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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)

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Results for BHLHE40

Z-value: 1.60

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Transcription factors associated with BHLHE40

Gene Symbol Gene ID Gene Info
BHLHE40
ENSG00000134107.4 basic helix-loop-helix family member e40

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
BHLHE40hg19_v2_chr3_+_5020801_50209520.045.3e-01Click!

Activity profile of BHLHE40 motif

Sorted Z-values of BHLHE40 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chrX_+_23685653 53.23 ENST00000379331.3
PRDX4
peroxiredoxin 4
chr1_+_203830703 39.48 ENST00000414487.2
SNRPE
small nuclear ribonucleoprotein polypeptide E
chrX_+_23685563 37.35 ENST00000379341.4
PRDX4
peroxiredoxin 4
chr8_+_55047763 37.08 ENST00000260102.4
ENST00000519831.1
MRPL15
mitochondrial ribosomal protein L15
chr1_-_43638168 32.12 ENST00000431635.2
EBNA1BP2
EBNA1 binding protein 2
chr2_-_10588630 30.69 ENST00000234111.4
ODC1
ornithine decarboxylase 1
chr4_+_57301896 28.79 ENST00000514888.1
ENST00000264221.2
ENST00000505164.1
PAICS
phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
chr2_-_10587897 28.18 ENST00000405333.1
ENST00000443218.1
ODC1
ornithine decarboxylase 1
chr19_+_35645618 28.12 ENST00000392218.2
ENST00000543307.1
ENST00000392219.2
ENST00000541435.2
ENST00000590686.1
ENST00000342879.3
ENST00000588699.1
FXYD5
FXYD domain containing ion transport regulator 5
chr1_-_43637915 27.14 ENST00000236051.2
EBNA1BP2
EBNA1 binding protein 2
chr4_+_57302297 25.93 ENST00000399688.3
ENST00000512576.1
PAICS
phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
chr19_+_35645817 25.14 ENST00000423817.3
FXYD5
FXYD domain containing ion transport regulator 5
chr2_-_47143160 25.07 ENST00000409800.1
ENST00000409218.1
MCFD2
multiple coagulation factor deficiency 2
chr12_+_66217911 24.25 ENST00000403681.2
HMGA2
high mobility group AT-hook 2
chr12_+_93861264 23.37 ENST00000549982.1
ENST00000361630.2
MRPL42
mitochondrial ribosomal protein L42
chr12_+_93861282 23.10 ENST00000552217.1
ENST00000393128.4
ENST00000547098.1
MRPL42
mitochondrial ribosomal protein L42
chr17_-_61850894 22.02 ENST00000403162.3
ENST00000582252.1
ENST00000225726.5
CCDC47
coiled-coil domain containing 47
chr2_-_47142884 21.41 ENST00000409105.1
ENST00000409973.1
ENST00000409913.1
ENST00000319466.4
MCFD2
multiple coagulation factor deficiency 2
chr11_+_60609537 21.41 ENST00000227520.5
CCDC86
coiled-coil domain containing 86
chr13_+_50656307 20.66 ENST00000378180.4
DLEU1
deleted in lymphocytic leukemia 1 (non-protein coding)
chr6_+_13615554 20.53 ENST00000451315.2
NOL7
nucleolar protein 7, 27kDa
chr7_-_107642348 19.60 ENST00000393561.1
LAMB1
laminin, beta 1
chr6_-_5261141 19.35 ENST00000330636.4
ENST00000500576.2
LYRM4
LYR motif containing 4
chr2_-_27545921 18.98 ENST00000402310.1
ENST00000405983.1
ENST00000403262.2
ENST00000428910.1
ENST00000402722.1
ENST00000399052.4
ENST00000380044.1
ENST00000405076.1
MPV17
MpV17 mitochondrial inner membrane protein
chr1_-_86174065 18.38 ENST00000370574.3
ENST00000431532.2
ZNHIT6
zinc finger, HIT-type containing 6
chr6_-_5260963 17.71 ENST00000464010.1
ENST00000468929.1
ENST00000480566.1
LYRM4
LYR motif containing 4
chr10_-_97416400 17.16 ENST00000371224.2
ENST00000371221.3
ALDH18A1
aldehyde dehydrogenase 18 family, member A1
chr8_-_99129338 16.72 ENST00000520507.1
HRSP12
heat-responsive protein 12
chrX_-_16887963 16.55 ENST00000380084.4
RBBP7
retinoblastoma binding protein 7
chr5_+_36152091 16.47 ENST00000274254.5
SKP2
S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
chr4_-_100009856 16.18 ENST00000296412.8
ADH5
alcohol dehydrogenase 5 (class III), chi polypeptide
chr8_-_48872686 15.37 ENST00000314191.2
ENST00000338368.3
PRKDC
protein kinase, DNA-activated, catalytic polypeptide
chr22_-_43411106 14.25 ENST00000453643.1
ENST00000263246.3
ENST00000337959.4
PACSIN2
protein kinase C and casein kinase substrate in neurons 2
chr19_-_45953983 14.22 ENST00000592083.1
ERCC1
excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence)
chr17_+_36908984 14.15 ENST00000225426.4
ENST00000579088.1
PSMB3
proteasome (prosome, macropain) subunit, beta type, 3
chrX_-_47518498 14.14 ENST00000335890.2
UXT
ubiquitously-expressed, prefoldin-like chaperone
chr5_+_36152163 13.84 ENST00000274255.6
SKP2
S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
chr21_-_27107344 13.44 ENST00000457143.2
ATP5J
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit F6
chr12_-_58165870 13.34 ENST00000257848.7
METTL1
methyltransferase like 1
chr21_-_27107881 13.17 ENST00000400090.3
ENST00000400087.3
ENST00000400093.3
ATP5J
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit F6
chrX_-_47518527 13.14 ENST00000333119.3
UXT
ubiquitously-expressed, prefoldin-like chaperone
chr5_-_71616043 13.11 ENST00000508863.2
ENST00000522095.1
ENST00000513900.1
ENST00000515404.1
ENST00000457646.4
ENST00000261413.5
MRPS27
mitochondrial ribosomal protein S27
chr1_-_200589859 12.41 ENST00000367350.4
KIF14
kinesin family member 14
chr19_-_5719860 12.31 ENST00000590729.1
LONP1
lon peptidase 1, mitochondrial
chr21_-_27107283 12.26 ENST00000284971.3
ENST00000400099.1
ATP5J
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit F6
chr22_-_30987849 12.17 ENST00000402284.3
ENST00000354694.7
PES1
pescadillo ribosomal biogenesis factor 1
chr2_+_207630081 11.89 ENST00000236980.6
ENST00000418289.1
ENST00000402774.3
ENST00000403094.3
FASTKD2
FAST kinase domains 2
chr2_-_136743169 11.68 ENST00000264161.4
DARS
aspartyl-tRNA synthetase
chr2_+_201676908 11.58 ENST00000409226.1
ENST00000452790.2
BZW1
basic leucine zipper and W2 domains 1
chr17_-_53046058 11.37 ENST00000571584.1
ENST00000299335.3
COX11
cytochrome c oxidase assembly homolog 11 (yeast)
chr11_-_65626753 11.15 ENST00000526975.1
ENST00000531413.1
CFL1
cofilin 1 (non-muscle)
chr11_+_6624970 10.88 ENST00000420936.2
ENST00000528995.1
ILK
integrin-linked kinase
chr12_-_122710556 10.84 ENST00000446652.1
ENST00000541273.1
ENST00000353548.6
ENST00000267169.6
ENST00000464942.2
DIABLO
diablo, IAP-binding mitochondrial protein
chr11_+_6624955 10.75 ENST00000299421.4
ENST00000537806.1
ILK
integrin-linked kinase
chr22_-_30987837 10.26 ENST00000335214.6
PES1
pescadillo ribosomal biogenesis factor 1
chr11_+_6625046 10.21 ENST00000396751.2
ILK
integrin-linked kinase
chr3_-_98312548 9.80 ENST00000264193.2
CPOX
coproporphyrinogen oxidase
chr2_+_74154032 9.77 ENST00000356837.6
DGUOK
deoxyguanosine kinase
chr2_+_74153953 9.71 ENST00000264093.4
ENST00000348222.1
DGUOK
deoxyguanosine kinase
chr11_-_61560053 9.64 ENST00000537328.1
TMEM258
transmembrane protein 258
chr8_-_99129384 9.01 ENST00000521560.1
ENST00000254878.3
HRSP12
heat-responsive protein 12
chr9_+_706842 8.40 ENST00000382293.3
KANK1
KN motif and ankyrin repeat domains 1
chr14_+_77924373 8.39 ENST00000216479.3
ENST00000535854.2
ENST00000555517.1
AHSA1
AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (yeast)
chr3_+_133293278 8.19 ENST00000508481.1
ENST00000420115.2
ENST00000504867.1
ENST00000507408.1
ENST00000511392.1
ENST00000515421.1
CDV3
CDV3 homolog (mouse)
chr20_+_23331373 8.13 ENST00000254998.2
NXT1
NTF2-like export factor 1
chr19_-_55652290 8.06 ENST00000589745.1
TNNT1
troponin T type 1 (skeletal, slow)
chr2_-_112642267 7.24 ENST00000341068.3
ANAPC1
anaphase promoting complex subunit 1
chr2_+_190649107 6.80 ENST00000441310.2
ENST00000409985.1
ENST00000446877.1
ENST00000418224.3
ENST00000409823.3
ENST00000374826.4
ENST00000424766.1
ENST00000447232.2
ENST00000432292.3
PMS1
PMS1 postmeiotic segregation increased 1 (S. cerevisiae)
chr8_+_109455845 6.58 ENST00000220853.3
EMC2
ER membrane protein complex subunit 2
chr13_-_38172863 5.87 ENST00000541481.1
ENST00000379743.4
ENST00000379742.4
ENST00000379749.4
ENST00000541179.1
ENST00000379747.4
POSTN
periostin, osteoblast specific factor
chr10_+_101491968 4.93 ENST00000370476.5
ENST00000370472.4
CUTC
cutC copper transporter
chr1_+_118472343 4.72 ENST00000369441.3
ENST00000349139.5
WDR3
WD repeat domain 3
chr4_-_57301748 4.63 ENST00000264220.2
PPAT
phosphoribosyl pyrophosphate amidotransferase
chr12_-_25102252 4.63 ENST00000261192.7
BCAT1
branched chain amino-acid transaminase 1, cytosolic
chr17_-_74733404 4.61 ENST00000508921.3
ENST00000583836.1
ENST00000358156.6
ENST00000392485.2
ENST00000359995.5
SRSF2
serine/arginine-rich splicing factor 2
chr5_+_89770696 4.55 ENST00000504930.1
ENST00000514483.1
POLR3G
polymerase (RNA) III (DNA directed) polypeptide G (32kD)
chr6_+_44215603 4.53 ENST00000371554.1
HSP90AB1
heat shock protein 90kDa alpha (cytosolic), class B member 1
chr5_+_89770664 4.32 ENST00000503973.1
ENST00000399107.1
POLR3G
polymerase (RNA) III (DNA directed) polypeptide G (32kD)
chr1_+_231376941 3.66 ENST00000436239.1
ENST00000366647.4
ENST00000366646.3
ENST00000416000.1
GNPAT
glyceronephosphate O-acyltransferase
chr12_-_6677422 3.61 ENST00000382421.3
ENST00000545200.1
ENST00000399466.2
ENST00000536124.1
ENST00000540228.1
ENST00000542867.1
ENST00000545492.1
ENST00000322166.5
ENST00000545915.1
NOP2
NOP2 nucleolar protein
chr16_-_56701933 3.59 ENST00000568675.1
ENST00000569500.1
ENST00000444837.2
ENST00000379811.3
MT1G
metallothionein 1G
chr17_+_72199721 3.47 ENST00000439590.2
ENST00000311111.6
ENST00000584577.1
ENST00000534490.1
ENST00000528433.2
ENST00000533498.1
RPL38
ribosomal protein L38
chr15_+_58724184 3.41 ENST00000433326.2
LIPC
lipase, hepatic
chr22_-_50964558 3.35 ENST00000535425.1
ENST00000439934.1
SCO2
SCO2 cytochrome c oxidase assembly protein
chr16_+_29911864 3.22 ENST00000308748.5
ASPHD1
aspartate beta-hydroxylase domain containing 1
chr7_+_141463897 2.98 ENST00000247879.2
TAS2R3
taste receptor, type 2, member 3
chr21_-_30391636 2.89 ENST00000493196.1
RWDD2B
RWD domain containing 2B
chr8_-_11710979 2.85 ENST00000415599.2
CTSB
cathepsin B
chr1_+_207070775 2.81 ENST00000391929.3
ENST00000294984.2
ENST00000367093.3
IL24
interleukin 24
chr6_-_109804412 2.73 ENST00000230122.3
ZBTB24
zinc finger and BTB domain containing 24
chrX_+_129040094 2.68 ENST00000425117.2
UTP14A
UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast)
chr10_-_35379524 2.66 ENST00000374751.3
ENST00000374742.1
ENST00000602371.1
CUL2
cullin 2
chrX_+_129040122 2.63 ENST00000394422.3
ENST00000371051.5
UTP14A
UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast)
chr10_-_35379241 2.60 ENST00000374748.1
ENST00000374749.3
CUL2
cullin 2
chr10_-_105677427 2.55 ENST00000369764.1
OBFC1
oligonucleotide/oligosaccharide-binding fold containing 1
chr17_-_13505219 2.16 ENST00000284110.1
HS3ST3A1
heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1
chr12_-_25101920 2.08 ENST00000539780.1
ENST00000546285.1
ENST00000342945.5
BCAT1
branched chain amino-acid transaminase 1, cytosolic
chr6_+_5261225 1.99 ENST00000324331.6
FARS2
phenylalanyl-tRNA synthetase 2, mitochondrial
chr17_+_48796905 1.64 ENST00000505658.1
ENST00000393227.2
ENST00000240304.1
