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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)

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Results for ARID5B

Z-value: 0.18

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Transcription factors associated with ARID5B

Gene Symbol Gene ID Gene Info
ARID5B
ENSG00000150347.10 AT-rich interaction domain 5B

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
ARID5Bhg19_v2_chr10_+_63661053_636610790.054.3e-01Click!

Activity profile of ARID5B motif

Sorted Z-values of ARID5B motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr22_-_22090064 6.87 ENST00000339468.3
YPEL1
yippee-like 1 (Drosophila)
chr3_-_98241760 6.35 ENST00000507874.1
ENST00000502299.1
ENST00000508659.1
ENST00000510545.1
ENST00000511667.1
ENST00000394185.2
ENST00000394181.2
ENST00000508902.1
ENST00000341181.6
ENST00000437922.1
ENST00000394180.2
CLDND1
claudin domain containing 1
chr3_-_98241358 6.03 ENST00000503004.1
ENST00000506575.1
ENST00000513452.1
ENST00000515620.1
CLDND1
claudin domain containing 1
chr12_+_79258547 5.67 ENST00000457153.2
SYT1
synaptotagmin I
chr12_+_79258444 5.62 ENST00000261205.4
SYT1
synaptotagmin I
chr4_-_57524061 4.97 ENST00000508121.1
HOPX
HOP homeobox
chr22_-_22090043 4.71 ENST00000403503.1
YPEL1
yippee-like 1 (Drosophila)
chr8_-_101322132 4.55 ENST00000523481.1
RNF19A
ring finger protein 19A, RBR E3 ubiquitin protein ligase
chr5_-_88179302 4.42 ENST00000504921.2
MEF2C
myocyte enhancer factor 2C
chr17_-_3599696 4.22 ENST00000225328.5
P2RX5
purinergic receptor P2X, ligand-gated ion channel, 5
chr7_-_37488834 4.05 ENST00000310758.4
ELMO1
engulfment and cell motility 1
chr4_-_71532339 3.88 ENST00000254801.4
IGJ
immunoglobulin J polypeptide, linker protein for immunoglobulin alpha and mu polypeptides
chr17_-_3599492 3.85 ENST00000435558.1
ENST00000345901.3
P2RX5
purinergic receptor P2X, ligand-gated ion channel, 5
chr18_-_53303123 3.84 ENST00000569357.1
ENST00000565124.1
ENST00000398339.1
TCF4
transcription factor 4
chr1_+_151739131 3.48 ENST00000400999.1
OAZ3
ornithine decarboxylase antizyme 3
chr4_+_76995855 3.45 ENST00000355810.4
ENST00000349321.3
ART3
ADP-ribosyltransferase 3
chr18_+_32556892 3.30 ENST00000591734.1
ENST00000413393.1
ENST00000589180.1
ENST00000587359.1
MAPRE2
microtubule-associated protein, RP/EB family, member 2
chr11_-_111794446 3.22 ENST00000527950.1
CRYAB
crystallin, alpha B
chr8_-_101321584 3.20 ENST00000523167.1
RNF19A
ring finger protein 19A, RBR E3 ubiquitin protein ligase
chr3_+_43328004 3.12 ENST00000454177.1
ENST00000429705.2
ENST00000296088.7
ENST00000437827.1
SNRK
SNF related kinase
chr5_-_88179017 2.98 ENST00000514028.1
ENST00000514015.1
ENST00000503075.1
ENST00000437473.2
MEF2C
myocyte enhancer factor 2C
chr7_+_153749732 2.97 ENST00000377770.3
DPP6
dipeptidyl-peptidase 6
chr17_-_76713100 2.96 ENST00000585509.1
CYTH1
cytohesin 1
chr7_-_104909435 2.95 ENST00000357311.3
SRPK2
SRSF protein kinase 2
chr1_+_158975744 2.83 ENST00000426592.2
IFI16
interferon, gamma-inducible protein 16
chr11_-_73882029 2.66 ENST00000539061.1
C2CD3
C2 calcium-dependent domain containing 3
chr15_+_25068773 2.61 ENST00000400100.1
ENST00000400098.1
SNRPN
small nuclear ribonucleoprotein polypeptide N
chrX_+_128913906 2.51 ENST00000356892.3
SASH3
SAM and SH3 domain containing 3
chr7_-_56119156 2.51 ENST00000421312.1
ENST00000416592.1
PSPH
phosphoserine phosphatase
chr10_+_126150369 2.48 ENST00000392757.4
ENST00000368842.5
ENST00000368839.1
LHPP
phospholysine phosphohistidine inorganic pyrophosphate phosphatase
chr13_+_52436111 2.28 ENST00000242819.4
CCDC70
coiled-coil domain containing 70
chr2_-_158345462 2.05 ENST00000439355.1
ENST00000540637.1
CYTIP
cytohesin 1 interacting protein
chr2_-_170430277 1.93 ENST00000438035.1
