ISMARA results: EMX1

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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)

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Results for EMX1

Z-value: 0.53

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Transcription factors associated with EMX1

Gene Symbol	Gene ID	Gene Info
EMX1 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000135638.9	empty spiracles homeobox 1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
EMX1	hg19_v2_chr2_+_73144604_73144654	0.49	2.9e-14	Click!

Activity profile of EMX1 motif

Sorted Z-values of EMX1 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr11_-_111794446 Show fit	53.74	ENST00000527950.1	CRYAB Ensembl NCBI GeneCards UniProt NextProt Show fit	crystallin, alpha B
chr11_-_117748138 Show fit	41.30	ENST00000527717.1	FXYD6 Ensembl NCBI GeneCards UniProt NextProt Show fit	FXYD domain containing ion transport regulator 6
chr12_-_91546926 Show fit	41.13	ENST00000550758.1	DCN Ensembl NCBI GeneCards UniProt NextProt Show fit	decorin
chr11_-_117747607 Show fit	34.22	ENST00000540359.1 ENST00000539526.1	FXYD6 Ensembl NCBI GeneCards UniProt NextProt Show fit	FXYD domain containing ion transport regulator 6
chr11_-_117747434 Show fit	33.93	ENST00000529335.2 ENST00000530956.1 ENST00000260282.4	FXYD6 Ensembl NCBI GeneCards UniProt NextProt Show fit	FXYD domain containing ion transport regulator 6
chrX_+_13671225 Show fit	33.37	ENST00000545566.1 ENST00000544987.1 ENST00000314720.4	TCEANC Ensembl NCBI GeneCards UniProt NextProt Show fit	transcription elongation factor A (SII) N-terminal and central domain containing
chr12_-_6233828 Show fit	25.41	ENST00000572068.1 ENST00000261405.5	VWF Ensembl NCBI GeneCards UniProt NextProt Show fit	von Willebrand factor
chrX_-_13835147 Show fit	24.44	ENST00000493677.1 ENST00000355135.2	GPM6B Ensembl NCBI GeneCards UniProt NextProt Show fit	glycoprotein M6B
chr6_+_153552455 Show fit	19.69	ENST00000392385.2	AL590867.1 Ensembl NCBI GeneCards UniProt NextProt Show fit	Uncharacterized protein; cDNA FLJ59044, highly similar to LINE-1 reverse transcriptase homolog
chr4_+_175204818 Show fit	16.51	ENST00000503780.1	CEP44 Ensembl NCBI GeneCards UniProt NextProt Show fit	centrosomal protein 44kDa

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of EMX1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.4	105.6	GO:2000649	regulation of sodium ion transmembrane transporter activity(GO:2000649)
3.0	53.7	GO:0007021	tubulin complex assembly(GO:0007021)
3.4	41.1	GO:1900747	negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747)
0.2	32.1	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
2.4	24.4	GO:0051611	negative regulation of neurotransmitter uptake(GO:0051581) serotonin uptake(GO:0051610) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612)
1.0	24.0	GO:0007597	blood coagulation, intrinsic pathway(GO:0007597)
0.8	19.5	GO:0003334	keratinocyte development(GO:0003334)
1.4	19.1	GO:0098828	positive regulation of inhibitory postsynaptic potential(GO:0097151) modulation of inhibitory postsynaptic potential(GO:0098828)
0.5	17.5	GO:0009083	branched-chain amino acid catabolic process(GO:0009083)
1.6	16.4	GO:0014894	response to muscle inactivity involved in regulation of muscle adaptation(GO:0014877) response to denervation involved in regulation of muscle adaptation(GO:0014894)

Showing 1 to 10 of 217 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	92.7	GO:0005887	integral component of plasma membrane(GO:0005887)
3.4	53.7	GO:0097512	cardiac myofibril(GO:0097512)
0.2	46.4	GO:0043209	myelin sheath(GO:0043209)
2.9	41.1	GO:0098647	collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.1	24.3	GO:0098857	membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.2	22.6	GO:0031093	platelet alpha granule lumen(GO:0031093)
0.1	22.2	GO:0005788	endoplasmic reticulum lumen(GO:0005788)
0.5	22.0	GO:0048786	presynaptic active zone(GO:0048786)
0.1	20.3	GO:0001650	fibrillar center(GO:0001650)
0.2	17.3	GO:0017053	transcriptional repressor complex(GO:0017053)

Showing 1 to 10 of 96 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.0	111.1	GO:0017080	sodium channel regulator activity(GO:0017080)
1.9	58.9	GO:0005212	structural constituent of eye lens(GO:0005212)
0.2	56.1	GO:0051015	actin filament binding(GO:0051015)
0.6	43.3	GO:0050840	extracellular matrix binding(GO:0050840)
0.1	35.9	GO:0005509	calcium ion binding(GO:0005509)
1.0	32.1	GO:0019865	immunoglobulin binding(GO:0019865)
0.3	29.4	GO:0004722	protein serine/threonine phosphatase activity(GO:0004722)
0.1	27.4	GO:0005096	GTPase activator activity(GO:0005096)
0.2	23.4	GO:0035591	signaling adaptor activity(GO:0035591)
0.2	20.4	GO:0004867	serine-type endopeptidase inhibitor activity(GO:0004867)

Showing 1 to 10 of 146 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.0	55.8	NABA PROTEOGLYCANS	Genes encoding proteoglycans
0.2	50.7	NABA ECM GLYCOPROTEINS	Genes encoding structural ECM glycoproteins
0.1	24.4	NABA SECRETED FACTORS	Genes encoding secreted soluble factors
0.1	24.0	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.2	14.5	PID AURORA B PATHWAY	Aurora B signaling
0.3	12.8	PID HIF2PATHWAY	HIF-2-alpha transcription factor network
0.3	12.7	ST DIFFERENTIATION PATHWAY IN PC12 CELLS	Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway.
0.3	10.1	PID INTEGRIN A9B1 PATHWAY	Alpha9 beta1 integrin signaling events
0.2	10.0	PID NCADHERIN PATHWAY	N-cadherin signaling events
0.1	9.3	PID TRKR PATHWAY	Neurotrophic factor-mediated Trk receptor signaling

Showing 1 to 10 of 41 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.5	41.1	REACTOME CS DS DEGRADATION	Genes involved in CS/DS degradation
1.5	25.4	REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN	Genes involved in Platelet Adhesion to exposed collagen
0.2	23.3	REACTOME INTEGRIN CELL SURFACE INTERACTIONS	Genes involved in Integrin cell surface interactions
0.4	23.0	REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS	Genes involved in Amino acid and oligopeptide SLC transporters
0.1	21.6	REACTOME G ALPHA Q SIGNALLING EVENTS	Genes involved in G alpha (q) signalling events
0.5	15.2	REACTOME ADHERENS JUNCTIONS INTERACTIONS	Genes involved in Adherens junctions interactions
0.1	14.0	REACTOME G ALPHA S SIGNALLING EVENTS	Genes involved in G alpha (s) signalling events
0.2	13.8	REACTOME NCAM1 INTERACTIONS	Genes involved in NCAM1 interactions
0.4	13.7	REACTOME KERATAN SULFATE BIOSYNTHESIS	Genes involved in Keratan sulfate biosynthesis
0.7	12.8	REACTOME DOPAMINE NEUROTRANSMITTER RELEASE CYCLE	Genes involved in Dopamine Neurotransmitter Release Cycle

Showing 1 to 10 of 76 entries

Results for EMX1

Z-value: 0.53

Motif logo

Transcription factors associated with EMX1

Activity-expression correlation:

Activity profile of EMX1 motif

Sorted Z-values of EMX1 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of EMX1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: