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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for CENPB
Z-value: 0.67
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Transcription factors associated with CENPB
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| CENPB | hg19_v2_chr20_-_3767324_3767443 | -0.48 | 1.1e-13 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of CENPB
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.5 | 44.5 | GO:0042424 | catechol-containing compound catabolic process(GO:0019614) catecholamine catabolic process(GO:0042424) |
| 2.0 | 27.3 | GO:0016081 | synaptic vesicle docking(GO:0016081) |
| 0.9 | 17.2 | GO:0002244 | hematopoietic progenitor cell differentiation(GO:0002244) |
| 0.9 | 17.1 | GO:1901663 | ubiquinone biosynthetic process(GO:0006744) quinone biosynthetic process(GO:1901663) |
| 4.9 | 14.6 | GO:0032887 | regulation of spindle elongation(GO:0032887) regulation of mitotic spindle elongation(GO:0032888) anastral spindle assembly(GO:0055048) protein localization to spindle pole body(GO:0071988) regulation of protein localization to spindle pole body(GO:1902363) positive regulation of protein localization to spindle pole body(GO:1902365) positive regulation of mitotic spindle elongation(GO:1902846) |
| 2.6 | 13.1 | GO:0036369 | transcription factor catabolic process(GO:0036369) |
| 0.1 | 12.0 | GO:0006614 | SRP-dependent cotranslational protein targeting to membrane(GO:0006614) |
| 3.5 | 10.5 | GO:1900104 | hyaluranon cable assembly(GO:0036118) regulation of hyaluranon cable assembly(GO:1900104) positive regulation of hyaluranon cable assembly(GO:1900106) |
| 0.3 | 10.5 | GO:0050982 | detection of mechanical stimulus(GO:0050982) |
| 0.1 | 10.2 | GO:0010923 | negative regulation of phosphatase activity(GO:0010923) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 63.2 | GO:0016021 | integral component of membrane(GO:0016021) |
| 0.1 | 26.0 | GO:0008021 | synaptic vesicle(GO:0008021) |
| 1.3 | 24.0 | GO:0031083 | BLOC-1 complex(GO:0031083) |
| 0.0 | 20.4 | GO:0005667 | transcription factor complex(GO:0005667) |
| 0.0 | 19.2 | GO:0009986 | cell surface(GO:0009986) |
| 4.9 | 14.6 | GO:0061673 | cortical microtubule(GO:0055028) mitotic spindle astral microtubule(GO:0061673) |
| 0.3 | 13.1 | GO:0044665 | MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339) |
| 0.2 | 11.6 | GO:0005844 | polysome(GO:0005844) |
| 0.2 | 11.3 | GO:0008023 | transcription elongation factor complex(GO:0008023) |
| 0.6 | 10.5 | GO:0031235 | intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 6.4 | 44.5 | GO:0016206 | catechol O-methyltransferase activity(GO:0016206) |
| 0.0 | 40.1 | GO:0003700 | nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700) |
| 0.2 | 24.0 | GO:0019905 | syntaxin binding(GO:0019905) |
| 0.2 | 18.1 | GO:0003707 | steroid hormone receptor activity(GO:0003707) |
| 5.7 | 17.1 | GO:0016731 | ferredoxin-NADP+ reductase activity(GO:0004324) NADPH-adrenodoxin reductase activity(GO:0015039) oxidoreductase activity, acting on iron-sulfur proteins as donors(GO:0016730) oxidoreductase activity, acting on iron-sulfur proteins as donors, NAD or NADP as acceptor(GO:0016731) |
| 1.1 | 14.6 | GO:0051011 | microtubule minus-end binding(GO:0051011) |
| 3.3 | 13.1 | GO:0061628 | H3K27me3 modified histone binding(GO:0061628) |
| 0.2 | 12.0 | GO:0019843 | rRNA binding(GO:0019843) |
| 0.8 | 10.5 | GO:0070700 | BMP receptor binding(GO:0070700) |
| 0.1 | 10.5 | GO:0005262 | calcium channel activity(GO:0005262) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 23.8 | PID TAP63 PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.2 | 16.3 | PID RB 1PATHWAY | Regulation of retinoblastoma protein |
| 0.1 | 14.6 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
| 0.6 | 10.5 | PID ALK2 PATHWAY | ALK2 signaling events |
| 0.3 | 8.7 | PID SYNDECAN 3 PATHWAY | Syndecan-3-mediated signaling events |
| 0.1 | 8.5 | PID E2F PATHWAY | E2F transcription factor network |
| 0.2 | 7.0 | ST GA12 PATHWAY | G alpha 12 Pathway |
| 0.1 | 5.6 | PID RHOA REG PATHWAY | Regulation of RhoA activity |
| 0.1 | 5.0 | PID ECADHERIN STABILIZATION PATHWAY | Stabilization and expansion of the E-cadherin adherens junction |
| 0.1 | 4.9 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 18.1 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.9 | 14.6 | REACTOME RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES | Genes involved in Recruitment of NuMA to mitotic centrosomes |
| 0.0 | 14.0 | REACTOME GENERIC TRANSCRIPTION PATHWAY | Genes involved in Generic Transcription Pathway |
| 0.2 | 13.1 | REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING | Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening |
| 0.2 | 12.0 | REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
| 0.6 | 8.7 | REACTOME SIGNALING BY NOTCH2 | Genes involved in Signaling by NOTCH2 |
| 0.2 | 6.9 | REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS | Genes involved in Association of TriC/CCT with target proteins during biosynthesis |
| 0.2 | 6.7 | REACTOME GLUCAGON TYPE LIGAND RECEPTORS | Genes involved in Glucagon-type ligand receptors |
| 0.1 | 6.7 | REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES | Genes involved in Loss of Nlp from mitotic centrosomes |
| 0.1 | 5.6 | REACTOME NRAGE SIGNALS DEATH THROUGH JNK | Genes involved in NRAGE signals death through JNK |