ENST00000453929.2
FASTKD1
FAST kinase domains 1
chr15_-_80263506 1.93 ENST00000335661.6
BCL2A1
BCL2-related protein A1
chr2_-_170430366 1.83 ENST00000453153.2
ENST00000445210.1
FASTKD1
FAST kinase domains 1
chrX_-_140786896 1.80 ENST00000370515.3
SPANXD
SPANX family, member D
chr19_+_56459198 1.77 ENST00000291971.3
ENST00000590542.1
NLRP8
NLR family, pyrin domain containing 8
chr1_-_153085984 1.71 ENST00000468739.1
SPRR2F
small proline-rich protein 2F
chr9_+_114287433 1.64 ENST00000358151.4
ENST00000355824.3
ENST00000374374.3
ENST00000309235.5
ZNF483
zinc finger protein 483
chr7_-_24797546 1.63 ENST00000414428.1
ENST00000419307.1
ENST00000342947.3
DFNA5
deafness, autosomal dominant 5
chr12_+_56324756 1.60 ENST00000331886.5
ENST00000555090.1
DGKA
diacylglycerol kinase, alpha 80kDa
chr17_+_3379284 1.58 ENST00000263080.2
ASPA
aspartoacylase
chr3_-_52713729 1.56 ENST00000296302.7
ENST00000356770.4
ENST00000337303.4
ENST00000409057.1
ENST00000410007.1
ENST00000409114.3
ENST00000409767.1
ENST00000423351.1
PBRM1
polybromo 1
chr5_+_173763250 1.56 ENST00000515513.1
ENST00000507361.1
ENST00000510234.1
RP11-267A15.1
RP11-267A15.1
chrX_+_140677562 1.47 ENST00000370518.3
SPANXA2
SPANX family, member A2
chr2_-_74618964 1.46 ENST00000417090.1
ENST00000409868.1
DCTN1
dynactin 1
chr3_-_79816965 1.46 ENST00000464233.1
ROBO1
roundabout, axon guidance receptor, homolog 1 (Drosophila)
chr4_+_71588372 1.44 ENST00000536664.1
RUFY3
RUN and FYVE domain containing 3
chr2_+_89999259 1.43 ENST00000558026.1
IGKV2D-28
immunoglobulin kappa variable 2D-28
chr17_-_10452929 1.42 ENST00000532183.2
ENST00000397183.2
ENST00000420805.1
MYH2
myosin, heavy chain 2, skeletal muscle, adult
chr7_+_116654935 1.41 ENST00000432298.1
ENST00000422922.1
ST7
suppression of tumorigenicity 7
chr12_+_56324933 1.36 ENST00000549629.1
ENST00000555218.1
DGKA
diacylglycerol kinase, alpha 80kDa
chr7_+_149535455 1.33 ENST00000223210.4
ENST00000460379.1
ZNF862
zinc finger protein 862
chr2_-_74619152 1.29 ENST00000440727.1
ENST00000409240.1
DCTN1
dynactin 1
chr1_+_104159999 1.26 ENST00000414303.2
ENST00000423678.1
AMY2A
amylase, alpha 2A (pancreatic)
chr20_-_9819674 1.26 ENST00000378429.3
PAK7
p21 protein (Cdc42/Rac)-activated kinase 7
chr1_+_43855560 1.18 ENST00000562955.1
SZT2
seizure threshold 2 homolog (mouse)
chr5_+_446253 1.16 ENST00000315013.5
EXOC3
exocyst complex component 3
chr1_+_78245303 1.16 ENST00000370791.3
ENST00000443751.2
FAM73A
family with sequence similarity 73, member A
chr2_-_89327228 1.15 ENST00000483158.1
IGKV3-11
immunoglobulin kappa variable 3-11
chr12_-_118796910 1.15 ENST00000541186.1
ENST00000539872.1
TAOK3
TAO kinase 3
chr1_-_153066998 1.11 ENST00000368750.3
SPRR2E
small proline-rich protein 2E
chrX_-_140336629 1.11 ENST00000358993.2
SPANXC
SPANX family, member C
chr6_+_32812568 1.07 ENST00000414474.1
PSMB9
proteasome (prosome, macropain) subunit, beta type, 9
chr11_-_74178582 1.05 ENST00000531854.1
ENST00000526855.1
ENST00000529425.1
ENST00000310128.4
ENST00000532569.1
KCNE3
potassium voltage-gated channel, Isk-related family, member 3
chr1_+_92632542 1.04 ENST00000409154.4
ENST00000370378.4
KIAA1107
KIAA1107
chrX_+_140084756 1.03 ENST00000449283.1
SPANXB2
SPANX family, member B2
chr1_-_114414316 1.03 ENST00000528414.1
ENST00000538253.1
ENST00000460620.1
ENST00000420377.2
ENST00000525799.1
ENST00000359785.5
PTPN22
protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
chr15_-_91565743 0.98 ENST00000535843.1
VPS33B
vacuolar protein sorting 33 homolog B (yeast)
chr14_-_24711865 0.97 ENST00000399423.4
ENST00000267415.7
TINF2
TERF1 (TRF1)-interacting nuclear factor 2
chr5_+_118691706 0.97 ENST00000415806.2
TNFAIP8
tumor necrosis factor, alpha-induced protein 8
chr5_+_131993856 0.96 ENST00000304506.3
IL13
interleukin 13
chr6_-_160210715 0.94 ENST00000392168.2
ENST00000321394.7
TCP1
t-complex 1
chrX_-_33229636 0.92 ENST00000357033.4
DMD
dystrophin
chr13_-_41706864 0.91 ENST00000379485.1
ENST00000499385.2
KBTBD6
kelch repeat and BTB (POZ) domain containing 6
chr1_-_144994909 0.90 ENST00000369347.4
ENST00000369354.3
PDE4DIP
phosphodiesterase 4D interacting protein
chr15_-_91565770 0.86 ENST00000535906.1
ENST00000333371.3
VPS33B
vacuolar protein sorting 33 homolog B (yeast)
chr4_+_106631966 0.85 ENST00000360505.5
ENST00000510865.1
ENST00000509336.1
GSTCD
glutathione S-transferase, C-terminal domain containing
chr4_-_90229142 0.84 ENST00000609438.1
GPRIN3
GPRIN family member 3
chr14_-_24711806 0.84 ENST00000540705.1
ENST00000538777.1
ENST00000558566.1
ENST00000559019.1
TINF2
TERF1 (TRF1)-interacting nuclear factor 2
chr14_+_64680854 0.84 ENST00000458046.2
SYNE2
spectrin repeat containing, nuclear envelope 2
chr19_+_17326141 0.77 ENST00000445667.2
ENST00000263897.5
USE1
unconventional SNARE in the ER 1 homolog (S. cerevisiae)
chr1_-_76076759 0.75 ENST00000370855.5
SLC44A5
solute carrier family 44, member 5
chr5_+_92919043 0.72 ENST00000327111.3
NR2F1
nuclear receptor subfamily 2, group F, member 1
chr1_+_32608566 0.69 ENST00000545542.1
KPNA6
karyopherin alpha 6 (importin alpha 7)
chr22_+_40573921 0.68 ENST00000454349.2
ENST00000335727.9
TNRC6B
trinucleotide repeat containing 6B
chr3_+_32726774 0.68 ENST00000538368.1
CNOT10
CCR4-NOT transcription complex, subunit 10
chr1_-_144995074 0.68 ENST00000534536.1
PDE4DIP
phosphodiesterase 4D interacting protein
chr5_+_161495038 0.65 ENST00000393933.4
GABRG2
gamma-aminobutyric acid (GABA) A receptor, gamma 2
chr19_-_56826157 0.61 ENST00000592509.1
ENST00000592679.1
ENST00000588442.1
ENST00000593106.1
ENST00000587492.1
ENST00000254165.3
ZSCAN5A
zinc finger and SCAN domain containing 5A
chrX_-_57164058 0.61 ENST00000374906.3
SPIN2A
spindlin family, member 2A
chr1_-_144994840 0.60 ENST00000369351.3
ENST00000369349.3
PDE4DIP
phosphodiesterase 4D interacting protein
chr22_+_19467261 0.60 ENST00000455750.1
ENST00000437685.2
ENST00000263201.1
ENST00000404724.3
CDC45
cell division cycle 45
chr22_+_39916558 0.56 ENST00000337304.2
ENST00000396680.1
ATF4
activating transcription factor 4
chrX_+_54466829 0.56 ENST00000375151.4
TSR2
TSR2, 20S rRNA accumulation, homolog (S. cerevisiae)
chr6_-_30080876 0.55 ENST00000376734.3
TRIM31
tripartite motif containing 31
chr4_-_80247162 0.55 ENST00000286794.4
NAA11
N(alpha)-acetyltransferase 11, NatA catalytic subunit
chr8_-_145652336 0.51 ENST00000529182.1
ENST00000526054.1
VPS28
vacuolar protein sorting 28 homolog (S. cerevisiae)
chr17_-_36358166 0.50 ENST00000537432.1
TBC1D3
TBC1 domain family, member 3
chr4_-_89978299 0.48 ENST00000511976.1
ENST00000509094.1
ENST00000264344.5
ENST00000515600.1
FAM13A
family with sequence similarity 13, member A
chr18_-_25616519 0.47 ENST00000399380.3
CDH2
cadherin 2, type 1, N-cadherin (neuronal)
chr12_+_120933859 0.47 ENST00000242577.6
ENST00000548214.1
ENST00000392508.2
DYNLL1
dynein, light chain, LC8-type 1
chr12_+_120933904 0.46 ENST00000550178.1
ENST00000550845.1
ENST00000549989.1
ENST00000552870.1
DYNLL1
dynein, light chain, LC8-type 1
chr8_-_66474884 0.45 ENST00000520902.1
CTD-3025N20.2
CTD-3025N20.2
chr12_+_57146233 0.45 ENST00000554643.1
ENST00000556650.1
ENST00000554150.1
ENST00000554155.1
HSD17B6
hydroxysteroid (17-beta) dehydrogenase 6
chr1_-_115292591 0.44 ENST00000438362.2
CSDE1
cold shock domain containing E1, RNA-binding
chr12_-_10007448 0.40 ENST00000538152.1
CLEC2B
C-type lectin domain family 2, member B
chr11_-_78052923 0.39 ENST00000340149.2
GAB2
GRB2-associated binding protein 2
chr1_+_3773825 0.35 ENST00000378209.3
ENST00000338895.3
ENST00000378212.2
