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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for DMBX1
Z-value: 0.54
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Transcription factors associated with DMBX1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| DMBX1 | hg19_v2_chr1_+_46972668_46972669 | -0.28 | 2.2e-05 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr4_-_170679024 Show fit | 5.41 |
ENST00000393381.2
|
chromosome 4 open reading frame 27 |
|
| chr12_+_53693812 Show fit | 5.39 |
ENST00000549488.1
|
chromosome 12 open reading frame 10 |
|
| chr9_-_21995300 Show fit | 5.04 |
ENST00000498628.2
|
cyclin-dependent kinase inhibitor 2A |
|
| chr3_+_136649311 Show fit | 4.45 |
ENST00000469404.1
ENST00000467911.1 |
NCK adaptor protein 1 |
|
| chr2_+_73461410 Show fit | 4.38 |
ENST00000399032.2
ENST00000398422.2 ENST00000537131.1 ENST00000538797.1 |
chaperonin containing TCP1, subunit 7 (eta) |
|
| chr2_+_73461364 Show fit | 4.38 |
ENST00000540468.1
ENST00000539919.1 ENST00000258091.5 |
chaperonin containing TCP1, subunit 7 (eta) |
|
| chr3_+_138340049 Show fit | 4.28 |
ENST00000464668.1
|
Fas apoptotic inhibitory molecule |
|
| chr2_+_223725652 Show fit | 4.24 |
ENST00000357430.3
ENST00000392066.3 |
acyl-CoA synthetase long-chain family member 3 |
|
| chr3_+_49058444 Show fit | 4.03 |
ENST00000326925.6
ENST00000395458.2 |
NADH dehydrogenase (ubiquinone) complex I, assembly factor 3 |
|
| chr3_+_49057876 Show fit | 3.93 |
ENST00000326912.4
|
NADH dehydrogenase (ubiquinone) complex I, assembly factor 3 |
Network of associatons between targets according to the STRING database.
First level regulatory network of DMBX1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.4 | 15.1 | GO:0035986 | senescence-associated heterochromatin focus assembly(GO:0035986) |
| 0.7 | 8.8 | GO:1904869 | regulation of protein localization to Cajal body(GO:1904869) positive regulation of protein localization to Cajal body(GO:1904871) |
| 0.1 | 8.0 | GO:0032981 | NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031) |
| 0.3 | 5.4 | GO:0035641 | locomotory exploration behavior(GO:0035641) |
| 0.1 | 4.9 | GO:0006081 | cellular aldehyde metabolic process(GO:0006081) |
| 1.5 | 4.4 | GO:1903676 | regulation of cap-dependent translational initiation(GO:1903674) positive regulation of cap-dependent translational initiation(GO:1903676) |
| 1.4 | 4.2 | GO:2001245 | regulation of phosphatidylcholine biosynthetic process(GO:2001245) |
| 0.2 | 2.4 | GO:0035414 | negative regulation of catenin import into nucleus(GO:0035414) |
| 0.1 | 2.3 | GO:0008045 | motor neuron axon guidance(GO:0008045) |
| 0.1 | 2.2 | GO:0002230 | positive regulation of defense response to virus by host(GO:0002230) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.4 | 15.1 | GO:0035985 | senescence-associated heterochromatin focus(GO:0035985) |
| 0.7 | 8.8 | GO:0002199 | zona pellucida receptor complex(GO:0002199) |
| 0.0 | 5.7 | GO:0005743 | mitochondrial inner membrane(GO:0005743) |
| 0.1 | 5.3 | GO:0005778 | peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903) |
| 0.3 | 4.4 | GO:0000164 | protein phosphatase type 1 complex(GO:0000164) |
| 0.0 | 2.0 | GO:0005643 | nuclear pore(GO:0005643) |
| 0.0 | 1.9 | GO:0055038 | recycling endosome membrane(GO:0055038) |
| 0.0 | 1.9 | GO:1904724 | tertiary granule lumen(GO:1904724) |
| 0.2 | 1.6 | GO:0061700 | GATOR2 complex(GO:0061700) |
| 0.0 | 1.2 | GO:0009295 | nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 15.1 | GO:0004861 | cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861) |
| 0.2 | 8.8 | GO:0044183 | protein binding involved in protein folding(GO:0044183) |
| 1.0 | 4.9 | GO:0018479 | benzaldehyde dehydrogenase (NAD+) activity(GO:0018479) |
| 0.9 | 4.4 | GO:0071074 | eukaryotic initiation factor eIF2 binding(GO:0071074) |
| 0.2 | 4.2 | GO:0102391 | decanoate--CoA ligase activity(GO:0102391) |
| 0.0 | 2.3 | GO:0046875 | ephrin receptor binding(GO:0046875) |
| 0.1 | 2.0 | GO:0017056 | structural constituent of nuclear pore(GO:0017056) |
| 0.6 | 1.9 | GO:0016603 | glutaminyl-peptide cyclotransferase activity(GO:0016603) |
| 0.1 | 1.9 | GO:0070300 | phosphatidic acid binding(GO:0070300) |
| 0.1 | 1.2 | GO:0004549 | tRNA-specific ribonuclease activity(GO:0004549) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 15.1 | SA REG CASCADE OF CYCLIN EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
| 0.1 | 7.9 | PID TRKR PATHWAY | Neurotrophic factor-mediated Trk receptor signaling |
| 0.1 | 4.4 | PID VEGFR1 PATHWAY | VEGFR1 specific signals |
| 0.0 | 2.3 | PID RAC1 REG PATHWAY | Regulation of RAC1 activity |
| 0.0 | 0.9 | PID RETINOIC ACID PATHWAY | Retinoic acid receptors-mediated signaling |
| 0.0 | 0.8 | PID P38 MKK3 6PATHWAY | p38 MAPK signaling pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 15.1 | REACTOME G1 PHASE | Genes involved in G1 Phase |
| 0.3 | 8.8 | REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC | Genes involved in Formation of tubulin folding intermediates by CCT/TriC |
| 0.2 | 4.4 | REACTOME ACTIVATION OF RAC | Genes involved in Activation of Rac |
| 0.2 | 4.2 | REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS | Genes involved in Synthesis of very long-chain fatty acyl-CoAs |
| 0.1 | 2.4 | REACTOME SIGNALING BY HIPPO | Genes involved in Signaling by Hippo |
| 0.0 | 2.3 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.0 | 1.6 | REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC | Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC |
| 0.0 | 0.9 | REACTOME CYTOSOLIC TRNA AMINOACYLATION | Genes involved in Cytosolic tRNA aminoacylation |
| 0.0 | 0.9 | REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS | Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits |
| 0.0 | 0.9 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |