ISMARA results: AGUGCAA

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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)

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Results for AGUGCAA

Z-value: 0.93

Motif logo

miRNA associated with seed AGUGCAA

Name	miRBASE accession
hsa-miR-130a-3p miRBase	MIMAT0000425
hsa-miR-130b-3p miRBase	MIMAT0000691
hsa-miR-301a-3p miRBase	MIMAT0000688
hsa-miR-301b-3p miRBase	MIMAT0004958
hsa-miR-454-3p miRBase	MIMAT0003885
hsa-miR-3666 miRBase	MIMAT0018088
hsa-miR-4295 miRBase	MIMAT0016844

Activity profile of AGUGCAA motif

Sorted Z-values of AGUGCAA motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr20_+_10199468 Show fit	30.51	ENST00000254976.2 ENST00000304886.2	SNAP25 Ensembl NCBI GeneCards UniProt NextProt Show fit	synaptosomal-associated protein, 25kDa
chr14_-_60097297 Show fit	24.17	ENST00000395090.1	RTN1 Ensembl NCBI GeneCards UniProt NextProt Show fit	reticulon 1
chr1_-_204380919 Show fit	23.56	ENST00000367188.4	PPP1R15B Ensembl NCBI GeneCards UniProt NextProt Show fit	protein phosphatase 1, regulatory subunit 15B
chr8_+_11141925 Show fit	15.05	ENST00000221086.3	MTMR9 Ensembl NCBI GeneCards UniProt NextProt Show fit	myotubularin related protein 9
chr17_-_78450398 Show fit	14.80	ENST00000306773.4	NPTX1 Ensembl NCBI GeneCards UniProt NextProt Show fit	neuronal pentraxin I
chr11_-_113746277 Show fit	14.25	ENST00000003302.4 ENST00000545540.1	USP28 Ensembl NCBI GeneCards UniProt NextProt Show fit	ubiquitin specific peptidase 28
chr3_+_115342159 Show fit	13.93	ENST00000305124.6	GAP43 Ensembl NCBI GeneCards UniProt NextProt Show fit	growth associated protein 43
chr5_+_71403061 Show fit	13.77	ENST00000512974.1 ENST00000296755.7	MAP1B Ensembl NCBI GeneCards UniProt NextProt Show fit	microtubule-associated protein 1B
chr20_+_1246908 Show fit	13.61	ENST00000381873.3 ENST00000381867.1	SNPH Ensembl NCBI GeneCards UniProt NextProt Show fit	syntaphilin
chr3_+_50712672 Show fit	13.46	ENST00000266037.9	DOCK3 Ensembl NCBI GeneCards UniProt NextProt Show fit	dedicator of cytokinesis 3

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of AGUGCAA

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
6.1	30.5	GO:0099590	neurotransmitter receptor internalization(GO:0099590)
2.6	23.6	GO:1903912	negative regulation of PERK-mediated unfolded protein response(GO:1903898) negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation(GO:1903912)
0.2	18.5	GO:0006334	nucleosome assembly(GO:0006334)
0.9	17.6	GO:0006012	galactose metabolic process(GO:0006012)
0.2	16.2	GO:0031338	regulation of vesicle fusion(GO:0031338)
0.8	13.8	GO:0061162	establishment of monopolar cell polarity(GO:0061162) establishment or maintenance of monopolar cell polarity(GO:0061339)
1.2	13.6	GO:0016081	synaptic vesicle docking(GO:0016081)
0.8	13.0	GO:0090361	platelet-derived growth factor production(GO:0090360) regulation of platelet-derived growth factor production(GO:0090361)
0.2	12.7	GO:0061178	regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0061178)
1.2	11.9	GO:0031580	membrane raft polarization(GO:0001766) membrane raft distribution(GO:0031580)

Showing 1 to 10 of 223 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
7.6	30.5	GO:0070032	synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032)
1.4	23.6	GO:0000164	protein phosphatase type 1 complex(GO:0000164)
0.1	21.2	GO:0005875	microtubule associated complex(GO:0005875)
0.3	20.9	GO:0005881	cytoplasmic microtubule(GO:0005881)
0.2	17.9	GO:0000776	kinetochore(GO:0000776)
2.0	13.9	GO:0032584	growth cone membrane(GO:0032584)
0.8	13.0	GO:1990124	messenger ribonucleoprotein complex(GO:1990124)
0.5	12.3	GO:0005721	pericentric heterochromatin(GO:0005721)
0.0	11.9	GO:0031965	nuclear membrane(GO:0031965)
0.5	11.8	GO:0034045	pre-autophagosomal structure membrane(GO:0034045)

Showing 1 to 10 of 111 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.2	67.1	GO:0017075	syntaxin-1 binding(GO:0017075)
0.2	22.8	GO:0019888	protein phosphatase regulator activity(GO:0019888)
0.1	22.6	GO:0017137	Rab GTPase binding(GO:0017137)
0.1	17.0	GO:0001227	transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
1.2	15.0	GO:0052629	phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity(GO:0052629)
1.4	13.9	GO:0035727	lysophosphatidic acid binding(GO:0035727)
0.8	13.0	GO:0035925	mRNA 3'-UTR AU-rich region binding(GO:0035925)
4.2	12.5	GO:0004157	dihydropyrimidinase activity(GO:0004157)
1.0	11.9	GO:0019911	structural constituent of myelin sheath(GO:0019911)
1.7	11.8	GO:0001517	N-acetylglucosamine 6-O-sulfotransferase activity(GO:0001517)

Showing 1 to 10 of 151 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.4	21.6	PID NCADHERIN PATHWAY	N-cadherin signaling events
0.3	16.9	PID ARF6 PATHWAY	Arf6 signaling events
0.4	16.5	PID NETRIN PATHWAY	Netrin-mediated signaling events
0.2	11.6	PID PI3K PLC TRK PATHWAY	Trk receptor signaling mediated by PI3K and PLC-gamma
0.3	10.7	PID IL3 PATHWAY	IL3-mediated signaling events
0.4	10.3	PID S1P META PATHWAY	Sphingosine 1-phosphate (S1P) pathway
0.3	10.3	ST G ALPHA I PATHWAY	G alpha i Pathway
0.1	9.3	PID MTOR 4PATHWAY	mTOR signaling pathway
0.1	8.4	NABA PROTEOGLYCANS	Genes encoding proteoglycans
0.1	7.7	PID CASPASE PATHWAY	Caspase cascade in apoptosis

Showing 1 to 10 of 49 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.7	30.5	REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE	Genes involved in Norepinephrine Neurotransmitter Release Cycle
0.1	12.5	REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2	Genes involved in Response to elevated platelet cytosolic Ca2+
0.4	10.7	REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS	Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.1	10.6	REACTOME G ALPHA I SIGNALLING EVENTS	Genes involved in G alpha (i) signalling events
0.2	10.5	REACTOME REGULATION OF INSULIN SECRETION BY GLUCAGON LIKE PEPTIDE1	Genes involved in Regulation of Insulin Secretion by Glucagon-like Peptide-1
0.2	10.4	REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE	Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.3	10.1	REACTOME EFFECTS OF PIP2 HYDROLYSIS	Genes involved in Effects of PIP2 hydrolysis
0.5	9.7	REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE	Genes involved in Synthesis of PIPs at the Golgi membrane
0.1	9.6	REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S	Genes involved in Activation of Chaperone Genes by XBP1(S)
0.2	9.2	REACTOME NOD1 2 SIGNALING PATHWAY	Genes involved in NOD1/2 Signaling Pathway

Showing 1 to 10 of 75 entries

Results for AGUGCAA

Z-value: 0.93

Motif logo

miRNA associated with seed AGUGCAA

Activity profile of AGUGCAA motif

Sorted Z-values of AGUGCAA motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of AGUGCAA

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: