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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)

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Results for EN2_GBX2_LBX2

Z-value: 0.13

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Transcription factors associated with EN2_GBX2_LBX2

Gene Symbol Gene ID Gene Info
EN2
ENSG00000164778.4 engrailed homeobox 2
GBX2
ENSG00000168505.6 gastrulation brain homeobox 2
LBX2
ENSG00000179528.11 ladybird homeobox 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
GBX2hg19_v2_chr2_-_237076992_237077012-0.143.5e-02Click!
EN2hg19_v2_chr7_+_155250824_1552508240.037.1e-01Click!

Activity profile of EN2_GBX2_LBX2 motif

Sorted Z-values of EN2_GBX2_LBX2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr3_+_115342349 8.84 ENST00000393780.3
GAP43
growth associated protein 43
chr2_-_224467093 8.34 ENST00000305409.2
SCG2
secretogranin II
chr16_-_29910853 7.65 ENST00000308713.5
SEZ6L2
seizure related 6 homolog (mouse)-like 2
chr15_-_55563072 6.30 ENST00000567380.1
ENST00000565972.1
ENST00000569493.1
RAB27A
RAB27A, member RAS oncogene family
chr3_+_111718173 6.18 ENST00000494932.1
TAGLN3
transgelin 3
chr15_-_55562479 6.06 ENST00000564609.1
RAB27A
RAB27A, member RAS oncogene family
chr15_-_37393406 5.88 ENST00000338564.5
ENST00000558313.1
ENST00000340545.5
MEIS2
Meis homeobox 2
chrM_+_12331 5.48 ENST00000361567.2
MT-ND5
mitochondrially encoded NADH dehydrogenase 5
chr3_+_111717600 5.36 ENST00000273368.4
TAGLN3
transgelin 3
chr3_+_111718036 5.29 ENST00000455401.2
TAGLN3
transgelin 3
chr3_+_111717511 5.21 ENST00000478951.1
ENST00000393917.2
TAGLN3
transgelin 3
chr15_-_55562582 5.13 ENST00000396307.2
RAB27A
RAB27A, member RAS oncogene family
chr6_+_39760129 5.02 ENST00000274867.4
DAAM2
dishevelled associated activator of morphogenesis 2
chr12_+_28410128 4.55 ENST00000381259.1
ENST00000381256.1
CCDC91
coiled-coil domain containing 91
chr7_+_77428149 4.00 ENST00000415251.2
ENST00000275575.7
PHTF2
putative homeodomain transcription factor 2
chr3_+_167453493 3.44 ENST00000295777.5
ENST00000472747.2
SERPINI1
serpin peptidase inhibitor, clade I (neuroserpin), member 1
chr1_+_101003687 3.26 ENST00000315033.4
GPR88
G protein-coupled receptor 88
chr6_-_111927062 3.15 ENST00000359831.4
TRAF3IP2
TRAF3 interacting protein 2
chr8_+_105235572 3.13 ENST00000523362.1
RIMS2
regulating synaptic membrane exocytosis 2
chr18_-_33709268 2.94 ENST00000269187.5
ENST00000590986.1
ENST00000440549.2
SLC39A6
solute carrier family 39 (zinc transporter), member 6
chr7_+_77428066 2.90 ENST00000422959.2
ENST00000307305.8
ENST00000424760.1
PHTF2
putative homeodomain transcription factor 2
chr12_-_89746173 2.68 ENST00000308385.6
DUSP6
dual specificity phosphatase 6
chr3_+_130569429 2.50 ENST00000505330.1
ENST00000504381.1
ENST00000507488.2
ENST00000393221.4
ATP2C1
ATPase, Ca++ transporting, type 2C, member 1
chr17_-_9929581 2.49 ENST00000437099.2
ENST00000396115.2
GAS7
growth arrest-specific 7
chr12_-_56694142 2.47 ENST00000550655.1
ENST00000548567.1
ENST00000551430.2
ENST00000351328.3
CS
citrate synthase
chr17_-_10017864 2.46 ENST00000323816.4
GAS7
growth arrest-specific 7
chr2_+_65216462 2.38 ENST00000234256.3
SLC1A4
solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
chr16_+_69345243 2.25 ENST00000254950.11
VPS4A
vacuolar protein sorting 4 homolog A (S. cerevisiae)
chr3_+_173116225 2.23 ENST00000457714.1
NLGN1
neuroligin 1
chr1_-_156399184 2.09 ENST00000368243.1
ENST00000357975.4
ENST00000310027.5
ENST00000400991.2
C1orf61
chromosome 1 open reading frame 61
chr9_+_12693336 2.04 ENST00000381137.2
ENST00000388918.5
TYRP1
tyrosinase-related protein 1
chr20_+_18488137 2.00 ENST00000450074.1
ENST00000262544.2
ENST00000336714.3
ENST00000377475.3
SEC23B
Sec23 homolog B (S. cerevisiae)
chrX_+_154444643 1.99 ENST00000286428.5
VBP1
von Hippel-Lindau binding protein 1
chr18_+_55888767 1.84 ENST00000431212.2
ENST00000586268.1
ENST00000587190.1
NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
chr9_+_2159850 1.83 ENST00000416751.1
SMARCA2
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
chr10_-_50970322 1.82 ENST00000374103.4
OGDHL
oxoglutarate dehydrogenase-like
chr15_+_58430567 1.78 ENST00000536493.1
AQP9
aquaporin 9
chr7_-_137028498 1.72 ENST00000393083.2
PTN
pleiotrophin
chr1_+_153746683 1.70 ENST00000271857.2
SLC27A3
solute carrier family 27 (fatty acid transporter), member 3
chr15_+_58430368 1.69 ENST00000558772.1
ENST00000219919.4
AQP9
aquaporin 9
chr4_-_57547454 1.68 ENST00000556376.2
HOPX
HOP homeobox
chr10_-_50970382 1.66 ENST00000419399.1
ENST00000432695.1
OGDHL
oxoglutarate dehydrogenase-like
chr1_+_145507587 1.62 ENST00000330165.8
ENST00000369307.3
RBM8A
RNA binding motif protein 8A
chr4_-_57547870 1.55 ENST00000381260.3
ENST00000420433.1
ENST00000554144.1
ENST00000557328.1
HOPX
HOP homeobox
chr1_+_62901968 1.51 ENST00000452143.1
ENST00000442679.1
ENST00000371146.1
USP1
ubiquitin specific peptidase 1
chr9_+_80912059 1.50 ENST00000347159.2
ENST00000376588.3
PSAT1
phosphoserine aminotransferase 1
chr6_-_39693111 1.49 ENST00000373215.3
ENST00000538893.1
ENST00000287152.7
ENST00000373216.3
KIF6
kinesin family member 6
chr5_+_125758865 1.45 ENST00000542322.1
ENST00000544396.1
GRAMD3
GRAM domain containing 3
chr1_-_190446759 1.45 ENST00000367462.3
BRINP3
bone morphogenetic protein/retinoic acid inducible neural-specific 3
chr16_+_103816 1.42 ENST00000383018.3
ENST00000417493.1
SNRNP25
small nuclear ribonucleoprotein 25kDa (U11/U12)
chr13_-_41593425 1.41 ENST00000239882.3
ELF1
E74-like factor 1 (ets domain transcription factor)
chr5_+_125758813 1.39 ENST00000285689.3
ENST00000515200.1
GRAMD3
GRAM domain containing 3
chr12_-_16759711 1.39 ENST00000447609.1
LMO3
LIM domain only 3 (rhombotin-like 2)
chr3_+_35722487 1.38 ENST00000441454.1
ARPP21
cAMP-regulated phosphoprotein, 21kDa
chr7_-_137028534 1.29 ENST00000348225.2
PTN
pleiotrophin
chr5_+_145826867 1.27 ENST00000296702.5
ENST00000394421.2
TCERG1
transcription elongation regulator 1
chr6_+_31783291 1.25 ENST00000375651.5
ENST00000608703.1
ENST00000458062.2
HSPA1A
heat shock 70kDa protein 1A
chr18_-_33702078 1.19 ENST00000586829.1
SLC39A6
solute carrier family 39 (zinc transporter), member 6
chr1_+_179923873 1.16 ENST00000367607.3
ENST00000491495.2
CEP350
centrosomal protein 350kDa
chr8_-_18744528 1.16 ENST00000523619.1
PSD3
pleckstrin and Sec7 domain containing 3
chr2_+_47630255 1.11 ENST00000406134.1
MSH2
mutS homolog 2
chr2_+_47630108 1.11 ENST00000233146.2
ENST00000454849.1
ENST00000543555.1
MSH2
mutS homolog 2
chr4_-_143227088 0.98 ENST00000511838.1
INPP4B
inositol polyphosphate-4-phosphatase, type II, 105kDa
chr4_+_71587669 0.96 ENST00000381006.3
ENST00000226328.4
RUFY3
RUN and FYVE domain containing 3
chr6_-_111927449 0.96 ENST00000368761.5
ENST00000392556.4
ENST00000340026.6
TRAF3IP2
TRAF3 interacting protein 2
chr7_+_138145076 0.95 ENST00000343526.4
TRIM24
tripartite motif containing 24
chr5_-_82969405 0.90 ENST00000510978.1
HAPLN1
hyaluronan and proteoglycan link protein 1
chr1_-_23670817 0.89 ENST00000478691.1
HNRNPR
heterogeneous nuclear ribonucleoprotein R
chr1_-_23670813 0.88 ENST00000374612.1
HNRNPR
heterogeneous nuclear ribonucleoprotein R
chrX_+_129473916 0.87 ENST00000545805.1
ENST00000543953.1
ENST00000218197.5
SLC25A14
solute carrier family 25 (mitochondrial carrier, brain), member 14
chr1_+_153747746 0.84 ENST00000368661.3
SLC27A3
solute carrier family 27 (fatty acid transporter), member 3
chr19_+_14640372 0.73 ENST00000215567.5
ENST00000598298.1
ENST00000596073.1
ENST00000600083.1
ENST00000436007.2
TECR
trans-2,3-enoyl-CoA reductase
chr11_-_33913708 0.69 ENST00000257818.2
LMO2
LIM domain only 2 (rhombotin-like 1)
chr6_+_26199737 0.69 ENST00000359985.1
HIST1H2BF
histone cluster 1, H2bf
chr1_-_23670752 0.68 ENST00000302271.6
ENST00000426846.2
ENST00000427764.2
ENST00000606561.1
ENST00000374616.3
HNRNPR
heterogeneous nuclear ribonucleoprotein R
chr2_+_86668464 0.67 ENST00000409064.1
KDM3A
lysine (K)-specific demethylase 3A
chr3_+_172468505 0.67 ENST00000427830.1
ENST00000417960.1
ENST00000428567.1
ENST00000366090.2
ENST00000426894.1
ECT2
epithelial cell transforming sequence 2 oncogene
chr17_+_7792101 0.66 ENST00000358181.4
ENST00000330494.7
CHD3
chromodomain helicase DNA binding protein 3
chr14_-_74551096 0.65 ENST00000350259.4
ALDH6A1
aldehyde dehydrogenase 6 family, member A1
chr18_-_31803435 0.63 ENST00000589544.1
ENST00000269185.4
ENST00000261592.5
NOL4
nucleolar protein 4
chr19_+_34287751 0.63 ENST00000590771.1
ENST00000589786.1
ENST00000284006.6
ENST00000588881.1
KCTD15
potassium channel tetramerization domain containing 15
chr17_+_47448102 0.62 ENST00000576461.1
RP11-81K2.1
Uncharacterized protein
chr4_-_143226979 0.62 ENST00000514525.1
INPP4B
inositol polyphosphate-4-phosphatase, type II, 105kDa
chr2_+_242089833 0.61 ENST00000404405.3
ENST00000439916.1
ENST00000406106.3
ENST00000401987.1
PPP1R7
protein phosphatase 1, regulatory subunit 7
chr14_+_72052983 0.55 ENST00000358550.2
SIPA1L1
signal-induced proliferation-associated 1 like 1
chr15_+_89631381 0.55 ENST00000352732.5
ABHD2
abhydrolase domain containing 2
chr5_+_53751445 0.55 ENST00000302005.1
HSPB3
heat shock 27kDa protein 3
chr3_+_172468472 0.53 ENST00000232458.5
ENST00000392692.3
ECT2
epithelial cell transforming sequence 2 oncogene
chr16_+_53164833 0.53 ENST00000564845.1
CHD9
chromodomain helicase DNA binding protein 9
chr1_+_118472343 0.51 ENST00000369441.3
ENST00000349139.5
WDR3
WD repeat domain 3
chr11_+_75526212 0.48 ENST00000356136.3
UVRAG
UV radiation resistance associated
chr7_-_99717463 0.47 ENST00000437822.2
TAF6
TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa
chr5_+_148737562 0.43 ENST00000274569.4
PCYOX1L
prenylcysteine oxidase 1 like
chr9_+_136501478 0.43 ENST00000393056.2
ENST00000263611.2
DBH
dopamine beta-hydroxylase (dopamine beta-monooxygenase)
chr6_-_32145861 0.43 ENST00000336984.6
AGPAT1
1-acylglycerol-3-phosphate O-acyltransferase 1
chr1_+_110881945 0.41 ENST00000602849.1
ENST00000487146.2
RBM15
RNA binding motif protein 15
chr5_+_176811431 0.41 ENST00000512593.1
ENST00000324417.5
SLC34A1
solute carrier family 34 (type II sodium/phosphate contransporter), member 1
chr11_+_67250490 0.40 ENST00000528641.2
ENST00000279146.3
AIP
aryl hydrocarbon receptor interacting protein
chr1_-_68698222 0.40 ENST00000370976.3
ENST00000354777.2
ENST00000262348.4
ENST00000540432.1
WLS
wntless Wnt ligand secretion mediator
chr3_-_52090461 0.39 ENST00000296483.6
ENST00000495880.1
DUSP7
dual specificity phosphatase 7
chr7_-_99716952 0.39 ENST00000523306.1
ENST00000344095.4
ENST00000417349.1
ENST00000493322.1
ENST00000520135.1
ENST00000418432.2
ENST00000460673.2
ENST00000452041.1
ENST00000452438.2
ENST00000451699.1
ENST00000453269.2
TAF6
TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa
chr19_-_14064114 0.38 ENST00000585607.1
ENST00000538517.2
ENST00000587458.1
ENST00000538371.2
PODNL1
podocan-like 1
chr5_+_179159813 0.33 ENST00000292599.3
MAML1
mastermind-like 1 (Drosophila)
chr19_+_51728316 0.31 ENST00000436584.2
ENST00000421133.2
ENST00000391796.3
ENST00000262262.4
CD33
CD33 molecule
chr6_-_26199499 0.30 ENST00000377831.5
HIST1H3D
histone cluster 1, H3d
chr3_-_119813264 0.29 ENST00000264235.8
GSK3B
glycogen synthase kinase 3 beta
chrX_+_95939638 0.28 ENST00000373061.3
ENST00000373054.4
ENST00000355827.4
DIAPH2
diaphanous-related formin 2
chr4_-_74486347 0.26 ENST00000342081.3
RASSF6
Ras association (RalGDS/AF-6) domain family member 6
chr6_-_161695042 0.24 ENST00000366908.5
ENST00000366911.5
ENST00000366905.3
AGPAT4
1-acylglycerol-3-phosphate O-acyltransferase 4
chr14_-_78083112 0.22 ENST00000216484.2
SPTLC2
serine palmitoyltransferase, long chain base subunit 2
chr18_-_31803169 0.22 ENST00000590712.1
NOL4
nucleolar protein 4
chr2_-_157189180 0.21 ENST00000539077.1
ENST00000424077.1
ENST00000426264.1
ENST00000339562.4
ENST00000421709.1
NR4A2
nuclear receptor subfamily 4, group A, member 2
chr6_-_161695074 0.15 ENST00000457520.2
ENST00000366906.5
ENST00000320285.4
AGPAT4
1-acylglycerol-3-phosphate O-acyltransferase 4
chr21_-_43816052 0.15 ENST00000398405.1
TMPRSS3
transmembrane protease, serine 3
chr14_+_104182105 0.15 ENST00000311141.2
ZFYVE21
zinc finger, FYVE domain containing 21
chr15_-_64673630 0.14 ENST00000558008.1
ENST00000559519.1
ENST00000380258.2
KIAA0101
KIAA0101
chr1_+_171227069 0.13 ENST00000354841.4
FMO1
flavin containing monooxygenase 1
chr2_-_242089677 0.13 ENST00000405260.1
PASK
PAS domain containing serine/threonine kinase
chr2_-_163008903 0.13 ENST00000418842.2
ENST00000375497.3
GCG
glucagon
chr4_-_74486217 0.13 ENST00000335049.5
ENST00000307439.5
RASSF6
Ras association (RalGDS/AF-6) domain family member 6
chr6_-_167040731 0.13 ENST00000265678.4
RPS6KA2
ribosomal protein S6 kinase, 90kDa, polypeptide 2
chr15_-_64673665 0.12 ENST00000300035.4
KIAA0101
KIAA0101
chr17_-_74163159 0.10 ENST00000591615.1
RNF157
ring finger protein 157
chrX_+_95939711 0.09 ENST00000373049.4
ENST00000324765.8
DIAPH2
diaphanous-related formin 2
chr19_-_59084647 0.09 ENST00000594234.1
ENST00000596039.1
MZF1
myeloid zinc finger 1
chr6_-_26032288 0.09 ENST00000244661.2
HIST1H3B
histone cluster 1, H3b
chr14_-_74551172 0.09 ENST00000553458.1
ALDH6A1
aldehyde dehydrogenase 6 family, member A1
chr14_+_22739823 0.09 ENST00000390464.2
TRAV38-1
T cell receptor alpha variable 38-1
chr4_-_120243545 0.08 ENST00000274024.3
FABP2
fatty acid binding protein 2, intestinal
chr2_+_196313239 0.06 ENST00000413290.1
AC064834.1
AC064834.1
chr11_-_71823266 0.06 ENST00000538919.1
ENST00000539395.1
ENST00000542531.1
ANAPC15
anaphase promoting complex subunit 15
chr6_-_26199471 0.05 ENST00000341023.1
HIST1H2AD
histone cluster 1, H2ad
chr14_+_104182061 0.04 ENST00000216602.6
ZFYVE21
zinc finger, FYVE domain containing 21
chr12_-_14849470 0.04 ENST00000261170.3
GUCY2C
guanylate cyclase 2C (heat stable enterotoxin receptor)
chr8_+_24298531 0.04 ENST00000175238.6
ADAM7
ADAM metallopeptidase domain 7
chr2_-_61697862 0.02 ENST00000398571.2
USP34
ubiquitin specific peptidase 34
chr11_-_71823796 0.02 ENST00000545680.1
ENST00000543587.1
ENST00000538393.1
ENST00000535234.1
ENST00000227618.4
ENST00000535503.1
ANAPC15
anaphase promoting complex subunit 15
chr8_+_24298597 0.01 ENST00000380789.1
ADAM7
ADAM metallopeptidase domain 7
chr12_-_10955226 0.01 ENST00000240687.2
TAS2R7
taste receptor, type 2, member 7
chr3_+_152879985 0.00 ENST00000323534.2
RAP2B
RAP2B, member of RAS oncogene family

Network of associatons between targets according to the STRING database.

First level regulatory network of EN2_GBX2_LBX2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
2.9 17.5 GO:1903435 positive regulation of constitutive secretory pathway(GO:1903435)
1.0 3.0 GO:1904395 retinal rod cell differentiation(GO:0060221) positive regulation of skeletal muscle acetylcholine-gated channel clustering(GO:1904395) negative regulation of neuromuscular junction development(GO:1904397)
0.9 2.7 GO:1903224 regulation of endodermal cell differentiation(GO:1903224)
0.9 8.8 GO:0016198 axon choice point recognition(GO:0016198)
0.8 3.3 GO:0061743 motor learning(GO:0061743)
0.8 2.3 GO:0090611 mitotic cytokinesis checkpoint(GO:0044878) ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway(GO:0090611)
0.7 2.2 GO:0099543 retrograde trans-synaptic signaling by soluble gas(GO:0098923) trans-synaptic signaling by soluble gas(GO:0099543) trans-synaptic signaling by trans-synaptic complex(GO:0099545)
0.7 3.5 GO:0015722 canalicular bile acid transport(GO:0015722) pyrimidine nucleobase transport(GO:0015855) urea transmembrane transport(GO:0071918) purine nucleobase transmembrane transport(GO:1904823)
0.6 2.4 GO:0015808 L-alanine transport(GO:0015808)
0.6 8.3 GO:0048245 eosinophil chemotaxis(GO:0048245)
0.4 2.2 GO:0010520 meiotic gene conversion(GO:0006311) regulation of reciprocal meiotic recombination(GO:0010520)
0.4 2.5 GO:0032468 Golgi calcium ion homeostasis(GO:0032468)
0.4 4.1 GO:0071578 zinc II ion transmembrane import(GO:0071578)
0.4 4.6 GO:0090160 Golgi to lysosome transport(GO:0090160)
0.4 1.8 GO:2001288 positive regulation of caveolin-mediated endocytosis(GO:2001288)
0.3 3.1 GO:0098814 spontaneous neurotransmitter secretion(GO:0061669) spontaneous synaptic transmission(GO:0098814)
0.3 1.3 GO:0070434 positive regulation of nucleotide-binding oligomerization domain containing signaling pathway(GO:0070426) positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway(GO:0070434)
0.3 1.5 GO:0042816 vitamin B6 metabolic process(GO:0042816)
0.2 1.4 GO:2000324 positive regulation of glucocorticoid receptor signaling pathway(GO:2000324)
0.2 2.0 GO:1900378 positive regulation of melanin biosynthetic process(GO:0048023) positive regulation of secondary metabolite biosynthetic process(GO:1900378)
0.2 0.7 GO:0007290 spermatid nucleus elongation(GO:0007290)
0.2 4.1 GO:0002230 positive regulation of defense response to virus by host(GO:0002230)
0.2 0.7 GO:0006208 pyrimidine nucleobase catabolic process(GO:0006208) thymine catabolic process(GO:0006210) thymine metabolic process(GO:0019859)
0.2 0.5 GO:0051684 maintenance of Golgi location(GO:0051684)
0.2 5.9 GO:0006099 tricarboxylic acid cycle(GO:0006099)
0.1 0.4 GO:0030327 prenylated protein catabolic process(GO:0030327)
0.1 3.2 GO:0001829 trophectodermal cell differentiation(GO:0001829)
0.1 0.9 GO:0070562 regulation of vitamin D receptor signaling pathway(GO:0070562)
0.1 0.4 GO:2000118 regulation of sodium-dependent phosphate transport(GO:2000118)
0.1 1.5 GO:0035520 monoubiquitinated protein deubiquitination(GO:0035520)
0.1 2.0 GO:0007021 tubulin complex assembly(GO:0007021)
0.1 0.3 GO:0060920 atrioventricular node development(GO:0003162) cardiac pacemaker cell differentiation(GO:0060920) cardiac pacemaker cell development(GO:0060926)
0.1 2.4 GO:0061157 mRNA destabilization(GO:0061157)
0.1 0.3 GO:0071109 superior temporal gyrus development(GO:0071109)
0.1 0.7 GO:0030497 fatty acid elongation(GO:0030497) very long-chain fatty acid biosynthetic process(GO:0042761)
0.1 6.3 GO:0008542 visual learning(GO:0008542)
0.1 0.4 GO:0007221 positive regulation of transcription of Notch receptor target(GO:0007221)
0.1 5.5 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.1 1.2 GO:0051988 regulation of attachment of spindle microtubules to kinetochore(GO:0051988)
0.1 0.2 GO:0021538 epithalamus development(GO:0021538) habenula development(GO:0021986)
0.1 0.4 GO:0051342 regulation of cyclic-nucleotide phosphodiesterase activity(GO:0051342) negative regulation of cyclic-nucleotide phosphodiesterase activity(GO:0051344)
0.1 1.2 GO:0032012 regulation of ARF protein signal transduction(GO:0032012)
0.1 1.4 GO:0050860 negative regulation of T cell receptor signaling pathway(GO:0050860)
0.1 0.2 GO:1904504 regulation of lipophagy(GO:1904502) positive regulation of lipophagy(GO:1904504)
0.1 0.8 GO:0016024 CDP-diacylglycerol biosynthetic process(GO:0016024)
0.0 5.0 GO:0007368 determination of left/right symmetry(GO:0007368)
0.0 0.1 GO:0035948 positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter(GO:0035948)
0.0 1.2 GO:0034453 microtubule anchoring(GO:0034453)
0.0 0.7 GO:0097067 cellular response to thyroid hormone stimulus(GO:0097067)
0.0 3.4 GO:0007422 peripheral nervous system development(GO:0007422)
0.0 1.0 GO:2000114 regulation of establishment of cell polarity(GO:2000114)
0.0 1.6 GO:0000381 regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.0 0.9 GO:0009060 aerobic respiration(GO:0009060)
0.0 6.0 GO:0007050 cell cycle arrest(GO:0007050)
0.0 0.1 GO:0061357 positive regulation of Wnt protein secretion(GO:0061357)
0.0 1.5 GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process(GO:0036092)
0.0 20.1 GO:0000122 negative regulation of transcription from RNA polymerase II promoter(GO:0000122)
0.0 2.5 GO:0001676 long-chain fatty acid metabolic process(GO:0001676)
0.0 0.1 GO:0070995 NADPH oxidation(GO:0070995)
0.0 0.1 GO:0045719 negative regulation of glycogen biosynthetic process(GO:0045719)
0.0 0.6 GO:0061001 regulation of dendritic spine morphogenesis(GO:0061001)
0.0 0.7 GO:0016575 histone deacetylation(GO:0016575)
0.0 0.5 GO:0006986 response to unfolded protein(GO:0006986)
0.0 0.5 GO:0030490 maturation of SSU-rRNA(GO:0030490)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 8.8 GO:0032584 growth cone membrane(GO:0032584)
1.1 19.5 GO:0045009 melanosome membrane(GO:0033162) chitosome(GO:0045009)
0.7 2.2 GO:0032302 MutSbeta complex(GO:0032302)
0.5 3.5 GO:0045252 oxoglutarate dehydrogenase complex(GO:0045252)
0.4 8.3 GO:0031045 dense core granule(GO:0031045)
0.3 2.0 GO:0016272 prefoldin complex(GO:0016272)
0.2 1.2 GO:0097149 centralspindlin complex(GO:0097149)
0.2 0.9 GO:0005726 perichromatin fibrils(GO:0005726)
0.2 2.3 GO:0000815 ESCRT III complex(GO:0000815)
0.1 2.2 GO:0032433 filopodium tip(GO:0032433)
0.1 1.5 GO:0001673 male germ cell nucleus(GO:0001673)
0.1 4.1 GO:0031258 lamellipodium membrane(GO:0031258)
0.1 0.5 GO:0034388 Pwp2p-containing subcomplex of 90S preribosome(GO:0034388)
0.1 0.4 GO:0034751 aryl hydrocarbon receptor complex(GO:0034751)
0.1 2.0 GO:0030127 COPII vesicle coat(GO:0030127)
0.1 5.5 GO:0005747 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.1 22.0 GO:0043209 myelin sheath(GO:0043209)
0.1 1.8 GO:0071564 npBAF complex(GO:0071564)
0.1 3.1 GO:0048786 presynaptic active zone(GO:0048786)
0.1 0.3 GO:0002193 MAML1-RBP-Jkappa- ICN1 complex(GO:0002193)
0.1 0.4 GO:0042584 chromaffin granule membrane(GO:0042584)
0.1 1.6 GO:0035145 exon-exon junction complex(GO:0035145)
0.1 0.2 GO:0017059 serine C-palmitoyltransferase complex(GO:0017059) endoplasmic reticulum palmitoyltransferase complex(GO:0031211)
0.1 1.4 GO:0005689 U12-type spliceosomal complex(GO:0005689)
0.1 1.0 GO:0071437 invadopodium(GO:0071437)
0.0 0.9 GO:0033276 transcription factor TFTC complex(GO:0033276)
0.0 3.0 GO:0031594 neuromuscular junction(GO:0031594)
0.0 0.5 GO:0030897 HOPS complex(GO:0030897)
0.0 1.8 GO:0005771 multivesicular body(GO:0005771)
0.0 7.1 GO:0005802 trans-Golgi network(GO:0005802)
0.0 3.4 GO:0043204 perikaryon(GO:0043204)
0.0 2.4 GO:0043679 axon terminus(GO:0043679)
0.0 1.3 GO:0016235 aggresome(GO:0016235)
0.0 0.3 GO:1990909 Wnt signalosome(GO:1990909)
0.0 0.7 GO:0090545 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.0 2.1 GO:0048770 melanosome(GO:0042470) pigment granule(GO:0048770)
0.0 3.5 GO:0016323 basolateral plasma membrane(GO:0016323)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 8.8 GO:0035727 lysophosphatidic acid binding(GO:0035727)
0.9 3.5 GO:0015265 glycerol channel activity(GO:0015254) urea channel activity(GO:0015265)
0.8 3.0 GO:0035373 chondroitin sulfate proteoglycan binding(GO:0035373)
0.7 2.2 GO:0000406 heteroduplex DNA loop binding(GO:0000404) double-strand/single-strand DNA junction binding(GO:0000406) dinucleotide repeat insertion binding(GO:0032181)
0.7 3.5 GO:0004591 oxoglutarate dehydrogenase (succinyl-transferring) activity(GO:0004591)
0.7 17.5 GO:0031489 myosin V binding(GO:0031489)
0.6 2.4 GO:0015180 L-alanine transmembrane transporter activity(GO:0015180) alanine transmembrane transporter activity(GO:0022858)
0.5 2.5 GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
0.3 1.6 GO:0017161 phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity(GO:0016316) inositol-1,3,4-trisphosphate 4-phosphatase activity(GO:0017161) phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity(GO:0034597) inositol-3,4-bisphosphate 4-phosphatase activity(GO:0052828)
0.2 1.8 GO:0019871 sodium channel inhibitor activity(GO:0019871)
0.2 4.1 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.2 3.1 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.2 0.7 GO:0004466 long-chain-acyl-CoA dehydrogenase activity(GO:0004466)
0.2 2.5 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.2 7.8 GO:0042056 chemoattractant activity(GO:0042056)
0.2 2.2 GO:0042043 neurexin family protein binding(GO:0042043)
0.1 4.9 GO:0001071 nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700)
0.1 1.3 GO:0055131 C3HC4-type RING finger domain binding(GO:0055131)
0.1 5.5 GO:0008137 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.1 1.3 GO:0017162 aryl hydrocarbon receptor binding(GO:0017162)
0.1 2.5 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.1 0.9 GO:0034056 estrogen response element binding(GO:0034056)
0.1 21.1 GO:0051015 actin filament binding(GO:0051015)
0.1 0.2 GO:0016454 serine C-palmitoyltransferase activity(GO:0004758) C-palmitoyltransferase activity(GO:0016454)
0.1 0.4 GO:0016715 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen(GO:0016715)
0.1 1.5 GO:0008483 transaminase activity(GO:0008483)
0.1 0.4 GO:0016670 oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor(GO:0016670)
0.1 6.6 GO:0017048 Rho GTPase binding(GO:0017048)
0.1 1.3 GO:0070064 proline-rich region binding(GO:0070064)
0.1 0.4 GO:0015321 sodium-dependent phosphate transmembrane transporter activity(GO:0015321)
0.0 1.2 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.0 0.8 GO:0071617 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841) lysophosphatidic acid acyltransferase activity(GO:0042171) lysophospholipid acyltransferase activity(GO:0071617)
0.0 0.7 GO:0032454 histone demethylase activity (H3-K9 specific)(GO:0032454)
0.0 0.7 GO:0000062 fatty-acyl-CoA binding(GO:0000062)
0.0 0.2 GO:0000285 1-phosphatidylinositol-3-phosphate 5-kinase activity(GO:0000285)
0.0 0.9 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 1.8 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
0.0 3.9 GO:0003774 motor activity(GO:0003774)
0.0 2.0 GO:0005507 copper ion binding(GO:0005507)
0.0 0.7 GO:0001190 transcriptional activator activity, RNA polymerase II transcription factor binding(GO:0001190) transcriptional repressor activity, RNA polymerase II activating transcription factor binding(GO:0098811)
0.0 2.4 GO:0003730 mRNA 3'-UTR binding(GO:0003730)
0.0 2.6 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 1.5 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843)
0.0 0.7 GO:0004407 histone deacetylase activity(GO:0004407)
0.0 3.1 GO:0017137 Rab GTPase binding(GO:0017137)
0.0 0.5 GO:0030515 snoRNA binding(GO:0030515)
0.0 4.5 GO:0003714 transcription corepressor activity(GO:0003714)
0.0 0.1 GO:0004499 N,N-dimethylaniline monooxygenase activity(GO:0004499)
0.0 0.3 GO:0034236 protein kinase A catalytic subunit binding(GO:0034236)
0.0 0.5 GO:0004386 helicase activity(GO:0004386)
0.0 0.6 GO:0046875 ephrin receptor binding(GO:0046875)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 8.8 PID NCADHERIN PATHWAY N-cadherin signaling events
0.1 3.0 PID SYNDECAN 3 PATHWAY Syndecan-3-mediated signaling events
0.0 2.8 ST ERK1 ERK2 MAPK PATHWAY ERK1/ERK2 MAPK Pathway
0.0 3.1 PID AR TF PATHWAY Regulation of Androgen receptor activity
0.0 1.4 PID IL2 STAT5 PATHWAY IL2 signaling events mediated by STAT5
0.0 3.3 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.0 1.8 PID TGFBR PATHWAY TGF-beta receptor signaling
0.0 4.3 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors
0.0 1.3 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.0 1.2 PID PLK1 PATHWAY PLK1 signaling events
0.0 2.3 PID CXCR4 PATHWAY CXCR4-mediated signaling events
0.0 0.8 PID FANCONI PATHWAY Fanconi anemia pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 17.5 REACTOME INSULIN SYNTHESIS AND PROCESSING Genes involved in Insulin Synthesis and Processing
0.3 4.1 REACTOME ZINC TRANSPORTERS Genes involved in Zinc transporters
0.2 3.5 REACTOME PASSIVE TRANSPORT BY AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.2 3.1 REACTOME ERKS ARE INACTIVATED Genes involved in ERKs are inactivated
0.1 1.5 REACTOME REGULATION OF THE FANCONI ANEMIA PATHWAY Genes involved in Regulation of the Fanconi anemia pathway
0.1 2.3 REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
0.1 1.6 REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane
0.1 2.5 REACTOME CITRIC ACID CYCLE TCA CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.1 2.4 REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.1 1.5 REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.1 2.0 REACTOME PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC Genes involved in Prefoldin mediated transfer of substrate to CCT/TriC
0.0 2.5 REACTOME ION TRANSPORT BY P TYPE ATPASES Genes involved in Ion transport by P-type ATPases
0.0 1.6 REACTOME MRNA 3 END PROCESSING Genes involved in mRNA 3'-end processing
0.0 0.7 REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.0 0.8 REACTOME TRIGLYCERIDE BIOSYNTHESIS Genes involved in Triglyceride Biosynthesis
0.0 0.3 REACTOME NOTCH HLH TRANSCRIPTION PATHWAY Genes involved in Notch-HLH transcription pathway
0.0 0.9 REACTOME SIGNALING BY FGFR1 FUSION MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.0 0.9 REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
0.0 2.4 REACTOME MRNA SPLICING Genes involved in mRNA Splicing
0.0 1.2 REACTOME NRAGE SIGNALS DEATH THROUGH JNK Genes involved in NRAGE signals death through JNK
0.0 0.4 REACTOME AMINE DERIVED HORMONES Genes involved in Amine-derived hormones
0.0 0.7 REACTOME PACKAGING OF TELOMERE ENDS Genes involved in Packaging Of Telomere Ends
0.0 0.3 REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM Genes involved in Branched-chain amino acid catabolism