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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for DPRX
Z-value: 0.30
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Transcription factors associated with DPRX
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr11_-_321340 Show fit | 180.70 |
ENST00000526811.1
|
interferon induced transmembrane protein 3 |
|
| chr11_-_321050 Show fit | 79.74 |
ENST00000399808.4
|
interferon induced transmembrane protein 3 |
|
| chr11_-_104817919 Show fit | 9.27 |
ENST00000533252.1
|
caspase 4, apoptosis-related cysteine peptidase |
|
| chr10_-_72362515 Show fit | 8.65 |
ENST00000373209.2
ENST00000441259.1 |
perforin 1 (pore forming protein) |
|
| chr19_+_2476116 Show fit | 7.06 |
ENST00000215631.4
ENST00000587345.1 |
growth arrest and DNA-damage-inducible, beta |
|
| chr2_-_235405168 Show fit | 7.00 |
ENST00000339728.3
|
ADP-ribosylation factor-like 4C |
|
| chr7_+_150264365 Show fit | 6.95 |
ENST00000255945.2
ENST00000461940.1 |
GTPase, IMAP family member 4 |
|
| chr5_+_35856951 Show fit | 6.71 |
ENST00000303115.3
ENST00000343305.4 ENST00000506850.1 ENST00000511982.1 |
interleukin 7 receptor |
|
| chr21_-_28217721 Show fit | 6.63 |
ENST00000284984.3
|
ADAM metallopeptidase with thrombospondin type 1 motif, 1 |
|
| chr1_-_184943610 Show fit | 6.46 |
ENST00000367511.3
|
family with sequence similarity 129, member A |
Network of associatons between targets according to the STRING database.
First level regulatory network of DPRX
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 9.3 | 260.4 | GO:0046597 | response to interferon-alpha(GO:0035455) negative regulation of viral entry into host cell(GO:0046597) |
| 1.2 | 13.0 | GO:1903265 | positive regulation of tumor necrosis factor-mediated signaling pathway(GO:1903265) |
| 0.7 | 9.9 | GO:0043374 | CD8-positive, alpha-beta T cell differentiation(GO:0043374) |
| 0.3 | 7.7 | GO:0006895 | Golgi to endosome transport(GO:0006895) |
| 0.6 | 7.6 | GO:0051712 | positive regulation of killing of cells of other organism(GO:0051712) |
| 0.3 | 7.1 | GO:0000185 | activation of MAPKKK activity(GO:0000185) |
| 0.6 | 6.7 | GO:0001915 | negative regulation of T cell mediated cytotoxicity(GO:0001915) |
| 0.4 | 6.6 | GO:0001542 | ovulation from ovarian follicle(GO:0001542) |
| 0.2 | 6.5 | GO:0032456 | endocytic recycling(GO:0032456) |
| 1.6 | 6.3 | GO:1902544 | oxidative DNA demethylation(GO:0035511) regulation of DNA N-glycosylase activity(GO:1902544) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.9 | 258.3 | GO:0031902 | late endosome membrane(GO:0031902) |
| 2.2 | 13.0 | GO:0072557 | IPAF inflammasome complex(GO:0072557) |
| 0.8 | 11.9 | GO:0030478 | actin cap(GO:0030478) |
| 0.0 | 11.4 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 0.1 | 9.5 | GO:0005604 | basement membrane(GO:0005604) |
| 1.0 | 8.7 | GO:0044194 | cytolytic granule(GO:0044194) |
| 0.2 | 8.0 | GO:0005720 | nuclear heterochromatin(GO:0005720) |
| 0.6 | 7.7 | GO:0008250 | oligosaccharyltransferase complex(GO:0008250) |
| 0.1 | 7.4 | GO:0016605 | PML body(GO:0016605) |
| 0.6 | 7.0 | GO:0044754 | autolysosome(GO:0044754) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 170.3 | GO:0005515 | protein binding(GO:0005515) |
| 0.9 | 13.0 | GO:0050700 | CARD domain binding(GO:0050700) |
| 0.4 | 11.9 | GO:0005523 | tropomyosin binding(GO:0005523) |
| 0.3 | 8.7 | GO:0022829 | wide pore channel activity(GO:0022829) |
| 0.0 | 8.1 | GO:0005525 | GTP binding(GO:0005525) |
| 0.2 | 7.0 | GO:0043014 | alpha-tubulin binding(GO:0043014) |
| 2.2 | 6.7 | GO:0004917 | interleukin-7 receptor activity(GO:0004917) |
| 0.0 | 6.6 | GO:0001227 | transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227) |
| 2.1 | 6.3 | GO:0043739 | G/U mismatch-specific uracil-DNA glycosylase activity(GO:0043739) |
| 0.1 | 6.3 | GO:0031369 | translation initiation factor binding(GO:0031369) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 20.9 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
| 0.1 | 8.8 | PID ILK PATHWAY | Integrin-linked kinase signaling |
| 0.3 | 8.7 | SA CASPASE CASCADE | Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. |
| 0.1 | 7.8 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 0.2 | 7.1 | PID P38 MKK3 6PATHWAY | p38 MAPK signaling pathway |
| 0.1 | 5.3 | PID PTP1B PATHWAY | Signaling events mediated by PTP1B |
| 0.0 | 5.2 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.1 | 4.5 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.1 | 4.2 | PID HIF1A PATHWAY | Hypoxic and oxygen homeostasis regulation of HIF-1-alpha |
| 0.1 | 4.1 | PID EPHRINB REV PATHWAY | Ephrin B reverse signaling |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.9 | 262.5 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.3 | 21.4 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 0.2 | 11.2 | REACTOME NOD1 2 SIGNALING PATHWAY | Genes involved in NOD1/2 Signaling Pathway |
| 0.1 | 8.9 | REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS | Genes involved in Apoptotic cleavage of cellular proteins |
| 0.3 | 8.8 | REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS | Genes involved in Cell-extracellular matrix interactions |
| 0.1 | 6.6 | REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
| 0.3 | 5.9 | REACTOME BASE FREE SUGAR PHOSPHATE REMOVAL VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY | Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway |
| 0.3 | 5.6 | REACTOME IL 7 SIGNALING | Genes involved in Interleukin-7 signaling |
| 0.0 | 3.9 | REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS | Genes involved in Golgi Associated Vesicle Biogenesis |
| 0.0 | 3.5 | REACTOME SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE | Genes involved in SRP-dependent cotranslational protein targeting to membrane |