Project
GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
Navigation
Downloads
Results for DLX1_HOXA3_BARX2
Z-value: 0.59
Motif logo
Transcription factors associated with DLX1_HOXA3_BARX2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| BARX2 | hg19_v2_chr11_+_129245796_129245835 | 0.23 | 6.5e-04 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr11_-_117748138 Show fit | 18.05 |
ENST00000527717.1
|
FXYD domain containing ion transport regulator 6 |
|
| chrX_-_13835147 Show fit | 17.57 |
ENST00000493677.1
ENST00000355135.2 |
glycoprotein M6B |
|
| chr11_-_117747607 Show fit | 15.72 |
ENST00000540359.1
ENST00000539526.1 |
FXYD domain containing ion transport regulator 6 |
|
| chr11_-_117747434 Show fit | 15.35 |
ENST00000529335.2
ENST00000530956.1 ENST00000260282.4 |
FXYD domain containing ion transport regulator 6 |
|
| chr19_+_50016610 Show fit | 12.67 |
ENST00000596975.1
|
Fc fragment of IgG, receptor, transporter, alpha |
|
| chr3_+_111718036 Show fit | 11.96 |
ENST00000455401.2
|
transgelin 3 |
|
| chr3_+_111718173 Show fit | 11.91 |
ENST00000494932.1
|
transgelin 3 |
|
| chr3_+_111717600 Show fit | 10.64 |
ENST00000273368.4
|
transgelin 3 |
|
| chr19_+_50016411 Show fit | 10.43 |
ENST00000426395.3
ENST00000600273.1 ENST00000599988.1 |
Fc fragment of IgG, receptor, transporter, alpha |
|
| chr3_+_111717511 Show fit | 10.36 |
ENST00000478951.1
ENST00000393917.2 |
transgelin 3 |
Network of associatons between targets according to the STRING database.
First level regulatory network of DLX1_HOXA3_BARX2
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 44.4 | GO:2000649 | regulation of sodium ion transmembrane transporter activity(GO:2000649) |
| 0.2 | 28.2 | GO:0006958 | complement activation, classical pathway(GO:0006958) |
| 3.3 | 23.1 | GO:0002414 | immunoglobulin transcytosis in epithelial cells(GO:0002414) |
| 0.8 | 19.1 | GO:0006068 | ethanol catabolic process(GO:0006068) |
| 1.8 | 17.6 | GO:0051581 | negative regulation of neurotransmitter uptake(GO:0051581) serotonin uptake(GO:0051610) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612) |
| 5.7 | 17.1 | GO:2001190 | positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell(GO:2001190) |
| 0.1 | 15.1 | GO:0002223 | stimulatory C-type lectin receptor signaling pathway(GO:0002223) |
| 1.7 | 12.1 | GO:0048241 | epinephrine transport(GO:0048241) |
| 0.3 | 10.2 | GO:0006099 | tricarboxylic acid cycle(GO:0006099) |
| 0.1 | 9.9 | GO:1902600 | hydrogen ion transmembrane transport(GO:1902600) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 40.5 | GO:0043209 | myelin sheath(GO:0043209) |
| 0.0 | 39.5 | GO:0031226 | intrinsic component of plasma membrane(GO:0031226) |
| 0.0 | 23.1 | GO:0005615 | extracellular space(GO:0005615) |
| 0.1 | 17.7 | GO:0016323 | basolateral plasma membrane(GO:0016323) |
| 0.8 | 17.1 | GO:0042613 | MHC class II protein complex(GO:0042613) |
| 0.1 | 12.1 | GO:0001650 | fibrillar center(GO:0001650) |
| 1.7 | 11.6 | GO:0045252 | oxoglutarate dehydrogenase complex(GO:0045252) |
| 0.4 | 11.4 | GO:0035371 | microtubule plus-end(GO:0035371) |
| 0.0 | 10.6 | GO:0005769 | early endosome(GO:0005769) |
| 0.2 | 10.0 | GO:0042571 | immunoglobulin complex, circulating(GO:0042571) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 43.9 | GO:0017080 | sodium channel regulator activity(GO:0017080) |
| 0.2 | 39.2 | GO:0051015 | actin filament binding(GO:0051015) |
| 0.2 | 37.4 | GO:0003823 | antigen binding(GO:0003823) |
| 5.8 | 23.1 | GO:0019770 | IgG receptor activity(GO:0019770) |
| 2.7 | 18.6 | GO:0047894 | flavonol 3-sulfotransferase activity(GO:0047894) |
| 0.6 | 17.1 | GO:0023026 | MHC class II protein complex binding(GO:0023026) |
| 0.0 | 14.6 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 3.0 | 12.1 | GO:0005277 | acetylcholine transmembrane transporter activity(GO:0005277) secondary active organic cation transmembrane transporter activity(GO:0008513) acetate ester transmembrane transporter activity(GO:1901375) |
| 0.2 | 12.0 | GO:0042162 | telomeric DNA binding(GO:0042162) |
| 0.6 | 11.7 | GO:0030169 | low-density lipoprotein particle binding(GO:0030169) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 24.5 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.1 | 8.8 | PID RHOA REG PATHWAY | Regulation of RhoA activity |
| 0.1 | 7.1 | PID IFNG PATHWAY | IFN-gamma pathway |
| 0.1 | 6.8 | ST GRANULE CELL SURVIVAL PATHWAY | Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway. |
| 0.1 | 6.4 | SIG BCR SIGNALING PATHWAY | Members of the BCR signaling pathway |
| 0.1 | 6.2 | PID CMYB PATHWAY | C-MYB transcription factor network |
| 0.1 | 6.1 | PID ENDOTHELIN PATHWAY | Endothelins |
| 0.1 | 5.6 | PID INTEGRIN A4B1 PATHWAY | Alpha4 beta1 integrin signaling events |
| 0.3 | 4.3 | ST G ALPHA S PATHWAY | G alpha s Pathway |
| 0.1 | 3.8 | PID IL8 CXCR2 PATHWAY | IL8- and CXCR2-mediated signaling events |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 18.6 | REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES | Genes involved in Cytosolic sulfonation of small molecules |
| 0.1 | 18.4 | REACTOME MHC CLASS II ANTIGEN PRESENTATION | Genes involved in MHC class II antigen presentation |
| 1.0 | 13.6 | REACTOME ABACAVIR TRANSPORT AND METABOLISM | Genes involved in Abacavir transport and metabolism |
| 0.1 | 11.2 | REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 0.2 | 9.8 | REACTOME MYOGENESIS | Genes involved in Myogenesis |
| 0.2 | 9.7 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.1 | 9.1 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.3 | 6.8 | REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS | Genes involved in Activation of the AP-1 family of transcription factors |
| 0.1 | 5.8 | REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES | Genes involved in Loss of Nlp from mitotic centrosomes |
| 0.2 | 5.7 | REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT | Genes involved in ABC-family proteins mediated transport |