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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)

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Results for E4F1

Z-value: 0.41

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Transcription factors associated with E4F1

Gene Symbol Gene ID Gene Info
E4F1
ENSG00000167967.11 E4F transcription factor 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
E4F1hg19_v2_chr16_+_2273558_22736370.392.9e-09Click!

Activity profile of E4F1 motif

Sorted Z-values of E4F1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr6_-_32812420 16.47 ENST00000374881.2
PSMB8
proteasome (prosome, macropain) subunit, beta type, 8
chr6_+_32812568 12.62 ENST00000414474.1
PSMB9
proteasome (prosome, macropain) subunit, beta type, 9
chr19_+_1941117 10.22 ENST00000255641.8
CSNK1G2
casein kinase 1, gamma 2
chr2_-_62115725 9.24 ENST00000538252.1
ENST00000544079.1
ENST00000394440.3
CCT4
chaperonin containing TCP1, subunit 4 (delta)
chr2_-_62115659 9.23 ENST00000544185.1
CCT4
chaperonin containing TCP1, subunit 4 (delta)
chr6_+_47445467 8.98 ENST00000359314.5
CD2AP
CD2-associated protein
chr2_-_64881018 8.69 ENST00000313349.3
SERTAD2
SERTA domain containing 2
chr7_-_86849883 8.09 ENST00000433078.1
TMEM243
transmembrane protein 243, mitochondrial
chr1_+_26496362 6.74 ENST00000374266.5
ENST00000270812.5
ZNF593
zinc finger protein 593
chr11_-_6633799 6.33 ENST00000299424.4
TAF10
TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 30kDa
chr6_+_139456226 6.30 ENST00000367658.2
HECA
headcase homolog (Drosophila)
chr17_-_80231300 6.14 ENST00000398519.5
ENST00000580446.1
CSNK1D
casein kinase 1, delta
chr14_+_105219437 6.11 ENST00000329967.6
ENST00000347067.5
ENST00000553810.1
SIVA1
SIVA1, apoptosis-inducing factor
chr6_-_53213780 6.01 ENST00000304434.6
ENST00000370918.4
ELOVL5
ELOVL fatty acid elongase 5
chr4_-_122744998 5.93 ENST00000274026.5
CCNA2
cyclin A2
chr3_-_156877997 5.92 ENST00000295926.3
CCNL1
cyclin L1
chr11_+_4116054 5.85 ENST00000423050.2
RRM1
ribonucleotide reductase M1
chr19_-_59066327 5.69 ENST00000596708.1
ENST00000601220.1
ENST00000597848.1
CHMP2A
charged multivesicular body protein 2A
chr11_+_4116005 5.62 ENST00000300738.5
RRM1
ribonucleotide reductase M1
chr21_-_40720995 5.51 ENST00000380749.5
HMGN1
high mobility group nucleosome binding domain 1
chr7_-_137686791 5.50 ENST00000452463.1
ENST00000330387.6
ENST00000456390.1
CREB3L2
cAMP responsive element binding protein 3-like 2
chr14_-_50053081 5.43 ENST00000396020.3
ENST00000245458.6
RPS29
ribosomal protein S29
chr19_-_59066452 5.30 ENST00000312547.2
CHMP2A
charged multivesicular body protein 2A
chr2_-_240964716 5.27 ENST00000404554.1
ENST00000407129.3
ENST00000307300.4
ENST00000443626.1
ENST00000252711.2
NDUFA10
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 10, 42kDa
chr3_+_140660743 5.19 ENST00000453248.2
SLC25A36
solute carrier family 25 (pyrimidine nucleotide carrier ), member 36
chr6_-_31774714 5.07 ENST00000375661.5
LSM2
LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae)
chr17_-_685559 4.99 ENST00000301329.6
GLOD4
glyoxalase domain containing 4
chr21_-_40720974 4.91 ENST00000380748.1
HMGN1
high mobility group nucleosome binding domain 1
chr17_-_685493 4.82 ENST00000536578.1
ENST00000301328.5
ENST00000576419.1
GLOD4
glyoxalase domain containing 4
chr11_-_67276100 4.61 ENST00000301488.3
CDK2AP2
cyclin-dependent kinase 2 associated protein 2
chr3_+_38206975 4.51 ENST00000446845.1
ENST00000311806.3
OXSR1
oxidative stress responsive 1
chr22_-_38902300 4.44 ENST00000403230.1
DDX17
DEAD (Asp-Glu-Ala-Asp) box helicase 17
chr17_+_7476136 4.32 ENST00000582169.1
ENST00000578754.1
ENST00000578495.1
ENST00000293831.8
ENST00000380512.5
ENST00000585024.1
ENST00000583802.1
ENST00000577269.1
ENST00000584784.1
ENST00000582746.1
EIF4A1
eukaryotic translation initiation factor 4A1
chr6_-_144416737 4.13 ENST00000367569.2
SF3B5
splicing factor 3b, subunit 5, 10kDa
chr17_-_40540377 4.09 ENST00000404395.3
ENST00000389272.3
ENST00000585517.1
ENST00000588065.1
STAT3
signal transducer and activator of transcription 3 (acute-phase response factor)
chr10_+_95256356 3.97 ENST00000371485.3
CEP55
centrosomal protein 55kDa
chr1_-_32110467 3.95 ENST00000440872.2
ENST00000373703.4
PEF1
penta-EF-hand domain containing 1
chrX_+_153672468 3.94 ENST00000393600.3
FAM50A
family with sequence similarity 50, member A
chr17_-_40540586 3.94 ENST00000264657.5
STAT3
signal transducer and activator of transcription 3 (acute-phase response factor)
chr19_+_54704610 3.88 ENST00000302907.4
RPS9
ribosomal protein S9
chr3_-_185655795 3.79 ENST00000342294.4
ENST00000382191.4
ENST00000453386.2
TRA2B
transformer 2 beta homolog (Drosophila)
chr16_-_3767506 3.76 ENST00000538171.1
TRAP1
TNF receptor-associated protein 1
chr19_+_54704990 3.70 ENST00000391753.2
RPS9
ribosomal protein S9
chr17_-_80231557 3.66 ENST00000392334.2
ENST00000314028.6
CSNK1D
casein kinase 1, delta
chr1_+_39456895 3.55 ENST00000432648.3
ENST00000446189.2
ENST00000372984.4
AKIRIN1
akirin 1
chr5_+_133707252 3.54 ENST00000506787.1
ENST00000507277.1
UBE2B
ubiquitin-conjugating enzyme E2B
chr1_-_16482554 3.47 ENST00000358432.5
EPHA2
EPH receptor A2
chr16_-_3767551 3.45 ENST00000246957.5
TRAP1
TNF receptor-associated protein 1
chr11_-_3818688 3.39 ENST00000355260.3
ENST00000397004.4
ENST00000397007.4
ENST00000532475.1
NUP98
nucleoporin 98kDa
chr4_-_104119528 3.14 ENST00000380026.3
ENST00000503705.1
ENST00000265148.3
CENPE
centromere protein E, 312kDa
chr22_-_38902325 2.97 ENST00000396821.3
ENST00000381633.3
DDX17
DEAD (Asp-Glu-Ala-Asp) box helicase 17
chr4_+_47487285 2.92 ENST00000273859.3
ENST00000504445.1
ATP10D
ATPase, class V, type 10D
chr11_-_3818932 2.86 ENST00000324932.7
ENST00000359171.4
NUP98
nucleoporin 98kDa
chr4_-_54930790 2.83 ENST00000263921.3
CHIC2
cysteine-rich hydrophobic domain 2
chr17_-_40540484 2.52 ENST00000588969.1
STAT3
signal transducer and activator of transcription 3 (acute-phase response factor)
chr4_-_76598544 2.50 ENST00000515457.1
ENST00000357854.3
G3BP2
GTPase activating protein (SH3 domain) binding protein 2
chr22_-_41252962 2.44 ENST00000216218.3
ST13
suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein)
chr19_+_54704718 2.28 ENST00000391752.1
ENST00000402367.1
ENST00000391751.3
RPS9
ribosomal protein S9
chr14_-_23388338 2.26 ENST00000555209.1
ENST00000554256.1
ENST00000557403.1
ENST00000557549.1
ENST00000555676.1
ENST00000557571.1
ENST00000557464.1
ENST00000554618.1
ENST00000556862.1
ENST00000555722.1
ENST00000346528.5
ENST00000542016.2
ENST00000399922.2
ENST00000557227.1
ENST00000359890.3
RBM23
RNA binding motif protein 23
chr4_+_75311019 2.26 ENST00000502307.1
AREG
amphiregulin
chr6_+_64281906 2.18 ENST00000370651.3
PTP4A1
protein tyrosine phosphatase type IVA, member 1
chr3_+_140660634 2.17 ENST00000446041.2
ENST00000507429.1
ENST00000324194.6
SLC25A36
solute carrier family 25 (pyrimidine nucleotide carrier ), member 36
chr4_+_75310851 2.16 ENST00000395748.3
ENST00000264487.2
AREG
amphiregulin
chr4_+_1873100 2.06 ENST00000508803.1
WHSC1
Wolf-Hirschhorn syndrome candidate 1
chr8_-_29208183 2.02 ENST00000240100.2
DUSP4
dual specificity phosphatase 4
chr1_+_212208919 2.00 ENST00000366991.4
ENST00000542077.1
DTL
denticleless E3 ubiquitin protein ligase homolog (Drosophila)
chr11_-_8680383 1.85 ENST00000299550.6
TRIM66
tripartite motif containing 66
chr15_+_50716576 1.83 ENST00000560297.1
ENST00000307179.4
ENST00000396444.3
ENST00000433963.1
ENST00000425032.3
USP8
ubiquitin specific peptidase 8
chr3_+_101292939 1.82 ENST00000265260.3
ENST00000469941.1
ENST00000296024.5
PCNP
PEST proteolytic signal containing nuclear protein
chr11_-_33183006 1.78 ENST00000524827.1
ENST00000323959.4
ENST00000431742.2
CSTF3
cleavage stimulation factor, 3' pre-RNA, subunit 3, 77kDa
chr22_+_39101728 1.75 ENST00000216044.5
ENST00000484657.1
GTPBP1
GTP binding protein 1
chr11_-_77185094 1.69 ENST00000278568.4
ENST00000356341.3
PAK1
p21 protein (Cdc42/Rac)-activated kinase 1
chr1_+_110527308 1.68 ENST00000369799.5
AHCYL1
adenosylhomocysteinase-like 1
chr7_-_129592471 1.62 ENST00000473814.2
ENST00000490974.1
UBE2H
ubiquitin-conjugating enzyme E2H
chr8_-_95274536 1.61 ENST00000297596.2
ENST00000396194.2
GEM
GTP binding protein overexpressed in skeletal muscle
chr11_+_3819049 1.59 ENST00000396986.2
ENST00000300730.6
ENST00000532535.1
ENST00000396993.4
ENST00000396991.2
ENST00000532523.1
ENST00000459679.1
ENST00000464261.1
ENST00000464906.2
ENST00000464441.1
PGAP2
post-GPI attachment to proteins 2
chr19_+_54705025 1.57 ENST00000441429.1
RPS9
ribosomal protein S9
chr7_-_129592700 1.39 ENST00000472396.1
ENST00000355621.3
UBE2H
ubiquitin-conjugating enzyme E2H
chr2_+_202899310 1.36 ENST00000286201.1
FZD7
frizzled family receptor 7
chr17_+_685513 1.31 ENST00000304478.4
RNMTL1
RNA methyltransferase like 1
chr6_-_29595779 1.28 ENST00000355973.3
ENST00000377012.4
GABBR1
gamma-aminobutyric acid (GABA) B receptor, 1
chr17_-_7165662 1.24 ENST00000571881.2
ENST00000360325.7
CLDN7
claudin 7
chr12_-_93836028 0.95 ENST00000318066.2
UBE2N
ubiquitin-conjugating enzyme E2N
chr12_+_122516626 0.93 ENST00000319080.7
MLXIP
MLX interacting protein
chr6_-_27440837 0.88 ENST00000211936.6
ZNF184
zinc finger protein 184
chr6_+_64282447 0.85 ENST00000370650.2
ENST00000578299.1
PTP4A1
protein tyrosine phosphatase type IVA, member 1
chr10_-_119134918 0.83 ENST00000334464.5
PDZD8
PDZ domain containing 8
chr19_+_45504688 0.82 ENST00000221452.8
ENST00000540120.1
ENST00000505236.1
RELB
v-rel avian reticuloendotheliosis viral oncogene homolog B
chr6_-_53213587 0.75 ENST00000542638.1
ENST00000370913.5
ENST00000541407.1
ELOVL5
ELOVL fatty acid elongase 5
chr3_+_150126101 0.66 ENST00000361875.3
ENST00000361136.2
TSC22D2
TSC22 domain family, member 2
chr5_+_133706865 0.56 ENST00000265339.2
UBE2B
ubiquitin-conjugating enzyme E2B
chr1_-_47184745 0.53 ENST00000544071.1
EFCAB14
EF-hand calcium binding domain 14
chr6_-_27440460 0.51 ENST00000377419.1
ZNF184
zinc finger protein 184
chr6_+_33176265 0.44 ENST00000374656.4
RING1
ring finger protein 1
chr17_+_7211656 0.37 ENST00000416016.2
EIF5A
eukaryotic translation initiation factor 5A
chr19_+_13858593 0.32 ENST00000221554.8
CCDC130
coiled-coil domain containing 130
chr1_-_47184723 0.30 ENST00000371933.3
EFCAB14
EF-hand calcium binding domain 14
chr12_-_93835665 0.25 ENST00000552442.1
ENST00000550657.1
UBE2N
ubiquitin-conjugating enzyme E2N
chr1_+_109289279 0.23 ENST00000370008.3
STXBP3
syntaxin binding protein 3
chr3_-_107941230 0.22 ENST00000264538.3
IFT57
intraflagellar transport 57 homolog (Chlamydomonas)
chr4_-_186456652 0.13 ENST00000284767.5
ENST00000284770.5
PDLIM3
PDZ and LIM domain 3
chr4_-_111558135 0.10 ENST00000394598.2
ENST00000394595.3
PITX2
paired-like homeodomain 2
chr15_-_41047421 0.07 ENST00000560460.1
ENST00000338376.3
ENST00000560905.1
RMDN3
regulator of microtubule dynamics 3
chr17_+_35294075 0.06 ENST00000254457.5
LHX1
LIM homeobox 1
chr4_-_186456766 0.05 ENST00000284771.6
PDLIM3
PDZ and LIM domain 3
chr10_-_64576105 0.04 ENST00000242480.3
ENST00000411732.1
EGR2
early growth response 2

Network of associatons between targets according to the STRING database.

First level regulatory network of E4F1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
3.7 11.0 GO:1903722 regulation of centriole elongation(GO:1903722)
3.0 9.0 GO:0032911 negative regulation of transforming growth factor beta1 production(GO:0032911)
2.6 10.5 GO:0010730 negative regulation of hydrogen peroxide biosynthetic process(GO:0010730)
1.9 11.4 GO:0045903 positive regulation of translational fidelity(GO:0045903)
1.8 18.5 GO:0090666 scaRNA localization to Cajal body(GO:0090666)
1.8 7.2 GO:0009386 translational attenuation(GO:0009386)
1.5 4.5 GO:2000681 negative regulation of rubidium ion transport(GO:2000681) negative regulation of rubidium ion transmembrane transporter activity(GO:2000687)
1.5 5.9 GO:0071373 cellular response to cocaine(GO:0071314) cellular response to luteinizing hormone stimulus(GO:0071373)
1.4 4.1 GO:0010845 positive regulation of reciprocal meiotic recombination(GO:0010845)
1.2 6.2 GO:0000973 posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery(GO:0000973)
1.2 3.5 GO:1901491 negative regulation of lymphangiogenesis(GO:1901491)
1.1 6.8 GO:0019367 fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.9 3.8 GO:0021796 cerebral cortex regionalization(GO:0021796)
0.9 4.6 GO:2000035 regulation of stem cell division(GO:2000035)
0.8 6.7 GO:0000055 ribosomal large subunit export from nucleus(GO:0000055) negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding(GO:1903026)
0.8 2.3 GO:0006864 pyrimidine nucleotide transport(GO:0006864) mitochondrial pyrimidine nucleotide import(GO:1990519)
0.7 1.4 GO:0009996 negative regulation of cell fate specification(GO:0009996)
0.6 5.9 GO:1901409 positive regulation of phosphorylation of RNA polymerase II C-terminal domain(GO:1901409)
0.6 3.9 GO:1902527 positive regulation of protein monoubiquitination(GO:1902527)
0.6 4.4 GO:0042695 thelarche(GO:0042695) mammary gland branching involved in thelarche(GO:0060744)
0.5 9.8 GO:2000052 positive regulation of non-canonical Wnt signaling pathway(GO:2000052)
0.5 1.6 GO:1901842 negative regulation of high voltage-gated calcium channel activity(GO:1901842)
0.5 3.1 GO:0007079 mitotic chromosome movement towards spindle pole(GO:0007079)
0.5 9.1 GO:0033148 positive regulation of intracellular estrogen receptor signaling pathway(GO:0033148)
0.5 11.5 GO:0009263 deoxyribonucleotide biosynthetic process(GO:0009263)
0.5 6.3 GO:0070365 hepatocyte differentiation(GO:0070365)
0.4 2.4 GO:0061084 regulation of protein refolding(GO:0061083) negative regulation of protein refolding(GO:0061084)
0.4 10.4 GO:0032786 positive regulation of DNA-templated transcription, elongation(GO:0032786)
0.3 29.1 GO:0006521 regulation of cellular amino acid metabolic process(GO:0006521)
0.3 4.0 GO:0000920 cell separation after cytokinesis(GO:0000920)
0.2 1.7 GO:0033353 S-adenosylmethionine cycle(GO:0033353)
0.1 5.1 GO:0043928 exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay(GO:0043928)
0.1 1.7 GO:0061014 positive regulation of mRNA catabolic process(GO:0061014)
0.1 2.9 GO:0045332 lipid translocation(GO:0034204) phospholipid translocation(GO:0045332)
0.1 10.2 GO:0030148 sphingolipid biosynthetic process(GO:0030148)
0.1 1.2 GO:0033182 regulation of histone ubiquitination(GO:0033182)
0.1 4.3 GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening(GO:0000289)
0.1 5.3 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.1 3.0 GO:0070979 protein K11-linked ubiquitination(GO:0070979)
0.1 0.1 GO:0060067 cervix development(GO:0060067)
0.1 1.3 GO:0071108 protein K48-linked deubiquitination(GO:0071108)
0.1 1.8 GO:0006379 mRNA cleavage(GO:0006379)
0.1 2.8 GO:0006893 Golgi to plasma membrane transport(GO:0006893)
0.0 0.8 GO:0032688 negative regulation of interferon-beta production(GO:0032688)
0.0 0.4 GO:0045905 translational frameshifting(GO:0006452) positive regulation of translational termination(GO:0045905)
0.0 1.6 GO:0006506 GPI anchor biosynthetic process(GO:0006506)
0.0 1.2 GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338)
0.0 2.0 GO:0019985 translesion synthesis(GO:0019985)
0.0 6.1 GO:0046718 viral entry into host cell(GO:0046718)
0.0 5.5 GO:0002062 chondrocyte differentiation(GO:0002062)
0.0 5.4 GO:0006614 SRP-dependent cotranslational protein targeting to membrane(GO:0006614)
0.0 0.1 GO:0035993 subthalamic nucleus development(GO:0021763) deltoid tuberosity development(GO:0035993) prolactin secreting cell differentiation(GO:0060127) left lung morphogenesis(GO:0060460) pulmonary vein morphogenesis(GO:0060577) superior vena cava morphogenesis(GO:0060578)
0.0 6.3 GO:0030323 respiratory tube development(GO:0030323)
0.0 1.3 GO:0007214 gamma-aminobutyric acid signaling pathway(GO:0007214)
0.0 0.4 GO:0035518 histone H2A monoubiquitination(GO:0035518)
0.0 2.0 GO:0070373 negative regulation of ERK1 and ERK2 cascade(GO:0070373)
0.0 0.2 GO:0022615 protein to membrane docking(GO:0022615)
0.0 0.2 GO:0060972 left/right pattern formation(GO:0060972)
0.0 0.0 GO:0021571 rhombomere 3 development(GO:0021569) rhombomere 5 development(GO:0021571) central nervous system segmentation(GO:0035283) brain segmentation(GO:0035284)
0.0 0.8 GO:0022604 regulation of cell morphogenesis(GO:0022604)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
3.6 29.1 GO:1990111 spermatoproteasome complex(GO:1990111)
2.9 11.5 GO:0005971 ribonucleoside-diphosphate reductase complex(GO:0005971)
2.3 6.8 GO:0097447 dendritic tree(GO:0097447)
2.0 5.9 GO:0097124 cyclin A2-CDK2 complex(GO:0097124)
1.4 18.5 GO:0002199 zona pellucida receptor complex(GO:0002199)
1.0 6.2 GO:0044614 nuclear pore cytoplasmic filaments(GO:0044614)
0.8 11.0 GO:0000815 ESCRT III complex(GO:0000815)
0.8 4.1 GO:0033503 HULC complex(GO:0033503)
0.7 5.1 GO:1990726 Lsm1-7-Pat1 complex(GO:1990726)
0.7 6.3 GO:0000125 PCAF complex(GO:0000125)
0.4 1.3 GO:0038039 G-protein coupled receptor heterodimeric complex(GO:0038039)
0.4 1.2 GO:0031372 UBC13-MMS2 complex(GO:0031372)
0.3 1.8 GO:0031313 extrinsic component of endosome membrane(GO:0031313)
0.3 4.3 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
0.3 4.0 GO:0090543 Flemming body(GO:0090543)
0.3 3.1 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.2 2.0 GO:0031465 Cul4B-RING E3 ubiquitin ligase complex(GO:0031465)
0.2 16.9 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.2 6.7 GO:0030687 preribosome, large subunit precursor(GO:0030687)
0.2 4.1 GO:0005686 U2 snRNP(GO:0005686)
0.2 3.9 GO:0030127 COPII vesicle coat(GO:0030127)
0.2 14.2 GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116)
0.1 5.9 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.1 1.7 GO:0000177 cytoplasmic exosome (RNase complex)(GO:0000177)
0.1 3.5 GO:0031258 lamellipodium membrane(GO:0031258)
0.1 7.2 GO:0005811 lipid particle(GO:0005811)
0.1 5.3 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.1 1.7 GO:0071437 invadopodium(GO:0071437)
0.1 0.8 GO:0033256 I-kappaB/NF-kappaB complex(GO:0033256)
0.1 1.6 GO:0051233 spindle midzone(GO:0051233)
0.0 0.4 GO:0005642 annulate lamellae(GO:0005642)
0.0 0.4 GO:0001739 sex chromatin(GO:0001739)
0.0 1.2 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.0 1.8 GO:0016235 aggresome(GO:0016235)
0.0 2.8 GO:0005798 Golgi-associated vesicle(GO:0005798)
0.0 1.4 GO:0055038 recycling endosome membrane(GO:0055038)
0.0 18.6 GO:0000785 chromatin(GO:0000785)
0.0 9.0 GO:0030139 endocytic vesicle(GO:0030139)
0.0 0.2 GO:0044292 dendrite terminus(GO:0044292)
0.0 0.9 GO:0019867 mitochondrial outer membrane(GO:0005741) outer membrane(GO:0019867) organelle outer membrane(GO:0031968)
0.0 3.0 GO:0009898 cytoplasmic side of plasma membrane(GO:0009898)
0.0 11.4 GO:0005789 endoplasmic reticulum membrane(GO:0005789)
0.0 4.7 GO:0005874 microtubule(GO:0005874)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
2.9 11.5 GO:0004748 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
2.2 6.7 GO:0031177 acyl binding(GO:0000035) phosphopantetheine binding(GO:0031177)
1.4 11.4 GO:1990932 5.8S rRNA binding(GO:1990932)
1.1 6.8 GO:0102336 fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)
1.1 10.5 GO:0031730 CCR5 chemokine receptor binding(GO:0031730)
1.0 29.1 GO:0070003 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.8 3.1 GO:0043515 kinetochore binding(GO:0043515)
0.8 2.3 GO:0015218 pyrimidine nucleotide transmembrane transporter activity(GO:0015218)
0.7 2.0 GO:0008330 protein tyrosine/threonine phosphatase activity(GO:0008330)
0.6 9.0 GO:0005172 vascular endothelial growth factor receptor binding(GO:0005172)
0.5 18.5 GO:0044183 protein binding involved in protein folding(GO:0044183)
0.4 9.8 GO:0050321 tau-protein kinase activity(GO:0050321)
0.4 1.3 GO:0004965 G-protein coupled GABA receptor activity(GO:0004965)
0.4 2.4 GO:0032564 adenyl deoxyribonucleotide binding(GO:0032558) dATP binding(GO:0032564)
0.4 11.0 GO:0031210 phosphatidylcholine binding(GO:0031210)
0.3 5.1 GO:0017160 Ral GTPase binding(GO:0017160)
0.3 1.7 GO:0016802 adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.3 13.3 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.3 5.5 GO:0035497 cAMP response element binding(GO:0035497)
0.2 10.4 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.2 6.2 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.2 13.7 GO:0030331 estrogen receptor binding(GO:0030331)
0.2 4.3 GO:0000339 RNA cap binding(GO:0000339)
0.2 7.1 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.1 5.9 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.1 2.9 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.1 4.4 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.1 3.8 GO:0070717 poly-purine tract binding(GO:0070717)
0.1 5.3 GO:0008137 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.1 3.9 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.1 10.2 GO:0051219 phosphoprotein binding(GO:0051219)
0.1 0.4 GO:0097027 ubiquitin-protein transferase activator activity(GO:0097027)
0.1 3.4 GO:0097472 cyclin-dependent protein kinase activity(GO:0097472)
0.1 1.4 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.0 3.5 GO:0001618 virus receptor activity(GO:0001618)
0.0 1.2 GO:0050839 cell adhesion molecule binding(GO:0050839)
0.0 6.1 GO:0000287 magnesium ion binding(GO:0000287)
0.0 5.4 GO:0003735 structural constituent of ribosome(GO:0003735)
0.0 0.7 GO:0003700 nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700)
0.0 1.7 GO:0048365 Rac GTPase binding(GO:0048365)
0.0 0.4 GO:0017070 U6 snRNA binding(GO:0017070)
0.0 1.3 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843)
0.0 1.6 GO:0008565 protein transporter activity(GO:0008565)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 10.5 ST STAT3 PATHWAY STAT3 Pathway
0.3 9.8 PID BETA CATENIN DEG PATHWAY Degradation of beta catenin
0.3 9.0 PID PRL SIGNALING EVENTS PATHWAY Signaling events mediated by PRL
0.2 9.0 PID VEGFR1 PATHWAY VEGFR1 specific signals
0.2 5.2 PID EPHA2 FWD PATHWAY EPHA2 forward signaling
0.2 10.2 PID HEDGEHOG GLI PATHWAY Hedgehog signaling events mediated by Gli proteins
0.1 4.4 PID ERBB NETWORK PATHWAY ErbB receptor signaling network
0.1 6.3 PID MYC PATHWAY C-MYC pathway
0.1 11.5 PID E2F PATHWAY E2F transcription factor network
0.1 7.4 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network
0.0 1.4 PID WNT SIGNALING PATHWAY Wnt signaling network
0.0 1.8 PID ERBB2 ERBB3 PATHWAY ErbB2/ErbB3 signaling events
0.0 2.0 ST JNK MAPK PATHWAY JNK MAPK Pathway
0.0 1.2 PID ATM PATHWAY ATM pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 18.5 REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC Genes involved in Formation of tubulin folding intermediates by CCT/TriC
0.6 10.5 REACTOME IL 6 SIGNALING Genes involved in Interleukin-6 signaling
0.4 11.0 REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
0.4 29.1 REACTOME CDK MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6 Genes involved in CDK-mediated phosphorylation and removal of Cdc6
0.4 6.8 REACTOME ALPHA LINOLENIC ACID ALA METABOLISM Genes involved in alpha-linolenic acid (ALA) metabolism
0.3 5.1 REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
0.3 11.5 REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.3 10.2 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.3 5.9 REACTOME SCFSKP2 MEDIATED DEGRADATION OF P27 P21 Genes involved in SCF(Skp2)-mediated degradation of p27/p21
0.3 9.0 REACTOME NEPHRIN INTERACTIONS Genes involved in Nephrin interactions
0.2 16.9 REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.2 4.3 REACTOME ACTIVATION OF THE MRNA UPON BINDING OF THE CAP BINDING COMPLEX AND EIFS AND SUBSEQUENT BINDING TO 43S Genes involved in Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
0.1 9.8 REACTOME CIRCADIAN CLOCK Genes involved in Circadian Clock
0.1 1.2 REACTOME IRAK1 RECRUITS IKK COMPLEX Genes involved in IRAK1 recruits IKK complex
0.1 1.8 REACTOME PROCESSING OF INTRONLESS PRE MRNAS Genes involved in Processing of Intronless Pre-mRNAs
0.1 1.7 REACTOME DSCAM INTERACTIONS Genes involved in DSCAM interactions
0.1 4.1 REACTOME MRNA SPLICING MINOR PATHWAY Genes involved in mRNA Splicing - Minor Pathway
0.1 1.8 REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.1 1.3 REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.1 5.3 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.1 2.9 REACTOME ION TRANSPORT BY P TYPE ATPASES Genes involved in Ion transport by P-type ATPases
0.0 1.3 REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
0.0 1.2 REACTOME TIGHT JUNCTION INTERACTIONS Genes involved in Tight junction interactions
0.0 3.9 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.0 1.4 REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 0.4 REACTOME PTM GAMMA CARBOXYLATION HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION Genes involved in PTM: gamma carboxylation, hypusine formation and arylsulfatase activation