0.0 1.9 GO:0006334 nucleosome assembly(GO:0006334)
0.0 0.1 GO:0071680 response to indole-3-methanol(GO:0071680) cellular response to indole-3-methanol(GO:0071681)
0.0 0.4 GO:0007568 aging(GO:0007568)
0.0 1.4 GO:0051291 protein heterooligomerization(GO:0051291)
0.0 0.0 GO:0035616 histone H2B conserved C-terminal lysine deubiquitination(GO:0035616)
0.0 0.1 GO:0006183 GTP biosynthetic process(GO:0006183)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 9.8 GO:0016600 flotillin complex(GO:0016600)
0.5 1.4 GO:0043512 inhibin complex(GO:0043511) inhibin A complex(GO:0043512)
0.4 3.1 GO:0098554 cytoplasmic side of endoplasmic reticulum membrane(GO:0098554)
0.4 3.0 GO:0046581 intercellular canaliculus(GO:0046581)
0.4 6.3 GO:0000109 nucleotide-excision repair complex(GO:0000109)
0.3 6.3 GO:0016580 Sin3 complex(GO:0016580)
0.2 1.4 GO:0044614 nuclear pore cytoplasmic filaments(GO:0044614)
0.2 1.1 GO:0070381 endosome to plasma membrane transport vesicle(GO:0070381)
0.2 1.9 GO:0016593 Cdc73/Paf1 complex(GO:0016593)
0.2 0.7 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
0.2 1.5 GO:0042382 paraspeckles(GO:0042382)
0.2 1.6 GO:0001739 sex chromatin(GO:0001739)
0.2 1.6 GO:0042587 glycogen granule(GO:0042587) PTW/PP1 phosphatase complex(GO:0072357)
0.2 2.5 GO:0031332 RISC complex(GO:0016442) RNAi effector complex(GO:0031332)
0.1 1.7 GO:0035749 myelin sheath adaxonal region(GO:0035749)
0.1 1.4 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.1 2.0 GO:0032059 bleb(GO:0032059)
0.1 1.9 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.1 1.3 GO:0033180 proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.1 2.7 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.1 3.0 GO:0016592 mediator complex(GO:0016592)
0.1 1.7 GO:0017101 aminoacyl-tRNA synthetase multienzyme complex(GO:0017101)
0.1 1.7 GO:0001527 microfibril(GO:0001527) fibril(GO:0043205)
0.1 1.5 GO:0071564 npBAF complex(GO:0071564)
0.1 1.4 GO:0031011 Ino80 complex(GO:0031011) DNA helicase complex(GO:0033202)
0.1 0.3 GO:0098837 postsynaptic recycling endosome(GO:0098837)
0.1 0.9 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.1 5.0 GO:0017053 transcriptional repressor complex(GO:0017053)
0.1 3.9 GO:0035577 azurophil granule membrane(GO:0035577)
0.1 1.4 GO:0097228 sperm principal piece(GO:0097228)
0.1 2.8 GO:0009295 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.0 0.6 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.0 4.8 GO:0005905 clathrin-coated pit(GO:0005905)
0.0 2.3 GO:0043034 costamere(GO:0043034)
0.0 0.4 GO:0070022 transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.0 1.0 GO:0032591 dendritic spine membrane(GO:0032591)
0.0 1.0 GO:0005852 eukaryotic translation initiation factor 3 complex(GO:0005852)
0.0 3.7 GO:0018995 host(GO:0018995) host cell(GO:0043657)
0.0 4.8 GO:0030175 filopodium(GO:0030175)
0.0 2.3 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.0 0.3 GO:0071011 precatalytic spliceosome(GO:0071011)
0.0 2.9 GO:0035578 azurophil granule lumen(GO:0035578)
0.0 1.6 GO:0055038 recycling endosome membrane(GO:0055038)
0.0 2.2 GO:0000777 condensed chromosome kinetochore(GO:0000777)
0.0 6.1 GO:0000790 nuclear chromatin(GO:0000790)
0.0 2.2 GO:0071013 catalytic step 2 spliceosome(GO:0071013)
0.0 2.2 GO:0031901 early endosome membrane(GO:0031901)
0.0 0.7 GO:0000407 pre-autophagosomal structure(GO:0000407)
0.0 0.6 GO:0005839 proteasome core complex(GO:0005839)
0.0 1.9 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.0 1.4 GO:0097517 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.0 6.8 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.0 8.3 GO:0030529 intracellular ribonucleoprotein complex(GO:0030529)
0.0 0.6 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.0 2.4 GO:0009898 cytoplasmic side of plasma membrane(GO:0009898)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.8 5.3 GO:0050510 N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity(GO:0050510)
0.9 6.6 GO:0050815 phosphoserine binding(GO:0050815)
0.9 2.7 GO:0043739 G/U mismatch-specific uracil-DNA glycosylase activity(GO:0043739)
0.9 7.2 GO:0004176 ATP-dependent peptidase activity(GO:0004176)
0.9 6.1 GO:0042978 ornithine decarboxylase activator activity(GO:0042978)
