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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)

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Results for BCL6B

Z-value: 0.09

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Transcription factors associated with BCL6B

Gene Symbol Gene ID Gene Info
BCL6B
ENSG00000161940.6 BCL6B transcription repressor

Activity profile of BCL6B motif

Sorted Z-values of BCL6B motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr11_-_104480019 6.61 ENST00000536529.1
ENST00000545630.1
ENST00000538641.1
RP11-886D15.1
RP11-886D15.1
chr12_-_10007448 5.69 ENST00000538152.1
CLEC2B
C-type lectin domain family 2, member B
chr12_+_104324112 4.44 ENST00000299767.5
HSP90B1
heat shock protein 90kDa beta (Grp94), member 1
chr5_-_172198190 4.01 ENST00000239223.3
DUSP1
dual specificity phosphatase 1
chr16_-_75498308 3.60 ENST00000569540.1
TMEM170A
transmembrane protein 170A
chr16_+_58283814 3.20 ENST00000443128.2
ENST00000219299.4
CCDC113
coiled-coil domain containing 113
chr1_-_108735440 2.82 ENST00000370041.4
SLC25A24
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 24
chr3_+_23958470 2.54 ENST00000434031.2
ENST00000413699.1
ENST00000456530.2
RPL15
ribosomal protein L15
chr6_+_42584847 2.53 ENST00000372883.3
UBR2
ubiquitin protein ligase E3 component n-recognin 2
chr5_+_54398463 2.46 ENST00000274306.6
GZMA
granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)
chr11_+_58912240 2.38 ENST00000527629.1
ENST00000361723.3
ENST00000531408.1
FAM111A
family with sequence similarity 111, member A
chr3_-_123512688 2.34 ENST00000475616.1
MYLK
myosin light chain kinase
chr1_+_158815588 2.30 ENST00000438394.1
MNDA
myeloid cell nuclear differentiation antigen
chr10_+_11207438 2.24 ENST00000609692.1
ENST00000354897.3
CELF2
CUGBP, Elav-like family member 2
chr15_+_45003675 2.23 ENST00000558401.1
ENST00000559916.1
ENST00000544417.1
B2M
beta-2-microglobulin
chr13_-_33112956 2.18 ENST00000505213.1
N4BP2L2
NEDD4 binding protein 2-like 2
chr13_-_33112899 2.05 ENST00000267068.3
ENST00000357505.6
ENST00000399396.3
N4BP2L2
NEDD4 binding protein 2-like 2
chr1_-_212004090 2.03 ENST00000366997.4
LPGAT1
lysophosphatidylglycerol acyltransferase 1
chr2_+_143635067 1.95 ENST00000264170.4
KYNU
kynureninase
chr12_-_91574142 1.95 ENST00000547937.1
DCN
decorin
chr12_+_93964746 1.94 ENST00000536696.2
SOCS2
suppressor of cytokine signaling 2
chr12_-_123201337 1.93 ENST00000528880.2
HCAR3
hydroxycarboxylic acid receptor 3
chr18_-_52989217 1.87 ENST00000570287.2
TCF4
transcription factor 4
chr7_+_134464414 1.86 ENST00000361901.2
CALD1
caldesmon 1
chr1_+_84609944 1.84 ENST00000370685.3
PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chr14_-_25103388 1.78 ENST00000526004.1
ENST00000415355.3
GZMB
granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
chr6_+_35995531 1.78 ENST00000229794.4
MAPK14
mitogen-activated protein kinase 14
chr12_-_123187890 1.76 ENST00000328880.5
HCAR2
hydroxycarboxylic acid receptor 2
chr18_-_52989525 1.70 ENST00000457482.3
TCF4
transcription factor 4
chr12_-_120687948 1.68 ENST00000458477.2
PXN
paxillin
chr17_-_48474828 1.59 ENST00000576448.1
ENST00000225972.7
LRRC59
leucine rich repeat containing 59
chr13_+_53191605 1.57 ENST00000342657.3
ENST00000398039.1
HNRNPA1L2
heterogeneous nuclear ribonucleoprotein A1-like 2
chr19_+_55128576 1.55 ENST00000396331.1
LILRB1
leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1
chr9_-_117880477 1.55 ENST00000534839.1
ENST00000340094.3
ENST00000535648.1
ENST00000346706.3
ENST00000345230.3
ENST00000350763.4
TNC
tenascin C
chr3_-_123603137 1.51 ENST00000360304.3
ENST00000359169.1
ENST00000346322.5
ENST00000360772.3
MYLK
myosin light chain kinase
chr14_-_25103472 1.43 ENST00000216341.4
ENST00000382542.1
ENST00000382540.1
GZMB
granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
chr7_-_29186008 1.41 ENST00000396276.3
ENST00000265394.5
CPVL
carboxypeptidase, vitellogenic-like
chr21_+_17102311 1.39 ENST00000285679.6
ENST00000351097.5
ENST00000285681.2
ENST00000400183.2
USP25
ubiquitin specific peptidase 25
chr6_+_35995552 1.37 ENST00000468133.1
MAPK14
mitogen-activated protein kinase 14
chr13_+_20207782 1.36 ENST00000414242.2
ENST00000361479.5
MPHOSPH8
M-phase phosphoprotein 8
chr6_+_35995488 1.36 ENST00000229795.3
MAPK14
mitogen-activated protein kinase 14
chr19_+_10197463 1.35 ENST00000590378.1
ENST00000397881.3
C19orf66
chromosome 19 open reading frame 66
chr19_-_13227463 1.34 ENST00000437766.1
ENST00000221504.8
TRMT1
tRNA methyltransferase 1 homolog (S. cerevisiae)
chr9_-_113018835 1.34 ENST00000374517.5
TXN
thioredoxin
chr2_-_216257849 1.28 ENST00000456923.1
FN1
fibronectin 1
chr2_-_188419200 1.25 ENST00000233156.3
ENST00000426055.1
ENST00000453013.1
ENST00000417013.1
TFPI
tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
chr2_-_55237484 1.22 ENST00000394609.2
RTN4
reticulon 4
chr1_-_150669604 1.21 ENST00000427665.1
ENST00000540514.1
GOLPH3L
golgi phosphoprotein 3-like
chr19_-_13227534 1.21 ENST00000588229.1
ENST00000357720.4
TRMT1
tRNA methyltransferase 1 homolog (S. cerevisiae)
chr14_+_75988851 1.19 ENST00000555504.1
BATF
basic leucine zipper transcription factor, ATF-like
chr2_+_70121075 1.15 ENST00000409116.1
SNRNP27
small nuclear ribonucleoprotein 27kDa (U4/U6.U5)
chr6_+_44194762 1.12 ENST00000371708.1
SLC29A1
solute carrier family 29 (equilibrative nucleoside transporter), member 1
chr7_+_134464376 1.10 ENST00000454108.1
ENST00000361675.2
CALD1
caldesmon 1
chr12_-_122985067 1.03 ENST00000540586.1
ENST00000543897.1
ZCCHC8
zinc finger, CCHC domain containing 8
chr11_+_18230685 1.02 ENST00000340135.3
ENST00000534640.1
RP11-113D6.10
Putative mitochondrial carrier protein LOC494141
chr2_+_143635222 1.01 ENST00000375773.2
ENST00000409512.1
ENST00000410015.2
KYNU
kynureninase
chr3_+_23959185 0.99 ENST00000354811.5
RPL15
ribosomal protein L15
chr1_+_221051699 0.93 ENST00000366903.6
HLX
H2.0-like homeobox
chrX_+_153775821 0.88 ENST00000263518.6
ENST00000470142.1
ENST00000393549.2
ENST00000455588.2
ENST00000369602.3
IKBKG
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
chr12_-_122985494 0.88 ENST00000336229.4
ZCCHC8
zinc finger, CCHC domain containing 8
chr13_+_73356197 0.87 ENST00000326291.6
PIBF1
progesterone immunomodulatory binding factor 1
chr18_+_72167096 0.85 ENST00000324301.8
CNDP2
CNDP dipeptidase 2 (metallopeptidase M20 family)
chr11_+_18230727 0.85 ENST00000527059.1
RP11-113D6.10
Putative mitochondrial carrier protein LOC494141
chr3_+_50649302 0.79 ENST00000446044.1
MAPKAPK3
mitogen-activated protein kinase-activated protein kinase 3
chr3_+_23958632 0.78 ENST00000412097.1
ENST00000415719.1
ENST00000435882.1
RPL15
ribosomal protein L15
chr6_+_150690133 0.78 ENST00000392255.3
ENST00000500320.3
IYD
iodotyrosine deiodinase
chr1_-_193029192 0.76 ENST00000417752.1
ENST00000367452.4
UCHL5
ubiquitin carboxyl-terminal hydrolase L5
chr1_-_150669500 0.74 ENST00000271732.3
GOLPH3L
golgi phosphoprotein 3-like
chr12_+_16064106 0.73 ENST00000428559.2
DERA
deoxyribose-phosphate aldolase (putative)
chr13_-_33112823 0.72 ENST00000504114.1
N4BP2L2
NEDD4 binding protein 2-like 2
chr19_-_40023450 0.71 ENST00000326282.4
EID2B
EP300 interacting inhibitor of differentiation 2B
chr17_-_42907564 0.70 ENST00000592524.1
GJC1
gap junction protein, gamma 1, 45kDa
chr5_-_140700322 0.67 ENST00000313368.5
TAF7
TAF7 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 55kDa
chr12_+_19358228 0.65 ENST00000424268.1
ENST00000543806.1
PLEKHA5
pleckstrin homology domain containing, family A member 5
chrX_+_95939638 0.62 ENST00000373061.3
ENST00000373054.4
ENST00000355827.4
DIAPH2
diaphanous-related formin 2
chrX_-_57147748 0.59 ENST00000374910.3
SPIN2B
spindlin family, member 2B
chr22_+_45725524 0.59 ENST00000405548.3
FAM118A
family with sequence similarity 118, member A
chr14_+_95078714 0.59 ENST00000393078.3
ENST00000393080.4
ENST00000467132.1
SERPINA3
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
chr12_+_8975061 0.57 ENST00000299698.7
A2ML1
alpha-2-macroglobulin-like 1
chr7_+_74072011 0.57 ENST00000324896.4
ENST00000353920.4
ENST00000346152.4
ENST00000416070.1
GTF2I
general transcription factor IIi
chr2_-_175499294 0.55 ENST00000392547.2
WIPF1
WAS/WASL interacting protein family, member 1
chr1_+_209878182 0.55 ENST00000367027.3
HSD11B1
hydroxysteroid (11-beta) dehydrogenase 1
chr1_-_168698433 0.51 ENST00000367817.3
DPT
dermatopontin
chr11_+_123986069 0.50 ENST00000456829.2
ENST00000361352.5
ENST00000449321.1
ENST00000392748.1
ENST00000360334.4
ENST00000392744.4
VWA5A
von Willebrand factor A domain containing 5A
chr2_-_188419078 0.43 ENST00000437725.1
ENST00000409676.1
ENST00000339091.4
ENST00000420747.1
TFPI
tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
chr11_+_113779704 0.42 ENST00000537778.1
HTR3B
5-hydroxytryptamine (serotonin) receptor 3B, ionotropic
chr10_-_70287172 0.40 ENST00000539557.1
SLC25A16
solute carrier family 25 (mitochondrial carrier; Graves disease autoantigen), member 16
chr19_+_45147313 0.38 ENST00000406449.4
PVR
poliovirus receptor
chr6_+_7541845 0.38 ENST00000418664.2
DSP
desmoplakin
chr3_+_158787041 0.37 ENST00000471575.1
ENST00000476809.1
ENST00000485419.1
IQCJ-SCHIP1
IQCJ-SCHIP1 readthrough
chr17_+_38497640 0.35 ENST00000394086.3
RARA
retinoic acid receptor, alpha
chr3_-_69101461 0.34 ENST00000543976.1
TMF1
TATA element modulatory factor 1
chr17_-_42908155 0.31 ENST00000426548.1
ENST00000590758.1
ENST00000591424.1
GJC1
gap junction protein, gamma 1, 45kDa
chr15_+_74610894 0.30 ENST00000558821.1
ENST00000268082.4
CCDC33
coiled-coil domain containing 33
chr3_-_69101413 0.28 ENST00000398559.2
TMF1
TATA element modulatory factor 1
chrX_-_135338503 0.27 ENST00000370663.5
MAP7D3
MAP7 domain containing 3
chr5_-_58295712 0.26 ENST00000317118.8
PDE4D
phosphodiesterase 4D, cAMP-specific
chr6_+_150690028 0.26 ENST00000229447.5
ENST00000344419.3
IYD
iodotyrosine deiodinase
chr1_+_235530675 0.25 ENST00000366601.3
ENST00000406207.1
ENST00000543662.1
TBCE
tubulin folding cofactor E
chr19_+_55235969 0.24 ENST00000402254.2
ENST00000538269.1
ENST00000541392.1
ENST00000291860.1
ENST00000396284.2
KIR3DL1
KIR3DL3
KIR2DL4
killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 1
killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 3
killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 4
chr9_+_70971815 0.22 ENST00000396392.1
ENST00000396396.1
PGM5
phosphoglucomutase 5
chr20_+_56136136 0.21 ENST00000319441.4
ENST00000543666.1
PCK1
phosphoenolpyruvate carboxykinase 1 (soluble)
chrX_-_54209640 0.21 ENST00000375180.2
ENST00000328235.4
ENST00000477084.1
FAM120C
family with sequence similarity 120C
chr6_+_7541808 0.20 ENST00000379802.3
DSP
desmoplakin
chr19_+_11200038 0.20 ENST00000558518.1
ENST00000557933.1
ENST00000455727.2
ENST00000535915.1
ENST00000545707.1
ENST00000558013.1
LDLR
low density lipoprotein receptor
chr9_+_88556036 0.19 ENST00000361671.5
ENST00000416045.1
NAA35
N(alpha)-acetyltransferase 35, NatC auxiliary subunit
chr8_-_141810634 0.16 ENST00000521986.1
ENST00000523539.1
ENST00000538769.1
PTK2
protein tyrosine kinase 2
chr16_-_18441131 0.14 ENST00000339303.5
NPIPA8
nuclear pore complex interacting protein family, member A8
chr1_+_111991474 0.13 ENST00000369722.3
ATP5F1
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit B1
chr4_+_95972822 0.10 ENST00000509540.1
ENST00000440890.2
BMPR1B
bone morphogenetic protein receptor, type IB
chr17_+_66539369 0.08 ENST00000600820.1
AC079210.1
Uncharacterized protein; cDNA FLJ45097 fis, clone BRAWH3031054
chr2_-_89266286 0.08 ENST00000464162.1
IGKV1-6
immunoglobulin kappa variable 1-6
chr6_+_31588478 0.07 ENST00000376007.4
ENST00000376033.2
PRRC2A
proline-rich coiled-coil 2A
chr15_-_75871589 0.06 ENST00000306726.2
PTPN9
protein tyrosine phosphatase, non-receptor type 9
chr4_-_153303658 0.04 ENST00000296555.5
FBXW7
F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
chr8_-_102216925 0.04 ENST00000517844.1
ZNF706
zinc finger protein 706
chrX_+_95939711 0.03 ENST00000373049.4
ENST00000324765.8
DIAPH2
diaphanous-related formin 2
chr1_-_153521597 0.02 ENST00000368712.1
S100A3
S100 calcium binding protein A3
chr2_-_84686552 0.02 ENST00000393868.2
SUCLG1
succinate-CoA ligase, alpha subunit
chr2_-_31361543 0.02 ENST00000349752.5
GALNT14
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 14 (GalNAc-T14)
chr16_-_66952742 0.01 ENST00000565235.2
ENST00000568632.1
ENST00000565796.1
CDH16
cadherin 16, KSP-cadherin
chr16_-_66952779 0.01 ENST00000570262.1
ENST00000394055.3
ENST00000299752.4
CDH16
cadherin 16, KSP-cadherin
chrX_-_153775426 0.01 ENST00000393562.2
G6PD
glucose-6-phosphate dehydrogenase
chr10_-_48416849 0.00 ENST00000249598.1
GDF2
growth differentiation factor 2
chr6_-_87804815 0.00 ENST00000369582.2
CGA
glycoprotein hormones, alpha polypeptide
chr13_-_72441315 0.00 ENST00000305425.4
ENST00000313174.7
ENST00000354591.4
DACH1
dachshund homolog 1 (Drosophila)

Network of associatons between targets according to the STRING database.

First level regulatory network of BCL6B

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 3.0 GO:0097052 tryptophan catabolic process to acetyl-CoA(GO:0019442) L-kynurenine metabolic process(GO:0097052)
0.9 4.5 GO:0014835 myoblast differentiation involved in skeletal muscle regeneration(GO:0014835)
0.7 2.2 GO:0034761 positive regulation of iron ion transport(GO:0034758) positive regulation of iron ion transmembrane transport(GO:0034761) regulation of iron ion import(GO:1900390) regulation of ferrous iron import into cell(GO:1903989) positive regulation of ferrous iron import into cell(GO:1903991) regulation of ferrous iron binding(GO:1904432) positive regulation of ferrous iron binding(GO:1904434) regulation of transferrin receptor binding(GO:1904435) positive regulation of transferrin receptor binding(GO:1904437) regulation of ferrous iron import across plasma membrane(GO:1904438) positive regulation of ferrous iron import across plasma membrane(GO:1904440)
0.7 4.9 GO:1902035 positive regulation of hematopoietic stem cell proliferation(GO:1902035)
0.5 1.6 GO:0060447 bud outgrowth involved in lung branching(GO:0060447)
0.5 3.8 GO:0060414 aorta smooth muscle tissue morphogenesis(GO:0060414)
0.5 2.8 GO:2001202 negative regulation of transforming growth factor-beta secretion(GO:2001202)
0.5 3.2 GO:0008626 granzyme-mediated apoptotic signaling pathway(GO:0008626)
0.4 2.5 GO:0071233 cellular response to leucine(GO:0071233)
0.4 1.8 GO:0097338 response to clozapine(GO:0097338)
0.4 2.8 GO:0015866 ADP transport(GO:0015866)
0.4 1.8 GO:0033031 positive regulation of neutrophil apoptotic process(GO:0033031)
0.3 4.4 GO:0036500 ATF6-mediated unfolded protein response(GO:0036500)
0.3 4.8 GO:0071786 endoplasmic reticulum tubular network organization(GO:0071786)
0.3 4.0 GO:0035970 peptidyl-threonine dephosphorylation(GO:0035970)
0.2 2.5 GO:0032074 negative regulation of nuclease activity(GO:0032074)
0.2 1.1 GO:0015862 uridine transport(GO:0015862)
0.2 0.9 GO:0032815 negative regulation of natural killer cell activation(GO:0032815)
0.2 1.7 GO:0007598 blood coagulation, extrinsic pathway(GO:0007598)
0.2 1.0 GO:0086053 SA node cell to atrial cardiac muscle cell communication by electrical coupling(GO:0086021) AV node cell to bundle of His cell communication by electrical coupling(GO:0086053)
0.2 0.9 GO:0045629 negative regulation of T-helper 2 cell differentiation(GO:0045629)
0.2 1.9 GO:0048194 Golgi vesicle budding(GO:0048194)
0.2 1.9 GO:1900747 negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747)
0.1 1.3 GO:0030091 protein repair(GO:0030091)
0.1 1.4 GO:1904293 negative regulation of ERAD pathway(GO:1904293)
0.1 0.6 GO:0035936 testosterone secretion(GO:0035936) regulation of testosterone secretion(GO:2000843) positive regulation of testosterone secretion(GO:2000845)
0.1 0.7 GO:0046121 deoxyribonucleoside catabolic process(GO:0046121)
0.1 2.0 GO:0036148 phosphatidylglycerol acyl-chain remodeling(GO:0036148)
0.1 0.6 GO:0014886 transition between slow and fast fiber(GO:0014886)
0.1 1.9 GO:0040015 negative regulation of multicellular organism growth(GO:0040015)
0.1 0.3 GO:0060370 susceptibility to T cell mediated cytotoxicity(GO:0060370)
0.1 0.8 GO:0044351 macropinocytosis(GO:0044351)
0.1 2.5 GO:0030488 tRNA methylation(GO:0030488)
0.1 2.3 GO:0030889 negative regulation of B cell proliferation(GO:0030889)
0.1 0.3 GO:0060010 Sertoli cell fate commitment(GO:0060010)
0.1 1.0 GO:0006570 tyrosine metabolic process(GO:0006570)
0.1 0.6 GO:0071896 protein localization to adherens junction(GO:0071896)
0.1 0.2 GO:0048936 peripheral nervous system neuron axonogenesis(GO:0048936)
0.1 1.8 GO:0007172 signal complex assembly(GO:0007172)
0.1 0.7 GO:0015846 polyamine transport(GO:0015846)
0.1 0.2 GO:1903978 regulation of microglial cell activation(GO:1903978) positive regulation of lysosomal protein catabolic process(GO:1905167)
0.1 1.2 GO:0072540 T-helper 17 cell lineage commitment(GO:0072540)
0.1 1.4 GO:0044030 regulation of DNA methylation(GO:0044030)
0.1 2.2 GO:0006376 mRNA splice site selection(GO:0006376)
0.1 0.2 GO:0006114 glycerol biosynthetic process(GO:0006114) response to methionine(GO:1904640)
0.0 0.8 GO:0021670 lateral ventricle development(GO:0021670)
0.0 4.3 GO:0002181 cytoplasmic translation(GO:0002181)
0.0 0.9 GO:0006750 glutathione biosynthetic process(GO:0006750)
0.0 0.6 GO:0030277 maintenance of gastrointestinal epithelium(GO:0030277)
0.0 0.3 GO:0086024 adrenergic receptor signaling pathway involved in positive regulation of heart rate(GO:0086024)
0.0 2.4 GO:0045071 negative regulation of viral genome replication(GO:0045071)
0.0 0.5 GO:0006704 glucocorticoid biosynthetic process(GO:0006704)
0.0 0.1 GO:0048165 ovarian cumulus expansion(GO:0001550) fused antrum stage(GO:0048165)
0.0 0.9 GO:0043276 anoikis(GO:0043276)
0.0 0.2 GO:0019388 galactose catabolic process(GO:0019388)
0.0 3.6 GO:0006367 transcription initiation from RNA polymerase II promoter(GO:0006367)
0.0 0.5 GO:0030199 collagen fibril organization(GO:0030199)
0.0 0.2 GO:0006474 N-terminal protein amino acid acetylation(GO:0006474)
0.0 3.1 GO:0060271 cilium morphogenesis(GO:0060271)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 2.2 GO:0031905 early endosome lumen(GO:0031905)
0.2 4.4 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.2 3.0 GO:0030478 actin cap(GO:0030478)
0.1 4.1 GO:0034451 centriolar satellite(GO:0034451)
0.1 1.6 GO:0005614 interstitial matrix(GO:0005614)
0.1 1.9 GO:0098647 collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.1 1.8 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.1 1.4 GO:0000788 nuclear nucleosome(GO:0000788)
0.1 5.7 GO:0001772 immunological synapse(GO:0001772)
0.1 0.7 GO:0008024 cyclin/CDK positive transcription elongation factor complex(GO:0008024)
0.1 1.2 GO:0071782 endoplasmic reticulum tubular network(GO:0071782)
0.1 4.3 GO:0031672 A band(GO:0031672)
0.1 1.0 GO:0005922 connexon complex(GO:0005922)
0.1 0.8 GO:0031597 cytosolic proteasome complex(GO:0031597)
0.0 3.8 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.0 0.2 GO:0031417 NatC complex(GO:0031417)
0.0 4.9 GO:0017053 transcriptional repressor complex(GO:0017053)
0.0 0.6 GO:0005916 fascia adherens(GO:0005916)
0.0 7.5 GO:0101002 ficolin-1-rich granule(GO:0101002) ficolin-1-rich granule lumen(GO:1904813)
0.0 1.3 GO:0005605 basal lamina(GO:0005605)
0.0 1.6 GO:0009295 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.0 1.9 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.0 2.1 GO:0097517 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.0 3.6 GO:0032993 protein-DNA complex(GO:0032993)
0.0 0.2 GO:0097443 sorting endosome(GO:0097443)
0.0 1.9 GO:0071013 catalytic step 2 spliceosome(GO:0071013)
0.0 2.4 GO:0001650 fibrillar center(GO:0001650)
0.0 1.6 GO:0005681 spliceosomal complex(GO:0005681)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 4.0 GO:0008330 protein tyrosine/threonine phosphatase activity(GO:0008330)
0.8 3.8 GO:0004687 myosin light chain kinase activity(GO:0004687)
0.7 3.0 GO:0016822 hydrolase activity, acting on acid carbon-carbon bonds(GO:0016822) hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances(GO:0016823)
0.6 2.5 GO:0004809 tRNA (guanine-N2-)-methyltransferase activity(GO:0004809)
0.5 2.5 GO:0070728 leucine binding(GO:0070728)
0.5 1.4 GO:1904455 ubiquitin-specific protease activity involved in negative regulation of ERAD pathway(GO:1904455)
0.4 4.5 GO:0051525 NFAT protein binding(GO:0051525)
0.4 1.6 GO:0030107 HLA-A specific inhibitory MHC class I receptor activity(GO:0030107)
0.4 4.0 GO:0046790 virion binding(GO:0046790)
0.4 2.8 GO:0000295 adenine nucleotide transmembrane transporter activity(GO:0000295) purine ribonucleotide transmembrane transporter activity(GO:0005346) ATP transmembrane transporter activity(GO:0005347) purine nucleotide transmembrane transporter activity(GO:0015216) ADP transmembrane transporter activity(GO:0015217)
0.3 1.9 GO:0008269 JAK pathway signal transduction adaptor activity(GO:0008269)
0.3 0.9 GO:0102008 cytosolic dipeptidase activity(GO:0102008)
0.3 3.6 GO:0001087 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.3 2.0 GO:0047144 2-acylglycerol-3-phosphate O-acyltransferase activity(GO:0047144)
0.2 0.7 GO:0004139 deoxyribose-phosphate aldolase activity(GO:0004139)
0.2 1.0 GO:0086077 gap junction channel activity involved in SA node cell-atrial cardiac muscle cell electrical coupling(GO:0086020) gap junction channel activity involved in AV node cell-bundle of His cell electrical coupling(GO:0086077)
0.2 1.3 GO:0047134 protein-disulfide reductase activity(GO:0047134)
0.2 0.5 GO:0003845 11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity(GO:0003845)
0.2 1.0 GO:0004447 iodide peroxidase activity(GO:0004447)
0.2 0.7 GO:0061628 H3K27me3 modified histone binding(GO:0061628)
0.2 1.6 GO:0045545 syndecan binding(GO:0045545)
0.1 2.6 GO:0070273 phosphatidylinositol-4-phosphate binding(GO:0070273)
0.1 0.2 GO:0030109 HLA-B specific inhibitory MHC class I receptor activity(GO:0030109)
0.1 4.9 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.1 1.8 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.1 3.0 GO:0005523 tropomyosin binding(GO:0005523)
0.1 0.4 GO:0022850 serotonin-gated cation channel activity(GO:0022850)
0.1 1.4 GO:0004185 serine-type carboxypeptidase activity(GO:0004185)
0.1 1.1 GO:0005337 nucleoside transmembrane transporter activity(GO:0005337)
0.1 0.2 GO:0004611 phosphoenolpyruvate carboxykinase activity(GO:0004611) phosphoenolpyruvate carboxykinase (GTP) activity(GO:0004613)
0.1 1.7 GO:0017166 vinculin binding(GO:0017166)
0.1 0.6 GO:0086083 cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication(GO:0086083)
0.1 0.9 GO:0042975 peroxisome proliferator activated receptor binding(GO:0042975)
0.0 2.2 GO:0036002 pre-mRNA binding(GO:0036002)
0.0 0.3 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.0 0.8 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.0 0.2 GO:0004614 phosphoglucomutase activity(GO:0004614)
0.0 0.8 GO:0070628 proteasome binding(GO:0070628)
0.0 0.6 GO:0005522 profilin binding(GO:0005522)
0.0 2.8 GO:0005518 collagen binding(GO:0005518)
0.0 0.2 GO:0030229 very-low-density lipoprotein particle receptor activity(GO:0030229)
0.0 1.4 GO:0035064 methylated histone binding(GO:0035064)
0.0 5.4 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 4.3 GO:0003735 structural constituent of ribosome(GO:0003735)
0.0 0.2 GO:0004596 peptide alpha-N-acetyltransferase activity(GO:0004596)
0.0 4.4 GO:0030246 carbohydrate binding(GO:0030246)
0.0 0.6 GO:0051019 mitogen-activated protein kinase binding(GO:0051019)
0.0 0.3 GO:0031698 beta-2 adrenergic receptor binding(GO:0031698)
0.0 0.2 GO:0008432 JUN kinase binding(GO:0008432)
0.0 0.1 GO:0005025 transforming growth factor beta receptor activity, type I(GO:0005025)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 9.0 SIG CD40PATHWAYMAP Genes related to CD40 signaling
0.1 4.5 PID INTEGRIN A9B1 PATHWAY Alpha9 beta1 integrin signaling events
0.1 3.2 SA CASPASE CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.1 4.4 PID IL6 7 PATHWAY IL6-mediated signaling events
0.1 3.8 SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES Genes related to regulation of the actin cytoskeleton
0.1 5.6 PID IL12 2PATHWAY IL12-mediated signaling events
0.1 1.3 PID P38 MKK3 6PATHWAY p38 MAPK signaling pathway
0.1 1.6 PID IL3 PATHWAY IL3-mediated signaling events
0.0 1.9 PID IL2 1PATHWAY IL2-mediated signaling events
0.0 1.8 PID SYNDECAN 4 PATHWAY Syndecan-4-mediated signaling events
0.0 4.2 PID AR PATHWAY Coregulation of Androgen receptor activity
0.0 1.9 PID FRA PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 0.8 PID P38 MK2 PATHWAY p38 signaling mediated by MAPKAP kinases
0.0 3.5 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 1.2 PID P75 NTR PATHWAY p75(NTR)-mediated signaling
0.0 0.6 PID FCER1 PATHWAY Fc-epsilon receptor I signaling in mast cells
0.0 0.3 PID RETINOIC ACID PATHWAY Retinoic acid receptors-mediated signaling
0.0 0.3 PID NECTIN PATHWAY Nectin adhesion pathway
0.0 0.6 PID AJDISS 2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 4.4 REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.2 2.2 REACTOME ENDOSOMAL VACUOLAR PATHWAY Genes involved in Endosomal/Vacuolar pathway
0.2 6.2 REACTOME ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION Genes involved in activated TAK1 mediates p38 MAPK activation
0.2 3.0 REACTOME TRYPTOPHAN CATABOLISM Genes involved in Tryptophan catabolism
0.1 2.0 REACTOME ACYL CHAIN REMODELLING OF PG Genes involved in Acyl chain remodelling of PG
0.1 6.8 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.1 1.9 REACTOME CS DS DEGRADATION Genes involved in CS/DS degradation
0.1 1.3 REACTOME THE NLRP3 INFLAMMASOME Genes involved in The NLRP3 inflammasome
0.1 3.1 REACTOME MYOGENESIS Genes involved in Myogenesis
0.1 1.8 REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.1 3.2 REACTOME INTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Intrinsic Pathway for Apoptosis
0.1 1.0 REACTOME GAP JUNCTION ASSEMBLY Genes involved in Gap junction assembly
0.0 1.0 REACTOME AMINE DERIVED HORMONES Genes involved in Amine-derived hormones
0.0 1.7 REACTOME GROWTH HORMONE RECEPTOR SIGNALING Genes involved in Growth hormone receptor signaling
0.0 0.6 REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
0.0 4.3 REACTOME PEPTIDE CHAIN ELONGATION Genes involved in Peptide chain elongation
0.0 0.9 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.0 2.1 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.0 1.1 REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.0 0.8 REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING Genes involved in Downregulation of TGF-beta receptor signaling
0.0 0.2 REACTOME ABACAVIR TRANSPORT AND METABOLISM Genes involved in Abacavir transport and metabolism
0.0 0.5 REACTOME STEROID HORMONES Genes involved in Steroid hormones
0.0 0.9 REACTOME INTEGRIN CELL SURFACE INTERACTIONS Genes involved in Integrin cell surface interactions
0.0 1.2 REACTOME P75 NTR RECEPTOR MEDIATED SIGNALLING Genes involved in p75 NTR receptor-mediated signalling
0.0 1.3 REACTOME CELL SURFACE INTERACTIONS AT THE VASCULAR WALL Genes involved in Cell surface interactions at the vascular wall
0.0 0.4 REACTOME LIGAND GATED ION CHANNEL TRANSPORT Genes involved in Ligand-gated ion channel transport