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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for AGCCCUU
Z-value: 1.27
Motif logo
miRNA associated with seed AGCCCUU
Network of associatons between targets according to the STRING database.
First level regulatory network of AGCCCUU
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.9 | 28.8 | GO:0051581 | negative regulation of neurotransmitter uptake(GO:0051581) serotonin uptake(GO:0051610) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612) |
| 0.5 | 21.6 | GO:0070884 | regulation of calcineurin-NFAT signaling cascade(GO:0070884) |
| 3.0 | 21.3 | GO:0060373 | regulation of ventricular cardiac muscle cell membrane depolarization(GO:0060373) |
| 0.4 | 18.1 | GO:0007214 | gamma-aminobutyric acid signaling pathway(GO:0007214) |
| 0.4 | 14.7 | GO:0048791 | calcium ion-regulated exocytosis of neurotransmitter(GO:0048791) |
| 2.8 | 14.1 | GO:0090258 | negative regulation of mitochondrial fission(GO:0090258) |
| 0.2 | 13.2 | GO:0010812 | negative regulation of cell-substrate adhesion(GO:0010812) |
| 3.8 | 11.4 | GO:1902948 | regulation of choline O-acetyltransferase activity(GO:1902769) positive regulation of choline O-acetyltransferase activity(GO:1902771) negative regulation of tau-protein kinase activity(GO:1902948) positive regulation of early endosome to recycling endosome transport(GO:1902955) negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902960) negative regulation of neurofibrillary tangle assembly(GO:1902997) negative regulation of aspartic-type peptidase activity(GO:1905246) |
| 0.0 | 11.4 | GO:0048232 | spermatogenesis(GO:0007283) male gamete generation(GO:0048232) |
| 0.1 | 10.9 | GO:0014902 | myotube differentiation(GO:0014902) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 32.9 | GO:0014069 | postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572) |
| 0.1 | 27.2 | GO:0045121 | membrane raft(GO:0045121) |
| 1.0 | 20.4 | GO:0033268 | node of Ranvier(GO:0033268) |
| 1.0 | 16.9 | GO:0001518 | voltage-gated sodium channel complex(GO:0001518) |
| 0.2 | 16.5 | GO:0031463 | Cul3-RING ubiquitin ligase complex(GO:0031463) |
| 0.3 | 14.7 | GO:0048786 | presynaptic active zone(GO:0048786) |
| 2.8 | 14.1 | GO:0045298 | tubulin complex(GO:0045298) |
| 0.8 | 11.4 | GO:0005641 | nuclear envelope lumen(GO:0005641) |
| 0.5 | 10.4 | GO:1990124 | messenger ribonucleoprotein complex(GO:1990124) |
| 3.3 | 9.9 | GO:0038039 | G-protein coupled receptor heterodimeric complex(GO:0038039) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.0 | 24.2 | GO:0010858 | calcium-dependent protein kinase regulator activity(GO:0010858) |
| 3.8 | 23.0 | GO:0008597 | calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597) |
| 0.1 | 19.0 | GO:0044325 | ion channel binding(GO:0044325) |
| 0.0 | 18.7 | GO:0004842 | ubiquitin-protein transferase activity(GO:0004842) |
| 3.4 | 16.9 | GO:0086006 | voltage-gated sodium channel activity involved in cardiac muscle cell action potential(GO:0086006) |
| 0.5 | 15.8 | GO:0004708 | MAP kinase kinase activity(GO:0004708) |
| 0.2 | 15.7 | GO:0043621 | protein self-association(GO:0043621) |
| 3.5 | 14.1 | GO:0099609 | microtubule lateral binding(GO:0099609) |
| 0.5 | 13.2 | GO:0008191 | metalloendopeptidase inhibitor activity(GO:0008191) |
| 0.7 | 11.4 | GO:0030306 | ADP-ribosylation factor binding(GO:0030306) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 24.4 | PID TCR CALCIUM PATHWAY | Calcium signaling in the CD4+ TCR pathway |
| 0.1 | 22.9 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 0.3 | 19.0 | ST JNK MAPK PATHWAY | JNK MAPK Pathway |
| 0.8 | 14.1 | PID P38 GAMMA DELTA PATHWAY | Signaling mediated by p38-gamma and p38-delta |
| 0.2 | 13.2 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.2 | 10.4 | PID AURORA A PATHWAY | Aurora A signaling |
| 0.1 | 7.9 | PID SHP2 PATHWAY | SHP2 signaling |
| 0.1 | 7.6 | PID ARF6 PATHWAY | Arf6 signaling events |
| 0.3 | 7.5 | PID ARF6 DOWNSTREAM PATHWAY | Arf6 downstream pathway |
| 0.1 | 7.3 | PID HDAC CLASSI PATHWAY | Signaling events mediated by HDAC Class I |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 16.9 | REACTOME INTERACTION BETWEEN L1 AND ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
| 0.4 | 14.1 | REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS | Genes involved in Caspase-mediated cleavage of cytoskeletal proteins |
| 0.5 | 9.9 | REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS | Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors) |
| 0.2 | 8.3 | REACTOME TRAFFICKING OF AMPA RECEPTORS | Genes involved in Trafficking of AMPA receptors |
| 0.3 | 8.2 | REACTOME GABA A RECEPTOR ACTIVATION | Genes involved in GABA A receptor activation |
| 0.0 | 8.2 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.1 | 8.0 | REACTOME NCAM1 INTERACTIONS | Genes involved in NCAM1 interactions |
| 0.1 | 6.3 | REACTOME ELONGATION ARREST AND RECOVERY | Genes involved in Elongation arrest and recovery |
| 0.3 | 5.9 | REACTOME JNK C JUN KINASES PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1 | Genes involved in JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 |
| 0.2 | 5.8 | REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS | Genes involved in Phosphorylation of CD3 and TCR zeta chains |