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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for BARX1
Z-value: 0.78
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Transcription factors associated with BARX1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| BARX1 | hg19_v2_chr9_-_96717654_96717666 | -0.22 | 1.4e-03 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of BARX1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 42.2 | GO:0043486 | histone exchange(GO:0043486) |
| 0.7 | 31.0 | GO:0015721 | bile acid and bile salt transport(GO:0015721) |
| 0.6 | 30.2 | GO:2000816 | negative regulation of mitotic sister chromatid separation(GO:2000816) |
| 0.3 | 26.1 | GO:0031146 | SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146) |
| 1.0 | 25.7 | GO:0001580 | detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580) |
| 2.6 | 25.6 | GO:0070973 | protein localization to endoplasmic reticulum exit site(GO:0070973) |
| 0.3 | 25.4 | GO:0010507 | negative regulation of autophagy(GO:0010507) |
| 0.4 | 23.7 | GO:0051123 | RNA polymerase II transcriptional preinitiation complex assembly(GO:0051123) |
| 1.8 | 22.1 | GO:0001778 | plasma membrane repair(GO:0001778) |
| 0.9 | 19.6 | GO:0032780 | negative regulation of ATPase activity(GO:0032780) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.8 | 37.3 | GO:0000812 | Swr1 complex(GO:0000812) |
| 0.1 | 31.7 | GO:0005759 | mitochondrial matrix(GO:0005759) |
| 0.2 | 30.5 | GO:0042641 | actomyosin(GO:0042641) |
| 0.3 | 28.8 | GO:0005901 | caveola(GO:0005901) |
| 0.8 | 25.1 | GO:0005838 | proteasome regulatory particle(GO:0005838) |
| 1.1 | 23.8 | GO:0016281 | eukaryotic translation initiation factor 4F complex(GO:0016281) |
| 2.6 | 20.5 | GO:0005672 | transcription factor TFIIA complex(GO:0005672) |
| 0.2 | 18.9 | GO:0005913 | cell-cell adherens junction(GO:0005913) |
| 2.5 | 17.5 | GO:0036449 | microtubule minus-end(GO:0036449) |
| 0.3 | 17.3 | GO:0001772 | immunological synapse(GO:0001772) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 36.1 | GO:0019212 | phosphatase inhibitor activity(GO:0019212) |
| 1.5 | 32.7 | GO:0015125 | bile acid transmembrane transporter activity(GO:0015125) |
| 0.1 | 31.6 | GO:0031625 | ubiquitin protein ligase binding(GO:0031625) |
| 1.1 | 27.6 | GO:0008143 | poly(A) binding(GO:0008143) |
| 2.3 | 25.7 | GO:0033038 | bitter taste receptor activity(GO:0033038) |
| 0.6 | 23.3 | GO:0017025 | TBP-class protein binding(GO:0017025) |
| 0.3 | 22.4 | GO:0003743 | translation initiation factor activity(GO:0003743) |
| 0.1 | 21.0 | GO:0003729 | mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822) |
| 0.7 | 20.6 | GO:0005523 | tropomyosin binding(GO:0005523) |
| 0.1 | 20.3 | GO:0005178 | integrin binding(GO:0005178) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 34.2 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.6 | 33.0 | PID FANCONI PATHWAY | Fanconi anemia pathway |
| 0.2 | 23.6 | PID VEGFR1 2 PATHWAY | Signaling events mediated by VEGFR1 and VEGFR2 |
| 0.2 | 22.0 | PID TRKR PATHWAY | Neurotrophic factor-mediated Trk receptor signaling |
| 1.0 | 14.6 | SA G2 AND M PHASES | Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. |
| 0.3 | 12.6 | PID RAS PATHWAY | Regulation of Ras family activation |
| 0.3 | 12.5 | PID EPHA2 FWD PATHWAY | EPHA2 forward signaling |
| 0.4 | 12.2 | PID HDAC CLASSIII PATHWAY | Signaling events mediated by HDAC Class III |
| 0.1 | 12.2 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.2 | 11.4 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 62.0 | REACTOME APC C CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 | Genes involved in APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 |
| 0.3 | 29.2 | REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES | Genes involved in Antiviral mechanism by IFN-stimulated genes |
| 0.2 | 22.1 | REACTOME PPARA ACTIVATES GENE EXPRESSION | Genes involved in PPARA Activates Gene Expression |
| 0.3 | 20.5 | REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING | Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening |
| 0.3 | 20.5 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 0.2 | 18.5 | REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
| 0.6 | 17.3 | REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING | Genes involved in Advanced glycosylation endproduct receptor signaling |
| 1.1 | 17.0 | REACTOME RECYCLING OF BILE ACIDS AND SALTS | Genes involved in Recycling of bile acids and salts |
| 0.5 | 15.8 | REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS | Genes involved in Sphingolipid de novo biosynthesis |
| 0.2 | 15.8 | REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES | Genes involved in Loss of Nlp from mitotic centrosomes |