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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for ATF2_ATF1_ATF3
Z-value: 1.35
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Transcription factors associated with ATF2_ATF1_ATF3
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
| ENSG00000115966.12 | activating transcription factor 2 | |
| ENSG00000123268.4 | activating transcription factor 1 | |
| ENSG00000162772.12 | activating transcription factor 3 |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| ATF2 | hg19_v2_chr2_-_176032843_176032941 | 0.33 | 4.5e-07 | Click! |
| ATF3 | hg19_v2_chr1_+_212738676_212738755, hg19_v2_chr1_+_212782012_212782257 | -0.09 | 2.0e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of ATF2_ATF1_ATF3
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.2 | 102.2 | GO:0006521 | regulation of cellular amino acid metabolic process(GO:0006521) |
| 0.4 | 94.0 | GO:0000398 | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile(GO:0000377) mRNA splicing, via spliceosome(GO:0000398) |
| 1.3 | 91.3 | GO:0070125 | mitochondrial translational elongation(GO:0070125) mitochondrial translational termination(GO:0070126) |
| 1.7 | 84.0 | GO:2000144 | positive regulation of DNA-templated transcription, initiation(GO:2000144) |
| 0.4 | 81.7 | GO:0006413 | translational initiation(GO:0006413) |
| 1.0 | 77.3 | GO:0006369 | termination of RNA polymerase II transcription(GO:0006369) |
| 0.4 | 76.4 | GO:0045930 | negative regulation of mitotic cell cycle(GO:0045930) |
| 4.6 | 72.8 | GO:0051315 | attachment of mitotic spindle microtubules to kinetochore(GO:0051315) |
| 0.7 | 70.7 | GO:0045727 | positive regulation of translation(GO:0045727) |
| 11.6 | 69.7 | GO:0046985 | positive regulation of hemoglobin biosynthetic process(GO:0046985) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.2 | 174.0 | GO:0015934 | large ribosomal subunit(GO:0015934) |
| 0.8 | 165.2 | GO:0005681 | spliceosomal complex(GO:0005681) |
| 10.1 | 131.0 | GO:0002199 | zona pellucida receptor complex(GO:0002199) |
| 5.5 | 98.7 | GO:0034709 | methylosome(GO:0034709) |
| 2.8 | 96.5 | GO:0000159 | protein phosphatase type 2A complex(GO:0000159) |
| 9.7 | 87.5 | GO:0071541 | eukaryotic translation initiation factor 3 complex, eIF3m(GO:0071541) |
| 1.4 | 78.0 | GO:0005876 | spindle microtubule(GO:0005876) |
| 3.7 | 76.8 | GO:0071011 | precatalytic spliceosome(GO:0071011) |
| 8.7 | 69.6 | GO:1990111 | spermatoproteasome complex(GO:1990111) |
| 1.0 | 64.2 | GO:0035577 | azurophil granule membrane(GO:0035577) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 214.0 | GO:0003723 | RNA binding(GO:0003723) |
| 0.8 | 175.1 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 3.4 | 125.9 | GO:0044183 | protein binding involved in protein folding(GO:0044183) |
| 4.4 | 95.8 | GO:0000339 | RNA cap binding(GO:0000339) |
| 1.4 | 88.6 | GO:0003743 | translation initiation factor activity(GO:0003743) |
| 3.0 | 77.8 | GO:0017056 | structural constituent of nuclear pore(GO:0017056) |
| 2.6 | 77.3 | GO:0070003 | threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003) |
| 1.7 | 77.1 | GO:0061631 | ubiquitin conjugating enzyme activity(GO:0061631) |
| 5.8 | 76.0 | GO:1990247 | N6-methyladenosine-containing RNA binding(GO:1990247) |
| 1.6 | 70.1 | GO:0050699 | WW domain binding(GO:0050699) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.8 | 165.5 | PID P53 REGULATION PATHWAY | p53 pathway |
| 1.2 | 127.3 | PID E2F PATHWAY | E2F transcription factor network |
| 1.0 | 121.9 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 2.0 | 82.8 | PID INSULIN GLUCOSE PATHWAY | Insulin-mediated glucose transport |
| 1.3 | 80.8 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.5 | 71.0 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 0.9 | 49.4 | PID IL1 PATHWAY | IL1-mediated signaling events |
| 0.5 | 40.7 | PID CMYB PATHWAY | C-MYB transcription factor network |
| 1.0 | 37.5 | PID TAP63 PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.7 | 36.7 | PID HIV NEF PATHWAY | HIV-1 Nef: Negative effector of Fas and TNF-alpha |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.9 | 143.1 | REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
| 4.2 | 130.5 | REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC | Genes involved in Formation of tubulin folding intermediates by CCT/TriC |
| 0.7 | 123.4 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 1.5 | 118.0 | REACTOME REGULATION OF ORNITHINE DECARBOXYLASE ODC | Genes involved in Regulation of ornithine decarboxylase (ODC) |
| 0.8 | 93.9 | REACTOME NONSENSE MEDIATED DECAY ENHANCED BY THE EXON JUNCTION COMPLEX | Genes involved in Nonsense Mediated Decay Enhanced by the Exon Junction Complex |
| 2.1 | 72.2 | REACTOME DEADENYLATION OF MRNA | Genes involved in Deadenylation of mRNA |
| 0.9 | 70.6 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 1.0 | 70.4 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 2.1 | 70.3 | REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES | Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates |
| 1.6 | 64.2 | REACTOME TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT | Genes involved in Transport of Mature mRNA Derived from an Intronless Transcript |