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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for ARID5B
Z-value: 0.18
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Transcription factors associated with ARID5B
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| ARID5B | hg19_v2_chr10_+_63661053_63661079 | 0.05 | 4.3e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of ARID5B
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.8 | 11.3 | GO:0098746 | fast, calcium ion-dependent exocytosis of neurotransmitter(GO:0098746) |
| 0.3 | 8.1 | GO:0035590 | purinergic nucleotide receptor signaling pathway(GO:0035590) |
| 0.1 | 7.8 | GO:0032436 | positive regulation of proteasomal ubiquitin-dependent protein catabolic process(GO:0032436) |
| 1.8 | 7.4 | GO:0003185 | primary heart field specification(GO:0003138) sinoatrial valve development(GO:0003172) sinoatrial valve morphogenesis(GO:0003185) |
| 0.2 | 5.0 | GO:0001829 | trophectodermal cell differentiation(GO:0001829) |
| 0.2 | 4.2 | GO:0007021 | tubulin complex assembly(GO:0007021) |
| 0.1 | 4.0 | GO:0016601 | Rac protein signal transduction(GO:0016601) |
| 0.7 | 3.5 | GO:1902268 | negative regulation of polyamine transmembrane transport(GO:1902268) |
| 0.1 | 3.1 | GO:0006471 | protein ADP-ribosylation(GO:0006471) |
| 0.0 | 3.1 | GO:0045333 | cellular respiration(GO:0045333) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 12.1 | GO:0016607 | nuclear speck(GO:0016607) |
| 2.3 | 11.3 | GO:0060200 | clathrin-sculpted acetylcholine transport vesicle(GO:0060200) clathrin-sculpted acetylcholine transport vesicle membrane(GO:0060201) |
| 0.0 | 10.5 | GO:0009986 | cell surface(GO:0009986) |
| 0.4 | 8.1 | GO:0031229 | integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229) nuclear membrane part(GO:0044453) |
| 0.0 | 7.3 | GO:0000151 | ubiquitin ligase complex(GO:0000151) |
| 0.0 | 6.1 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.2 | 6.0 | GO:0035371 | microtubule plus-end(GO:0035371) |
| 0.3 | 4.0 | GO:0032045 | guanyl-nucleotide exchange factor complex(GO:0032045) |
| 0.0 | 4.0 | GO:0000790 | nuclear chromatin(GO:0000790) |
| 0.0 | 3.3 | GO:0031234 | extrinsic component of cytoplasmic side of plasma membrane(GO:0031234) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.3 | 11.3 | GO:0030348 | syntaxin-3 binding(GO:0030348) |
| 0.7 | 8.1 | GO:0035381 | extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381) |
| 0.2 | 7.8 | GO:0031624 | ubiquitin conjugating enzyme binding(GO:0031624) |
| 0.4 | 6.9 | GO:0003680 | AT DNA binding(GO:0003680) |
| 0.0 | 5.1 | GO:0017124 | SH3 domain binding(GO:0017124) |
| 0.3 | 3.8 | GO:0001011 | transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087) |
| 0.7 | 3.5 | GO:0008073 | ornithine decarboxylase inhibitor activity(GO:0008073) |
| 0.7 | 3.5 | GO:0003956 | NAD(P)+-protein-arginine ADP-ribosyltransferase activity(GO:0003956) |
| 0.1 | 3.2 | GO:0005212 | structural constituent of eye lens(GO:0005212) |
| 0.2 | 3.0 | GO:0004143 | diacylglycerol kinase activity(GO:0004143) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 11.3 | SIG CD40PATHWAYMAP | Genes related to CD40 signaling |
| 0.1 | 7.4 | PID MAPK TRK PATHWAY | Trk receptor signaling mediated by the MAPK pathway |
| 0.1 | 4.0 | PID NETRIN PATHWAY | Netrin-mediated signaling events |
| 0.0 | 3.6 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 0.1 | 3.2 | PID NCADHERIN PATHWAY | N-cadherin signaling events |
| 0.0 | 3.0 | PID PI3KCI PATHWAY | Class I PI3K signaling events |
| 0.1 | 2.7 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.0 | 2.3 | PID NFAT TFPATHWAY | Calcineurin-regulated NFAT-dependent transcription in lymphocytes |
| 0.0 | 1.8 | PID TELOMERASE PATHWAY | Regulation of Telomerase |
| 0.0 | 1.7 | PID AJDISS 2PATHWAY | Posttranslational regulation of adherens junction stability and dissassembly |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 11.7 | REACTOME MYOGENESIS | Genes involved in Myogenesis |
| 0.6 | 11.3 | REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Norepinephrine Neurotransmitter Release Cycle |
| 0.1 | 4.6 | REACTOME REGULATION OF ORNITHINE DECARBOXYLASE ODC | Genes involved in Regulation of ornithine decarboxylase (ODC) |
| 0.1 | 4.0 | REACTOME THE ROLE OF NEF IN HIV1 REPLICATION AND DISEASE PATHOGENESIS | Genes involved in The role of Nef in HIV-1 replication and disease pathogenesis |
| 0.0 | 3.7 | REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES | Genes involved in Loss of Nlp from mitotic centrosomes |
| 0.1 | 3.0 | REACTOME EFFECTS OF PIP2 HYDROLYSIS | Genes involved in Effects of PIP2 hydrolysis |
| 0.1 | 2.7 | REACTOME ACTIVATION OF RAC | Genes involved in Activation of Rac |
| 0.1 | 2.7 | REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION | Genes involved in Amino acid synthesis and interconversion (transamination) |
| 0.0 | 1.8 | REACTOME PACKAGING OF TELOMERE ENDS | Genes involved in Packaging Of Telomere Ends |
| 0.1 | 1.6 | REACTOME DIGESTION OF DIETARY CARBOHYDRATE | Genes involved in Digestion of dietary carbohydrate |