Project
GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
Navigation
Downloads
Results for BHLHE40
Z-value: 1.60
Motif logo
Transcription factors associated with BHLHE40
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| BHLHE40 | hg19_v2_chr3_+_5020801_5020952 | 0.04 | 5.3e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of BHLHE40
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.3 | 96.7 | GO:0070126 | mitochondrial translational elongation(GO:0070125) mitochondrial translational termination(GO:0070126) |
| 18.1 | 90.6 | GO:2000255 | negative regulation of male germ cell proliferation(GO:2000255) |
| 0.9 | 66.3 | GO:0042273 | ribosomal large subunit biogenesis(GO:0042273) |
| 5.9 | 59.4 | GO:0006189 | 'de novo' IMP biosynthetic process(GO:0006189) |
| 14.7 | 58.9 | GO:0033387 | putrescine biosynthetic process from ornithine(GO:0033387) |
| 17.8 | 53.3 | GO:0046586 | regulation of calcium-dependent cell-cell adhesion(GO:0046586) |
| 0.5 | 46.5 | GO:0048207 | vesicle targeting, rough ER to cis-Golgi(GO:0048207) COPII vesicle coating(GO:0048208) |
| 1.2 | 39.5 | GO:0008334 | histone mRNA metabolic process(GO:0008334) |
| 1.2 | 38.9 | GO:0042776 | mitochondrial ATP synthesis coupled proton transport(GO:0042776) |
| 1.3 | 31.8 | GO:0045663 | positive regulation of myoblast differentiation(GO:0045663) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.0 | 87.1 | GO:0005790 | smooth endoplasmic reticulum(GO:0005790) |
| 2.1 | 83.6 | GO:0005762 | organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762) |
| 0.1 | 65.0 | GO:0005743 | mitochondrial inner membrane(GO:0005743) |
| 2.4 | 59.3 | GO:0030687 | preribosome, large subunit precursor(GO:0030687) |
| 0.2 | 50.2 | GO:0005759 | mitochondrial matrix(GO:0005759) |
| 0.6 | 46.5 | GO:0012507 | ER to Golgi transport vesicle membrane(GO:0012507) |
| 4.9 | 39.5 | GO:0005683 | U7 snRNP(GO:0005683) pICln-Sm protein complex(GO:0034715) |
| 2.2 | 38.9 | GO:0000276 | mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276) |
| 0.6 | 31.8 | GO:0043034 | costamere(GO:0043034) |
| 0.5 | 29.0 | GO:0019005 | SCF ubiquitin ligase complex(GO:0019005) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 102.5 | GO:0003723 | RNA binding(GO:0003723) |
| 11.3 | 90.6 | GO:0008379 | thioredoxin peroxidase activity(GO:0008379) |
| 0.4 | 87.0 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 1.1 | 58.9 | GO:0016831 | carboxy-lyase activity(GO:0016831) |
| 2.4 | 54.1 | GO:0016881 | acid-amino acid ligase activity(GO:0016881) |
| 1.0 | 53.3 | GO:0017080 | sodium channel regulator activity(GO:0017080) |
| 3.9 | 39.5 | GO:1990446 | U1 snRNP binding(GO:1990446) |
| 0.4 | 37.7 | GO:0015078 | hydrogen ion transmembrane transporter activity(GO:0015078) |
| 0.1 | 34.2 | GO:0061630 | ubiquitin protein ligase activity(GO:0061630) |
| 2.2 | 32.6 | GO:0001094 | TFIID-class transcription factor binding(GO:0001094) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 65.6 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.5 | 37.9 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.6 | 29.0 | PID MYC PATHWAY | C-MYC pathway |
| 0.8 | 25.7 | SA PTEN PATHWAY | PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. |
| 0.3 | 25.4 | PID E2F PATHWAY | E2F transcription factor network |
| 0.9 | 19.6 | PID INTEGRIN4 PATHWAY | Alpha6 beta4 integrin-ligand interactions |
| 0.6 | 19.0 | SA G1 AND S PHASES | Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. |
| 0.3 | 16.6 | PID HEDGEHOG GLI PATHWAY | Hedgehog signaling events mediated by Gli proteins |
| 0.5 | 15.4 | PID DNA PK PATHWAY | DNA-PK pathway in nonhomologous end joining |
| 0.1 | 10.8 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.5 | 59.4 | REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS | Genes involved in Purine ribonucleoside monophosphate biosynthesis |
| 2.4 | 58.9 | REACTOME METABOLISM OF POLYAMINES | Genes involved in Metabolism of polyamines |
| 0.5 | 50.4 | REACTOME APC C CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 | Genes involved in APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 |
| 0.8 | 47.4 | REACTOME TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION | Genes involved in Transport to the Golgi and subsequent modification |
| 2.5 | 39.5 | REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS | Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs |
| 1.7 | 38.9 | REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING | Genes involved in Formation of ATP by chemiosmotic coupling |
| 1.1 | 31.8 | REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS | Genes involved in Cell-extracellular matrix interactions |
| 0.1 | 19.6 | REACTOME L1CAM INTERACTIONS | Genes involved in L1CAM interactions |
| 0.8 | 19.5 | REACTOME PURINE SALVAGE | Genes involved in Purine salvage |
| 0.6 | 17.2 | REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION | Genes involved in Amino acid synthesis and interconversion (transamination) |