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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for EN2_GBX2_LBX2
Z-value: 0.13
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Transcription factors associated with EN2_GBX2_LBX2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| GBX2 | hg19_v2_chr2_-_237076992_237077012 | -0.14 | 3.5e-02 | Click! |
| EN2 | hg19_v2_chr7_+_155250824_155250824 | 0.03 | 7.1e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr3_+_115342349 Show fit | 8.84 |
ENST00000393780.3
|
growth associated protein 43 |
|
| chr2_-_224467093 Show fit | 8.34 |
ENST00000305409.2
|
secretogranin II |
|
| chr16_-_29910853 Show fit | 7.65 |
ENST00000308713.5
|
seizure related 6 homolog (mouse)-like 2 |
|
| chr15_-_55563072 Show fit | 6.30 |
ENST00000567380.1
ENST00000565972.1 ENST00000569493.1 |
RAB27A, member RAS oncogene family |
|
| chr3_+_111718173 Show fit | 6.18 |
ENST00000494932.1
|
transgelin 3 |
|
| chr15_-_55562479 Show fit | 6.06 |
ENST00000564609.1
|
RAB27A, member RAS oncogene family |
|
| chr15_-_37393406 Show fit | 5.88 |
ENST00000338564.5
ENST00000558313.1 ENST00000340545.5 |
Meis homeobox 2 |
|
| chrM_+_12331 Show fit | 5.48 |
ENST00000361567.2
|
mitochondrially encoded NADH dehydrogenase 5 |
|
| chr3_+_111717600 Show fit | 5.36 |
ENST00000273368.4
|
transgelin 3 |
|
| chr3_+_111718036 Show fit | 5.29 |
ENST00000455401.2
|
transgelin 3 |
Network of associatons between targets according to the STRING database.
First level regulatory network of EN2_GBX2_LBX2
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 20.1 | GO:0000122 | negative regulation of transcription from RNA polymerase II promoter(GO:0000122) |
| 2.9 | 17.5 | GO:1903435 | positive regulation of constitutive secretory pathway(GO:1903435) |
| 0.9 | 8.8 | GO:0016198 | axon choice point recognition(GO:0016198) |
| 0.6 | 8.3 | GO:0048245 | eosinophil chemotaxis(GO:0048245) |
| 0.1 | 6.3 | GO:0008542 | visual learning(GO:0008542) |
| 0.0 | 6.0 | GO:0007050 | cell cycle arrest(GO:0007050) |
| 0.2 | 5.9 | GO:0006099 | tricarboxylic acid cycle(GO:0006099) |
| 0.1 | 5.5 | GO:0006120 | mitochondrial electron transport, NADH to ubiquinone(GO:0006120) |
| 0.0 | 5.0 | GO:0007368 | determination of left/right symmetry(GO:0007368) |
| 0.4 | 4.6 | GO:0090160 | Golgi to lysosome transport(GO:0090160) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 22.0 | GO:0043209 | myelin sheath(GO:0043209) |
| 1.1 | 19.5 | GO:0045009 | melanosome membrane(GO:0033162) chitosome(GO:0045009) |
| 1.3 | 8.8 | GO:0032584 | growth cone membrane(GO:0032584) |
| 0.4 | 8.3 | GO:0031045 | dense core granule(GO:0031045) |
| 0.0 | 7.1 | GO:0005802 | trans-Golgi network(GO:0005802) |
| 0.1 | 5.5 | GO:0005747 | mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271) |
| 0.1 | 4.1 | GO:0031258 | lamellipodium membrane(GO:0031258) |
| 0.5 | 3.5 | GO:0045252 | oxoglutarate dehydrogenase complex(GO:0045252) |
| 0.0 | 3.5 | GO:0016323 | basolateral plasma membrane(GO:0016323) |
| 0.0 | 3.4 | GO:0043204 | perikaryon(GO:0043204) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 21.1 | GO:0051015 | actin filament binding(GO:0051015) |
| 0.7 | 17.5 | GO:0031489 | myosin V binding(GO:0031489) |
| 0.9 | 8.8 | GO:0035727 | lysophosphatidic acid binding(GO:0035727) |
| 0.2 | 7.8 | GO:0042056 | chemoattractant activity(GO:0042056) |
| 0.1 | 6.6 | GO:0017048 | Rho GTPase binding(GO:0017048) |
| 0.1 | 5.5 | GO:0008137 | NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136) |
| 0.1 | 4.9 | GO:0001071 | nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700) |
| 0.0 | 4.5 | GO:0003714 | transcription corepressor activity(GO:0003714) |
| 0.2 | 4.1 | GO:0005385 | zinc ion transmembrane transporter activity(GO:0005385) |
| 0.0 | 3.9 | GO:0003774 | motor activity(GO:0003774) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 8.8 | PID NCADHERIN PATHWAY | N-cadherin signaling events |
| 0.0 | 4.3 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 0.0 | 3.3 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.0 | 3.1 | PID AR TF PATHWAY | Regulation of Androgen receptor activity |
| 0.1 | 3.0 | PID SYNDECAN 3 PATHWAY | Syndecan-3-mediated signaling events |
| 0.0 | 2.8 | ST ERK1 ERK2 MAPK PATHWAY | ERK1/ERK2 MAPK Pathway |
| 0.0 | 2.3 | PID CXCR4 PATHWAY | CXCR4-mediated signaling events |
| 0.0 | 1.8 | PID TGFBR PATHWAY | TGF-beta receptor signaling |
| 0.0 | 1.4 | PID IL2 STAT5 PATHWAY | IL2 signaling events mediated by STAT5 |
| 0.0 | 1.3 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 17.5 | REACTOME INSULIN SYNTHESIS AND PROCESSING | Genes involved in Insulin Synthesis and Processing |
| 0.3 | 4.1 | REACTOME ZINC TRANSPORTERS | Genes involved in Zinc transporters |
| 0.2 | 3.5 | REACTOME PASSIVE TRANSPORT BY AQUAPORINS | Genes involved in Passive Transport by Aquaporins |
| 0.2 | 3.1 | REACTOME ERKS ARE INACTIVATED | Genes involved in ERKs are inactivated |
| 0.1 | 2.5 | REACTOME CITRIC ACID CYCLE TCA CYCLE | Genes involved in Citric acid cycle (TCA cycle) |
| 0.0 | 2.5 | REACTOME ION TRANSPORT BY P TYPE ATPASES | Genes involved in Ion transport by P-type ATPases |
| 0.1 | 2.4 | REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE | Genes involved in Amino acid transport across the plasma membrane |
| 0.0 | 2.4 | REACTOME MRNA SPLICING | Genes involved in mRNA Splicing |
| 0.1 | 2.3 | REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT | Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT) |
| 0.1 | 2.0 | REACTOME PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC | Genes involved in Prefoldin mediated transfer of substrate to CCT/TriC |