0.6 1.7 GO:0016314 phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity(GO:0016314)
0.6 1.7 GO:0004822 isoleucine-tRNA ligase activity(GO:0004822)
0.5 5.5 GO:0039706 co-receptor binding(GO:0039706)
0.5 3.0 GO:0008046 axon guidance receptor activity(GO:0008046)
0.5 6.3 GO:1990247 N6-methyladenosine-containing RNA binding(GO:1990247)
0.5 1.4 GO:0015235 cobalamin transporter activity(GO:0015235)
0.5 1.4 GO:0070699 type II activin receptor binding(GO:0070699)
0.4 1.8 GO:0070905 serine binding(GO:0070905)
0.4 9.0 GO:0005092 GDP-dissociation inhibitor activity(GO:0005092)
0.3 3.1 GO:0055131 C3HC4-type RING finger domain binding(GO:0055131)
0.3 2.5 GO:0050072 m7G(5')pppN diphosphatase activity(GO:0050072)
0.3 1.6 GO:0017018 myosin phosphatase activity(GO:0017018)
0.2 5.0 GO:0035497 cAMP response element binding(GO:0035497)
0.2 1.3 GO:0050291 sphingosine N-acyltransferase activity(GO:0050291)
0.2 1.7 GO:0030023 extracellular matrix constituent conferring elasticity(GO:0030023)
0.2 2.1 GO:0002151 G-quadruplex RNA binding(GO:0002151) RNA strand annealing activity(GO:0033592)
0.2 0.8 GO:0034481 chondroitin sulfotransferase activity(GO:0034481)
0.2 3.0 GO:0042809 vitamin D receptor binding(GO:0042809)
0.2 2.4 GO:0016884 carbon-nitrogen ligase activity, with glutamine as amido-N-donor(GO:0016884)
0.1 1.4 GO:0004579 dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.1 6.3 GO:0031593 polyubiquitin binding(GO:0031593)
0.1 2.7 GO:0045504 dynein heavy chain binding(GO:0045504)
0.1 4.6 GO:0030159 receptor signaling complex scaffold activity(GO:0030159)
0.1 2.0 GO:0017049 GTP-Rho binding(GO:0017049)
0.1 1.4 GO:0042301 phosphate ion binding(GO:0042301)
0.1 1.4 GO:0097100 supercoiled DNA binding(GO:0097100)
0.1 8.3 GO:0048365 Rac GTPase binding(GO:0048365)
0.1 0.7 GO:0004839 ubiquitin activating enzyme activity(GO:0004839)
0.1 4.8 GO:0050699 WW domain binding(GO:0050699)
0.1 0.4 GO:0005026 transforming growth factor beta receptor activity, type II(GO:0005026)
0.1 7.3 GO:0003743 translation initiation factor activity(GO:0003743)
0.1 3.7 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.1 0.6 GO:0051032 nucleic acid transmembrane transporter activity(GO:0051032) RNA transmembrane transporter activity(GO:0051033)
0.1 1.1 GO:0032050 clathrin heavy chain binding(GO:0032050)
0.1 6.8 GO:0019003 GDP binding(GO:0019003)
0.1 3.0 GO:0051059 NF-kappaB binding(GO:0051059)
0.1 0.6 GO:0005005 transmembrane-ephrin receptor activity(GO:0005005)
0.1 1.4 GO:0000400 four-way junction DNA binding(GO:0000400)
0.1 1.4 GO:0019789 SUMO transferase activity(GO:0019789)
0.1 0.3 GO:0047238 glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity(GO:0047238)
0.1 0.9 GO:0042043 neurexin family protein binding(GO:0042043)
0.1 2.5 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.1 3.7 GO:0035064 methylated histone binding(GO:0035064)
0.1 0.8 GO:0035256 G-protein coupled glutamate receptor binding(GO:0035256)
0.1 2.8 GO:0016831 carboxy-lyase activity(GO:0016831)
0.0 2.7 GO:0031491 nucleosome binding(GO:0031491)
0.0 1.7 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)
0.0 1.3 GO:0046961 proton-transporting ATPase activity, rotational mechanism(GO:0046961)
0.0 1.0 GO:0070840 dynein complex binding(GO:0070840)
0.0 0.8 GO:0045295 gamma-catenin binding(GO:0045295)
0.0 0.1 GO:0015403 thiamine transmembrane transporter activity(GO:0015234) thiamine uptake transmembrane transporter activity(GO:0015403)
0.0 0.6 GO:0070628 proteasome binding(GO:0070628)
0.0 1.3 GO:0061650 ubiquitin conjugating enzyme activity(GO:0061631) ubiquitin-like protein conjugating enzyme activity(GO:0061650)
0.0 0.4 GO:0030215 semaphorin receptor binding(GO:0030215)
0.0 1.0 GO:0017025 TBP-class protein binding(GO:0017025)
0.0 2.9 GO:0051082 unfolded protein binding(GO:0051082)
0.0 1.5 GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980)
0.0 2.3 GO:0042393 histone binding(GO:0042393)
0.0 0.1 GO:0004594 pantothenate kinase activity(GO:0004594)
0.0 1.0 GO:0030165 PDZ domain binding(GO:0030165)
0.0 0.6 GO:0017091 AU-rich element binding(GO:0017091)
0.0 0.6 GO:0036002 pre-mRNA binding(GO:0036002)
0.0 2.2 GO:0008201 heparin binding(GO:0008201)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 6.8 ST WNT BETA CATENIN PATHWAY Wnt/beta-catenin Pathway
0.1 9.4 PID ECADHERIN NASCENT AJ PATHWAY E-cadherin signaling in the nascent adherens junction
0.1 8.1 ST PHOSPHOINOSITIDE 3 KINASE PATHWAY PI3K Pathway
0.1 2.0 PID THROMBIN PAR4 PATHWAY PAR4-mediated thrombin signaling events
0.1 1.4 PID RANBP2 PATHWAY Sumoylation by RanBP2 regulates transcriptional repression
0.1 3.5 SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES Genes related to regulation of the actin cytoskeleton
0.1 1.4 PID S1P META PATHWAY Sphingosine 1-phosphate (S1P) pathway
0.1 3.3 PID AJDISS 2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.0 3.0 PID PLK1 PATHWAY PLK1 signaling events
0.0 2.0 PID AR TF PATHWAY Regulation of Androgen receptor activity
0.0 1.6 ST TUMOR NECROSIS FACTOR PATHWAY Tumor Necrosis Factor Pathway.
0.0 3.1 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.0 1.8 PID MTOR 4PATHWAY mTOR signaling pathway
0.0 0.5 PID HIF1A PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.0 0.8 PID ARF6 TRAFFICKING PATHWAY Arf6 trafficking events
0.0 0.2 PID PRL SIGNALING EVENTS PATHWAY Signaling events mediated by PRL
0.0 0.4 PID ALK1 PATHWAY ALK1 signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 3.0 REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK Genes involved in Negative regulation of the PI3K/AKT network
0.4 7.2 REACTOME DESTABILIZATION OF MRNA BY BRF1 Genes involved in Destabilization of mRNA by Butyrate Response Factor 1 (BRF1)
0.3 4.6 REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.2 6.3 REACTOME FORMATION OF INCISION COMPLEX IN GG NER Genes involved in Formation of incision complex in GG-NER
0.2 6.3 REACTOME CHONDROITIN SULFATE BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.2 4.5 REACTOME P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS Genes involved in p130Cas linkage to MAPK signaling for integrins
0.2 1.4 REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.1 2.7 REACTOME BASE FREE SUGAR PHOSPHATE REMOVAL VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway
0.1 7.5 REACTOME SIGNALING BY ROBO RECEPTOR Genes involved in Signaling by Robo receptor
0.1 2.8 REACTOME METABOLISM OF POLYAMINES Genes involved in Metabolism of polyamines
0.1 1.4 REACTOME GLYCOPROTEIN HORMONES Genes involved in Glycoprotein hormones
0.1 5.0 REACTOME MYOGENESIS Genes involved in Myogenesis
0.1 6.7 REACTOME REGULATION OF ORNITHINE DECARBOXYLASE ODC Genes involved in Regulation of ornithine decarboxylase (ODC)
0.1 0.5 REACTOME VIF MEDIATED DEGRADATION OF APOBEC3G Genes involved in Vif-mediated degradation of APOBEC3G
0.1 0.9 REACTOME P38MAPK EVENTS Genes involved in p38MAPK events
0.1 1.6 REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.1 1.4 REACTOME KINESINS Genes involved in Kinesins
0.0 5.1 REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES Genes involved in Antiviral mechanism by IFN-stimulated genes
0.0 7.3 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.0 2.0 REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.0 1.7 REACTOME CYTOSOLIC TRNA AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.0 2.8 REACTOME MITOCHONDRIAL PROTEIN IMPORT Genes involved in Mitochondrial Protein Import
0.0 1.3 REACTOME INSULIN RECEPTOR RECYCLING Genes involved in Insulin receptor recycling
0.0 1.3 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.0 6.0 REACTOME MRNA SPLICING Genes involved in mRNA Splicing
0.0 1.4 REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT Genes involved in ABC-family proteins mediated transport
0.0 0.4 REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.0 0.4 REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.0 2.7 REACTOME MHC CLASS II ANTIGEN PRESENTATION Genes involved in MHC class II antigen presentation
0.0 4.6 REACTOME TRANSLATION Genes involved in Translation
0.0 1.1 REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.0 1.4 REACTOME ASPARAGINE N LINKED GLYCOSYLATION Genes involved in Asparagine N-linked glycosylation
0.0 0.5 REACTOME PACKAGING OF TELOMERE ENDS Genes involved in Packaging Of Telomere Ends
0.0 2.0 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.0 1.8 REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES Genes involved in Metabolism of amino acids and derivatives