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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for E2F4
Z-value: 0.93
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Transcription factors associated with E2F4
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| E2F4 | hg19_v2_chr16_+_67226019_67226127 | 0.21 | 2.1e-03 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of E2F4
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.5 | 40.7 | GO:0043570 | maintenance of DNA repeat elements(GO:0043570) |
| 1.3 | 38.8 | GO:0051290 | protein heterotetramerization(GO:0051290) |
| 1.2 | 37.5 | GO:0034080 | CENP-A containing nucleosome assembly(GO:0034080) CENP-A containing chromatin organization(GO:0061641) |
| 6.7 | 33.4 | GO:0006398 | mRNA 3'-end processing by stem-loop binding and cleavage(GO:0006398) |
| 3.3 | 32.8 | GO:0006268 | DNA unwinding involved in DNA replication(GO:0006268) |
| 1.1 | 29.9 | GO:0060148 | positive regulation of posttranscriptional gene silencing(GO:0060148) positive regulation of gene silencing by miRNA(GO:2000637) |
| 3.7 | 29.5 | GO:0006348 | chromatin silencing at telomere(GO:0006348) |
| 0.8 | 27.8 | GO:0006270 | DNA replication initiation(GO:0006270) |
| 4.5 | 27.2 | GO:0072133 | kidney mesenchyme morphogenesis(GO:0072131) metanephric mesenchyme morphogenesis(GO:0072133) |
| 3.9 | 23.6 | GO:0007079 | mitotic chromosome movement towards spindle pole(GO:0007079) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 49.5 | GO:0016363 | nuclear matrix(GO:0016363) |
| 10.0 | 39.9 | GO:0032301 | MutSalpha complex(GO:0032301) |
| 2.9 | 35.0 | GO:0042555 | MCM complex(GO:0042555) |
| 4.2 | 33.4 | GO:0071204 | histone pre-mRNA 3'end processing complex(GO:0071204) |
| 0.1 | 27.8 | GO:0005635 | nuclear envelope(GO:0005635) |
| 3.5 | 24.7 | GO:0005663 | DNA replication factor C complex(GO:0005663) |
| 0.5 | 24.4 | GO:0043034 | costamere(GO:0043034) |
| 4.0 | 24.2 | GO:0005658 | alpha DNA polymerase:primase complex(GO:0005658) |
| 6.0 | 24.1 | GO:0005971 | ribonucleoside-diphosphate reductase complex(GO:0005971) |
| 1.7 | 23.6 | GO:0031616 | spindle pole centrosome(GO:0031616) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 8.5 | 42.7 | GO:0071208 | histone pre-mRNA DCP binding(GO:0071208) |
| 10.0 | 39.9 | GO:0032143 | single thymine insertion binding(GO:0032143) |
| 0.8 | 35.0 | GO:0004003 | ATP-dependent DNA helicase activity(GO:0004003) |
| 0.8 | 33.4 | GO:0031492 | nucleosomal DNA binding(GO:0031492) |
| 2.9 | 32.4 | GO:0001135 | transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135) |
| 2.8 | 31.3 | GO:0002151 | G-quadruplex RNA binding(GO:0002151) |
| 0.5 | 27.2 | GO:0070888 | E-box binding(GO:0070888) |
| 3.7 | 25.9 | GO:0047134 | protein-disulfide reductase activity(GO:0047134) |
| 1.3 | 25.4 | GO:0010485 | H4 histone acetyltransferase activity(GO:0010485) |
| 0.1 | 24.9 | GO:0004721 | phosphoprotein phosphatase activity(GO:0004721) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 102.6 | PID E2F PATHWAY | E2F transcription factor network |
| 1.1 | 59.3 | PID MYC PATHWAY | C-MYC pathway |
| 0.4 | 37.9 | PID CMYB PATHWAY | C-MYB transcription factor network |
| 0.3 | 32.1 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.6 | 27.9 | PID PLK1 PATHWAY | PLK1 signaling events |
| 0.2 | 25.7 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 0.4 | 23.6 | PID AURORA A PATHWAY | Aurora A signaling |
| 0.4 | 22.4 | PID FANCONI PATHWAY | Fanconi anemia pathway |
| 0.5 | 17.7 | PID SMAD2 3PATHWAY | Regulation of cytoplasmic and nuclear SMAD2/3 signaling |
| 0.4 | 16.8 | PID ALK1 PATHWAY | ALK1 signaling events |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.5 | 56.4 | REACTOME UNWINDING OF DNA | Genes involved in Unwinding of DNA |
| 0.5 | 50.7 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 2.7 | 42.7 | REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS | Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs |
| 1.7 | 41.0 | REACTOME G1 S SPECIFIC TRANSCRIPTION | Genes involved in G1/S-Specific Transcription |
| 1.1 | 35.5 | REACTOME PYRIMIDINE METABOLISM | Genes involved in Pyrimidine metabolism |
| 2.2 | 32.3 | REACTOME POL SWITCHING | Genes involved in Polymerase switching |
| 0.6 | 28.4 | REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION | Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription |
| 0.7 | 27.8 | REACTOME TRANSPORT OF RIBONUCLEOPROTEINS INTO THE HOST NUCLEUS | Genes involved in Transport of Ribonucleoproteins into the Host Nucleus |
| 1.2 | 23.1 | REACTOME THE NLRP3 INFLAMMASOME | Genes involved in The NLRP3 inflammasome |
| 0.2 | 22.8 | REACTOME MRNA SPLICING | Genes involved in mRNA Splicing |