ISMARA results: E4F1

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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)

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Results for E4F1

Z-value: 0.41

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Transcription factors associated with E4F1

Gene Symbol	Gene ID	Gene Info
E4F1 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000167967.11	E4F transcription factor 1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
E4F1	hg19_v2_chr16_+_2273558_2273637	0.39	2.9e-09	Click!

Activity profile of E4F1 motif

Sorted Z-values of E4F1 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr6_-_32812420 Show fit	16.47	ENST00000374881.2	PSMB8 Ensembl NCBI GeneCards UniProt NextProt Show fit	proteasome (prosome, macropain) subunit, beta type, 8
chr6_+_32812568 Show fit	12.62	ENST00000414474.1	PSMB9 Ensembl NCBI GeneCards UniProt NextProt Show fit	proteasome (prosome, macropain) subunit, beta type, 9
chr19_+_1941117 Show fit	10.22	ENST00000255641.8	CSNK1G2 Ensembl NCBI GeneCards UniProt NextProt Show fit	casein kinase 1, gamma 2
chr2_-_62115725 Show fit	9.24	ENST00000538252.1 ENST00000544079.1 ENST00000394440.3	CCT4 Ensembl NCBI GeneCards UniProt NextProt Show fit	chaperonin containing TCP1, subunit 4 (delta)
chr2_-_62115659 Show fit	9.23	ENST00000544185.1	CCT4 Ensembl NCBI GeneCards UniProt NextProt Show fit	chaperonin containing TCP1, subunit 4 (delta)
chr6_+_47445467 Show fit	8.98	ENST00000359314.5	CD2AP Ensembl NCBI GeneCards UniProt NextProt Show fit	CD2-associated protein
chr2_-_64881018 Show fit	8.69	ENST00000313349.3	SERTAD2 Ensembl NCBI GeneCards UniProt NextProt Show fit	SERTA domain containing 2
chr7_-_86849883 Show fit	8.09	ENST00000433078.1	TMEM243 Ensembl NCBI GeneCards UniProt NextProt Show fit	transmembrane protein 243, mitochondrial
chr1_+_26496362 Show fit	6.74	ENST00000374266.5 ENST00000270812.5	ZNF593 Ensembl NCBI GeneCards UniProt NextProt Show fit	zinc finger protein 593
chr11_-_6633799 Show fit	6.33	ENST00000299424.4	TAF10 Ensembl NCBI GeneCards UniProt NextProt Show fit	TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 30kDa

Showing 1 to 10 of 106 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of E4F1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	29.1	GO:0006521	regulation of cellular amino acid metabolic process(GO:0006521)
1.8	18.5	GO:0090666	scaRNA localization to Cajal body(GO:0090666)
0.5	11.5	GO:0009263	deoxyribonucleotide biosynthetic process(GO:0009263)
1.9	11.4	GO:0045903	positive regulation of translational fidelity(GO:0045903)
3.7	11.0	GO:1903722	regulation of centriole elongation(GO:1903722)
2.6	10.5	GO:0010730	negative regulation of hydrogen peroxide biosynthetic process(GO:0010730)
0.4	10.4	GO:0032786	positive regulation of DNA-templated transcription, elongation(GO:0032786)
0.1	10.2	GO:0030148	sphingolipid biosynthetic process(GO:0030148)
0.5	9.8	GO:2000052	positive regulation of non-canonical Wnt signaling pathway(GO:2000052)
0.5	9.1	GO:0033148	positive regulation of intracellular estrogen receptor signaling pathway(GO:0033148)

Showing 1 to 10 of 60 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
3.6	29.1	GO:1990111	spermatoproteasome complex(GO:1990111)
0.0	18.6	GO:0000785	chromatin(GO:0000785)
1.4	18.5	GO:0002199	zona pellucida receptor complex(GO:0002199)
0.2	16.9	GO:0022627	cytosolic small ribosomal subunit(GO:0022627)
0.2	14.2	GO:0033116	endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116)
2.9	11.5	GO:0005971	ribonucleoside-diphosphate reductase complex(GO:0005971)
0.0	11.4	GO:0005789	endoplasmic reticulum membrane(GO:0005789)
0.8	11.0	GO:0000815	ESCRT III complex(GO:0000815)
0.0	9.0	GO:0030139	endocytic vesicle(GO:0030139)
0.1	7.2	GO:0005811	lipid particle(GO:0005811)

Showing 1 to 10 of 43 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.0	29.1	GO:0070003	threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.5	18.5	GO:0044183	protein binding involved in protein folding(GO:0044183)
0.2	13.7	GO:0030331	estrogen receptor binding(GO:0030331)
0.3	13.3	GO:0005164	tumor necrosis factor receptor binding(GO:0005164)
2.9	11.5	GO:0004748	ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
1.4	11.4	GO:1990932	5.8S rRNA binding(GO:1990932)
0.4	11.0	GO:0031210	phosphatidylcholine binding(GO:0031210)
1.1	10.5	GO:0031730	CCR5 chemokine receptor binding(GO:0031730)
0.2	10.4	GO:0031492	nucleosomal DNA binding(GO:0031492)
0.1	10.2	GO:0051219	phosphoprotein binding(GO:0051219)

Showing 1 to 10 of 43 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	11.5	PID E2F PATHWAY	E2F transcription factor network
0.6	10.5	ST STAT3 PATHWAY	STAT3 Pathway
0.2	10.2	PID HEDGEHOG GLI PATHWAY	Hedgehog signaling events mediated by Gli proteins
0.3	9.8	PID BETA CATENIN DEG PATHWAY	Degradation of beta catenin
0.3	9.0	PID PRL SIGNALING EVENTS PATHWAY	Signaling events mediated by PRL
0.2	9.0	PID VEGFR1 PATHWAY	VEGFR1 specific signals
0.1	7.4	PID ERA GENOMIC PATHWAY	Validated nuclear estrogen receptor alpha network
0.1	6.3	PID MYC PATHWAY	C-MYC pathway
0.2	5.2	PID EPHA2 FWD PATHWAY	EPHA2 forward signaling
0.1	4.4	PID ERBB NETWORK PATHWAY	ErbB receptor signaling network

Showing 1 to 10 of 14 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.4	29.1	REACTOME CDK MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6	Genes involved in CDK-mediated phosphorylation and removal of Cdc6
0.6	18.5	REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC	Genes involved in Formation of tubulin folding intermediates by CCT/TriC
0.2	16.9	REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX	Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.3	11.5	REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES	Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.4	11.0	REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT	Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
0.6	10.5	REACTOME IL 6 SIGNALING	Genes involved in Interleukin-6 signaling
0.3	10.2	REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS	Genes involved in Sphingolipid de novo biosynthesis
0.1	9.8	REACTOME CIRCADIAN CLOCK	Genes involved in Circadian Clock
0.3	9.0	REACTOME NEPHRIN INTERACTIONS	Genes involved in Nephrin interactions
0.4	6.8	REACTOME ALPHA LINOLENIC ACID ALA METABOLISM	Genes involved in alpha-linolenic acid (ALA) metabolism

Showing 1 to 10 of 26 entries

Results for E4F1

Z-value: 0.41

Motif logo

Transcription factors associated with E4F1

Activity-expression correlation:

Activity profile of E4F1 motif

Sorted Z-values of E4F1 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of E4F1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: