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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)

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Results for DMC1

Z-value: 0.03

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Transcription factors associated with DMC1

Gene Symbol Gene ID Gene Info
DMC1
ENSG00000100206.5 DNA meiotic recombinase 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
DMC1hg19_v2_chr22_-_38966172_389662910.127.0e-02Click!

Activity profile of DMC1 motif

Sorted Z-values of DMC1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr12_-_8803128 7.65 ENST00000543467.1
MFAP5
microfibrillar associated protein 5
chr2_-_190044480 7.42 ENST00000374866.3
COL5A2
collagen, type V, alpha 2
chr12_-_9268707 6.16 ENST00000318602.7
A2M
alpha-2-macroglobulin
chr2_+_187454749 4.97 ENST00000261023.3
ENST00000374907.3
ITGAV
integrin, alpha V
chr12_-_50677255 4.46 ENST00000551691.1
ENST00000394943.3
ENST00000341247.4
LIMA1
LIM domain and actin binding 1
chr3_+_148457585 3.15 ENST00000402260.1
AGTR1
angiotensin II receptor, type 1
chr11_-_85779971 2.85 ENST00000393346.3
PICALM
phosphatidylinositol binding clathrin assembly protein
chr14_-_21492113 2.77 ENST00000554094.1
NDRG2
NDRG family member 2
chr11_+_71238313 2.66 ENST00000398536.4
KRTAP5-7
keratin associated protein 5-7
chr3_+_101546827 2.54 ENST00000461724.1
ENST00000483180.1
ENST00000394054.2
NFKBIZ
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta
chr14_-_21492251 2.47 ENST00000554398.1
NDRG2
NDRG family member 2
chr19_+_11466062 2.32 ENST00000251473.5
ENST00000591329.1
ENST00000586380.1
DKFZP761J1410
Lipid phosphate phosphatase-related protein type 2
chr11_-_85780086 2.10 ENST00000532317.1
ENST00000528256.1
ENST00000526033.1
PICALM
phosphatidylinositol binding clathrin assembly protein
chr14_-_21491477 1.96 ENST00000298684.5
ENST00000557169.1
ENST00000553563.1
NDRG2
NDRG family member 2
chr10_+_17851362 1.87 ENST00000331429.2
ENST00000457317.1
MRC1L1
cDNA FLJ56855, highly similar to Macrophage mannose receptor 1
chr4_-_76944621 1.72 ENST00000306602.1
CXCL10
chemokine (C-X-C motif) ligand 10
chr2_+_201173667 1.65 ENST00000409755.3
SPATS2L
spermatogenesis associated, serine-rich 2-like
chr2_+_233497931 1.63 ENST00000264059.3
EFHD1
EF-hand domain family, member D1
chr10_-_74856608 1.55 ENST00000307116.2
ENST00000373008.2
ENST00000412021.2
ENST00000394890.2
ENST00000263556.3
ENST00000440381.1
P4HA1
prolyl 4-hydroxylase, alpha polypeptide I
chr3_-_99569821 1.50 ENST00000487087.1
FILIP1L
filamin A interacting protein 1-like
chr18_+_56892724 1.34 ENST00000456142.3
ENST00000530323.1
GRP
gastrin-releasing peptide
chrX_+_65382433 1.28 ENST00000374727.3
HEPH
hephaestin
chr17_+_57297807 1.24 ENST00000284116.4
ENST00000581140.1
ENST00000581276.1
GDPD1
glycerophosphodiester phosphodiesterase domain containing 1
chrX_-_134305322 1.23 ENST00000276241.6
ENST00000344129.2
CXorf48
cancer/testis antigen 55
chr12_-_71031185 1.15 ENST00000548122.1
ENST00000551525.1
ENST00000550358.1
PTPRB
protein tyrosine phosphatase, receptor type, B
chr19_-_3600549 1.11 ENST00000589966.1
TBXA2R
thromboxane A2 receptor
chr22_+_21133469 1.09 ENST00000406799.1
SERPIND1
serpin peptidase inhibitor, clade D (heparin cofactor), member 1
chr5_-_82969405 1.08 ENST00000510978.1
HAPLN1
hyaluronan and proteoglycan link protein 1
chr10_-_104597286 1.05 ENST00000369887.3
CYP17A1
cytochrome P450, family 17, subfamily A, polypeptide 1
chr1_+_18958008 0.98 ENST00000420770.2
ENST00000400661.3
PAX7
paired box 7
chr15_-_49103235 0.96 ENST00000380950.2
CEP152
centrosomal protein 152kDa
chr4_+_106473768 0.95 ENST00000265154.2
ENST00000420470.2
ARHGEF38
Rho guanine nucleotide exchange factor (GEF) 38
chr10_-_62332357 0.85 ENST00000503366.1
ANK3
ankyrin 3, node of Ranvier (ankyrin G)
chr2_+_219246746 0.84 ENST00000233202.6
SLC11A1
solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1
chr7_-_22539771 0.80 ENST00000406890.2
ENST00000424363.1
STEAP1B
STEAP family member 1B
chr12_-_71031220 0.76 ENST00000334414.6
PTPRB
protein tyrosine phosphatase, receptor type, B
chr1_-_11863571 0.71 ENST00000376583.3
MTHFR
methylenetetrahydrofolate reductase (NAD(P)H)
chr11_+_71846764 0.70 ENST00000456237.1
ENST00000442948.2
ENST00000546166.1
FOLR3
folate receptor 3 (gamma)
chr3_-_141747950 0.62 ENST00000497579.1
TFDP2
transcription factor Dp-2 (E2F dimerization partner 2)
chr11_+_71846748 0.61 ENST00000445078.2
FOLR3
folate receptor 3 (gamma)
chr7_+_47694842 0.51 ENST00000408988.2
C7orf65
chromosome 7 open reading frame 65
chr2_-_48982708 0.51 ENST00000428232.1
ENST00000405626.1
ENST00000294954.7
LHCGR
luteinizing hormone/choriogonadotropin receptor
chr14_+_74318513 0.49 ENST00000555228.1
ENST00000555661.1
PTGR2
prostaglandin reductase 2
chr10_+_74870253 0.48 ENST00000544879.1
ENST00000537969.1
ENST00000372997.3
NUDT13
nudix (nucleoside diphosphate linked moiety X)-type motif 13
chr7_+_150758304 0.47 ENST00000482950.1
ENST00000463414.1
ENST00000310317.5
SLC4A2
solute carrier family 4 (anion exchanger), member 2
chr18_-_5396271 0.47 ENST00000579951.1
EPB41L3
erythrocyte membrane protein band 4.1-like 3
chr10_+_74870206 0.46 ENST00000357321.4
ENST00000349051.5
NUDT13
nudix (nucleoside diphosphate linked moiety X)-type motif 13
chr2_-_48982857 0.43 ENST00000403273.1
ENST00000401907.1
ENST00000344775.3
LHCGR
luteinizing hormone/choriogonadotropin receptor
chr2_-_21022818 0.39 ENST00000440866.2
ENST00000541941.1
ENST00000402479.2
ENST00000435420.2
ENST00000432947.1
ENST00000403006.2
ENST00000419825.2
ENST00000381090.3
ENST00000237822.3
ENST00000412261.1
C2orf43
chromosome 2 open reading frame 43
chr14_+_74318611 0.39 ENST00000555976.1
ENST00000267568.4
PTGR2
prostaglandin reductase 2
chr19_+_44617511 0.37 ENST00000262894.6
ENST00000588926.1
ENST00000592780.1
ZNF225
zinc finger protein 225
chr11_-_73720276 0.36 ENST00000348534.4
UCP3
uncoupling protein 3 (mitochondrial, proton carrier)
chr20_+_123010 0.35 ENST00000382398.3
DEFB126
defensin, beta 126
chr6_-_62996066 0.34 ENST00000281156.4
KHDRBS2
KH domain containing, RNA binding, signal transduction associated 2
chr16_-_30122717 0.32 ENST00000566613.1
GDPD3
glycerophosphodiester phosphodiesterase domain containing 3
chr11_-_73720122 0.28 ENST00000426995.2
UCP3
uncoupling protein 3 (mitochondrial, proton carrier)
chr10_-_135187193 0.27 ENST00000368547.3
ECHS1
enoyl CoA hydratase, short chain, 1, mitochondrial
chr20_-_21378666 0.26 ENST00000351817.4
NKX2-4
NK2 homeobox 4
chr3_-_119276575 0.22 ENST00000383669.3
ENST00000383668.3
CD80
CD80 molecule
chr2_-_31637560 0.22 ENST00000379416.3
XDH
xanthine dehydrogenase
chr1_-_190446759 0.18 ENST00000367462.3
BRINP3
bone morphogenetic protein/retinoic acid inducible neural-specific 3
chr3_-_141747459 0.16 ENST00000477292.1
ENST00000478006.1
ENST00000495310.1
ENST00000486111.1
TFDP2
transcription factor Dp-2 (E2F dimerization partner 2)
chr8_-_101734907 0.16 ENST00000318607.5
ENST00000521865.1
ENST00000520804.1
ENST00000522720.1
ENST00000521067.1
PABPC1
poly(A) binding protein, cytoplasmic 1
chr2_-_75426826 0.13 ENST00000305249.5
TACR1
tachykinin receptor 1
chr12_-_53901266 0.02 ENST00000609999.1
ENST00000267017.3
NPFF
neuropeptide FF-amide peptide precursor
chrX_-_49965663 0.01 ENST00000376056.2
ENST00000376058.2
ENST00000358526.2
AKAP4
A kinase (PRKA) anchor protein 4

Network of associatons between targets according to the STRING database.

First level regulatory network of DMC1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.9 7.4 GO:1903224 regulation of endodermal cell differentiation(GO:1903224)
1.2 5.0 GO:0045715 negative regulation of low-density lipoprotein particle receptor biosynthetic process(GO:0045715)
0.8 3.1 GO:0086097 phospholipase C-activating angiotensin-activated signaling pathway(GO:0086097)
0.7 4.9 GO:1902963 regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902962) negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902963)
0.5 6.2 GO:0001867 complement activation, lectin pathway(GO:0001867)
0.4 7.2 GO:0090360 platelet-derived growth factor production(GO:0090360) regulation of platelet-derived growth factor production(GO:0090361)
0.4 1.1 GO:0038193 thromboxane A2 signaling pathway(GO:0038193)
0.3 1.7 GO:1901509 regulation of endothelial tube morphogenesis(GO:1901509)
0.3 1.3 GO:0036343 psychomotor behavior(GO:0036343)
0.3 0.9 GO:0042700 luteinizing hormone signaling pathway(GO:0042700)
0.2 1.0 GO:0014816 skeletal muscle satellite cell differentiation(GO:0014816)
0.2 0.8 GO:0010650 positive regulation of cell communication by electrical coupling(GO:0010650) maintenance of protein location in membrane(GO:0072658) maintenance of protein location in plasma membrane(GO:0072660) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.2 1.5 GO:0018401 peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401)
0.2 7.7 GO:0060216 definitive hemopoiesis(GO:0060216)
0.2 0.6 GO:0055073 cadmium ion homeostasis(GO:0055073)
0.2 0.8 GO:0098706 ferric iron import into cell(GO:0097461) ferric iron import across plasma membrane(GO:0098706)
0.2 1.0 GO:0098535 de novo centriole assembly(GO:0098535)
0.2 1.1 GO:0008218 bioluminescence(GO:0008218)
0.1 0.7 GO:0033274 response to vitamin B2(GO:0033274) heterochromatin maintenance(GO:0070829)
0.1 1.3 GO:0015884 folic acid transport(GO:0015884)
0.1 0.2 GO:0006145 purine nucleobase catabolic process(GO:0006145)
0.1 0.5 GO:0002175 protein localization to paranode region of axon(GO:0002175)
0.1 4.5 GO:0031529 ruffle organization(GO:0031529)
0.1 1.0 GO:0006702 androgen biosynthetic process(GO:0006702)
0.0 0.9 GO:0006825 copper ion transport(GO:0006825)
0.0 0.6 GO:1990845 adaptive thermogenesis(GO:1990845)
0.0 0.2 GO:0045425 regulation of granulocyte macrophage colony-stimulating factor biosynthetic process(GO:0045423) positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process(GO:0045425)
0.0 0.1 GO:0003051 angiotensin-mediated drinking behavior(GO:0003051) operant conditioning(GO:0035106)
0.0 0.9 GO:0006692 prostanoid metabolic process(GO:0006692) prostaglandin metabolic process(GO:0006693)
0.0 0.8 GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0000083)
0.0 2.7 GO:0031424 keratinization(GO:0031424)
0.0 0.9 GO:0015949 nucleobase-containing small molecule interconversion(GO:0015949)
0.0 0.2 GO:2000622 regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000622) negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000623)
0.0 1.2 GO:0034308 primary alcohol metabolic process(GO:0034308)
0.0 1.9 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
2.5 7.4 GO:0005588 collagen type V trimer(GO:0005588)
1.7 5.0 GO:0034686 integrin alphav-beta6 complex(GO:0034685) integrin alphav-beta8 complex(GO:0034686)
0.8 4.9 GO:0070381 endosome to plasma membrane transport vesicle(GO:0070381)
0.5 1.5 GO:0016222 procollagen-proline 4-dioxygenase complex(GO:0016222)
0.3 7.7 GO:0001527 microfibril(GO:0001527) fibril(GO:0043205)
0.3 1.0 GO:0098536 deuterosome(GO:0098536)
0.1 0.2 GO:0098636 protein complex involved in cell adhesion(GO:0098636)
0.1 2.7 GO:0045095 keratin filament(GO:0045095)
0.1 4.5 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.0 0.8 GO:0043194 axon initial segment(GO:0043194)
0.0 6.2 GO:0031093 platelet alpha granule lumen(GO:0031093)
0.0 7.2 GO:0030426 growth cone(GO:0030426)
0.0 0.5 GO:0033270 paranode region of axon(GO:0033270)
0.0 2.5 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.0 1.3 GO:1904724 tertiary granule lumen(GO:1904724)
0.0 0.2 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.0 1.1 GO:0001669 acrosomal vesicle(GO:0001669)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
2.1 6.2 GO:0019959 interleukin-8 binding(GO:0019959)
1.0 3.1 GO:0001596 angiotensin type I receptor activity(GO:0001596)
1.0 5.0 GO:1990430 extracellular matrix protein binding(GO:1990430)
0.4 4.9 GO:0032050 clathrin heavy chain binding(GO:0032050)
0.4 1.1 GO:0004960 thromboxane receptor activity(GO:0004960) thromboxane A2 receptor activity(GO:0004961)
0.3 1.7 GO:0048248 CXCR3 chemokine receptor binding(GO:0048248)
0.3 1.5 GO:0004656 procollagen-proline 4-dioxygenase activity(GO:0004656) procollagen-proline dioxygenase activity(GO:0019798)
0.2 0.9 GO:0004963 follicle-stimulating hormone receptor activity(GO:0004963)
0.2 0.8 GO:0008823 cupric reductase activity(GO:0008823) ferric-chelate reductase (NADPH) activity(GO:0052851)
0.2 0.6 GO:0051139 metal ion:proton antiporter activity(GO:0051139)
0.2 16.2 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.1 0.7 GO:0004489 methylenetetrahydrofolate reductase (NAD(P)H) activity(GO:0004489)
0.1 0.9 GO:0004322 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.1 4.5 GO:0003785 actin monomer binding(GO:0003785)
0.1 0.6 GO:0017077 oxidative phosphorylation uncoupler activity(GO:0017077)
0.1 1.3 GO:0005542 folic acid binding(GO:0005542)
0.1 1.9 GO:0019198 transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.0 1.0 GO:0016832 aldehyde-lyase activity(GO:0016832)
0.0 1.2 GO:0004622 lysophospholipase activity(GO:0004622)
0.0 1.4 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.0 0.2 GO:0043546 molybdopterin cofactor binding(GO:0043546)
0.0 0.9 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor(GO:0016628)
0.0 0.1 GO:0004995 tachykinin receptor activity(GO:0004995)
0.0 0.5 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.0 0.3 GO:0004300 enoyl-CoA hydratase activity(GO:0004300)
0.0 1.0 GO:0000983 transcription factor activity, RNA polymerase II core promoter sequence-specific(GO:0000983)
0.0 0.5 GO:0008266 poly(U) RNA binding(GO:0008266)
0.0 0.8 GO:0030507 spectrin binding(GO:0030507)
0.0 1.1 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 5.0 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.2 7.4 NABA COLLAGENS Genes encoding collagen proteins
0.1 7.7 PID NOTCH PATHWAY Notch signaling pathway
0.1 4.5 PID ECADHERIN STABILIZATION PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.1 6.2 PID IL6 7 PATHWAY IL6-mediated signaling events
0.1 4.1 PID ARF6 PATHWAY Arf6 signaling events
0.1 7.8 PID MYC REPRESS PATHWAY Validated targets of C-MYC transcriptional repression
0.0 1.1 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.0 1.1 ST GA13 PATHWAY G alpha 13 Pathway
0.0 2.6 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 6.2 REACTOME INTRINSIC PATHWAY Genes involved in Intrinsic Pathway
0.3 5.0 REACTOME PECAM1 INTERACTIONS Genes involved in PECAM1 interactions
0.1 7.4 REACTOME NCAM1 INTERACTIONS Genes involved in NCAM1 interactions
0.1 1.1 REACTOME PROSTANOID LIGAND RECEPTORS Genes involved in Prostanoid ligand receptors
0.1 1.0 REACTOME ANDROGEN BIOSYNTHESIS Genes involved in Androgen biosynthesis
0.1 0.9 REACTOME HORMONE LIGAND BINDING RECEPTORS Genes involved in Hormone ligand-binding receptors
0.1 4.9 REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.1 1.4 REACTOME METAL ION SLC TRANSPORTERS Genes involved in Metal ion SLC transporters
0.0 1.0 REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GLP1 Genes involved in Synthesis, Secretion, and Inactivation of Glucagon-like Peptide-1 (GLP-1)
0.0 0.3 REACTOME BETA DEFENSINS Genes involved in Beta defensins
0.0 1.7 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.0 3.3 REACTOME PEPTIDE LIGAND BINDING RECEPTORS Genes involved in Peptide ligand-binding receptors
0.0 0.8 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.0 0.2 REACTOME PURINE CATABOLISM Genes involved in Purine catabolism
0.0 0.3 REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.0 0.2 REACTOME CD28 DEPENDENT VAV1 PATHWAY Genes involved in CD28 dependent Vav1 pathway