ENST00000311571.3
ENST00000505619.1
ENST00000544170.1
ENST00000510984.1
LUC7L3
LUC7-like 3 (S. cerevisiae)
chr15_-_74988281 1.44 ENST00000566828.1
ENST00000563009.1
ENST00000568176.1
ENST00000566243.1
ENST00000566219.1
ENST00000426797.3
ENST00000566119.1
ENST00000315127.4
EDC3
enhancer of mRNA decapping 3
chr4_+_47487285 1.27 ENST00000273859.3
ENST00000504445.1
ATP10D
ATPase, class V, type 10D
chr1_+_44445549 0.90 ENST00000356836.6
B4GALT2
UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2
chr8_+_32405728 0.82 ENST00000523079.1
ENST00000338921.4
ENST00000356819.4
ENST00000287845.5
ENST00000341377.5
NRG1
neuregulin 1
chr5_-_114880533 0.80 ENST00000274457.3
FEM1C
fem-1 homolog c (C. elegans)
chr1_-_113498943 0.57 ENST00000369626.3
SLC16A1
solute carrier family 16 (monocarboxylate transporter), member 1
chr19_+_41497178 0.25 ENST00000324071.4
CYP2B6
cytochrome P450, family 2, subfamily B, polypeptide 6
chr7_-_151574191 0.19 ENST00000287878.4
PRKAG2
protein kinase, AMP-activated, gamma 2 non-catalytic subunit

Network of associatons between targets according to the STRING database.

First level regulatory network of BHLHE40

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
18.1 90.6 GO:2000255 negative regulation of male germ cell proliferation(GO:2000255)
17.8 53.3 GO:0046586 regulation of calcium-dependent cell-cell adhesion(GO:0046586)
14.7 58.9 GO:0033387 putrescine biosynthetic process from ornithine(GO:0033387)
8.1 24.3 GO:0003131 mesodermal-endodermal cell signaling(GO:0003131) programmed DNA elimination(GO:0031049) chromosome breakage(GO:0031052) histone H2A-S139 phosphorylation(GO:0035978) positive regulation of cellular response to X-ray(GO:2000685)
5.9 59.4 GO:0006189 'de novo' IMP biosynthetic process(GO:0006189)
5.8 29.0 GO:0071460 cellular response to cell-matrix adhesion(GO:0071460)
5.4 16.2 GO:0046294 formaldehyde catabolic process(GO:0046294)
4.9 19.6 GO:0021812 neuronal-glial interaction involved in cerebral cortex radial glia guided migration(GO:0021812)
4.9 19.5 GO:0046122 purine deoxyribonucleoside metabolic process(GO:0046122)
4.1 12.3 GO:0070407 oxidation-dependent protein catabolic process(GO:0070407)
3.3 16.6 GO:0010286 heat acclimation(GO:0010286) cellular heat acclimation(GO:0070370)
3.1 18.4 GO:0048254 snoRNA localization(GO:0048254)
2.9 17.2 GO:0055129 proline biosynthetic process(GO:0006561) L-proline biosynthetic process(GO:0055129)
2.8 11.4 GO:0033132 negative regulation of glucokinase activity(GO:0033132) negative regulation of hexokinase activity(GO:1903300)
2.8 8.4 GO:2000393 negative regulation of lamellipodium morphogenesis(GO:2000393)
2.5 12.4 GO:0032487 regulation of Rap protein signal transduction(GO:0032487)
2.4 11.9 GO:1902775 mitochondrial ribosome assembly(GO:0061668) mitochondrial large ribosomal subunit assembly(GO:1902775)
2.4 14.2 GO:0000720 pyrimidine dimer repair by nucleotide-excision repair(GO:0000720) positive regulation of t-circle formation(GO:1904431)
2.3 6.8 GO:0006422 aspartyl-tRNA aminoacylation(GO:0006422)
2.2 22.4 GO:0007000 nucleolus organization(GO:0007000)
2.2 10.8 GO:0071964 regulation of unidimensional cell growth(GO:0051510) negative regulation of unidimensional cell growth(GO:0051511) establishment of cell polarity regulating cell shape(GO:0071964) regulation of establishment or maintenance of cell polarity regulating cell shape(GO:2000769) positive regulation of establishment or maintenance of cell polarity regulating cell shape(GO:2000771) regulation of establishment of cell polarity regulating cell shape(GO:2000782) positive regulation of establishment of cell polarity regulating cell shape(GO:2000784) regulation of barbed-end actin filament capping(GO:2000812) positive regulation of barbed-end actin filament capping(GO:2000814)
2.0 22.0 GO:0006983 ER overload response(GO:0006983)
2.0 5.9 GO:1990523 bone regeneration(GO:1990523)
1.9 15.4 GO:0002326 B cell lineage commitment(GO:0002326) immunoglobulin V(D)J recombination(GO:0033152) ectopic germ cell programmed cell death(GO:0035234)
1.4 14.3 GO:0070836 caveola assembly(GO:0070836)
1.3 31.8 GO:0045663 positive regulation of myoblast differentiation(GO:0045663)
1.3 96.7 GO:0070126 mitochondrial translational elongation(GO:0070125) mitochondrial translational termination(GO:0070126)
1.2 3.7 GO:0008611 ether lipid biosynthetic process(GO:0008611) glycerol ether biosynthetic process(GO:0046504) ether biosynthetic process(GO:1901503)
1.2 38.9 GO:0042776 mitochondrial ATP synthesis coupled proton transport(GO:0042776)
1.2 19.0 GO:0032836 glomerular basement membrane development(GO:0032836)
1.2 39.5 GO:0008334 histone mRNA metabolic process(GO:0008334)
1.1 4.5 GO:1903660 negative regulation of complement-dependent cytotoxicity(GO:1903660)
1.1 6.7 GO:0009098 branched-chain amino acid biosynthetic process(GO:0009082) leucine biosynthetic process(GO:0009098) valine biosynthetic process(GO:0009099)
1.1 27.3 GO:0034643 establishment of mitochondrion localization, microtubule-mediated(GO:0034643) mitochondrion transport along microtubule(GO:0047497)
1.0 9.8 GO:0051597 response to methylmercury(GO:0051597)
0.9 8.1 GO:0031444 slow-twitch skeletal muscle fiber contraction(GO:0031444)
0.9 66.3 GO:0042273 ribosomal large subunit biogenesis(GO:0042273)
0.7 10.8 GO:0008635 activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c(GO:0008635)
0.5 2.0 GO:0006432 phenylalanyl-tRNA aminoacylation(GO:0006432)
0.5 46.5 GO:0048207 vesicle targeting, rough ER to cis-Golgi(GO:0048207) COPII vesicle coating(GO:0048208)
0.4 6.6 GO:0034975 protein folding in endoplasmic reticulum(GO:0034975)
0.4 3.6 GO:0042117 monocyte activation(GO:0042117)
0.4 4.6 GO:0033197 response to vitamin E(GO:0033197)
0.3 8.3 GO:0055070 copper ion homeostasis(GO:0055070)
0.3 9.8 GO:0044764 viral process(GO:0016032) multi-organism cellular process(GO:0044764)
0.3 7.9 GO:0006359 regulation of transcription from RNA polymerase III promoter(GO:0006359)
0.2 3.4 GO:0034372 very-low-density lipoprotein particle remodeling(GO:0034372) phosphatidylcholine catabolic process(GO:0034638)
0.2 2.2 GO:0006023 aminoglycan metabolic process(GO:0006022) aminoglycan biosynthetic process(GO:0006023) glycosaminoglycan biosynthetic process(GO:0006024) glycosaminoglycan metabolic process(GO:0030203)
0.2 13.3 GO:0006400 tRNA modification(GO:0006400)
0.2 9.6 GO:0006487 protein N-linked glycosylation(GO:0006487)
0.2 1.4 GO:0031087 deadenylation-independent decapping of nuclear-transcribed mRNA(GO:0031087)
0.2 21.4 GO:0051436 negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle(GO:0051436)
0.1 0.6 GO:0035879 plasma membrane lactate transport(GO:0035879)
0.1 2.9 GO:0097067 cellular response to thyroid hormone stimulus(GO:0097067)
0.1 2.7 GO:0002244 hematopoietic progenitor cell differentiation(GO:0002244)
0.1 3.0 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.1 5.3 GO:0061418 regulation of transcription from RNA polymerase II promoter in response to hypoxia(GO:0061418)
0.1 2.8 GO:0042501 serine phosphorylation of STAT protein(GO:0042501)
0.1 8.4 GO:0032781 positive regulation of ATPase activity(GO:0032781)
0.1 8.1 GO:0006406 mRNA export from nucleus(GO:0006406) mRNA-containing ribonucleoprotein complex export from nucleus(GO:0071427)
0.1 1.6 GO:0006376 mRNA splice site selection(GO:0006376)
0.0 1.3 GO:0034204 lipid translocation(GO:0034204) phospholipid translocation(GO:0045332)
0.0 0.9 GO:0021680 cerebellar Purkinje cell layer development(GO:0021680)
0.0 1.4 GO:0030490 maturation of SSU-rRNA(GO:0030490)
0.0 0.3 GO:0042738 exogenous drug catabolic process(GO:0042738)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
6.5 19.6 GO:0005607 laminin-2 complex(GO:0005607)
4.9 39.5 GO:0005683 U7 snRNP(GO:0005683) pICln-Sm protein complex(GO:0034715)
3.7 22.4 GO:0070545 PeBoW complex(GO:0070545)
2.7 13.3 GO:0043527 tRNA methyltransferase complex(GO:0043527)
2.6 15.4 GO:0005958 DNA-dependent protein kinase-DNA ligase 4 complex(GO:0005958)
2.4 59.3 GO:0030687 preribosome, large subunit precursor(GO:0030687)
2.3 18.4 GO:0070761 pre-snoRNP complex(GO:0070761)
2.2 24.3 GO:0035985 senescence-associated heterochromatin focus(GO:0035985)
2.2 38.9 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
2.1 83.6 GO:0005762 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
2.0 14.2 GO:0000110 nucleotide-excision repair factor 1 complex(GO:0000110) ERCC4-ERCC1 complex(GO:0070522)
2.0 87.1 GO:0005790 smooth endoplasmic reticulum(GO:0005790)
1.1 4.5 GO:0034751 aryl hydrocarbon receptor complex(GO:0034751)
1.1 5.3 GO:0030891 VCB complex(GO:0030891)
0.9 4.7 GO:0034388 Pwp2p-containing subcomplex of 90S preribosome(GO:0034388)
0.9 4.6 GO:0035061 interchromatin granule(GO:0035061)
0.9 14.2 GO:0019774 proteasome core complex, beta-subunit complex(GO:0019774)
0.9 6.8 GO:0032389 MutLalpha complex(GO:0032389)
0.8 9.6 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.8 10.8 GO:0035631 CD40 receptor complex(GO:0035631)
0.7 6.6 GO:0072546 ER membrane protein complex(GO:0072546)
0.6 31.8 GO:0043034 costamere(GO:0043034)
0.6 16.6 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.6 46.5 GO:0012507 ER to Golgi transport vesicle membrane(GO:0012507)
0.6 15.2 GO:0000930 gamma-tubulin complex(GO:0000930)
0.5 29.0 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.4 24.2 GO:0009295 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.4 2.9 GO:0036021 endolysosome lumen(GO:0036021)
0.4 12.4 GO:0051233 spindle midzone(GO:0051233)
0.4 8.9 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)
0.3 8.1 GO:0005861 troponin complex(GO:0005861)
0.3 6.8 GO:0017101 aminoacyl-tRNA synthetase multienzyme complex(GO:0017101)
0.3 10.8 GO:0031258 lamellipodium membrane(GO:0031258)
0.2 7.2 GO:0005680 anaphase-promoting complex(GO:0005680)
0.2 20.7 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.2 14.3 GO:0055038 recycling endosome membrane(GO:0055038)
0.2 50.2 GO:0005759 mitochondrial matrix(GO:0005759)
0.1 65.0 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.1 1.6 GO:0071004 U2-type prespliceosome(GO:0071004)
0.1 3.4 GO:0034364 high-density lipoprotein particle(GO:0034364)
0.1 3.7 GO:0005782 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.1 8.1 GO:0005643 nuclear pore(GO:0005643)
0.1 8.4 GO:0032587 ruffle membrane(GO:0032587)
0.1 4.2 GO:0031594 neuromuscular junction(GO:0031594)
0.0 3.5 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.0 0.9 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.0 0.2 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.0 1.4 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
11.3 90.6 GO:0008379 thioredoxin peroxidase activity(GO:0008379)
8.1 24.3 GO:0035501 MH1 domain binding(GO:0035501)
5.1 15.4 GO:0004677 DNA-dependent protein kinase activity(GO:0004677)
4.3 17.2 GO:0016774 phosphotransferase activity, carboxyl group as acceptor(GO:0016774)
4.1 12.3 GO:0070364 mitochondrial light strand promoter anti-sense binding(GO:0070361) mitochondrial heavy strand promoter anti-sense binding(GO:0070362) mitochondrial heavy strand promoter sense binding(GO:0070364)
3.9 39.5 GO:1990446 U1 snRNP binding(GO:1990446)
3.2 19.5 GO:0019136 deoxynucleoside kinase activity(GO:0019136)
2.4 54.1 GO:0016881 acid-amino acid ligase activity(GO:0016881)
2.2 32.6 GO:0001094 TFIID-class transcription factor binding(GO:0001094)
1.6 16.2 GO:0004022 alcohol dehydrogenase (NAD) activity(GO:0004022)
1.5 4.5 GO:0032551 pyrimidine nucleoside binding(GO:0001884) UTP binding(GO:0002134) sulfonylurea receptor binding(GO:0017098) pyrimidine ribonucleoside binding(GO:0032551)
1.2 3.6 GO:0016434 rRNA (cytosine) methyltransferase activity(GO:0016434)
1.1 6.7 GO:0052655 branched-chain-amino-acid transaminase activity(GO:0004084) L-leucine transaminase activity(GO:0052654) L-valine transaminase activity(GO:0052655) L-isoleucine transaminase activity(GO:0052656)
1.1 13.3 GO:0016423 tRNA (guanine) methyltransferase activity(GO:0016423)
1.1 58.9 GO:0016831 carboxy-lyase activity(GO:0016831)
1.0 6.8 GO:0004046 aminoacylase activity(GO:0004046)
1.0 53.3 GO:0017080 sodium channel regulator activity(GO:0017080)
0.8 9.8 GO:0016634 oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor(GO:0016634)
0.6 27.3 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.6 14.3 GO:0070300 phosphatidic acid binding(GO:0070300)
0.6 8.1 GO:0031014 troponin T binding(GO:0031014)
0.5 2.0 GO:0004826 phenylalanine-tRNA ligase activity(GO:0004826)
0.5 14.2 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.4 12.4 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.4 11.4 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.4 37.7 GO:0015078 hydrogen ion transmembrane transporter activity(GO:0015078)
0.4 87.0 GO:0003735 structural constituent of ribosome(GO:0003735)
0.4 2.2 GO:0008467 [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity(GO:0008467)
0.3 3.7 GO:0016290 palmitoyl-CoA hydrolase activity(GO:0016290) O-acetyltransferase activity(GO:0016413)
0.3 16.6 GO:0004407 histone deacetylase activity(GO:0004407)
0.3 3.3 GO:0004645 phosphorylase activity(GO:0004645)
0.3 3.0 GO:0033038 bitter taste receptor activity(GO:0033038)
0.3 8.4 GO:0001671 ATPase activator activity(GO:0001671)
0.2 0.9 GO:0004461 lactose synthase activity(GO:0004461)
0.2 4.7 GO:0030515 snoRNA binding(GO:0030515)
0.2 17.3 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.2 8.1 GO:0008536 Ran GTPase binding(GO:0008536)
0.2 8.9 GO:0003899 DNA-directed RNA polymerase activity(GO:0003899)
0.2 31.9 GO:0005178 integrin binding(GO:0005178)
0.2 3.4 GO:0034185 apolipoprotein binding(GO:0034185)
0.1 34.2 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.1 3.2 GO:0019843 rRNA binding(GO:0019843)
0.1 10.8 GO:1902936 phosphatidylinositol bisphosphate binding(GO:1902936)
0.1 6.8 GO:0003697 single-stranded DNA binding(GO:0003697)
0.1 4.6 GO:0005080 protein kinase C binding(GO:0005080)
0.1 4.6 GO:0016763 transferase activity, transferring pentosyl groups(GO:0016763)
0.1 2.9 GO:0043394 proteoglycan binding(GO:0043394)
0.1 4.9 GO:0005507 copper ion binding(GO:0005507)
0.1 7.5 GO:0008013 beta-catenin binding(GO:0008013)
0.1 0.6 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
0.1 102.5 GO:0003723 RNA binding(GO:0003723)
0.1 1.3 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.0 5.9 GO:0008201 heparin binding(GO:0008201)
0.0 17.5 GO:0005509 calcium ion binding(GO:0005509)
0.0 1.9 GO:0051213 dioxygenase activity(GO:0051213)
0.0 0.2 GO:0008607 phosphorylase kinase regulator activity(GO:0008607)
0.0 2.8 GO:0005125 cytokine activity(GO:0005125)
0.0 0.3 GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen(GO:0016712)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 19.6 PID INTEGRIN4 PATHWAY Alpha6 beta4 integrin-ligand interactions
0.8 25.7 SA PTEN PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.6 29.0 PID MYC PATHWAY C-MYC pathway
0.6 65.6 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.6 19.0 SA G1 AND S PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
0.5 15.4 PID DNA PK PATHWAY DNA-PK pathway in nonhomologous end joining
0.5 37.9 PID HNF3A PATHWAY FOXA1 transcription factor network
0.3 25.4 PID E2F PATHWAY E2F transcription factor network
0.3 16.6 PID HEDGEHOG GLI PATHWAY Hedgehog signaling events mediated by Gli proteins
0.2 5.3 PID HIF1A PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.1 10.8 PID CASPASE PATHWAY Caspase cascade in apoptosis
0.1 2.8 PID IL23 PATHWAY IL23-mediated signaling events
0.0 4.5 PID VEGFR1 2 PATHWAY Signaling events mediated by VEGFR1 and VEGFR2
0.0 5.9 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 2.9 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
3.5 59.4 REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
2.5 39.5 REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
2.4 58.9 REACTOME METABOLISM OF POLYAMINES Genes involved in Metabolism of polyamines
1.7 38.9 REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING Genes involved in Formation of ATP by chemiosmotic coupling
1.1 31.8 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.8 19.5 REACTOME PURINE SALVAGE Genes involved in Purine salvage
0.8 47.4 REACTOME TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION Genes involved in Transport to the Golgi and subsequent modification
0.6 17.2 REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.5 15.4 REACTOME SEMA3A PAK DEPENDENT AXON REPULSION Genes involved in Sema3A PAK dependent Axon repulsion
0.5 14.2 REACTOME FORMATION OF INCISION COMPLEX IN GG NER Genes involved in Formation of incision complex in GG-NER
0.5 15.4 REACTOME DOUBLE STRAND BREAK REPAIR Genes involved in Double-Strand Break Repair
0.5 50.4 REACTOME APC C CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 Genes involved in APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
0.4 9.8 REACTOME METABOLISM OF PORPHYRINS Genes involved in Metabolism of porphyrins
0.3 15.8 REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.2 6.7 REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.2 2.9 REACTOME TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR Genes involved in Trafficking and processing of endosomal TLR
0.2 6.8 REACTOME CYTOSOLIC TRNA AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.2 5.3 REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.2 3.4 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.1 19.6 REACTOME L1CAM INTERACTIONS Genes involved in L1CAM interactions
0.1 8.1 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.1 4.6 REACTOME CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION Genes involved in Cleavage of Growing Transcript in the Termination Region
0.1 3.7 REACTOME PEROXISOMAL LIPID METABOLISM Genes involved in Peroxisomal lipid metabolism
0.1 1.4 REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
0.1 2.2 REACTOME HS GAG BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.1 3.5 REACTOME INTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Intrinsic Pathway for Apoptosis
0.0 0.6 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.0 1.3 REACTOME ION TRANSPORT BY P TYPE ATPASES Genes involved in Ion transport by P-type ATPases
0.0 3.5 REACTOME PEPTIDE CHAIN ELONGATION Genes involved in Peptide chain elongation
0.0 0.3 REACTOME XENOBIOTICS Genes involved in Xenobiotics