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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for EGR1_EGR4
Z-value: 0.54
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Transcription factors associated with EGR1_EGR4
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| EGR1 | hg19_v2_chr5_+_137801160_137801179 | 0.36 | 4.5e-08 | Click! |
| EGR4 | hg19_v2_chr2_-_73520667_73520833 | 0.18 | 8.2e-03 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr13_-_41635512 Show fit | 20.08 |
ENST00000405737.2
|
E74-like factor 1 (ets domain transcription factor) |
|
| chr10_+_49514698 Show fit | 12.50 |
ENST00000432379.1
ENST00000429041.1 ENST00000374189.1 |
mitogen-activated protein kinase 8 |
|
| chr16_-_402639 Show fit | 10.91 |
ENST00000262320.3
|
axin 1 |
|
| chr15_+_74833518 Show fit | 10.60 |
ENST00000346246.5
|
AT rich interactive domain 3B (BRIGHT-like) |
|
| chr19_+_16435625 Show fit | 10.30 |
ENST00000248071.5
ENST00000592003.1 |
Kruppel-like factor 2 |
|
| chr11_-_64512803 Show fit | 9.93 |
ENST00000377489.1
ENST00000354024.3 |
RAS guanyl releasing protein 2 (calcium and DAG-regulated) |
|
| chr12_+_77158021 Show fit | 9.78 |
ENST00000550876.1
|
zinc finger, DHHC-type containing 17 |
|
| chr19_-_49622348 Show fit | 9.76 |
ENST00000408991.2
|
chromosome 19 open reading frame 73 |
|
| chr6_+_37137939 Show fit | 9.59 |
ENST00000373509.5
|
pim-1 oncogene |
|
| chr19_-_33793430 Show fit | 9.35 |
ENST00000498907.2
|
CCAAT/enhancer binding protein (C/EBP), alpha |
Network of associatons between targets according to the STRING database.
First level regulatory network of EGR1_EGR4
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 40.3 | GO:0071277 | cellular response to calcium ion(GO:0071277) |
| 1.6 | 25.7 | GO:0045721 | negative regulation of gluconeogenesis(GO:0045721) |
| 0.7 | 20.1 | GO:0050860 | negative regulation of T cell receptor signaling pathway(GO:0050860) |
| 0.2 | 13.1 | GO:0042787 | protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0042787) |
| 3.2 | 12.8 | GO:0001743 | optic placode formation(GO:0001743) |
| 0.9 | 12.7 | GO:1903830 | magnesium ion transmembrane transport(GO:1903830) |
| 4.2 | 12.5 | GO:1902595 | regulation of DNA replication origin binding(GO:1902595) |
| 0.1 | 12.5 | GO:0007601 | visual perception(GO:0007601) |
| 4.1 | 12.2 | GO:0071409 | cellular response to cycloheximide(GO:0071409) |
| 0.3 | 12.0 | GO:0090022 | regulation of neutrophil chemotaxis(GO:0090022) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 39.5 | GO:0032587 | ruffle membrane(GO:0032587) |
| 0.2 | 25.9 | GO:0034705 | voltage-gated potassium channel complex(GO:0008076) potassium channel complex(GO:0034705) |
| 0.1 | 25.5 | GO:0005667 | transcription factor complex(GO:0005667) |
| 0.1 | 22.4 | GO:0016607 | nuclear speck(GO:0016607) |
| 0.3 | 14.3 | GO:0005891 | voltage-gated calcium channel complex(GO:0005891) |
| 0.1 | 14.2 | GO:0016323 | basolateral plasma membrane(GO:0016323) |
| 0.3 | 12.8 | GO:0097542 | ciliary tip(GO:0097542) |
| 0.5 | 11.8 | GO:0071141 | SMAD protein complex(GO:0071141) |
| 0.7 | 10.9 | GO:0030877 | beta-catenin destruction complex(GO:0030877) |
| 0.1 | 10.0 | GO:0042734 | presynaptic membrane(GO:0042734) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.1 | 37.1 | GO:0019992 | diacylglycerol binding(GO:0019992) |
| 0.1 | 28.2 | GO:0001228 | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228) |
| 0.1 | 25.6 | GO:0030695 | GTPase regulator activity(GO:0030695) |
| 0.2 | 20.1 | GO:0003705 | transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705) |
| 0.0 | 19.7 | GO:0003700 | nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700) |
| 0.4 | 19.5 | GO:0001205 | transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205) |
| 0.1 | 17.3 | GO:0004896 | cytokine receptor activity(GO:0004896) |
| 5.4 | 16.1 | GO:0004676 | 3-phosphoinositide-dependent protein kinase activity(GO:0004676) |
| 0.6 | 15.2 | GO:0071837 | HMG box domain binding(GO:0071837) |
| 1.5 | 15.1 | GO:0061578 | Lys63-specific deubiquitinase activity(GO:0061578) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 52.0 | PID RAS PATHWAY | Regulation of Ras family activation |
| 0.6 | 29.9 | PID IL2 STAT5 PATHWAY | IL2 signaling events mediated by STAT5 |
| 0.3 | 21.6 | PID TNF PATHWAY | TNF receptor signaling pathway |
| 0.7 | 20.5 | SA PTEN PATHWAY | PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. |
| 0.6 | 19.9 | PID WNT CANONICAL PATHWAY | Canonical Wnt signaling pathway |
| 0.5 | 19.3 | ST GA12 PATHWAY | G alpha 12 Pathway |
| 0.2 | 13.8 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.3 | 13.6 | PID MAPK TRK PATHWAY | Trk receptor signaling mediated by the MAPK pathway |
| 0.6 | 11.8 | PID ALK2 PATHWAY | ALK2 signaling events |
| 0.2 | 11.7 | PID IL4 2PATHWAY | IL4-mediated signaling events |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 55.8 | REACTOME INTEGRIN ALPHAIIB BETA3 SIGNALING | Genes involved in Integrin alphaIIb beta3 signaling |
| 0.5 | 18.9 | REACTOME NOD1 2 SIGNALING PATHWAY | Genes involved in NOD1/2 Signaling Pathway |
| 0.2 | 18.3 | REACTOME MEIOTIC SYNAPSIS | Genes involved in Meiotic Synapsis |
| 0.9 | 15.5 | REACTOME DSCAM INTERACTIONS | Genes involved in DSCAM interactions |
| 0.1 | 15.3 | REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |
| 0.6 | 13.4 | REACTOME CTNNB1 PHOSPHORYLATION CASCADE | Genes involved in Beta-catenin phosphorylation cascade |
| 0.5 | 10.8 | REACTOME INITIAL TRIGGERING OF COMPLEMENT | Genes involved in Initial triggering of complement |
| 0.2 | 10.5 | REACTOME VOLTAGE GATED POTASSIUM CHANNELS | Genes involved in Voltage gated Potassium channels |
| 0.4 | 9.5 | REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| 0.5 | 9.2 | REACTOME INTRINSIC PATHWAY | Genes involved in Intrinsic Pathway |