ISMARA results: DMC1

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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)

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Results for DMC1

Z-value: 0.03

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Transcription factors associated with DMC1

Gene Symbol	Gene ID	Gene Info
DMC1 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000100206.5	DNA meiotic recombinase 1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
DMC1	hg19_v2_chr22_-_38966172_38966291	0.12	7.0e-02	Click!

Activity profile of DMC1 motif

Sorted Z-values of DMC1 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr12_-_8803128 Show fit	7.65	ENST00000543467.1	MFAP5 Ensembl NCBI GeneCards UniProt NextProt Show fit	microfibrillar associated protein 5
chr2_-_190044480 Show fit	7.42	ENST00000374866.3	COL5A2 Ensembl NCBI GeneCards UniProt NextProt Show fit	collagen, type V, alpha 2
chr12_-_9268707 Show fit	6.16	ENST00000318602.7	A2M Ensembl NCBI GeneCards UniProt NextProt Show fit	alpha-2-macroglobulin
chr2_+_187454749 Show fit	4.97	ENST00000261023.3 ENST00000374907.3	ITGAV Ensembl NCBI GeneCards UniProt NextProt Show fit	integrin, alpha V
chr12_-_50677255 Show fit	4.46	ENST00000551691.1 ENST00000394943.3 ENST00000341247.4	LIMA1 Ensembl NCBI GeneCards UniProt NextProt Show fit	LIM domain and actin binding 1
chr3_+_148457585 Show fit	3.15	ENST00000402260.1	AGTR1 Ensembl NCBI GeneCards UniProt NextProt Show fit	angiotensin II receptor, type 1
chr11_-_85779971 Show fit	2.85	ENST00000393346.3	PICALM Ensembl NCBI GeneCards UniProt NextProt Show fit	phosphatidylinositol binding clathrin assembly protein
chr14_-_21492113 Show fit	2.77	ENST00000554094.1	NDRG2 Ensembl NCBI GeneCards UniProt NextProt Show fit	NDRG family member 2
chr11_+_71238313 Show fit	2.66	ENST00000398536.4	KRTAP5-7 Ensembl NCBI GeneCards UniProt NextProt Show fit	keratin associated protein 5-7
chr3_+_101546827 Show fit	2.54	ENST00000461724.1 ENST00000483180.1 ENST00000394054.2	NFKBIZ Ensembl NCBI GeneCards UniProt NextProt Show fit	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta

Showing 1 to 10 of 66 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of DMC1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	7.7	GO:0060216	definitive hemopoiesis(GO:0060216)
1.9	7.4	GO:1903224	regulation of endodermal cell differentiation(GO:1903224)
0.4	7.2	GO:0090360	platelet-derived growth factor production(GO:0090360) regulation of platelet-derived growth factor production(GO:0090361)
0.5	6.2	GO:0001867	complement activation, lectin pathway(GO:0001867)
1.2	5.0	GO:0045715	negative regulation of low-density lipoprotein particle receptor biosynthetic process(GO:0045715)
0.7	4.9	GO:1902963	regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902962) negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902963)
0.1	4.5	GO:0031529	ruffle organization(GO:0031529)
0.8	3.1	GO:0086097	phospholipase C-activating angiotensin-activated signaling pathway(GO:0086097)
0.0	2.7	GO:0031424	keratinization(GO:0031424)
0.0	1.9	GO:0035335	peptidyl-tyrosine dephosphorylation(GO:0035335)

Showing 1 to 10 of 35 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	7.7	GO:0001527	microfibril(GO:0001527) fibril(GO:0043205)
2.5	7.4	GO:0005588	collagen type V trimer(GO:0005588)
0.0	7.2	GO:0030426	growth cone(GO:0030426)
0.0	6.2	GO:0031093	platelet alpha granule lumen(GO:0031093)
1.7	5.0	GO:0034686	integrin alphav-beta6 complex(GO:0034685) integrin alphav-beta8 complex(GO:0034686)
0.8	4.9	GO:0070381	endosome to plasma membrane transport vesicle(GO:0070381)
0.1	4.5	GO:0097610	cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.1	2.7	GO:0045095	keratin filament(GO:0045095)
0.0	2.5	GO:0000932	cytoplasmic mRNA processing body(GO:0000932)
0.5	1.5	GO:0016222	procollagen-proline 4-dioxygenase complex(GO:0016222)

Showing 1 to 10 of 17 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	16.2	GO:0005201	extracellular matrix structural constituent(GO:0005201)
2.1	6.2	GO:0019959	interleukin-8 binding(GO:0019959)
1.0	5.0	GO:1990430	extracellular matrix protein binding(GO:1990430)
0.4	4.9	GO:0032050	clathrin heavy chain binding(GO:0032050)
0.1	4.5	GO:0003785	actin monomer binding(GO:0003785)
1.0	3.1	GO:0001596	angiotensin type I receptor activity(GO:0001596)
0.1	1.9	GO:0019198	transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.3	1.7	GO:0048248	CXCR3 chemokine receptor binding(GO:0048248)
0.3	1.5	GO:0004656	procollagen-proline 4-dioxygenase activity(GO:0004656) procollagen-proline dioxygenase activity(GO:0019798)
0.0	1.4	GO:0005184	neuropeptide hormone activity(GO:0005184)

Showing 1 to 10 of 29 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	7.8	PID MYC REPRESS PATHWAY	Validated targets of C-MYC transcriptional repression
0.1	7.7	PID NOTCH PATHWAY	Notch signaling pathway
0.2	7.4	NABA COLLAGENS	Genes encoding collagen proteins
0.1	6.2	PID IL6 7 PATHWAY	IL6-mediated signaling events
0.2	5.0	PID INTEGRIN5 PATHWAY	Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.1	4.5	PID ECADHERIN STABILIZATION PATHWAY	Stabilization and expansion of the E-cadherin adherens junction
0.1	4.1	PID ARF6 PATHWAY	Arf6 signaling events
0.0	2.6	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0	1.1	NABA PROTEOGLYCANS	Genes encoding proteoglycans
0.0	1.1	ST GA13 PATHWAY	G alpha 13 Pathway

Showing 1 to 10 of 10 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	7.4	REACTOME NCAM1 INTERACTIONS	Genes involved in NCAM1 interactions
0.3	6.2	REACTOME INTRINSIC PATHWAY	Genes involved in Intrinsic Pathway
0.3	5.0	REACTOME PECAM1 INTERACTIONS	Genes involved in PECAM1 interactions
0.1	4.9	REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS	Genes involved in Golgi Associated Vesicle Biogenesis
0.0	3.3	REACTOME PEPTIDE LIGAND BINDING RECEPTORS	Genes involved in Peptide ligand-binding receptors
0.0	1.7	REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES	Genes involved in Chemokine receptors bind chemokines
0.1	1.4	REACTOME METAL ION SLC TRANSPORTERS	Genes involved in Metal ion SLC transporters
0.1	1.1	REACTOME PROSTANOID LIGAND RECEPTORS	Genes involved in Prostanoid ligand receptors
0.1	1.0	REACTOME ANDROGEN BIOSYNTHESIS	Genes involved in Androgen biosynthesis
0.0	1.0	REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GLP1	Genes involved in Synthesis, Secretion, and Inactivation of Glucagon-like Peptide-1 (GLP-1)

Showing 1 to 10 of 16 entries

Results for DMC1

Z-value: 0.03

Motif logo

Transcription factors associated with DMC1

Activity-expression correlation:

Activity profile of DMC1 motif

Sorted Z-values of DMC1 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of DMC1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: