GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)


Results for DMC1

Z-value: 0.03

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Transcription factors associated with DMC1

Gene Symbol Gene ID Gene Info
ENSG00000100206.5 DNA meiotic recombinase 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot

Activity profile of DMC1 motif

Sorted Z-values of DMC1 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr12_-_8803128 7.65 ENST00000543467.1
microfibrillar associated protein 5
chr2_-_190044480 7.42 ENST00000374866.3
collagen, type V, alpha 2
chr12_-_9268707 6.16 ENST00000318602.7
chr2_+_187454749 4.97 ENST00000261023.3
integrin, alpha V
chr12_-_50677255 4.46 ENST00000551691.1
LIM domain and actin binding 1
chr3_+_148457585 3.15 ENST00000402260.1
angiotensin II receptor, type 1
chr11_-_85779971 2.85 ENST00000393346.3
phosphatidylinositol binding clathrin assembly protein
chr14_-_21492113 2.77 ENST00000554094.1
NDRG family member 2
chr11_+_71238313 2.66 ENST00000398536.4
keratin associated protein 5-7
chr3_+_101546827 2.54 ENST00000461724.1
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta
chr14_-_21492251 2.47 ENST00000554398.1
NDRG family member 2
chr19_+_11466062 2.32 ENST00000251473.5
Lipid phosphate phosphatase-related protein type 2
chr11_-_85780086 2.10 ENST00000532317.1
phosphatidylinositol binding clathrin assembly protein
chr14_-_21491477 1.96 ENST00000298684.5
NDRG family member 2
chr10_+_17851362 1.87 ENST00000331429.2
cDNA FLJ56855, highly similar to Macrophage mannose receptor 1
chr4_-_76944621 1.72 ENST00000306602.1
chemokine (C-X-C motif) ligand 10
chr2_+_201173667 1.65 ENST00000409755.3
spermatogenesis associated, serine-rich 2-like
chr2_+_233497931 1.63 ENST00000264059.3
EF-hand domain family, member D1
chr10_-_74856608 1.55 ENST00000307116.2
prolyl 4-hydroxylase, alpha polypeptide I
chr3_-_99569821 1.50 ENST00000487087.1
filamin A interacting protein 1-like
chr18_+_56892724 1.34 ENST00000456142.3
gastrin-releasing peptide
chrX_+_65382433 1.28 ENST00000374727.3
chr17_+_57297807 1.24 ENST00000284116.4
glycerophosphodiester phosphodiesterase domain containing 1
chrX_-_134305322 1.23 ENST00000276241.6
cancer/testis antigen 55
chr12_-_71031185 1.15 ENST00000548122.1
protein tyrosine phosphatase, receptor type, B
chr19_-_3600549 1.11 ENST00000589966.1
thromboxane A2 receptor
chr22_+_21133469 1.09 ENST00000406799.1
serpin peptidase inhibitor, clade D (heparin cofactor), member 1
chr5_-_82969405 1.08 ENST00000510978.1
hyaluronan and proteoglycan link protein 1
chr10_-_104597286 1.05 ENST00000369887.3
cytochrome P450, family 17, subfamily A, polypeptide 1
chr1_+_18958008 0.98 ENST00000420770.2
paired box 7
chr15_-_49103235 0.96 ENST00000380950.2
centrosomal protein 152kDa
chr4_+_106473768 0.95 ENST00000265154.2
Rho guanine nucleotide exchange factor (GEF) 38
chr10_-_62332357 0.85 ENST00000503366.1
ankyrin 3, node of Ranvier (ankyrin G)
chr2_+_219246746 0.84 ENST00000233202.6
solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1
chr7_-_22539771 0.80 ENST00000406890.2
STEAP family member 1B
chr12_-_71031220 0.76 ENST00000334414.6
protein tyrosine phosphatase, receptor type, B
chr1_-_11863571 0.71 ENST00000376583.3
methylenetetrahydrofolate reductase (NAD(P)H)
chr11_+_71846764 0.70 ENST00000456237.1
folate receptor 3 (gamma)
chr3_-_141747950 0.62 ENST00000497579.1
transcription factor Dp-2 (E2F dimerization partner 2)
chr11_+_71846748 0.61 ENST00000445078.2
folate receptor 3 (gamma)
chr7_+_47694842 0.51 ENST00000408988.2
chromosome 7 open reading frame 65
chr2_-_48982708 0.51 ENST00000428232.1
luteinizing hormone/choriogonadotropin receptor
chr14_+_74318513 0.49 ENST00000555228.1
prostaglandin reductase 2
chr10_+_74870253 0.48 ENST00000544879.1
nudix (nucleoside diphosphate linked moiety X)-type motif 13
chr7_+_150758304 0.47 ENST00000482950.1
solute carrier family 4 (anion exchanger), member 2
chr18_-_5396271 0.47 ENST00000579951.1
erythrocyte membrane protein band 4.1-like 3
chr10_+_74870206 0.46 ENST00000357321.4
nudix (nucleoside diphosphate linked moiety X)-type motif 13
chr2_-_48982857 0.43 ENST00000403273.1
luteinizing hormone/choriogonadotropin receptor
chr2_-_21022818 0.39 ENST00000440866.2
chromosome 2 open reading frame 43
chr14_+_74318611 0.39 ENST00000555976.1
prostaglandin reductase 2
chr19_+_44617511 0.37 ENST00000262894.6
zinc finger protein 225
chr11_-_73720276 0.36 ENST00000348534.4
uncoupling protein 3 (mitochondrial, proton carrier)
chr20_+_123010 0.35 ENST00000382398.3
defensin, beta 126
chr6_-_62996066 0.34 ENST00000281156.4
KH domain containing, RNA binding, signal transduction associated 2
chr16_-_30122717 0.32 ENST00000566613.1
glycerophosphodiester phosphodiesterase domain containing 3
chr11_-_73720122 0.28 ENST00000426995.2
uncoupling protein 3 (mitochondrial, proton carrier)
chr10_-_135187193 0.27 ENST00000368547.3
enoyl CoA hydratase, short chain, 1, mitochondrial
chr20_-_21378666 0.26 ENST00000351817.4
NK2 homeobox 4
chr3_-_119276575 0.22 ENST00000383669.3
CD80 molecule
chr2_-_31637560 0.22 ENST00000379416.3
xanthine dehydrogenase
chr1_-_190446759 0.18 ENST00000367462.3
bone morphogenetic protein/retinoic acid inducible neural-specific 3
chr3_-_141747459 0.16 ENST00000477292.1
transcription factor Dp-2 (E2F dimerization partner 2)
chr8_-_101734907 0.16 ENST00000318607.5
poly(A) binding protein, cytoplasmic 1
chr2_-_75426826 0.13 ENST00000305249.5
tachykinin receptor 1
chr12_-_53901266 0.02 ENST00000609999.1
neuropeptide FF-amide peptide precursor
chrX_-_49965663 0.01 ENST00000376056.2
A kinase (PRKA) anchor protein 4

Network of associatons between targets according to the STRING database.

First level regulatory network of DMC1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.9 7.4 GO:1903224 regulation of endodermal cell differentiation(GO:1903224)
1.2 5.0 GO:0045715 negative regulation of low-density lipoprotein particle receptor biosynthetic process(GO:0045715)
0.8 3.1 GO:0086097 phospholipase C-activating angiotensin-activated signaling pathway(GO:0086097)
0.7 4.9 GO:1902963 regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902962) negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902963)
0.5 6.2 GO:0001867 complement activation, lectin pathway(GO:0001867)
0.4 7.2 GO:0090360 platelet-derived growth factor production(GO:0090360) regulation of platelet-derived growth factor production(GO:0090361)
0.4 1.1 GO:0038193 thromboxane A2 signaling pathway(GO:0038193)
0.3 1.7 GO:1901509 regulation of endothelial tube morphogenesis(GO:1901509)
0.3 1.3 GO:0036343 psychomotor behavior(GO:0036343)
0.3 0.9 GO:0042700 luteinizing hormone signaling pathway(GO:0042700)
0.2 1.0 GO:0014816 skeletal muscle satellite cell differentiation(GO:0014816)
0.2 0.8 GO:0010650 positive regulation of cell communication by electrical coupling(GO:0010650) maintenance of protein location in membrane(GO:0072658) maintenance of protein location in plasma membrane(GO:0072660) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.2 1.5 GO:0018401 peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401)
0.2 7.7 GO:0060216 definitive hemopoiesis(GO:0060216)
0.2 0.6 GO:0055073 cadmium ion homeostasis(GO:0055073)
0.2 0.8 GO:0098706 ferric iron import into cell(GO:0097461) ferric iron import across plasma membrane(GO:0098706)
0.2 1.0 GO:0098535 de novo centriole assembly(GO:0098535)
0.2 1.1 GO:0008218 bioluminescence(GO:0008218)
0.1 0.7 GO:0033274 response to vitamin B2(GO:0033274) heterochromatin maintenance(GO:0070829)
0.1 1.3 GO:0015884 folic acid transport(GO:0015884)
0.1 0.2 GO:0006145 purine nucleobase catabolic process(GO:0006145)
0.1 0.5 GO:0002175 protein localization to paranode region of axon(GO:0002175)
0.1 4.5 GO:0031529 ruffle organization(GO:0031529)
0.1 1.0 GO:0006702 androgen biosynthetic process(GO:0006702)
0.0 0.9 GO:0006825 copper ion transport(GO:0006825)
0.0 0.6 GO:1990845 adaptive thermogenesis(GO:1990845)
0.0 0.2 GO:0045425 regulation of granulocyte macrophage colony-stimulating factor biosynthetic process(GO:0045423) positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process(GO:0045425)
0.0 0.1 GO:0003051 angiotensin-mediated drinking behavior(GO:0003051) operant conditioning(GO:0035106)
0.0 0.9 GO:0006692 prostanoid metabolic process(GO:0006692) prostaglandin metabolic process(GO:0006693)
0.0 0.8 GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0000083)
0.0 2.7 GO:0031424 keratinization(GO:0031424)
0.0 0.9 GO:0015949 nucleobase-containing small molecule interconversion(GO:0015949)
0.0 0.2 GO:2000622 regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000622) negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000623)
0.0 1.2 GO:0034308 primary alcohol metabolic process(GO:0034308)
0.0 1.9 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
2.5 7.4 GO:0005588 collagen type V trimer(GO:0005588)
1.7 5.0 GO:0034686 integrin alphav-beta6 complex(GO:0034685) integrin alphav-beta8 complex(GO:0034686)
0.8 4.9 GO:0070381 endosome to plasma membrane transport vesicle(GO:0070381)
0.5 1.5 GO:0016222 procollagen-proline 4-dioxygenase complex(GO:0016222)
0.3 7.7 GO:0001527 microfibril(GO:0001527) fibril(GO:0043205)
0.3 1.0 GO:0098536 deuterosome(GO:0098536)
0.1 0.2 GO:0098636 protein complex involved in cell adhesion(GO:0098636)
0.1 2.7 GO:0045095 keratin filament(GO:0045095)
0.1 4.5 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.0 0.8 GO:0043194 axon initial segment(GO:0043194)
0.0 6.2 GO:0031093 platelet alpha granule lumen(GO:0031093)
0.0 7.2 GO:0030426 growth cone(GO:0030426)
0.0 0.5 GO:0033270 paranode region of axon(GO:0033270)
0.0 2.5 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.0 1.3 GO:1904724 tertiary granule lumen(GO:1904724)
0.0 0.2 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.0 1.1 GO:0001669 acrosomal vesicle(GO:0001669)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
2.1 6.2 GO:0019959 interleukin-8 binding(GO:0019959)
1.0 3.1 GO:0001596 angiotensin type I receptor activity(GO:0001596)
1.0 5.0 GO:1990430 extracellular matrix protein binding(GO:1990430)
0.4 4.9 GO:0032050 clathrin heavy chain binding(GO:0032050)
0.4 1.1 GO:0004960 thromboxane receptor activity(GO:0004960) thromboxane A2 receptor activity(GO:0004961)
0.3 1.7 GO:0048248 CXCR3 chemokine receptor binding(GO:0048248)
0.3 1.5 GO:0004656 procollagen-proline 4-dioxygenase activity(GO:0004656) procollagen-proline dioxygenase activity(GO:0019798)
0.2 0.9 GO:0004963 follicle-stimulating hormone receptor activity(GO:0004963)
0.2 0.8 GO:0008823 cupric reductase activity(GO:0008823) ferric-chelate reductase (NADPH) activity(GO:0052851)
0.2 0.6 GO:0051139 metal ion:proton antiporter activity(GO:0051139)
0.2 16.2 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.1 0.7 GO:0004489 methylenetetrahydrofolate reductase (NAD(P)H) activity(GO:0004489)
0.1 0.9 GO:0004322 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.1 4.5 GO:0003785 actin monomer binding(GO:0003785)
0.1 0.6 GO:0017077 oxidative phosphorylation uncoupler activity(GO:0017077)
0.1 1.3 GO:0005542 folic acid binding(GO:0005542)
0.1 1.9 GO:0019198 transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.0 1.0 GO:0016832 aldehyde-lyase activity(GO:0016832)
0.0 1.2 GO:0004622 lysophospholipase activity(GO:0004622)
0.0 1.4 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.0 0.2 GO:0043546 molybdopterin cofactor binding(GO:0043546)
0.0 0.9 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor(GO:0016628)
0.0 0.1 GO:0004995 tachykinin receptor activity(GO:0004995)
0.0 0.5 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.0 0.3 GO:0004300 enoyl-CoA hydratase activity(GO:0004300)
0.0 1.0 GO:0000983 transcription factor activity, RNA polymerase II core promoter sequence-specific(GO:0000983)
0.0 0.5 GO:0008266 poly(U) RNA binding(GO:0008266)
0.0 0.8 GO:0030507 spectrin binding(GO:0030507)
0.0 1.1 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 5.0 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.2 7.4 NABA COLLAGENS Genes encoding collagen proteins
0.1 7.7 PID NOTCH PATHWAY Notch signaling pathway
0.1 4.5 PID ECADHERIN STABILIZATION PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.1 6.2 PID IL6 7 PATHWAY IL6-mediated signaling events
0.1 4.1 PID ARF6 PATHWAY Arf6 signaling events
0.1 7.8 PID MYC REPRESS PATHWAY Validated targets of C-MYC transcriptional repression
0.0 1.1 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.0 1.1 ST GA13 PATHWAY G alpha 13 Pathway
0.0 2.6 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 6.2 REACTOME INTRINSIC PATHWAY Genes involved in Intrinsic Pathway
0.3 5.0 REACTOME PECAM1 INTERACTIONS Genes involved in PECAM1 interactions
0.1 7.4 REACTOME NCAM1 INTERACTIONS Genes involved in NCAM1 interactions
0.1 1.1 REACTOME PROSTANOID LIGAND RECEPTORS Genes involved in Prostanoid ligand receptors
0.1 1.0 REACTOME ANDROGEN BIOSYNTHESIS Genes involved in Androgen biosynthesis
0.1 0.9 REACTOME HORMONE LIGAND BINDING RECEPTORS Genes involved in Hormone ligand-binding receptors
0.1 4.9 REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.1 1.4 REACTOME METAL ION SLC TRANSPORTERS Genes involved in Metal ion SLC transporters
0.0 1.0 REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GLP1 Genes involved in Synthesis, Secretion, and Inactivation of Glucagon-like Peptide-1 (GLP-1)
0.0 0.3 REACTOME BETA DEFENSINS Genes involved in Beta defensins
0.0 1.7 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.0 3.3 REACTOME PEPTIDE LIGAND BINDING RECEPTORS Genes involved in Peptide ligand-binding receptors
0.0 0.8 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.0 0.2 REACTOME PURINE CATABOLISM Genes involved in Purine catabolism
0.0 0.3 REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.0 0.2 REACTOME CD28 DEPENDENT VAV1 PATHWAY Genes involved in CD28 dependent Vav1 pathway