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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for ESRRA_ESR2
Z-value: 0.60
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Transcription factors associated with ESRRA_ESR2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| ESR2 | hg19_v2_chr14_-_64761078_64761128 | 0.37 | 1.9e-08 | Click! |
| ESRRA | hg19_v2_chr11_+_64073699_64073918 | 0.31 | 2.1e-06 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr14_-_106174960 Show fit | 137.89 |
ENST00000390547.2
|
immunoglobulin heavy constant alpha 1 |
|
| chr22_+_23237555 Show fit | 101.06 |
ENST00000390321.2
|
immunoglobulin lambda constant 1 (Mcg marker) |
|
| chr22_+_23248512 Show fit | 100.61 |
ENST00000390325.2
|
immunoglobulin lambda constant 3 (Kern-Oz+ marker) |
|
| chr22_+_23243156 Show fit | 91.62 |
ENST00000390323.2
|
immunoglobulin lambda constant 2 (Kern-Oz- marker) |
|
| chr14_-_106209368 Show fit | 90.70 |
ENST00000390548.2
ENST00000390549.2 ENST00000390542.2 |
immunoglobulin heavy constant gamma 1 (G1m marker) |
|
| chr14_-_106054659 Show fit | 86.73 |
ENST00000390539.2
|
immunoglobulin heavy constant alpha 2 (A2m marker) |
|
| chr22_+_23264766 Show fit | 74.03 |
ENST00000390331.2
|
immunoglobulin lambda constant 7 |
|
| chr22_+_23241661 Show fit | 61.89 |
ENST00000390322.2
|
immunoglobulin lambda joining 2 |
|
| chr22_+_23247030 Show fit | 61.15 |
ENST00000390324.2
|
immunoglobulin lambda joining 3 |
|
| chr22_+_23229960 Show fit | 58.05 |
ENST00000526893.1
ENST00000532223.2 ENST00000531372.1 |
immunoglobulin lambda-like polypeptide 5 |
Network of associatons between targets according to the STRING database.
First level regulatory network of ESRRA_ESR2
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 10.7 | 739.9 | GO:0006910 | phagocytosis, recognition(GO:0006910) |
| 4.4 | 390.2 | GO:0006958 | complement activation, classical pathway(GO:0006958) |
| 2.4 | 261.3 | GO:0031295 | T cell costimulation(GO:0031295) |
| 1.8 | 240.6 | GO:0002377 | immunoglobulin production(GO:0002377) |
| 24.0 | 240.4 | GO:0060267 | positive regulation of respiratory burst(GO:0060267) |
| 1.0 | 180.5 | GO:0002250 | adaptive immune response(GO:0002250) |
| 1.9 | 103.8 | GO:0006953 | acute-phase response(GO:0006953) |
| 4.3 | 99.7 | GO:0006957 | complement activation, alternative pathway(GO:0006957) |
| 7.1 | 92.2 | GO:2001199 | negative regulation of dendritic cell differentiation(GO:2001199) |
| 6.8 | 88.6 | GO:0045059 | positive thymic T cell selection(GO:0045059) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 15.1 | 708.9 | GO:0042571 | immunoglobulin complex, circulating(GO:0042571) |
| 0.5 | 569.9 | GO:0005615 | extracellular space(GO:0005615) |
| 3.3 | 562.5 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.3 | 408.8 | GO:0031226 | intrinsic component of plasma membrane(GO:0031226) |
| 81.0 | 242.9 | GO:0071749 | IgA immunoglobulin complex(GO:0071745) IgA immunoglobulin complex, circulating(GO:0071746) monomeric IgA immunoglobulin complex(GO:0071748) polymeric IgA immunoglobulin complex(GO:0071749) secretory IgA immunoglobulin complex(GO:0071751) |
| 11.5 | 241.9 | GO:0042613 | MHC class II protein complex(GO:0042613) |
| 0.7 | 147.1 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 1.1 | 136.0 | GO:0005796 | Golgi lumen(GO:0005796) |
| 1.0 | 90.5 | GO:0043202 | lysosomal lumen(GO:0043202) |
| 6.9 | 76.4 | GO:0042611 | MHC protein complex(GO:0042611) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 17.1 | 939.9 | GO:0034987 | immunoglobulin receptor binding(GO:0034987) |
| 4.6 | 667.3 | GO:0003823 | antigen binding(GO:0003823) |
| 1.7 | 375.2 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 7.5 | 286.5 | GO:0042605 | peptide antigen binding(GO:0042605) |
| 1.9 | 194.5 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.4 | 152.7 | GO:0000978 | RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978) |
| 0.5 | 138.5 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 0.8 | 90.1 | GO:0005179 | hormone activity(GO:0005179) |
| 6.3 | 62.9 | GO:0016176 | superoxide-generating NADPH oxidase activator activity(GO:0016176) |
| 8.9 | 62.4 | GO:0017077 | oxidative phosphorylation uncoupler activity(GO:0017077) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.4 | 249.0 | PID IL4 2PATHWAY | IL4-mediated signaling events |
| 0.9 | 233.3 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 1.1 | 181.2 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 3.2 | 167.4 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
| 2.5 | 166.8 | PID CD8 TCR PATHWAY | TCR signaling in naïve CD8+ T cells |
| 1.6 | 115.4 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 1.0 | 107.3 | PID SMAD2 3NUCLEAR PATHWAY | Regulation of nuclear SMAD2/3 signaling |
| 1.4 | 101.6 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 2.1 | 87.4 | ST GAQ PATHWAY | G alpha q Pathway |
| 1.8 | 80.3 | PID BCR 5PATHWAY | BCR signaling pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.4 | 269.8 | REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
| 11.6 | 266.8 | REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE | Genes involved in Translocation of ZAP-70 to Immunological synapse |
| 6.4 | 133.5 | REACTOME INITIAL TRIGGERING OF COMPLEMENT | Genes involved in Initial triggering of complement |
| 0.5 | 123.7 | REACTOME CLASS A1 RHODOPSIN LIKE RECEPTORS | Genes involved in Class A/1 (Rhodopsin-like receptors) |
| 1.0 | 116.1 | REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |
| 1.9 | 83.7 | REACTOME EFFECTS OF PIP2 HYDROLYSIS | Genes involved in Effects of PIP2 hydrolysis |
| 1.3 | 81.0 | REACTOME GAB1 SIGNALOSOME | Genes involved in GAB1 signalosome |
| 3.2 | 79.1 | REACTOME HDL MEDIATED LIPID TRANSPORT | Genes involved in HDL-mediated lipid transport |
| 0.5 | 74.3 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 6.7 | 67.4 | REACTOME ENDOSOMAL VACUOLAR PATHWAY | Genes involved in Endosomal/Vacuolar pathway |