ISMARA results: ESR1

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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)

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Results for ESR1

Z-value: 0.51

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Transcription factors associated with ESR1

Gene Symbol	Gene ID	Gene Info
ESR1 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000091831.17	estrogen receptor 1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
ESR1	hg19_v2_chr6_+_152128810_152128827	0.32	1.5e-06	Click!

Activity profile of ESR1 motif

Sorted Z-values of ESR1 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr14_-_106209368 Show fit	29.55	ENST00000390548.2 ENST00000390549.2 ENST00000390542.2	IGHG1 Ensembl NCBI GeneCards UniProt NextProt Show fit	immunoglobulin heavy constant gamma 1 (G1m marker)
chr14_-_106054659 Show fit	29.47	ENST00000390539.2	IGHA2 Ensembl NCBI GeneCards UniProt NextProt Show fit	immunoglobulin heavy constant alpha 2 (A2m marker)
chr22_+_23248512 Show fit	26.26	ENST00000390325.2	IGLC3 Ensembl NCBI GeneCards UniProt NextProt Show fit	immunoglobulin lambda constant 3 (Kern-Oz+ marker)
chr22_+_23165153 Show fit	23.62	ENST00000390317.2	IGLV2-8 Ensembl NCBI GeneCards UniProt NextProt Show fit	immunoglobulin lambda variable 2-8
chr22_+_23247030 Show fit	22.32	ENST00000390324.2	IGLJ3 Ensembl NCBI GeneCards UniProt NextProt Show fit	immunoglobulin lambda joining 3
chr19_-_45826125 Show fit	20.93	ENST00000221476.3	CKM Ensembl NCBI GeneCards UniProt NextProt Show fit	creatine kinase, muscle
chr22_+_23046750 Show fit	19.92	ENST00000390307.2	IGLV3-22 Ensembl NCBI GeneCards UniProt NextProt Show fit	immunoglobulin lambda variable 3-22 (gene/pseudogene)
chr2_-_89513402 Show fit	19.55	ENST00000498435.1	IGKV1-27 Ensembl NCBI GeneCards UniProt NextProt Show fit	immunoglobulin kappa variable 1-27
chr22_+_23243156 Show fit	18.76	ENST00000390323.2	IGLC2 Ensembl NCBI GeneCards UniProt NextProt Show fit	immunoglobulin lambda constant 2 (Kern-Oz- marker)
chr22_+_23241661 Show fit	17.35	ENST00000390322.2	IGLJ2 Ensembl NCBI GeneCards UniProt NextProt Show fit	immunoglobulin lambda joining 2

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of ESR1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.8	138.9	GO:0002377	immunoglobulin production(GO:0002377)
1.2	85.8	GO:0006910	phagocytosis, recognition(GO:0006910)
0.7	64.1	GO:0006958	complement activation, classical pathway(GO:0006958)
0.2	42.8	GO:0002250	adaptive immune response(GO:0002250)
9.8	29.5	GO:0000738	DNA catabolic process, exonucleolytic(GO:0000738)
2.9	29.5	GO:0060267	positive regulation of respiratory burst(GO:0060267)
0.3	27.2	GO:0031338	regulation of vesicle fusion(GO:0031338)
7.0	21.1	GO:0090341	negative regulation of secretion of lysosomal enzymes(GO:0090341)
1.9	20.9	GO:0006600	creatine metabolic process(GO:0006600)
1.2	18.5	GO:1990118	sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118)

Showing 1 to 10 of 285 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	167.2	GO:0005615	extracellular space(GO:0005615)
1.8	85.8	GO:0042571	immunoglobulin complex, circulating(GO:0042571)
0.3	56.8	GO:0072562	blood microparticle(GO:0072562)
0.5	31.9	GO:0015030	Cajal body(GO:0015030)
9.8	29.5	GO:0071746	IgA immunoglobulin complex(GO:0071745) IgA immunoglobulin complex, circulating(GO:0071746) monomeric IgA immunoglobulin complex(GO:0071748) polymeric IgA immunoglobulin complex(GO:0071749) secretory IgA immunoglobulin complex(GO:0071751)
0.1	18.1	GO:0090575	RNA polymerase II transcription factor complex(GO:0090575)
0.2	14.9	GO:0016459	myosin complex(GO:0016459)
0.2	13.1	GO:0001772	immunological synapse(GO:0001772)
1.7	11.7	GO:0019815	B cell receptor complex(GO:0019815)
1.6	11.5	GO:0097013	phagocytic vesicle lumen(GO:0097013)

Showing 1 to 10 of 121 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.0	179.4	GO:0003823	antigen binding(GO:0003823)
2.1	115.3	GO:0034987	immunoglobulin receptor binding(GO:0034987)
0.1	32.1	GO:0004252	serine-type endopeptidase activity(GO:0004252)
9.8	29.5	GO:0008859	exoribonuclease II activity(GO:0008859)
0.1	22.3	GO:0017137	Rab GTPase binding(GO:0017137)
5.3	21.1	GO:0032810	sterol response element binding(GO:0032810)
2.6	20.9	GO:0004111	creatine kinase activity(GO:0004111)
1.9	18.5	GO:0015385	sodium:proton antiporter activity(GO:0015385) potassium:proton antiporter activity(GO:0015386)
1.0	17.7	GO:0102391	decanoate--CoA ligase activity(GO:0102391)
0.4	13.5	GO:0001530	lipopolysaccharide binding(GO:0001530)

Showing 1 to 10 of 220 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	34.0	PID IL4 2PATHWAY	IL4-mediated signaling events
0.2	20.9	PID RB 1PATHWAY	Regulation of retinoblastoma protein
0.4	19.8	PID RXR VDR PATHWAY	RXR and RAR heterodimerization with other nuclear receptor
0.0	15.6	NABA SECRETED FACTORS	Genes encoding secreted soluble factors
0.3	14.1	PID P38 MK2 PATHWAY	p38 signaling mediated by MAPKAP kinases
0.1	11.0	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.4	9.8	SIG IL4RECEPTOR IN B LYPHOCYTES	Genes related to IL4 rceptor signaling in B lymphocytes
0.4	9.1	SA REG CASCADE OF CYCLIN EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.2	8.3	PID BCR 5PATHWAY	BCR signaling pathway
0.2	7.5	PID EPHA FWDPATHWAY	EPHA forward signaling

Showing 1 to 10 of 55 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.4	35.8	REACTOME INTERFERON ALPHA BETA SIGNALING	Genes involved in Interferon alpha/beta signaling
0.5	27.1	REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS	Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.2	26.7	REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES	Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.9	18.2	REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS	Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.2	16.6	REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY	Genes involved in Nuclear Receptor transcription pathway
0.2	14.8	REACTOME AMYLOIDS	Genes involved in Amyloids
0.3	14.0	REACTOME ION TRANSPORT BY P TYPE ATPASES	Genes involved in Ion transport by P-type ATPases
0.3	12.0	REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX	Genes involved in Degradation of the extracellular matrix
0.6	11.9	REACTOME SYNTHESIS OF PE	Genes involved in Synthesis of PE
0.4	11.2	REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES	Genes involved in Cytosolic sulfonation of small molecules

Showing 1 to 10 of 89 entries

Results for ESR1

Z-value: 0.51

Motif logo

Transcription factors associated with ESR1

Activity-expression correlation:

Activity profile of ESR1 motif

Sorted Z-values of ESR1 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of ESR1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: