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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for AUGGCUU
Z-value: 0.68
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miRNA associated with seed AUGGCUU
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr8_+_24772455 Show fit | 18.33 |
ENST00000433454.2
|
neurofilament, medium polypeptide |
|
| chr15_-_48470558 Show fit | 16.31 |
ENST00000324324.7
|
myelin expression factor 2 |
|
| chr16_+_58497567 Show fit | 14.80 |
ENST00000258187.5
|
NDRG family member 4 |
|
| chr9_-_93405352 Show fit | 12.42 |
ENST00000375765.3
|
DIRAS family, GTP-binding RAS-like 2 |
|
| chr12_+_79258547 Show fit | 12.08 |
ENST00000457153.2
|
synaptotagmin I |
|
| chr15_+_91643442 Show fit | 11.47 |
ENST00000394232.1
|
synaptic vesicle glycoprotein 2B |
|
| chr16_+_1662326 Show fit | 11.25 |
ENST00000397412.3
|
Crm, cramped-like (Drosophila) |
|
| chr3_+_49591881 Show fit | 10.31 |
ENST00000296452.4
|
bassoon presynaptic cytomatrix protein |
|
| chr18_+_32558208 Show fit | 9.59 |
ENST00000436190.2
|
microtubule-associated protein, RP/EB family, member 2 |
|
| chr15_+_31619013 Show fit | 9.58 |
ENST00000307145.3
|
Kruppel-like factor 13 |
Network of associatons between targets according to the STRING database.
First level regulatory network of AUGGCUU
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 6.1 | 18.3 | GO:0033693 | neurofilament bundle assembly(GO:0033693) |
| 0.1 | 17.8 | GO:0014902 | myotube differentiation(GO:0014902) |
| 1.5 | 14.8 | GO:2001135 | regulation of endocytic recycling(GO:2001135) |
| 4.0 | 12.1 | GO:0098746 | fast, calcium ion-dependent exocytosis of neurotransmitter(GO:0098746) |
| 0.1 | 10.9 | GO:0006836 | neurotransmitter transport(GO:0006836) |
| 0.1 | 10.7 | GO:0035418 | protein localization to synapse(GO:0035418) |
| 1.0 | 9.6 | GO:0045647 | negative regulation of erythrocyte differentiation(GO:0045647) |
| 0.5 | 9.3 | GO:0071420 | cellular response to histamine(GO:0071420) |
| 1.3 | 8.9 | GO:1903593 | regulation of histamine secretion by mast cell(GO:1903593) |
| 2.0 | 8.1 | GO:1904450 | negative regulation of gamma-aminobutyric acid secretion(GO:0014053) aspartate secretion(GO:0061528) regulation of aspartate secretion(GO:1904448) positive regulation of aspartate secretion(GO:1904450) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.6 | 21.0 | GO:0060199 | clathrin-sculpted glutamate transport vesicle(GO:0060199) clathrin-sculpted glutamate transport vesicle membrane(GO:0060203) |
| 0.1 | 19.5 | GO:0016323 | basolateral plasma membrane(GO:0016323) |
| 1.3 | 19.3 | GO:0005883 | neurofilament(GO:0005883) |
| 0.4 | 18.6 | GO:0048786 | presynaptic active zone(GO:0048786) |
| 1.0 | 16.3 | GO:0033270 | paranode region of axon(GO:0033270) |
| 0.4 | 15.2 | GO:1902711 | GABA-A receptor complex(GO:1902711) |
| 0.2 | 13.6 | GO:0030672 | synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501) |
| 0.1 | 12.8 | GO:0030426 | growth cone(GO:0030426) |
| 0.3 | 10.8 | GO:0035371 | microtubule plus-end(GO:0035371) |
| 0.4 | 10.1 | GO:0033268 | node of Ranvier(GO:0033268) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 23.0 | GO:0005525 | GTP binding(GO:0005525) |
| 0.1 | 20.4 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
| 0.7 | 18.8 | GO:0017075 | syntaxin-1 binding(GO:0017075) |
| 0.1 | 15.6 | GO:0015631 | tubulin binding(GO:0015631) |
| 0.7 | 14.6 | GO:0050811 | GABA receptor binding(GO:0050811) |
| 0.7 | 12.4 | GO:0050998 | nitric-oxide synthase binding(GO:0050998) |
| 2.4 | 12.1 | GO:0030348 | syntaxin-3 binding(GO:0030348) |
| 0.7 | 11.7 | GO:0030306 | ADP-ribosylation factor binding(GO:0030306) |
| 0.1 | 10.5 | GO:0003697 | single-stranded DNA binding(GO:0003697) |
| 2.0 | 8.1 | GO:0032145 | 4-aminobutyrate transaminase activity(GO:0003867) succinate-semialdehyde dehydrogenase binding(GO:0032145) (S)-3-amino-2-methylpropionate transaminase activity(GO:0047298) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 14.8 | SIG CD40PATHWAYMAP | Genes related to CD40 signaling |
| 0.3 | 14.0 | ST GA12 PATHWAY | G alpha 12 Pathway |
| 0.1 | 8.2 | PID RAC1 REG PATHWAY | Regulation of RAC1 activity |
| 0.2 | 7.4 | PID TRAIL PATHWAY | TRAIL signaling pathway |
| 0.2 | 6.1 | ST GRANULE CELL SURVIVAL PATHWAY | Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway. |
| 0.3 | 5.8 | PID P38 GAMMA DELTA PATHWAY | Signaling mediated by p38-gamma and p38-delta |
| 0.1 | 5.3 | PID INSULIN GLUCOSE PATHWAY | Insulin-mediated glucose transport |
| 0.1 | 5.0 | PID P38 ALPHA BETA PATHWAY | Regulation of p38-alpha and p38-beta |
| 0.1 | 4.4 | PID HDAC CLASSIII PATHWAY | Signaling events mediated by HDAC Class III |
| 0.3 | 4.1 | PID RANBP2 PATHWAY | Sumoylation by RanBP2 regulates transcriptional repression |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.3 | 24.0 | REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Norepinephrine Neurotransmitter Release Cycle |
| 0.2 | 15.4 | REACTOME POTASSIUM CHANNELS | Genes involved in Potassium Channels |
| 0.5 | 15.2 | REACTOME GABA A RECEPTOR ACTIVATION | Genes involved in GABA A receptor activation |
| 0.3 | 10.4 | REACTOME INTERACTION BETWEEN L1 AND ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
| 0.4 | 8.1 | REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION | Genes involved in GABA synthesis, release, reuptake and degradation |
| 0.3 | 7.9 | REACTOME G BETA GAMMA SIGNALLING THROUGH PLC BETA | Genes involved in G beta:gamma signalling through PLC beta |
| 0.4 | 7.4 | REACTOME IL 7 SIGNALING | Genes involved in Interleukin-7 signaling |
| 0.2 | 5.9 | REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA | Genes involved in Circadian Repression of Expression by REV-ERBA |
| 0.3 | 5.5 | REACTOME CALNEXIN CALRETICULIN CYCLE | Genes involved in Calnexin/calreticulin cycle |
| 0.2 | 5.0 | REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS | Genes involved in Cell-extracellular matrix interactions |