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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for BCL6B
Z-value: 0.09
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Transcription factors associated with BCL6B
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr11_-_104480019 Show fit | 6.61 |
ENST00000536529.1
ENST00000545630.1 ENST00000538641.1 |
RP11-886D15.1 |
|
| chr12_-_10007448 Show fit | 5.69 |
ENST00000538152.1
|
C-type lectin domain family 2, member B |
|
| chr12_+_104324112 Show fit | 4.44 |
ENST00000299767.5
|
heat shock protein 90kDa beta (Grp94), member 1 |
|
| chr5_-_172198190 Show fit | 4.01 |
ENST00000239223.3
|
dual specificity phosphatase 1 |
|
| chr16_-_75498308 Show fit | 3.60 |
ENST00000569540.1
|
transmembrane protein 170A |
|
| chr16_+_58283814 Show fit | 3.20 |
ENST00000443128.2
ENST00000219299.4 |
coiled-coil domain containing 113 |
|
| chr1_-_108735440 Show fit | 2.82 |
ENST00000370041.4
|
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 24 |
|
| chr3_+_23958470 Show fit | 2.54 |
ENST00000434031.2
ENST00000413699.1 ENST00000456530.2 |
ribosomal protein L15 |
|
| chr6_+_42584847 Show fit | 2.53 |
ENST00000372883.3
|
ubiquitin protein ligase E3 component n-recognin 2 |
|
| chr5_+_54398463 Show fit | 2.46 |
ENST00000274306.6
|
granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3) |
Network of associatons between targets according to the STRING database.
First level regulatory network of BCL6B
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 4.9 | GO:1902035 | positive regulation of hematopoietic stem cell proliferation(GO:1902035) |
| 0.3 | 4.8 | GO:0071786 | endoplasmic reticulum tubular network organization(GO:0071786) |
| 0.9 | 4.5 | GO:0014835 | myoblast differentiation involved in skeletal muscle regeneration(GO:0014835) |
| 0.3 | 4.4 | GO:0036500 | ATF6-mediated unfolded protein response(GO:0036500) |
| 0.0 | 4.3 | GO:0002181 | cytoplasmic translation(GO:0002181) |
| 0.3 | 4.0 | GO:0035970 | peptidyl-threonine dephosphorylation(GO:0035970) |
| 0.5 | 3.8 | GO:0060414 | aorta smooth muscle tissue morphogenesis(GO:0060414) |
| 0.0 | 3.6 | GO:0006367 | transcription initiation from RNA polymerase II promoter(GO:0006367) |
| 0.5 | 3.2 | GO:0008626 | granzyme-mediated apoptotic signaling pathway(GO:0008626) |
| 0.0 | 3.1 | GO:0060271 | cilium morphogenesis(GO:0060271) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 7.5 | GO:0101002 | ficolin-1-rich granule(GO:0101002) ficolin-1-rich granule lumen(GO:1904813) |
| 0.1 | 5.7 | GO:0001772 | immunological synapse(GO:0001772) |
| 0.0 | 4.9 | GO:0017053 | transcriptional repressor complex(GO:0017053) |
| 0.2 | 4.4 | GO:0034663 | endoplasmic reticulum chaperone complex(GO:0034663) |
| 0.1 | 4.3 | GO:0031672 | A band(GO:0031672) |
| 0.1 | 4.1 | GO:0034451 | centriolar satellite(GO:0034451) |
| 0.0 | 3.8 | GO:0097610 | cleavage furrow(GO:0032154) cell surface furrow(GO:0097610) |
| 0.0 | 3.6 | GO:0032993 | protein-DNA complex(GO:0032993) |
| 0.2 | 3.0 | GO:0030478 | actin cap(GO:0030478) |
| 0.0 | 2.4 | GO:0001650 | fibrillar center(GO:0001650) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 5.4 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.1 | 4.9 | GO:0001106 | RNA polymerase II transcription corepressor activity(GO:0001106) |
| 0.4 | 4.5 | GO:0051525 | NFAT protein binding(GO:0051525) |
| 0.0 | 4.4 | GO:0030246 | carbohydrate binding(GO:0030246) |
| 0.0 | 4.3 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 1.3 | 4.0 | GO:0008330 | protein tyrosine/threonine phosphatase activity(GO:0008330) |
| 0.4 | 4.0 | GO:0046790 | virion binding(GO:0046790) |
| 0.8 | 3.8 | GO:0004687 | myosin light chain kinase activity(GO:0004687) |
| 0.3 | 3.6 | GO:0001087 | transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087) |
| 0.7 | 3.0 | GO:0016822 | hydrolase activity, acting on acid carbon-carbon bonds(GO:0016822) hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances(GO:0016823) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 9.0 | SIG CD40PATHWAYMAP | Genes related to CD40 signaling |
| 0.1 | 5.6 | PID IL12 2PATHWAY | IL12-mediated signaling events |
| 0.1 | 4.5 | PID INTEGRIN A9B1 PATHWAY | Alpha9 beta1 integrin signaling events |
| 0.1 | 4.4 | PID IL6 7 PATHWAY | IL6-mediated signaling events |
| 0.0 | 4.2 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 0.1 | 3.8 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.0 | 3.5 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.1 | 3.2 | SA CASPASE CASCADE | Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. |
| 0.0 | 1.9 | PID IL2 1PATHWAY | IL2-mediated signaling events |
| 0.0 | 1.9 | PID FRA PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 6.8 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 0.2 | 6.2 | REACTOME ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION | Genes involved in activated TAK1 mediates p38 MAPK activation |
| 0.3 | 4.4 | REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA | Genes involved in Activation of Chaperone Genes by ATF6-alpha |
| 0.0 | 4.3 | REACTOME PEPTIDE CHAIN ELONGATION | Genes involved in Peptide chain elongation |
| 0.1 | 3.2 | REACTOME INTRINSIC PATHWAY FOR APOPTOSIS | Genes involved in Intrinsic Pathway for Apoptosis |
| 0.1 | 3.1 | REACTOME MYOGENESIS | Genes involved in Myogenesis |
| 0.2 | 3.0 | REACTOME TRYPTOPHAN CATABOLISM | Genes involved in Tryptophan catabolism |
| 0.2 | 2.2 | REACTOME ENDOSOMAL VACUOLAR PATHWAY | Genes involved in Endosomal/Vacuolar pathway |
| 0.0 | 2.1 | REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
| 0.1 | 2.0 | REACTOME ACYL CHAIN REMODELLING OF PG | Genes involved in Acyl chain remodelling of PG |