GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)


Results for CCUUGGC

Z-value: 0.89

Motif logo

miRNA associated with seed CCUUGGC

NamemiRBASE accession

Activity profile of CCUUGGC motif

Sorted Z-values of CCUUGGC motif

Promoter Log-likelihood Transcript Gene Gene Info
chr7_-_71801980 0.81 ENST00000329008.5
calneuron 1
chr1_+_54519242 0.64 ENST00000234827.1
transcription elongation factor A (SII) N-terminal and central domain containing 2
chr16_-_46865047 0.60 ENST00000394806.2
chromosome 16 open reading frame 87
chr4_+_128554081 0.59 ENST00000335251.6
inturned planar cell polarity protein
chr19_+_42724423 0.58 ENST00000301215.3
zinc finger protein 526
chr3_-_114790179 0.50 ENST00000462705.1
zinc finger and BTB domain containing 20
chr16_+_50775948 0.50 ENST00000569681.1
cylindromatosis (turban tumor syndrome)
chr17_+_47865917 0.42 ENST00000259021.4
K(lysine) acetyltransferase 7
chr15_+_75118888 0.41 ENST00000395018.4
complexin 3
chr17_+_57232690 0.41 ENST00000262293.4
proline rich 11
chr5_+_176560742 0.40 ENST00000439151.2
nuclear receptor binding SET domain protein 1
chr17_+_38599693 0.40 ENST00000542955.1
insulin-like growth factor binding protein 4
chr2_-_201936302 0.40 ENST00000453765.1
family with sequence similarity 126, member B
chr15_+_41952591 0.39 ENST00000566718.1
MGA, MAX dimerization protein
chrX_-_50557014 0.38 ENST00000376020.2
shroom family member 4
chr16_+_81348528 0.37 ENST00000568107.2
chr9_-_110251836 0.37 ENST00000374672.4
Kruppel-like factor 4 (gut)
chr9_-_127269661 0.36 ENST00000373588.4
nuclear receptor subfamily 5, group A, member 1
chr17_-_76713100 0.35 ENST00000585509.1
cytohesin 1
chr7_+_77325738 0.34 ENST00000334955.8
round spermatid basic protein 1-like
chrY_+_15016725 0.33 ENST00000336079.3
DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
chr8_-_82024290 0.33 ENST00000220597.4
phosphoprotein associated with glycosphingolipid microdomains 1
chrX_+_122993827 0.33 ENST00000371199.3
X-linked inhibitor of apoptosis
chr16_-_2264779 0.33 ENST00000333503.7
phosphoglycolate phosphatase
chr18_+_42260861 0.33 ENST00000282030.5
SET binding protein 1
chr6_-_91006461 0.32 ENST00000257749.4
BTB and CNC homology 1, basic leucine zipper transcription factor 2
chr15_-_34628951 0.30 ENST00000397707.2
solute carrier family 12 (potassium/chloride transporter), member 6
chr4_-_87855851 0.30 ENST00000473559.1
chromosome 4 open reading frame 36
chr16_-_71610985 0.30 ENST00000355962.4
tyrosine aminotransferase
chr11_-_117103208 0.29 ENST00000320934.3
proprotein convertase subtilisin/kexin type 7
chr9_-_35665165 0.28 ENST00000343259.3
Rho guanine nucleotide exchange factor (GEF) 39
chr3_-_53880401 0.28 ENST00000315251.6
choline dehydrogenase
chr9_-_127533519 0.27 ENST00000487099.2
nuclear receptor subfamily 6, group A, member 1
chr16_-_89007491 0.27 ENST00000327483.5
core-binding factor, runt domain, alpha subunit 2; translocated to, 3
chrX_+_77166172 0.27 ENST00000343533.5
ATPase, Cu++ transporting, alpha polypeptide
chr17_-_62207485 0.26 ENST00000433197.3
endoplasmic reticulum to nucleus signaling 1
chr2_-_27938593 0.25 ENST00000379677.2
Uncharacterized protein
chr5_-_37839782 0.25 ENST00000326524.2
glial cell derived neurotrophic factor
chr1_+_11751748 0.25 ENST00000294485.5
dorsal inhibitory axon guidance protein
chr2_+_61108650 0.24 ENST00000295025.8
v-rel avian reticuloendotheliosis viral oncogene homolog
chr1_-_89591749 0.24 ENST00000370466.3
guanylate binding protein 2, interferon-inducible
chr9_+_132427883 0.24 ENST00000372469.4
paired related homeobox 2
chr17_+_47572647 0.24 ENST00000172229.3
nerve growth factor receptor
chr21_+_33245548 0.24 ENST00000270112.2
hormonally up-regulated Neu-associated kinase
chr18_+_13218769 0.23 ENST00000399848.3
low density lipoprotein receptor class A domain containing 4
chr17_-_8151353 0.23 ENST00000315684.8
CTS telomere maintenance complex component 1
chr9_-_135996537 0.22 ENST00000372050.3
ral guanine nucleotide dissociation stimulator
chr8_+_56014949 0.22 ENST00000327381.6
XK, Kell blood group complex subunit-related family, member 4
chr5_-_107006596 0.22 ENST00000333274.6
chr3_-_15374033 0.20 ENST00000253688.5
SH3-domain binding protein 5 (BTK-associated)
chr17_+_8213590 0.20 ENST00000361926.3
Rho guanine nucleotide exchange factor (GEF) 15
chr11_-_119599794 0.19 ENST00000264025.3
poliovirus receptor-related 1 (herpesvirus entry mediator C)
chr20_+_37434329 0.19 ENST00000299824.1
protein phosphatase 1, regulatory subunit 16B
chr1_+_16330723 0.19 ENST00000329454.2
chromosome 1 open reading frame 64
chr10_+_72164135 0.19 ENST00000373218.4
eukaryotic translation initiation factor 4E binding protein 2
chr17_-_38657849 0.19 ENST00000254051.6
tensin 4
chr5_+_109025067 0.18 ENST00000261483.4
mannosidase, alpha, class 2A, member 1
chr16_-_18937726 0.18 ENST00000389467.3
SMG1 phosphatidylinositol 3-kinase-related kinase
chr1_-_150979333 0.18 ENST00000312210.5
family with sequence similarity 63, member A
chr2_+_219264466 0.18 ENST00000273062.2
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1
chr9_-_27529726 0.17 ENST00000262244.5
MOB kinase activator 3B
chr14_+_103851712 0.17 ENST00000440884.3
MAP/microtubule affinity-regulating kinase 3
chr19_+_7953384 0.16 ENST00000306708.6
leucine rich repeat containing 8 family, member E
chr9_+_104161123 0.16 ENST00000374861.3
zinc finger protein 189
chr10_-_74114714 0.15 ENST00000338820.3
DnaJ (Hsp40) homolog, subfamily B, member 12
chr1_-_40105617 0.14 ENST00000372852.3
hes-related family bHLH transcription factor with YRPW motif-like
chr12_-_117319236 0.14 ENST00000257572.5
harakiri, BCL2 interacting protein (contains only BH3 domain)
chr1_-_117664317 0.14 ENST00000256649.4
tripartite motif containing 45
chr9_-_20622478 0.14 ENST00000355930.6
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3
chr3_+_38495333 0.13 ENST00000352511.4
activin A receptor, type IIB
chr22_+_50247449 0.12 ENST00000216268.5
zinc finger, BED-type containing 4
chr10_-_103874692 0.12 ENST00000361198.5
LIM domain binding 1
chr16_-_15736953 0.12 ENST00000548025.1
chr5_+_139927213 0.12 ENST00000310331.2
eukaryotic translation initiation factor 4E binding protein 3
chrX_-_13956737 0.12 ENST00000454189.2
glycoprotein M6B
chr9_-_16870704 0.11 ENST00000380672.4
basonuclin 2
chr14_-_95786200 0.11 ENST00000298912.4
calmin (calponin-like, transmembrane)
chr1_+_25757376 0.11 ENST00000399766.3
transmembrane protein 57
chr20_+_33814457 0.11 ENST00000246186.6
matrix metallopeptidase 24 (membrane-inserted)
chr3_+_30648066 0.11 ENST00000359013.4
transforming growth factor, beta receptor II (70/80kDa)
chr11_-_82782861 0.11 ENST00000524635.1
RAB30, member RAS oncogene family
chr3_-_116164306 0.11 ENST00000490035.2
limbic system-associated membrane protein
chr1_+_214161272 0.11 ENST00000498508.2
prospero homeobox 1
chr8_+_128426535 0.10 ENST00000465342.2
POU class 5 homeobox 1B
chr2_+_168725458 0.10 ENST00000392690.3
UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1
chr2_-_96931679 0.09 ENST00000258439.3
transmembrane protein 127
chr13_-_79177673 0.09 ENST00000377208.5
POU class 4 homeobox 1
chr6_+_50786414 0.09 ENST00000344788.3
transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
chr1_-_23495340 0.08 ENST00000418342.1
leucine zipper protein 1
chrX_+_49687216 0.07 ENST00000376088.3
chloride channel, voltage-sensitive 5
chr13_-_36920420 0.07 ENST00000438666.2
spastic paraplegia 20 (Troyer syndrome)
chr2_+_192542850 0.06 ENST00000410026.2
nucleic acid binding protein 1
chr1_+_205012293 0.06 ENST00000331830.4
contactin 2 (axonal)
chr15_+_27111510 0.06 ENST00000335625.5
gamma-aminobutyric acid (GABA) A receptor, alpha 5
chr17_-_45266542 0.06 ENST00000531206.1
cell division cycle 27
chr10_+_48189612 0.06 ENST00000453919.1
ArfGAP with GTPase domain, ankyrin repeat and PH domain 9
chr1_+_2985760 0.06 ENST00000378391.2
PR domain containing 16
chr1_-_208417620 0.06 ENST00000367033.3
plexin A2
chr6_-_99395787 0.05 ENST00000369244.2
F-box and leucine-rich repeat protein 4
chr3_+_57261743 0.05 ENST00000288266.3
adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1
chr20_-_48099182 0.05 ENST00000371741.4
potassium voltage-gated channel, Shab-related subfamily, member 1
chr5_+_139781445 0.04 ENST00000532219.1
ANKHD1-EIF4EBP3 readthrough
ankyrin repeat and KH domain containing 1
chr10_-_105677886 0.04 ENST00000224950.3
oligonucleotide/oligosaccharide-binding fold containing 1
chr8_-_8751068 0.04 ENST00000276282.6
malignant fibrous histiocytoma amplified sequence 1
chr12_-_54673871 0.04 ENST00000209875.4
chromobox homolog 5
chr7_+_44788430 0.04 ENST00000457123.1
zinc finger, MIZ-type containing 2
chr3_-_50396978 0.02 ENST00000266025.3
transmembrane protein 115
chrX_+_69664706 0.02 ENST00000194900.4
discs, large homolog 3 (Drosophila)
chr12_-_58240470 0.02 ENST00000548823.1
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2
chr15_-_35261996 0.01 ENST00000156471.5
aquarius intron-binding spliceosomal factor
chr4_+_6784401 0.01 ENST00000425103.1
chr11_+_120207787 0.00 ENST00000397843.2
Rho guanine nucleotide exchange factor (GEF) 12
chr19_+_48216600 0.00 ENST00000263277.3
EH-domain containing 2
chr12_+_120972147 0.00 ENST00000325954.4
ring finger protein 10

Network of associatons between targets according to the STRING database.

First level regulatory network of CCUUGGC

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.5 GO:1990108 protein linear deubiquitination(GO:1990108)
0.1 0.4 GO:0071409 negative regulation of muscle hyperplasia(GO:0014740) cellular response to cycloheximide(GO:0071409)
0.1 0.3 GO:1902530 regulation of protein linear polyubiquitination(GO:1902528) positive regulation of protein linear polyubiquitination(GO:1902530)
0.1 0.4 GO:0043983 histone H4-K12 acetylation(GO:0043983)
0.1 0.4 GO:0007538 primary sex determination(GO:0007538)
0.1 0.3 GO:0071284 cellular response to lead ion(GO:0071284)
0.1 0.3 GO:0006114 glycerol biosynthetic process(GO:0006114)
0.1 0.4 GO:1903587 regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:1903587)
0.1 0.2 GO:0021784 postganglionic parasympathetic fiber development(GO:0021784)
0.1 0.3 GO:0042539 hypotonic salinity response(GO:0042539) cellular hypotonic salinity response(GO:0071477)
0.1 0.4 GO:0000414 regulation of histone H3-K36 methylation(GO:0000414)
0.0 0.1 GO:2000824 negative regulation of androgen receptor activity(GO:2000824)
0.0 0.2 GO:0048539 bone marrow development(GO:0048539)
0.0 0.3 GO:0006572 tyrosine catabolic process(GO:0006572)
0.0 0.6 GO:0010839 negative regulation of keratinocyte proliferation(GO:0010839)
0.0 0.3 GO:0042426 choline catabolic process(GO:0042426)
0.0 0.3 GO:1903715 regulation of aerobic respiration(GO:1903715)
0.0 0.3 GO:0036289 peptidyl-serine autophosphorylation(GO:0036289)
0.0 0.1 GO:0002661 B cell tolerance induction(GO:0002514) regulation of B cell tolerance induction(GO:0002661) positive regulation of B cell tolerance induction(GO:0002663)
0.0 0.1 GO:0046619 optic placode formation involved in camera-type eye formation(GO:0046619)
0.0 0.1 GO:0021538 epithalamus development(GO:0021538) habenula development(GO:0021986)
0.0 0.2 GO:0035331 negative regulation of hippo signaling(GO:0035331)
0.0 0.1 GO:0046985 positive regulation of hemoglobin biosynthetic process(GO:0046985)
0.0 0.2 GO:0006013 mannose metabolic process(GO:0006013)
0.0 0.2 GO:0048672 positive regulation of collateral sprouting(GO:0048672)
0.0 0.1 GO:0031133 regulation of axon diameter(GO:0031133) positive regulation of adenosine receptor signaling pathway(GO:0060168)
0.0 0.2 GO:0010991 negative regulation of SMAD protein complex assembly(GO:0010991)
0.0 0.4 GO:0044342 positive regulation of insulin-like growth factor receptor signaling pathway(GO:0043568) type B pancreatic cell proliferation(GO:0044342)
0.0 0.2 GO:0061299 retina vasculature morphogenesis in camera-type eye(GO:0061299)
0.0 0.1 GO:0061298 retina vasculature development in camera-type eye(GO:0061298)
0.0 0.4 GO:0032012 regulation of ARF protein signal transduction(GO:0032012)
0.0 0.1 GO:0048696 regulation of collateral sprouting in absence of injury(GO:0048696) negative regulation of collateral sprouting in absence of injury(GO:0048698)
0.0 0.2 GO:0021516 dorsal spinal cord development(GO:0021516)
0.0 0.2 GO:0032688 negative regulation of interferon-beta production(GO:0032688)
0.0 0.0 GO:0010701 positive regulation of norepinephrine secretion(GO:0010701)
0.0 0.1 GO:0051612 negative regulation of neurotransmitter uptake(GO:0051581) serotonin uptake(GO:0051610) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612)
0.0 0.3 GO:0045947 negative regulation of translational initiation(GO:0045947)
0.0 0.1 GO:0007379 segment specification(GO:0007379) positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096)
0.0 0.1 GO:0072501 cellular divalent inorganic anion homeostasis(GO:0072501)
0.0 0.1 GO:0006682 galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375)
0.0 0.2 GO:0070389 chaperone cofactor-dependent protein refolding(GO:0070389)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:1990604 IRE1-TRAF2-ASK1 complex(GO:1990604)
0.0 0.2 GO:0033256 I-kappaB/NF-kappaB complex(GO:0033256)
0.0 0.1 GO:0070876 SOSS complex(GO:0070876)
0.0 0.2 GO:0031362 anchored component of external side of plasma membrane(GO:0031362)
0.0 0.2 GO:0000783 telomere cap complex(GO:0000782) nuclear telomere cap complex(GO:0000783)
0.0 0.1 GO:0070022 transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.0 1.1 GO:0036064 ciliary basal body(GO:0036064)
0.0 0.4 GO:0005719 nuclear euchromatin(GO:0005719)
0.0 0.4 GO:0044665 MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339)
0.0 0.7 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0042799 histone methyltransferase activity (H4-K20 specific)(GO:0042799)
0.1 0.3 GO:0098519 nucleotide phosphatase activity, acting on free nucleotides(GO:0098519)
0.1 0.3 GO:0080130 L-phenylalanine aminotransferase activity(GO:0070546) L-phenylalanine:2-oxoglutarate aminotransferase activity(GO:0080130)
0.1 0.3 GO:0032767 copper-dependent protein binding(GO:0032767)
0.1 0.4 GO:0001010 transcription factor activity, sequence-specific DNA binding transcription factor recruiting(GO:0001010)
0.1 0.2 GO:0005169 neurotrophin TRKB receptor binding(GO:0005169)
0.0 0.5 GO:1990380 Lys63-specific deubiquitinase activity(GO:0061578) Lys48-specific deubiquitinase activity(GO:1990380)
0.0 0.2 GO:0008420 CTD phosphatase activity(GO:0008420)
0.0 0.1 GO:0035939 microsatellite binding(GO:0035939)
0.0 0.4 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.0 0.1 GO:0047275 glucosaminylgalactosylglucosylceramide beta-galactosyltransferase activity(GO:0047275)
0.0 0.3 GO:0001206 transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206)
0.0 0.3 GO:0015379 potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820)
0.0 0.1 GO:0005026 transforming growth factor beta receptor activity, type II(GO:0005026)
0.0 0.4 GO:0003688 DNA replication origin binding(GO:0003688)
0.0 0.2 GO:0048406 nerve growth factor binding(GO:0048406)
0.0 0.2 GO:0098505 G-rich strand telomeric DNA binding(GO:0098505)
0.0 0.1 GO:0017002 activin-activated receptor activity(GO:0017002)
0.0 0.3 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
0.0 0.2 GO:0005225 volume-sensitive anion channel activity(GO:0005225)
0.0 0.2 GO:0015924 mannosyl-oligosaccharide mannosidase activity(GO:0015924)
0.0 0.4 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.0 0.1 GO:0050692 DBD domain binding(GO:0050692)
0.0 0.3 GO:0005161 platelet-derived growth factor receptor binding(GO:0005161)
0.0 0.1 GO:0030274 LIM domain binding(GO:0030274)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 PID WNT SIGNALING PATHWAY Wnt signaling network
0.0 0.5 PID NFKAPPAB CANONICAL PATHWAY Canonical NF-kappaB pathway
0.0 0.3 SA CASPASE CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.0 0.2 REACTOME NFKB IS ACTIVATED AND SIGNALS SURVIVAL Genes involved in NF-kB is activated and signals survival
0.0 0.4 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0 0.3 REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.0 0.2 REACTOME P38MAPK EVENTS Genes involved in p38MAPK events
0.0 0.5 REACTOME NOD1 2 SIGNALING PATHWAY Genes involved in NOD1/2 Signaling Pathway
0.0 0.2 REACTOME NONSENSE MEDIATED DECAY ENHANCED BY THE EXON JUNCTION COMPLEX Genes involved in Nonsense Mediated Decay Enhanced by the Exon Junction Complex