ENST00000341385.3
DFFB
DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase)
chr5_-_64920115 0.33 ENST00000381018.3
ENST00000274327.7
TRIM23
tripartite motif containing 23
chr18_+_32173276 0.32 ENST00000591816.1
ENST00000588125.1
ENST00000598334.1
ENST00000588684.1
ENST00000554864.3
ENST00000399121.5
ENST00000595022.1
ENST00000269190.7
ENST00000399097.3
DTNA
dystrobrevin, alpha
chr11_-_33774944 0.31 ENST00000532057.1
ENST00000531080.1
FBXO3
F-box protein 3
chr1_-_168698433 0.30 ENST00000367817.3
DPT
dermatopontin
chr1_+_104293028 0.30 ENST00000370079.3
AMY1C
amylase, alpha 1C (salivary)
chr5_+_137225158 0.29 ENST00000290431.5
PKD2L2
polycystic kidney disease 2-like 2
chr6_+_25754927 0.28 ENST00000377905.4
ENST00000439485.2
SLC17A4
solute carrier family 17, member 4
chr9_+_706842 0.26 ENST00000382293.3
KANK1
KN motif and ankyrin repeat domains 1
chr9_+_116267536 0.25 ENST00000374136.1
RGS3
regulator of G-protein signaling 3
chr1_+_152975488 0.23 ENST00000542696.1
SPRR3
small proline-rich protein 3
chr11_-_102714534 0.22 ENST00000299855.5
MMP3
matrix metallopeptidase 3 (stromelysin 1, progelatinase)
chr1_+_44435646 0.20 ENST00000255108.3
ENST00000412950.2
ENST00000396758.2
DPH2
DPH2 homolog (S. cerevisiae)
chr6_+_122720681 0.19 ENST00000368455.4
ENST00000452194.1
HSF2
heat shock transcription factor 2
chr7_-_56119238 0.19 ENST00000275605.3
ENST00000395471.3
PSPH
phosphoserine phosphatase
chr1_+_150039369 0.18 ENST00000369130.3
ENST00000369128.5
VPS45
vacuolar protein sorting 45 homolog (S. cerevisiae)
chr7_-_155604967 0.16 ENST00000297261.2
SHH
sonic hedgehog
chr5_+_135496675 0.15 ENST00000507637.1
SMAD5
SMAD family member 5
chr11_+_73882144 0.14 ENST00000328257.8
PPME1
protein phosphatase methylesterase 1
chr2_+_223725652 0.14 ENST00000357430.3
ENST00000392066.3
ACSL3
acyl-CoA synthetase long-chain family member 3
chr22_-_42086477 0.14 ENST00000402458.1
NHP2L1
NHP2 non-histone chromosome protein 2-like 1 (S. cerevisiae)
chr4_-_159094194 0.14 ENST00000592057.1
ENST00000585682.1
ENST00000393807.5
FAM198B
family with sequence similarity 198, member B
chr7_-_115608304 0.13 ENST00000457268.1
TFEC
transcription factor EC
chr10_+_53806501 0.13 ENST00000373975.2
PRKG1
protein kinase, cGMP-dependent, type I
chr18_+_21032781 0.13 ENST00000339486.3
RIOK3
RIO kinase 3
chr6_-_30080863 0.11 ENST00000540829.1
TRIM31
tripartite motif containing 31
chr14_+_22458631 0.11 ENST00000390444.1
TRAV16
T cell receptor alpha variable 16
chr1_-_31538517 0.10 ENST00000440538.2
ENST00000423018.2
ENST00000424085.2
ENST00000426105.2
ENST00000257075.5
ENST00000373747.3
ENST00000525843.1
ENST00000373742.2
PUM1
pumilio RNA-binding family member 1
chr2_+_181845843 0.09 ENST00000602710.1
UBE2E3
ubiquitin-conjugating enzyme E2E 3
chrX_-_11308598 0.06 ENST00000380717.3
ARHGAP6
Rho GTPase activating protein 6
chr5_-_179047881 0.03 ENST00000521173.1
HNRNPH1
heterogeneous nuclear ribonucleoprotein H1 (H)
chr12_-_67197760 0.03 ENST00000539540.1
ENST00000540433.1
ENST00000541947.1
ENST00000538373.1
GRIP1
glutamate receptor interacting protein 1
chr16_+_58426296 0.03 ENST00000426538.2
ENST00000328514.7
ENST00000318129.5
GINS3
GINS complex subunit 3 (Psf3 homolog)
chr5_+_175288631 0.02 ENST00000509837.1
CPLX2
complexin 2
chr7_+_138145145 0.02 ENST00000415680.2
TRIM24
tripartite motif containing 24
chr3_+_184018352 0.01 ENST00000435761.1
ENST00000439383.1
PSMD2
proteasome (prosome, macropain) 26S subunit, non-ATPase, 2
chr9_+_125796806 0.00 ENST00000373642.1
GPR21
G protein-coupled receptor 21
chr11_+_73882311 0.00 ENST00000398427.4
ENST00000544401.1
PPME1
protein phosphatase methylesterase 1
chr2_-_178753465 0.00 ENST00000389683.3
PDE11A
phosphodiesterase 11A

Network of associatons between targets according to the STRING database.

First level regulatory network of ARID5B

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
3.8 11.3 GO:0098746 fast, calcium ion-dependent exocytosis of neurotransmitter(GO:0098746)
1.8 7.4 GO:0003185 primary heart field specification(GO:0003138) sinoatrial valve development(GO:0003172) sinoatrial valve morphogenesis(GO:0003185)
0.7 3.5 GO:1902268 negative regulation of polyamine transmembrane transport(GO:1902268)
0.7 2.7 GO:0021997 neural plate axis specification(GO:0021997)
0.6 2.9 GO:0035063 nuclear speck organization(GO:0035063)
0.5 1.6 GO:0006533 aspartate catabolic process(GO:0006533)
0.5 1.5 GO:0021823 cerebral cortex tangential migration using cell-cell interactions(GO:0021823) postnatal olfactory bulb interneuron migration(GO:0021827) chemorepulsion involved in postnatal olfactory bulb interneuron migration(GO:0021836) regulation of negative chemotaxis(GO:0050923)
0.3 1.0 GO:1902303 negative regulation of potassium ion export(GO:1902303)
0.3 1.0 GO:1902523 positive regulation of protein K63-linked ubiquitination(GO:1902523)
0.3 2.7 GO:0090063 positive regulation of microtubule nucleation(GO:0090063)
0.3 1.0 GO:0033861 negative regulation of NAD(P)H oxidase activity(GO:0033861)
0.3 1.8 GO:0010836 negative regulation of protein ADP-ribosylation(GO:0010836)
0.3 8.1 GO:0035590 purinergic nucleotide receptor signaling pathway(GO:0035590)
0.2 4.2 GO:0007021 tubulin complex assembly(GO:0007021)
0.2 1.8 GO:0017185 peptidyl-lysine hydroxylation(GO:0017185)
0.2 5.0 GO:0001829 trophectodermal cell differentiation(GO:0001829)
0.2 2.7 GO:0006564 L-serine biosynthetic process(GO:0006564)
0.2 0.6 GO:0031938 pre-replicative complex assembly involved in nuclear cell cycle DNA replication(GO:0006267) regulation of chromatin silencing at telomere(GO:0031938) pre-replicative complex assembly(GO:0036388) pre-replicative complex assembly involved in cell cycle DNA replication(GO:1902299)
0.2 1.2 GO:1901668 regulation of superoxide dismutase activity(GO:1901668)
0.2 0.6 GO:0061394 regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance(GO:0061394) response to manganese-induced endoplasmic reticulum stress(GO:1990737)
0.2 1.3 GO:0044245 polysaccharide digestion(GO:0044245)
0.2 0.5 GO:2000395 protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043328) ubiquitin-dependent endocytosis(GO:0070086) regulation of ubiquitin-dependent endocytosis(GO:2000395) positive regulation of ubiquitin-dependent endocytosis(GO:2000397)
0.1 3.0 GO:0032012 regulation of ARF protein signal transduction(GO:0032012)
0.1 0.8 GO:0031022 nuclear migration along microfilament(GO:0031022)
0.1 0.5 GO:0017198 N-terminal peptidyl-serine acetylation(GO:0017198) N-terminal peptidyl-glutamic acid acetylation(GO:0018002) peptidyl-serine acetylation(GO:0030920)
0.1 3.0 GO:0046339 diacylglycerol metabolic process(GO:0046339)
0.1 1.4 GO:0001778 plasma membrane repair(GO:0001778)
0.1 2.5 GO:0002726 positive regulation of T cell cytokine production(GO:0002726)
0.1 0.4 GO:0006710 androgen catabolic process(GO:0006710)
0.1 1.2 GO:0051601 exocyst localization(GO:0051601)
0.1 4.0 GO:0016601 Rac protein signal transduction(GO:0016601)
0.1 3.1 GO:0006471 protein ADP-ribosylation(GO:0006471)
0.1 0.5 GO:2000809 positive regulation of synaptic vesicle clustering(GO:2000809)
0.1 0.9 GO:2000580 positive regulation of microtubule motor activity(GO:2000576) regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000580) positive regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000582)
0.1 0.3 GO:2000393 negative regulation of lamellipodium morphogenesis(GO:2000393)
0.1 0.9 GO:0014809 regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion(GO:0014809)
0.1 0.7 GO:0015871 choline transport(GO:0015871)
0.1 1.9 GO:0008053 mitochondrial fusion(GO:0008053)
0.1 0.4 GO:0070966 nuclear-transcribed mRNA catabolic process, no-go decay(GO:0070966)
0.1 7.8 GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process(GO:0032436)
0.1 2.8 GO:0042149 cellular response to glucose starvation(GO:0042149)
0.1 0.2 GO:2000729 bud outgrowth involved in lung branching(GO:0060447) positive regulation of mesenchymal cell proliferation involved in ureter development(GO:2000729)
0.1 1.4 GO:2000114 regulation of establishment of cell polarity(GO:2000114)
0.0 0.1 GO:2001245 regulation of phosphatidylcholine biosynthetic process(GO:2001245)
0.0 1.2 GO:0007095 mitotic G2 DNA damage checkpoint(GO:0007095)
0.0 0.7 GO:0060211 regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060211) positive regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060213)
0.0 0.3 GO:0030263 apoptotic chromosome condensation(GO:0030263)
0.0 2.0 GO:0018149 peptide cross-linking(GO:0018149)
0.0 0.6 GO:0071420 cellular response to histamine(GO:0071420)
0.0 0.1 GO:0039534 negative regulation of MDA-5 signaling pathway(GO:0039534)
0.0 0.7 GO:0046597 negative regulation of viral entry into host cell(GO:0046597)
0.0 0.2 GO:0010727 negative regulation of hydrogen peroxide metabolic process(GO:0010727)
0.0 1.6 GO:0060113 inner ear receptor cell differentiation(GO:0060113)
0.0 0.1 GO:0001880 Mullerian duct regression(GO:0001880)
0.0 0.2 GO:0017183 peptidyl-diphthamide metabolic process(GO:0017182) peptidyl-diphthamide biosynthetic process from peptidyl-histidine(GO:0017183)
0.0 2.5 GO:0009168 purine nucleoside monophosphate biosynthetic process(GO:0009127) purine ribonucleoside monophosphate biosynthetic process(GO:0009168)
0.0 0.4 GO:0033008 positive regulation of mast cell activation involved in immune response(GO:0033008) positive regulation of mast cell degranulation(GO:0043306)
0.0 1.8 GO:1901379 regulation of potassium ion transmembrane transport(GO:1901379)
0.0 0.7 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
0.0 0.7 GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening(GO:0000289)
0.0 3.1 GO:0045333 cellular respiration(GO:0045333)
0.0 2.6 GO:0002433 immune response-regulating cell surface receptor signaling pathway involved in phagocytosis(GO:0002433) Fc-gamma receptor signaling pathway involved in phagocytosis(GO:0038096)
0.0 0.6 GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000462)
0.0 0.3 GO:0035435 phosphate ion transmembrane transport(GO:0035435)
0.0 1.1 GO:0006521 regulation of cellular amino acid metabolic process(GO:0006521)
0.0 1.5 GO:0006338 chromatin remodeling(GO:0006338)
0.0 2.8 GO:0065004 protein-DNA complex assembly(GO:0065004)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
2.3 11.3 GO:0060200 clathrin-sculpted acetylcholine transport vesicle(GO:0060200) clathrin-sculpted acetylcholine transport vesicle membrane(GO:0060201)
0.5 1.4 GO:0005826 actomyosin contractile ring(GO:0005826)
0.4 8.1 GO:0031229 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229) nuclear membrane part(GO:0044453)
0.4 1.8 GO:0010370 perinucleolar chromocenter(GO:0010370)
0.3 4.0 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
0.2 1.8 GO:0071439 clathrin complex(GO:0071439)
0.2 3.2 GO:0097512 cardiac myofibril(GO:0097512)
0.2 0.6 GO:0036387 nuclear pre-replicative complex(GO:0005656) pre-replicative complex(GO:0036387)
0.2 1.2 GO:1990130 Iml1 complex(GO:1990130)
0.2 6.0 GO:0035371 microtubule plus-end(GO:0035371)
0.2 2.6 GO:0005687 U4 snRNP(GO:0005687)
0.1 1.1 GO:1990111 spermatoproteasome complex(GO:1990111)
0.1 0.8 GO:0034993 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.1 0.9 GO:0016013 syntrophin complex(GO:0016013)
0.1 2.7 GO:0034451 centriolar satellite(GO:0034451)
0.1 0.6 GO:1990037 Lewy body core(GO:1990037)
0.1 0.5 GO:0031415 NatA complex(GO:0031415)
0.1 0.5 GO:0000813 ESCRT I complex(GO:0000813)
0.1 0.9 GO:0002199 zona pellucida receptor complex(GO:0002199)
0.1 1.2 GO:0000145 exocyst(GO:0000145)
0.1 3.1 GO:0001533 cornified envelope(GO:0001533)
0.0 0.5 GO:0005916 fascia adherens(GO:0005916) catenin complex(GO:0016342)
0.0 0.4 GO:0070937 CRD-mediated mRNA stability complex(GO:0070937)
0.0 1.6 GO:0090544 BAF-type complex(GO:0090544)
0.0 1.2 GO:0071437 invadopodium(GO:0071437)
0.0 0.7 GO:0030014 CCR4-NOT complex(GO:0030014)
0.0 0.7 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.0 1.0 GO:0032809 neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298)
0.0 0.8 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.0 6.1 GO:0072562 blood microparticle(GO:0072562)
0.0 12.1 GO:0016607 nuclear speck(GO:0016607)
0.0 7.3 GO:0000151 ubiquitin ligase complex(GO:0000151)
0.0 0.6 GO:1902711 GABA-A receptor complex(GO:1902711)
0.0 2.1 GO:0008076 voltage-gated potassium channel complex(GO:0008076) potassium channel complex(GO:0034705)
0.0 3.3 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.0 2.8 GO:0031225 anchored component of membrane(GO:0031225)
0.0 0.1 GO:0030688 preribosome, small subunit precursor(GO:0030688)
0.0 0.1 GO:0071141 SMAD protein complex(GO:0071141)
0.0 10.5 GO:0009986 cell surface(GO:0009986)
0.0 4.0 GO:0000790 nuclear chromatin(GO:0000790)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
2.3 11.3 GO:0030348 syntaxin-3 binding(GO:0030348)
0.7 8.1 GO:0035381 extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381)
0.7 3.5 GO:0008073 ornithine decarboxylase inhibitor activity(GO:0008073)
0.7 3.5 GO:0003956 NAD(P)+-protein-arginine ADP-ribosyltransferase activity(GO:0003956)
0.6 2.5 GO:0004427 inorganic diphosphatase activity(GO:0004427)
0.5 2.7 GO:0004647 phosphoserine phosphatase activity(GO:0004647)
0.4 6.9 GO:0003680 AT DNA binding(GO:0003680)
0.3 1.3 GO:0016160 amylase activity(GO:0016160)
0.3 3.8 GO:0001011 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.2 1.5 GO:0008046 axon guidance receptor activity(GO:0008046)
0.2 1.6 GO:0004046 aminoacylase activity(GO:0004046)
0.2 7.8 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.2 0.7 GO:0015220 choline transmembrane transporter activity(GO:0015220)
0.2 3.0 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.1 0.5 GO:1990190 peptide-glutamate-N-acetyltransferase activity(GO:1990190)
0.1 3.0 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)
0.1 3.0 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.1 3.2 GO:0005212 structural constituent of eye lens(GO:0005212)
0.1 1.9 GO:0051400 BH domain binding(GO:0051400)
0.1 0.7 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.1 2.9 GO:0071889 14-3-3 protein binding(GO:0071889)
0.1 2.7 GO:0070840 dynein complex binding(GO:0070840)
0.1 1.1 GO:0030280 structural constituent of epidermis(GO:0030280)
0.1 0.9 GO:0045505 dynein intermediate chain binding(GO:0045505)
0.0 0.6 GO:0008503 benzodiazepine receptor activity(GO:0008503)
0.0 0.9 GO:0050998 nitric-oxide synthase binding(GO:0050998)
0.0 0.4 GO:0047035 testosterone dehydrogenase (NAD+) activity(GO:0047035)
0.0 0.6 GO:0043138 3'-5' DNA helicase activity(GO:0043138)
0.0 1.4 GO:0000146 microfilament motor activity(GO:0000146)
0.0 1.8 GO:0042162 telomeric DNA binding(GO:0042162)
0.0 0.5 GO:0045294 alpha-catenin binding(GO:0045294)
0.0 1.1 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.0 0.6 GO:0043522 leucine zipper domain binding(GO:0043522)
0.0 5.1 GO:0017124 SH3 domain binding(GO:0017124)
0.0 0.2 GO:0043237 laminin-1 binding(GO:0043237)
0.0 0.9 GO:0044183 protein binding involved in protein folding(GO:0044183)
0.0 0.1 GO:0004692 cGMP-dependent protein kinase activity(GO:0004692)
0.0 1.0 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.0 0.3 GO:0005436 sodium:phosphate symporter activity(GO:0005436)
0.0 0.2 GO:0001162 RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding(GO:0001162)
0.0 0.4 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
0.0 0.7 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.0 0.1 GO:0089720 caspase binding(GO:0089720)
0.0 0.1 GO:0017151 DEAD/H-box RNA helicase binding(GO:0017151) transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity(GO:0030618)
0.0 2.6 GO:0000287 magnesium ion binding(GO:0000287)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 11.3 SIG CD40PATHWAYMAP Genes related to CD40 signaling
0.1 7.4 PID MAPK TRK PATHWAY Trk receptor signaling mediated by the MAPK pathway
0.1 1.0 ST IL 13 PATHWAY Interleukin 13 (IL-13) Pathway
0.1 4.0 PID NETRIN PATHWAY Netrin-mediated signaling events
0.1 3.2 PID NCADHERIN PATHWAY N-cadherin signaling events
0.1 2.7 SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES Genes related to regulation of the actin cytoskeleton
0.0 3.0 PID PI3KCI PATHWAY Class I PI3K signaling events
0.0 1.2 PID P38 MKK3 6PATHWAY p38 MAPK signaling pathway
0.0 0.6 PID FRA PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 3.6 PID AR PATHWAY Coregulation of Androgen receptor activity
0.0 2.3 PID NFAT TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.0 1.7 PID AJDISS 2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.0 1.2 PID ECADHERIN STABILIZATION PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.0 1.8 PID TELOMERASE PATHWAY Regulation of Telomerase
0.0 0.3 SA CASPASE CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.0 0.4 PID IL2 STAT5 PATHWAY IL2 signaling events mediated by STAT5

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 11.3 REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Norepinephrine Neurotransmitter Release Cycle
0.2 11.7 REACTOME MYOGENESIS Genes involved in Myogenesis
0.1 1.6 REACTOME DIGESTION OF DIETARY CARBOHYDRATE Genes involved in Digestion of dietary carbohydrate
0.1 2.7 REACTOME ACTIVATION OF RAC Genes involved in Activation of Rac
0.1 2.7 REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.1 4.0 REACTOME THE ROLE OF NEF IN HIV1 REPLICATION AND DISEASE PATHOGENESIS Genes involved in The role of Nef in HIV-1 replication and disease pathogenesis
0.1 3.0 REACTOME EFFECTS OF PIP2 HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.1 4.6 REACTOME REGULATION OF ORNITHINE DECARBOXYLASE ODC Genes involved in Regulation of ornithine decarboxylase (ODC)
0.1 0.5 REACTOME MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS Genes involved in Membrane binding and targetting of GAG proteins
0.0 0.6 REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.0 0.9 REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC Genes involved in Formation of tubulin folding intermediates by CCT/TriC
0.0 3.7 REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.0 0.6 REACTOME UNWINDING OF DNA Genes involved in Unwinding of DNA
0.0 1.8 REACTOME PACKAGING OF TELOMERE ENDS Genes involved in Packaging Of Telomere Ends
0.0 0.7 REACTOME PRE NOTCH TRANSCRIPTION AND TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation
0.0 0.7 REACTOME SYNTHESIS OF PC Genes involved in Synthesis of PC
0.0 0.6 REACTOME GABA A RECEPTOR ACTIVATION Genes involved in GABA A receptor activation
0.0 0.8 REACTOME MEIOTIC SYNAPSIS Genes involved in Meiotic Synapsis
0.0 0.7 REACTOME DEADENYLATION OF MRNA Genes involved in Deadenylation of mRNA
0.0 0.3 REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.0 0.9 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.0 0.4 REACTOME SIGNALING BY FGFR1 FUSION MUTANTS Genes involved in Signaling by FGFR1 fusion mutants