ISMARA results: AUUGCAC

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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)

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Results for AUUGCAC

Z-value: 0.11

Motif logo

miRNA associated with seed AUUGCAC

Name	miRBASE accession
hsa-miR-25-3p miRBase	MIMAT0000081
hsa-miR-32-5p miRBase	MIMAT0000090
hsa-miR-92a-3p miRBase	MIMAT0000092
hsa-miR-92b-3p miRBase	MIMAT0003218
hsa-miR-363-3p miRBase	MIMAT0000707
hsa-miR-367-3p miRBase	MIMAT0000719

Activity profile of AUUGCAC motif

Sorted Z-values of AUUGCAC motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr11_-_12030629 Show fit	10.52	ENST00000396505.2	DKK3 Ensembl NCBI GeneCards UniProt NextProt Show fit	dickkopf WNT signaling pathway inhibitor 3
chr4_-_176923483 Show fit	9.88	ENST00000280187.7 ENST00000512509.1	GPM6A Ensembl NCBI GeneCards UniProt NextProt Show fit	glycoprotein M6A
chr8_+_24772455 Show fit	9.74	ENST00000433454.2	NEFM Ensembl NCBI GeneCards UniProt NextProt Show fit	neurofilament, medium polypeptide
chr5_+_71403061 Show fit	9.40	ENST00000512974.1 ENST00000296755.7	MAP1B Ensembl NCBI GeneCards UniProt NextProt Show fit	microtubule-associated protein 1B
chr12_+_79258547 Show fit	8.31	ENST00000457153.2	SYT1 Ensembl NCBI GeneCards UniProt NextProt Show fit	synaptotagmin I
chr20_+_44657845 Show fit	7.97	ENST00000243964.3	SLC12A5 Ensembl NCBI GeneCards UniProt NextProt Show fit	solute carrier family 12 (potassium/chloride transporter), member 5
chr1_+_10271674 Show fit	7.35	ENST00000377086.1	KIF1B Ensembl NCBI GeneCards UniProt NextProt Show fit	kinesin family member 1B
chr1_+_51701924 Show fit	7.31	ENST00000242719.3	RNF11 Ensembl NCBI GeneCards UniProt NextProt Show fit	ring finger protein 11
chr8_+_132916318 Show fit	6.40	ENST00000254624.5 ENST00000522709.1	EFR3A Ensembl NCBI GeneCards UniProt NextProt Show fit	EFR3 homolog A (S. cerevisiae)
chr15_-_73925651 Show fit	6.37	ENST00000545878.1 ENST00000287226.8 ENST00000345330.4	NPTN Ensembl NCBI GeneCards UniProt NextProt Show fit	neuroplastin

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of AUUGCAC

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
4.5	13.5	GO:0033693	neurofilament bundle assembly(GO:0033693)
2.6	10.5	GO:1990262	regulation of anti-Mullerian hormone signaling pathway(GO:1902612) negative regulation of anti-Mullerian hormone signaling pathway(GO:1902613) anti-Mullerian hormone signaling pathway(GO:1990262)
0.5	9.4	GO:0061339	establishment of monopolar cell polarity(GO:0061162) establishment or maintenance of monopolar cell polarity(GO:0061339)
0.2	8.4	GO:0051491	positive regulation of filopodium assembly(GO:0051491)
2.8	8.3	GO:0098746	fast, calcium ion-dependent exocytosis of neurotransmitter(GO:0098746)
2.0	8.0	GO:0030644	cellular chloride ion homeostasis(GO:0030644)
2.5	7.4	GO:1904647	response to rotenone(GO:1904647)
0.7	7.0	GO:0016198	axon choice point recognition(GO:0016198)
0.1	6.8	GO:0051865	protein autoubiquitination(GO:0051865)
0.0	6.8	GO:0090002	establishment of protein localization to plasma membrane(GO:0090002)

Showing 1 to 10 of 178 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	16.4	GO:0043198	dendritic shaft(GO:0043198)
0.1	15.0	GO:0001750	photoreceptor outer segment(GO:0001750)
0.9	13.2	GO:0005883	neurofilament(GO:0005883)
0.6	11.5	GO:0044295	axonal growth cone(GO:0044295)
0.2	9.9	GO:1904115	axon cytoplasm(GO:1904115)
0.1	8.5	GO:0055037	recycling endosome(GO:0055037)
1.7	8.3	GO:0060201	clathrin-sculpted acetylcholine transport vesicle(GO:0060200) clathrin-sculpted acetylcholine transport vesicle membrane(GO:0060201)
0.2	7.0	GO:0048786	presynaptic active zone(GO:0048786)
0.0	6.3	GO:0019898	extrinsic component of membrane(GO:0019898)
0.8	5.7	GO:0032584	growth cone membrane(GO:0032584)

Showing 1 to 10 of 94 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	20.3	GO:0008017	microtubule binding(GO:0008017)
0.2	12.1	GO:0019894	kinesin binding(GO:0019894)
1.7	8.3	GO:0030348	syntaxin-3 binding(GO:0030348)
0.7	8.0	GO:0015379	potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820)
2.2	6.7	GO:0032184	SUMO polymer binding(GO:0032184)
0.1	6.6	GO:0005262	calcium channel activity(GO:0005262)
1.6	6.4	GO:0005105	type 1 fibroblast growth factor receptor binding(GO:0005105)
0.6	5.7	GO:0035727	lysophosphatidic acid binding(GO:0035727)
0.2	4.8	GO:0017075	syntaxin-1 binding(GO:0017075)
0.9	4.7	GO:0034046	poly(G) binding(GO:0034046)

Showing 1 to 10 of 125 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	14.0	ST WNT BETA CATENIN PATHWAY	Wnt/beta-catenin Pathway
0.3	12.8	PID LIS1 PATHWAY	Lissencephaly gene (LIS1) in neuronal migration and development
0.2	10.3	SIG CD40PATHWAYMAP	Genes related to CD40 signaling
0.2	8.7	PID NCADHERIN PATHWAY	N-cadherin signaling events
0.2	5.0	PID INTEGRIN5 PATHWAY	Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.1	3.9	SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES	Genes related to regulation of the actin cytoskeleton
0.1	3.9	PID RHOA REG PATHWAY	Regulation of RhoA activity
0.1	3.3	PID INTEGRIN A4B1 PATHWAY	Alpha4 beta1 integrin signaling events
0.1	3.2	PID MYC PATHWAY	C-MYC pathway
0.1	3.1	NABA PROTEOGLYCANS	Genes encoding proteoglycans

Showing 1 to 10 of 31 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	12.5	REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES	Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.5	8.3	REACTOME DOPAMINE NEUROTRANSMITTER RELEASE CYCLE	Genes involved in Dopamine Neurotransmitter Release Cycle
0.3	7.5	REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS	Genes involved in Trafficking of GluR2-containing AMPA receptors
0.2	5.1	REACTOME RAS ACTIVATION UOPN CA2 INFUX THROUGH NMDA RECEPTOR	Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.0	5.0	REACTOME SIGNALING BY RHO GTPASES	Genes involved in Signaling by Rho GTPases
0.2	4.6	REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS	Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.1	4.6	REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS	Genes involved in Golgi Associated Vesicle Biogenesis
0.2	4.2	REACTOME PECAM1 INTERACTIONS	Genes involved in PECAM1 interactions
0.1	4.1	REACTOME SMOOTH MUSCLE CONTRACTION	Genes involved in Smooth Muscle Contraction
0.1	4.0	REACTOME DARPP 32 EVENTS	Genes involved in DARPP-32 events

Showing 1 to 10 of 58 entries

Results for AUUGCAC

Z-value: 0.11

Motif logo

miRNA associated with seed AUUGCAC

Activity profile of AUUGCAC motif

Sorted Z-values of AUUGCAC motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of AUUGCAC

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: