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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)

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Results for CENPB

Z-value: 0.67

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Transcription factors associated with CENPB

Gene Symbol Gene ID Gene Info
CENPB
ENSG00000125817.7 centromere protein B

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
CENPBhg19_v2_chr20_-_3767324_3767443-0.481.1e-13Click!

Activity profile of CENPB motif

Sorted Z-values of CENPB motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr11_+_71791849 23.26 ENST00000423494.2
ENST00000539587.1
ENST00000538478.1
ENST00000324866.7
ENST00000439209.1
LRTOMT
leucine rich transmembrane and O-methyltransferase domain containing
chr11_+_71791693 21.27 ENST00000289488.2
ENST00000447974.1
LRTOMT
leucine rich transmembrane and O-methyltransferase domain containing
chr11_+_82612740 20.48 ENST00000524921.1
ENST00000528759.1
ENST00000525361.1
ENST00000430323.2
ENST00000533655.1
ENST00000532764.1
ENST00000532589.1
ENST00000525388.1
C11orf82
chromosome 11 open reading frame 82
chr1_-_156390128 18.90 ENST00000368242.3
C1orf61
chromosome 1 open reading frame 61
chr15_+_45879321 13.03 ENST00000220531.3
ENST00000567461.1
BLOC1S6
biogenesis of lysosomal organelles complex-1, subunit 6, pallidin
chr8_-_56685859 12.06 ENST00000523423.1
ENST00000523073.1
ENST00000519784.1
ENST00000434581.2
ENST00000519780.1
ENST00000521229.1
ENST00000522576.1
ENST00000523180.1
ENST00000522090.1
TMEM68
transmembrane protein 68
chr3_+_15468862 11.32 ENST00000396842.2
EAF1
ELL associated factor 1
chr15_+_45879534 10.95 ENST00000564080.1
ENST00000562384.1
ENST00000569076.1
ENST00000566753.1
RP11-96O20.4
BLOC1S6
Uncharacterized protein
biogenesis of lysosomal organelles complex-1, subunit 6, pallidin
chr19_+_57831829 10.82 ENST00000321545.4
ZNF543
zinc finger protein 543
chr3_-_15469006 10.26 ENST00000443029.1
ENST00000383790.3
ENST00000383789.5
METTL6
methyltransferase like 6
chr5_+_80597419 10.25 ENST00000254037.2
ENST00000407610.3
ENST00000380199.5
ZCCHC9
zinc finger, CCHC domain containing 9
chr17_-_72869086 9.46 ENST00000581530.1
ENST00000420580.2
ENST00000455107.2
ENST00000413947.2
ENST00000581219.1
ENST00000582944.1
FDXR
ferredoxin reductase
chr18_-_51750948 9.46 ENST00000583046.1
ENST00000398398.2
MBD2
methyl-CpG binding domain protein 2
chr18_+_54318566 9.18 ENST00000589935.1
ENST00000357574.3
WDR7
WD repeat domain 7
chr19_+_12035913 9.12 ENST00000591944.1
ZNF763
Uncharacterized protein; Zinc finger protein 763
chr19_+_48867652 8.81 ENST00000344846.2
SYNGR4
synaptogyrin 4
chr9_-_127533582 8.62 ENST00000416460.2
NR6A1
nuclear receptor subfamily 6, group A, member 1
chr18_+_54318616 8.02 ENST00000254442.3
WDR7
WD repeat domain 7
chr22_-_20104700 8.00 ENST00000439169.2
ENST00000445045.1
ENST00000404751.3
ENST00000252136.7
ENST00000403707.3
TRMT2A
tRNA methyltransferase 2 homolog A (S. cerevisiae)
chr17_-_72869140 7.67 ENST00000583917.1
ENST00000293195.5
ENST00000442102.2
FDXR
ferredoxin reductase
chr9_-_139096955 7.51 ENST00000371748.5
LHX3
LIM homeobox 3
chr7_-_102158157 7.33 ENST00000541662.1
ENST00000306682.6
ENST00000465829.1
RASA4B
RAS p21 protein activator 4B
chr22_+_20104947 7.21 ENST00000402752.1
RANBP1
RAN binding protein 1
chr19_+_35168567 7.13 ENST00000457781.2
ENST00000505163.1
ENST00000505242.1
ENST00000423823.2
ENST00000507959.1
ENST00000446502.2
ZNF302
zinc finger protein 302
chrX_+_70586140 7.12 ENST00000276072.3
TAF1
TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa
chr15_-_48470558 7.04 ENST00000324324.7
MYEF2
myelin expression factor 2
chr1_+_11724167 6.95 ENST00000376753.4
FBXO6
F-box protein 6
chr19_-_58609570 6.86 ENST00000600845.1
ENST00000240727.6
ENST00000600897.1
ENST00000421612.2
ENST00000601063.1
ENST00000601144.1
ZSCAN18
zinc finger and SCAN domain containing 18
chr7_-_158937633 6.72 ENST00000262178.2
VIPR2
vasoactive intestinal peptide receptor 2
chr20_+_55205825 6.69 ENST00000544508.1
TFAP2C
transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
chr9_-_123342415 6.66 ENST00000349780.4
ENST00000360190.4
ENST00000360822.3
ENST00000359309.3
CDK5RAP2
CDK5 regulatory subunit associated protein 2
chr2_-_241500447 6.32 ENST00000536462.1
ENST00000405002.1
ENST00000441168.1
ENST00000403283.1
ANKMY1
ankyrin repeat and MYND domain containing 1
chrY_+_2709906 6.27 ENST00000430575.1
RPS4Y1
ribosomal protein S4, Y-linked 1
chr5_+_137225158 6.27 ENST00000290431.5
PKD2L2
polycystic kidney disease 2-like 2
chr2_-_103353277 5.99 ENST00000258436.5
MFSD9
major facilitator superfamily domain containing 9
chrX_+_70586082 5.93 ENST00000373790.4
ENST00000449580.1
ENST00000423759.1
TAF1
TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa
chr16_+_66968343 5.85 ENST00000417689.1
ENST00000561697.1
ENST00000317091.4
ENST00000566182.1
CES2
carboxylesterase 2
chr7_-_150038704 5.79 ENST00000466675.1
ENST00000482669.1
ENST00000467793.1
ENST00000223271.3
RARRES2
retinoic acid receptor responder (tazarotene induced) 2
chr9_-_127533519 5.78 ENST00000487099.2
ENST00000344523.4
ENST00000373584.3
NR6A1
nuclear receptor subfamily 6, group A, member 1
chrY_+_2709527 5.73 ENST00000250784.8
RPS4Y1
ribosomal protein S4, Y-linked 1
chr1_-_151319283 5.73 ENST00000392746.3
RFX5
regulatory factor X, 5 (influences HLA class II expression)
chr20_-_41818373 5.62 ENST00000373187.1
ENST00000356100.2
ENST00000373184.1
ENST00000373190.1
PTPRT
protein tyrosine phosphatase, receptor type, T
chr11_+_73019282 5.60 ENST00000263674.3
ARHGEF17
Rho guanine nucleotide exchange factor (GEF) 17
chr11_-_71791435 5.58 ENST00000351960.6
ENST00000541719.1
ENST00000535111.1
NUMA1
nuclear mitotic apparatus protein 1
chr20_-_55841662 5.38 ENST00000395863.3
ENST00000450594.2
BMP7
bone morphogenetic protein 7
chr6_-_39197226 5.19 ENST00000359534.3
KCNK5
potassium channel, subfamily K, member 5
chr20_-_55841398 5.16 ENST00000395864.3
BMP7
bone morphogenetic protein 7
chr22_+_39853258 5.05 ENST00000341184.6
MGAT3
mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase
chr11_-_71791518 4.95 ENST00000537217.1
ENST00000366394.3
ENST00000358965.6
ENST00000546131.1
ENST00000543937.1
ENST00000368959.5
ENST00000541641.1
NUMA1
nuclear mitotic apparatus protein 1
chr16_-_30569801 4.91 ENST00000395091.2
ZNF764
zinc finger protein 764
chr15_+_63569785 4.89 ENST00000380343.4
ENST00000560353.1
APH1B
APH1B gamma secretase subunit
chr6_-_166582107 4.86 ENST00000296946.2
ENST00000461348.2
ENST00000366871.3
T
T, brachyury homolog (mouse)
chr8_+_27168988 4.82 ENST00000397501.1
ENST00000338238.4
ENST00000544172.1
PTK2B
protein tyrosine kinase 2 beta
chr16_-_30569584 4.73 ENST00000252797.2
ENST00000568114.1
ZNF764
AC002310.13
zinc finger protein 764
Uncharacterized protein
chr6_-_30524951 4.72 ENST00000376621.3
GNL1
guanine nucleotide binding protein-like 1
chrX_+_135230712 4.72 ENST00000535737.1
FHL1
four and a half LIM domains 1
chr6_+_27356497 4.61 ENST00000244576.4
ZNF391
zinc finger protein 391
chrX_+_147582130 4.60 ENST00000370460.2
ENST00000370457.5
AFF2
AF4/FMR2 family, member 2
chr3_-_142166904 4.53 ENST00000264951.4
XRN1
5'-3' exoribonuclease 1
chr19_+_12075844 4.51 ENST00000592625.1
ENST00000586494.1
ENST00000343949.5
ENST00000545530.1
ENST00000358987.3
ZNF763
zinc finger protein 763
chr20_-_41818536 4.34 ENST00000373193.3
ENST00000373198.4
ENST00000373201.1
PTPRT
protein tyrosine phosphatase, receptor type, T
chr9_-_32552551 4.24 ENST00000360538.2
ENST00000379858.1
TOPORS
topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase
chr5_+_137225125 4.20 ENST00000350250.4
ENST00000508638.1
ENST00000502810.1
ENST00000508883.1
PKD2L2
polycystic kidney disease 2-like 2
chr19_-_19739007 4.13 ENST00000586703.1
ENST00000591042.1
ENST00000407877.3
LPAR2
lysophosphatidic acid receptor 2
chr18_+_268148 4.11 ENST00000581677.1
RP11-705O1.8
RP11-705O1.8
chr11_-_71791726 4.09 ENST00000393695.3
NUMA1
nuclear mitotic apparatus protein 1
chr17_+_53342311 4.04 ENST00000226067.5
HLF
hepatic leukemia factor
chr11_-_66115032 4.04 ENST00000311181.4
B3GNT1
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 1
chr11_-_61197480 3.92 ENST00000439958.3
ENST00000394888.4
CPSF7
cleavage and polyadenylation specific factor 7, 59kDa
chr15_+_63569731 3.81 ENST00000261879.5
APH1B
APH1B gamma secretase subunit
chr6_+_30525051 3.76 ENST00000376557.3
PRR3
proline rich 3
chr6_+_108487245 3.72 ENST00000368986.4
NR2E1
nuclear receptor subfamily 2, group E, member 1
chr11_+_126152954 3.44 ENST00000392679.1
TIRAP
toll-interleukin 1 receptor (TIR) domain containing adaptor protein
chr6_+_45389893 3.28 ENST00000371432.3
RUNX2
runt-related transcription factor 2
chr7_-_102257139 3.21 ENST00000521076.1
ENST00000462172.1
ENST00000522801.1
ENST00000449970.2
ENST00000262940.7
RASA4
RAS p21 protein activator 4
chr6_+_30524663 2.81 ENST00000376560.3
PRR3
proline rich 3
chr4_-_82136114 2.78 ENST00000395578.1
ENST00000418486.2
PRKG2
protein kinase, cGMP-dependent, type II
chr11_+_89764274 2.58 ENST00000448984.1
ENST00000432771.1
TRIM49C
tripartite motif containing 49C
chrX_+_100353153 2.53 ENST00000423383.1
ENST00000218507.5
ENST00000403304.2
ENST00000435570.1
CENPI
centromere protein I
chr19_+_44529479 2.48 ENST00000587846.1
ENST00000187879.8
ENST00000391960.3
ZNF222
zinc finger protein 222
chr12_-_25348007 2.47 ENST00000354189.5
ENST00000545133.1
ENST00000554347.1
ENST00000395987.3
ENST00000320267.9
ENST00000395990.2
ENST00000537577.1
CASC1
cancer susceptibility candidate 1
chr9_-_99775862 2.46 ENST00000602917.1
ENST00000375223.4
HIATL2
hippocampus abundant transcript-like 2
chr17_-_64188177 2.31 ENST00000535342.2
CEP112
centrosomal protein 112kDa
chr11_+_59522837 2.28 ENST00000437946.2
STX3
syntaxin 3
chr22_+_23412479 2.08 ENST00000248996.4
GNAZ
guanine nucleotide binding protein (G protein), alpha z polypeptide
chr10_-_14996070 1.98 ENST00000378258.1
ENST00000453695.2
ENST00000378246.2
DCLRE1C
DNA cross-link repair 1C
chr4_-_170533723 1.93 ENST00000510533.1
ENST00000439128.2
ENST00000511633.1
ENST00000512193.1
ENST00000507142.1
NEK1
NIMA-related kinase 1
chr6_+_160327974 1.92 ENST00000252660.4
MAS1
MAS1 oncogene
chr9_-_136039282 1.92 ENST00000372036.3
ENST00000372038.3
ENST00000540636.1
ENST00000372043.3
ENST00000542690.1
GBGT1
RALGDS
globoside alpha-1,3-N-acetylgalactosaminyltransferase 1
ral guanine nucleotide dissociation stimulator
chr17_+_72427477 1.91 ENST00000342648.5
ENST00000481232.1
GPRC5C
G protein-coupled receptor, family C, group 5, member C
chr19_-_45996465 1.85 ENST00000430715.2
RTN2
reticulon 2
chr16_-_20367584 1.84 ENST00000570689.1
UMOD
uromodulin
chr1_+_64239657 1.80 ENST00000371080.1
ENST00000371079.1
ROR1
receptor tyrosine kinase-like orphan receptor 1
chr18_-_268019 1.72 ENST00000261600.6
THOC1
THO complex 1
chr16_-_19729502 1.65 ENST00000219837.7
KNOP1
lysine-rich nucleolar protein 1
chr16_+_25123041 1.46 ENST00000399069.3
ENST00000380966.4
LCMT1
leucine carboxyl methyltransferase 1
chr10_+_30722866 1.44 ENST00000263056.1
MAP3K8
mitogen-activated protein kinase kinase kinase 8
chr2_-_136875712 1.42 ENST00000241393.3
CXCR4
chemokine (C-X-C motif) receptor 4
chr20_-_45061695 1.39 ENST00000445496.2
ELMO2
engulfment and cell motility 2
chr7_+_50348268 1.32 ENST00000438033.1
ENST00000439701.1
IKZF1
IKAROS family zinc finger 1 (Ikaros)
chr1_-_6052463 1.21 ENST00000378156.4
NPHP4
nephronophthisis 4
chr11_+_67033881 1.21 ENST00000308595.5
ENST00000526285.1
ADRBK1
adrenergic, beta, receptor kinase 1
chr17_+_38296576 1.16 ENST00000264645.7
CASC3
cancer susceptibility candidate 3
chr10_+_1102721 1.09 ENST00000263150.4
WDR37
WD repeat domain 37
chr6_-_57087042 1.07 ENST00000317483.3
RAB23
RAB23, member RAS oncogene family
chr11_+_59522900 1.06 ENST00000529177.1
STX3
syntaxin 3
chr6_-_46620522 1.02 ENST00000275016.2
CYP39A1
cytochrome P450, family 39, subfamily A, polypeptide 1
chr20_+_5107532 1.02 ENST00000450570.1
ENST00000379062.4
CDS2
CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2
chr14_+_50779071 0.84 ENST00000426751.2
ATP5S
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit s (factor B)
chr14_-_45722605 0.83 ENST00000310806.4
MIS18BP1
MIS18 binding protein 1
chr2_+_74757050 0.66 ENST00000352222.3
ENST00000437202.1
HTRA2
HtrA serine peptidase 2
chr11_+_64008525 0.56 ENST00000449942.2
FKBP2
FK506 binding protein 2, 13kDa
chr5_-_59064458 0.52 ENST00000502575.1
ENST00000507116.1
PDE4D
phosphodiesterase 4D, cAMP-specific
chr16_-_11730213 0.40 ENST00000576334.1
ENST00000574848.1
LITAF
lipopolysaccharide-induced TNF factor
chr12_-_49351148 0.38 ENST00000398092.4
ENST00000539611.1
RP11-302B13.5
ARF3
ADP-ribosylation factor 3
ADP-ribosylation factor 3
chr3_+_149530836 0.36 ENST00000466478.1
ENST00000491086.1
ENST00000467977.1
RNF13
ring finger protein 13
chr15_-_43622736 0.35 ENST00000544735.1
ENST00000567039.1
ENST00000305641.5
LCMT2
leucine carboxyl methyltransferase 2
chr11_-_18610246 0.34 ENST00000379387.4
ENST00000541984.1
UEVLD
UEV and lactate/malate dehyrogenase domains
chr1_-_221915418 0.20 ENST00000323825.3
ENST00000366899.3
DUSP10
dual specificity phosphatase 10
chr11_+_560956 0.11 ENST00000397582.3
ENST00000344375.4
ENST00000397583.3
RASSF7
Ras association (RalGDS/AF-6) domain family (N-terminal) member 7
chr4_+_26321284 0.02 ENST00000506956.1
ENST00000512671.1
ENST00000345843.3
ENST00000342295.1
RBPJ
recombination signal binding protein for immunoglobulin kappa J region
chr6_-_26124138 0.00 ENST00000314332.5
ENST00000396984.1
HIST1H2BC
histone cluster 1, H2bc

Network of associatons between targets according to the STRING database.

First level regulatory network of CENPB

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
4.9 14.6 GO:0032887 regulation of spindle elongation(GO:0032887) regulation of mitotic spindle elongation(GO:0032888) anastral spindle assembly(GO:0055048) protein localization to spindle pole body(GO:0071988) regulation of protein localization to spindle pole body(GO:1902363) positive regulation of protein localization to spindle pole body(GO:1902365) positive regulation of mitotic spindle elongation(GO:1902846)
3.5 10.5 GO:1900104 hyaluranon cable assembly(GO:0036118) regulation of hyaluranon cable assembly(GO:1900104) positive regulation of hyaluranon cable assembly(GO:1900106)
2.6 13.1 GO:0036369 transcription factor catabolic process(GO:0036369)
2.5 44.5 GO:0042424 catechol-containing compound catabolic process(GO:0019614) catecholamine catabolic process(GO:0042424)
2.0 27.3 GO:0016081 synaptic vesicle docking(GO:0016081)
1.9 5.8 GO:0061760 antifungal innate immune response(GO:0061760)
1.6 4.9 GO:0007509 mesoderm migration involved in gastrulation(GO:0007509)
1.5 4.5 GO:0071409 cellular response to cycloheximide(GO:0071409)
1.3 7.5 GO:0021523 somatic motor neuron differentiation(GO:0021523)
1.2 3.7 GO:0060164 regulation of timing of neuron differentiation(GO:0060164)
1.2 4.8 GO:2000537 regulation of cGMP-mediated signaling(GO:0010752) regulation of B cell chemotaxis(GO:2000537) positive regulation of B cell chemotaxis(GO:2000538)
0.9 4.6 GO:0035063 nuclear speck organization(GO:0035063)
0.9 17.1 GO:1901663 ubiquinone biosynthetic process(GO:0006744) quinone biosynthetic process(GO:1901663)
0.9 17.2 GO:0002244 hematopoietic progenitor cell differentiation(GO:0002244)
0.6 4.2 GO:0042670 retinal cone cell differentiation(GO:0042670) retinal cone cell development(GO:0046549)
0.5 6.7 GO:0046600 negative regulation of centriole replication(GO:0046600)
0.5 1.9 GO:0030259 lipid glycosylation(GO:0030259)
0.5 5.2 GO:0030322 stabilization of membrane potential(GO:0030322)
0.5 8.7 GO:0007220 Notch receptor processing(GO:0007220)
0.4 1.7 GO:0045829 negative regulation of isotype switching(GO:0045829)
0.4 3.3 GO:0002051 osteoblast fate commitment(GO:0002051)
0.4 1.2 GO:1903348 positive regulation of bicellular tight junction assembly(GO:1903348)
0.4 2.8 GO:0036289 peptidyl-serine autophosphorylation(GO:0036289)
0.4 3.4 GO:2000343 positive regulation of chemokine (C-X-C motif) ligand 2 production(GO:2000343)
0.4 2.6 GO:0046604 positive regulation of mitotic centrosome separation(GO:0046604)
0.4 1.8 GO:0072233 thick ascending limb development(GO:0072023) metanephric thick ascending limb development(GO:0072233)
0.4 6.9 GO:0006516 glycoprotein catabolic process(GO:0006516)
0.3 10.5 GO:0050982 detection of mechanical stimulus(GO:0050982)
0.2 0.7 GO:1904924 negative regulation of mitophagy in response to mitochondrial depolarization(GO:1904924)
0.2 1.4 GO:0044800 fusion of virus membrane with host plasma membrane(GO:0019064) membrane fusion involved in viral entry into host cell(GO:0039663) multi-organism membrane fusion(GO:0044800)
0.2 2.0 GO:0031848 protection from non-homologous end joining at telomere(GO:0031848)
0.1 1.0 GO:0006655 phosphatidylglycerol biosynthetic process(GO:0006655)
0.1 5.9 GO:0006693 prostanoid metabolic process(GO:0006692) prostaglandin metabolic process(GO:0006693)
0.1 6.7 GO:0007190 activation of adenylate cyclase activity(GO:0007190)
0.1 4.1 GO:0007202 activation of phospholipase C activity(GO:0007202)
0.1 8.9 GO:0046580 negative regulation of Ras protein signal transduction(GO:0046580)
0.1 10.2 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.1 1.9 GO:0038166 angiotensin-activated signaling pathway(GO:0038166)
0.1 3.4 GO:0034080 CENP-A containing nucleosome assembly(GO:0034080) CENP-A containing chromatin organization(GO:0061641)
0.1 1.0 GO:0016127 cholesterol catabolic process(GO:0006707) sterol catabolic process(GO:0016127)
0.1 0.2 GO:0060266 negative regulation of respiratory burst involved in inflammatory response(GO:0060266)
0.1 1.2 GO:0008298 intracellular mRNA localization(GO:0008298)
0.1 5.3 GO:0032259 methylation(GO:0032259)
0.1 1.5 GO:0090266 regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090266) regulation of mitotic spindle checkpoint(GO:1903504)
0.1 4.7 GO:0043268 positive regulation of potassium ion transport(GO:0043268)
0.1 4.2 GO:0001510 RNA methylation(GO:0001510)
0.1 12.0 GO:0006614 SRP-dependent cotranslational protein targeting to membrane(GO:0006614)
0.1 1.3 GO:0097120 receptor localization to synapse(GO:0097120)
0.1 8.4 GO:0006368 transcription elongation from RNA polymerase II promoter(GO:0006368)
0.1 10.0 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.1 0.5 GO:0086024 adrenergic receptor signaling pathway involved in positive regulation of heart rate(GO:0086024)
0.1 1.1 GO:0097094 craniofacial suture morphogenesis(GO:0097094)
0.1 7.0 GO:0014902 myotube differentiation(GO:0014902)
0.1 1.1 GO:0000470 maturation of LSU-rRNA(GO:0000470)
0.1 1.8 GO:0014002 astrocyte development(GO:0014002)
0.0 5.0 GO:0006487 protein N-linked glycosylation(GO:0006487)
0.0 3.9 GO:0006369 termination of RNA polymerase II transcription(GO:0006369)
0.0 1.9 GO:0042769 DNA damage response, detection of DNA damage(GO:0042769)
0.0 5.6 GO:0035023 regulation of Rho protein signal transduction(GO:0035023)
0.0 8.6 GO:0006367 transcription initiation from RNA polymerase II promoter(GO:0006367)
0.0 6.7 GO:0008584 male gonad development(GO:0008584) development of primary male sexual characteristics(GO:0046546)
0.0 0.3 GO:0042711 maternal behavior(GO:0042711) parental behavior(GO:0060746)
0.0 2.1 GO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway(GO:0007193)
0.0 1.4 GO:0000186 activation of MAPKK activity(GO:0000186)
0.0 1.8 GO:0065002 intracellular protein transmembrane transport(GO:0065002)
0.0 4.7 GO:0042254 ribosome biogenesis(GO:0042254)
0.0 0.4 GO:0042347 negative regulation of NF-kappaB import into nucleus(GO:0042347)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
4.9 14.6 GO:0061673 cortical microtubule(GO:0055028) mitotic spindle astral microtubule(GO:0061673)
1.3 24.0 GO:0031083 BLOC-1 complex(GO:0031083)
0.8 3.3 GO:1990796 photoreceptor cell terminal bouton(GO:1990796)
0.8 8.7 GO:0070765 gamma-secretase complex(GO:0070765)
0.6 10.5 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.5 6.7 GO:0097431 mitotic spindle pole(GO:0097431)
0.3 13.1 GO:0044665 MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339)
0.3 5.8 GO:0031089 platelet dense granule lumen(GO:0031089)
0.3 3.8 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.2 1.7 GO:0000445 THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445)
0.2 1.8 GO:0014802 terminal cisterna(GO:0014802)
0.2 6.9 GO:0044322 endoplasmic reticulum quality control compartment(GO:0044322)
0.2 11.3 GO:0008023 transcription elongation factor complex(GO:0008023)
0.2 3.9 GO:0005849 mRNA cleavage factor complex(GO:0005849)
0.2 2.3 GO:0060077 inhibitory synapse(GO:0060077)
0.2 1.1 GO:0070545 PeBoW complex(GO:0070545)
0.2 11.6 GO:0005844 polysome(GO:0005844)
0.2 4.2 GO:0000930 gamma-tubulin complex(GO:0000930)
0.1 2.0 GO:0070419 nonhomologous end joining complex(GO:0070419)
0.1 26.0 GO:0008021 synaptic vesicle(GO:0008021)
0.1 1.2 GO:0097470 ribbon synapse(GO:0097470)
0.1 1.9 GO:0000242 pericentriolar material(GO:0000242)
0.1 1.3 GO:0031618 nuclear pericentric heterochromatin(GO:0031618)
0.1 0.8 GO:0000778 condensed nuclear chromosome kinetochore(GO:0000778)
0.1 0.4 GO:0098559 cytoplasmic side of early endosome membrane(GO:0098559) cytoplasmic side of late endosome membrane(GO:0098560)
0.0 0.7 GO:0035631 CD40 receptor complex(GO:0035631)
0.0 20.4 GO:0005667 transcription factor complex(GO:0005667)
0.0 1.2 GO:0035145 exon-exon junction complex(GO:0035145)
0.0 2.1 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 4.5 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.0 2.8 GO:0016324 apical plasma membrane(GO:0016324)
0.0 1.8 GO:0060170 ciliary membrane(GO:0060170)
0.0 2.5 GO:0000776 kinetochore(GO:0000776)
0.0 19.2 GO:0009986 cell surface(GO:0009986)
0.0 1.1 GO:0030670 phagocytic vesicle membrane(GO:0030670)
0.0 1.9 GO:0005903 brush border(GO:0005903)
0.0 1.8 GO:0032587 ruffle membrane(GO:0032587)
0.0 8.0 GO:0005759 mitochondrial matrix(GO:0005759)
0.0 63.2 GO:0016021 integral component of membrane(GO:0016021)
0.0 6.5 GO:0031012 extracellular matrix(GO:0031012)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
6.4 44.5 GO:0016206 catechol O-methyltransferase activity(GO:0016206)
5.7 17.1 GO:0016731 ferredoxin-NADP+ reductase activity(GO:0004324) NADPH-adrenodoxin reductase activity(GO:0015039) oxidoreductase activity, acting on iron-sulfur proteins as donors(GO:0016730) oxidoreductase activity, acting on iron-sulfur proteins as donors, NAD or NADP as acceptor(GO:0016731)
3.3 13.1 GO:0061628 H3K27me3 modified histone binding(GO:0061628)
2.0 10.0 GO:0070097 delta-catenin binding(GO:0070097)
1.6 4.8 GO:0043423 3-phosphoinositide-dependent protein kinase binding(GO:0043423)
1.3 6.7 GO:0004999 vasoactive intestinal polypeptide receptor activity(GO:0004999)
1.2 5.9 GO:0047374 methylumbelliferyl-acetate deacetylase activity(GO:0047374)
1.1 3.4 GO:0035662 Toll-like receptor 4 binding(GO:0035662) Toll-like receptor 2 binding(GO:0035663)
1.1 14.6 GO:0051011 microtubule minus-end binding(GO:0051011)
0.8 9.1 GO:0002151 G-quadruplex RNA binding(GO:0002151)
0.8 10.5 GO:0070700 BMP receptor binding(GO:0070700)
0.7 4.2 GO:0044547 DNA topoisomerase binding(GO:0044547)
0.6 2.8 GO:0004692 cGMP-dependent protein kinase activity(GO:0004692)
0.5 5.2 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.5 4.1 GO:0070915 lysophosphatidic acid receptor activity(GO:0070915)
0.4 1.9 GO:0004945 angiotensin receptor activity(GO:0001595) angiotensin type II receptor activity(GO:0004945)
0.4 3.3 GO:0050542 icosanoid binding(GO:0050542) arachidonic acid binding(GO:0050544) fatty acid derivative binding(GO:1901567)
0.3 1.0 GO:0004605 phosphatidate cytidylyltransferase activity(GO:0004605)
0.2 2.0 GO:0035312 5'-3' exodeoxyribonuclease activity(GO:0035312)
0.2 24.0 GO:0019905 syntaxin binding(GO:0019905)
0.2 2.1 GO:0031821 G-protein coupled serotonin receptor binding(GO:0031821)
0.2 12.0 GO:0019843 rRNA binding(GO:0019843)
0.2 18.1 GO:0003707 steroid hormone receptor activity(GO:0003707)
0.1 1.4 GO:0016494 C-X-C chemokine receptor activity(GO:0016494)
0.1 2.6 GO:0005092 GDP-dissociation inhibitor activity(GO:0005092)
0.1 1.8 GO:0019864 IgG binding(GO:0019864)
0.1 4.2 GO:0008173 RNA methyltransferase activity(GO:0008173)
0.1 4.9 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.1 5.0 GO:0008375 acetylglucosaminyltransferase activity(GO:0008375)
0.1 10.5 GO:0005262 calcium channel activity(GO:0005262)
0.1 1.9 GO:0008376 acetylgalactosaminyltransferase activity(GO:0008376)
0.1 7.5 GO:0001085 RNA polymerase II transcription factor binding(GO:0001085)
0.1 3.3 GO:0043425 bHLH transcription factor binding(GO:0043425)
0.1 1.9 GO:0071889 14-3-3 protein binding(GO:0071889)
0.1 5.6 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.0 1.4 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.0 10.5 GO:0005096 GTPase activator activity(GO:0005096)
0.0 0.3 GO:0003696 satellite DNA binding(GO:0003696)
0.0 8.2 GO:0016746 transferase activity, transferring acyl groups(GO:0016746)
0.0 40.1 GO:0003700 nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700)
0.0 1.0 GO:0008395 steroid hydroxylase activity(GO:0008395)
0.0 5.2 GO:0044325 ion channel binding(GO:0044325)
0.0 6.7 GO:0008017 microtubule binding(GO:0008017)
0.0 1.4 GO:0030971 receptor tyrosine kinase binding(GO:0030971)
0.0 4.9 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.0 1.8 GO:0004714 transmembrane receptor protein tyrosine kinase activity(GO:0004714)
0.0 0.2 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 1.9 SA G2 AND M PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.6 10.5 PID ALK2 PATHWAY ALK2 signaling events
0.3 23.8 PID TAP63 PATHWAY Validated transcriptional targets of TAp63 isoforms
0.3 8.7 PID SYNDECAN 3 PATHWAY Syndecan-3-mediated signaling events
0.2 7.0 ST GA12 PATHWAY G alpha 12 Pathway
0.2 16.3 PID RB 1PATHWAY Regulation of retinoblastoma protein
0.2 4.8 SA PTEN PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.1 14.6 PID CASPASE PATHWAY Caspase cascade in apoptosis
0.1 2.1 PID S1P S1P4 PATHWAY S1P4 pathway
0.1 3.4 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.1 8.5 PID E2F PATHWAY E2F transcription factor network
0.1 3.2 PID RAS PATHWAY Regulation of Ras family activation
0.1 1.4 PID TCR RAS PATHWAY Ras signaling in the CD4+ TCR pathway
0.1 1.4 PID S1P S1P3 PATHWAY S1P3 pathway
0.1 5.6 PID RHOA REG PATHWAY Regulation of RhoA activity
0.1 4.9 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.1 5.0 PID ECADHERIN STABILIZATION PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.1 2.0 PID DNA PK PATHWAY DNA-PK pathway in nonhomologous end joining
0.1 4.1 PID LYSOPHOSPHOLIPID PATHWAY LPA receptor mediated events
0.1 1.2 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family
0.0 1.1 PID HEDGEHOG GLI PATHWAY Hedgehog signaling events mediated by Gli proteins
0.0 1.4 PID ILK PATHWAY Integrin-linked kinase signaling
0.0 1.3 PID NFAT TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.0 1.9 PID ERBB1 DOWNSTREAM PATHWAY ErbB1 downstream signaling

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 14.6 REACTOME RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES Genes involved in Recruitment of NuMA to mitotic centrosomes
0.6 8.7 REACTOME SIGNALING BY NOTCH2 Genes involved in Signaling by NOTCH2
0.3 4.5 REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
0.3 1.4 REACTOME BINDING AND ENTRY OF HIV VIRION Genes involved in Binding and entry of HIV virion
0.2 13.1 REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
0.2 6.9 REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.2 18.1 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.2 4.0 REACTOME KERATAN SULFATE BIOSYNTHESIS Genes involved in Keratan sulfate biosynthesis
0.2 5.0 REACTOME N GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS GOLGI Genes involved in N-glycan antennae elongation in the medial/trans-Golgi
0.2 12.0 REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.2 6.7 REACTOME GLUCAGON TYPE LIGAND RECEPTORS Genes involved in Glucagon-type ligand receptors
0.1 4.8 REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.1 3.3 REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins
0.1 2.1 REACTOME G PROTEIN ACTIVATION Genes involved in G-protein activation
0.1 1.0 REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24 HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol
0.1 5.6 REACTOME NRAGE SIGNALS DEATH THROUGH JNK Genes involved in NRAGE signals death through JNK
0.1 1.9 REACTOME P38MAPK EVENTS Genes involved in p38MAPK events
0.1 6.7 REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.1 2.8 REACTOME CGMP EFFECTS Genes involved in cGMP effects
0.1 1.0 REACTOME PROCESSING OF INTRONLESS PRE MRNAS Genes involved in Processing of Intronless Pre-mRNAs
0.1 1.2 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo
0.0 14.0 REACTOME GENERIC TRANSCRIPTION PATHWAY Genes involved in Generic Transcription Pathway
0.0 2.8 REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.0 2.6 REACTOME LATE PHASE OF HIV LIFE CYCLE Genes involved in Late Phase of HIV Life Cycle
0.0 1.4 REACTOME CD28 DEPENDENT PI3K AKT SIGNALING Genes involved in CD28 dependent PI3K/Akt signaling
0.0 1.2 REACTOME CA DEPENDENT EVENTS Genes involved in Ca-dependent events
0.0 3.4 REACTOME MYD88 MAL CASCADE INITIATED ON PLASMA MEMBRANE Genes involved in MyD88:Mal cascade initiated on plasma membrane
0.0 4.1 REACTOME G ALPHA I SIGNALLING EVENTS Genes involved in G alpha (i) signalling events
0.0 0.5 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
0.0 0.3 REACTOME RNA POL I PROMOTER OPENING Genes involved in RNA Polymerase I Promoter Opening