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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for FOXD3_FOXI1_FOXF1
Z-value: 0.56
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Transcription factors associated with FOXD3_FOXI1_FOXF1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| FOXI1 | hg19_v2_chr5_+_169532896_169532917 | 0.09 | 2.0e-01 | Click! |
| FOXD3 | hg19_v2_chr1_+_63788730_63788730 | 0.02 | 7.7e-01 | Click! |
| FOXF1 | hg19_v2_chr16_+_86544113_86544145 | -0.01 | 8.9e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr4_-_153303658 Show fit | 21.82 |
ENST00000296555.5
|
F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase |
|
| chr4_+_158142750 Show fit | 18.95 |
ENST00000505888.1
ENST00000449365.1 |
glutamate receptor, ionotropic, AMPA 2 |
|
| chr11_-_111781610 Show fit | 14.57 |
ENST00000525823.1
|
crystallin, alpha B |
|
| chr5_-_88179302 Show fit | 14.25 |
ENST00000504921.2
|
myocyte enhancer factor 2C |
|
| chr4_+_71587669 Show fit | 12.23 |
ENST00000381006.3
ENST00000226328.4 |
RUN and FYVE domain containing 3 |
|
| chr3_+_50712672 Show fit | 12.18 |
ENST00000266037.9
|
dedicator of cytokinesis 3 |
|
| chr11_-_111781454 Show fit | 12.08 |
ENST00000533280.1
|
crystallin, alpha B |
|
| chr11_-_111781554 Show fit | 11.78 |
ENST00000526167.1
ENST00000528961.1 |
crystallin, alpha B |
|
| chr5_-_146302078 Show fit | 11.06 |
ENST00000508545.2
|
protein phosphatase 2, regulatory subunit B, beta |
|
| chr17_-_29641084 Show fit | 10.89 |
ENST00000544462.1
|
ecotropic viral integration site 2B |
Network of associatons between targets according to the STRING database.
First level regulatory network of FOXD3_FOXI1_FOXF1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.1 | 38.4 | GO:0007021 | tubulin complex assembly(GO:0007021) |
| 4.8 | 24.2 | GO:2000638 | regulation of SREBP signaling pathway(GO:2000638) negative regulation of SREBP signaling pathway(GO:2000639) |
| 0.6 | 23.2 | GO:0006536 | glutamate metabolic process(GO:0006536) |
| 0.5 | 21.3 | GO:0035235 | ionotropic glutamate receptor signaling pathway(GO:0035235) |
| 0.1 | 20.4 | GO:0050806 | positive regulation of synaptic transmission(GO:0050806) |
| 0.6 | 18.6 | GO:2000114 | regulation of establishment of cell polarity(GO:2000114) |
| 1.1 | 18.3 | GO:0040015 | negative regulation of multicellular organism growth(GO:0040015) |
| 0.1 | 17.3 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
| 1.6 | 16.3 | GO:0090292 | nuclear matrix anchoring at nuclear membrane(GO:0090292) |
| 1.6 | 15.7 | GO:0051581 | negative regulation of neurotransmitter uptake(GO:0051581) serotonin uptake(GO:0051610) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.4 | 38.4 | GO:0097512 | cardiac myofibril(GO:0097512) |
| 0.0 | 29.2 | GO:0005887 | integral component of plasma membrane(GO:0005887) |
| 0.0 | 29.1 | GO:0045202 | synapse(GO:0045202) |
| 0.0 | 27.4 | GO:0016021 | integral component of membrane(GO:0016021) |
| 3.5 | 24.2 | GO:1990452 | Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452) |
| 0.2 | 24.2 | GO:0016234 | inclusion body(GO:0016234) |
| 0.6 | 19.6 | GO:0031092 | platelet alpha granule membrane(GO:0031092) |
| 3.8 | 18.9 | GO:0098843 | postsynaptic endocytic zone(GO:0098843) |
| 0.9 | 18.5 | GO:0001891 | phagocytic cup(GO:0001891) |
| 0.4 | 17.8 | GO:0032590 | dendrite membrane(GO:0032590) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.2 | 38.3 | GO:0005212 | structural constituent of eye lens(GO:0005212) |
| 0.2 | 37.3 | GO:0017124 | SH3 domain binding(GO:0017124) |
| 1.9 | 24.5 | GO:0001087 | transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087) |
| 1.7 | 24.4 | GO:1903136 | cuprous ion binding(GO:1903136) |
| 3.0 | 24.2 | GO:0050816 | phosphothreonine binding(GO:0050816) |
| 3.9 | 19.6 | GO:0047820 | D-glutamate cyclase activity(GO:0047820) |
| 1.6 | 18.9 | GO:0004971 | AMPA glutamate receptor activity(GO:0004971) |
| 0.7 | 17.9 | GO:0005521 | lamin binding(GO:0005521) |
| 0.7 | 15.1 | GO:0035198 | miRNA binding(GO:0035198) |
| 0.3 | 14.9 | GO:0019894 | kinesin binding(GO:0019894) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 32.2 | PID IL8 CXCR2 PATHWAY | IL8- and CXCR2-mediated signaling events |
| 0.4 | 28.4 | ST T CELL SIGNAL TRANSDUCTION | T Cell Signal Transduction |
| 0.4 | 22.8 | SIG CD40PATHWAYMAP | Genes related to CD40 signaling |
| 0.4 | 21.8 | SIG BCR SIGNALING PATHWAY | Members of the BCR signaling pathway |
| 0.4 | 21.3 | PID NCADHERIN PATHWAY | N-cadherin signaling events |
| 0.3 | 14.4 | PID MAPK TRK PATHWAY | Trk receptor signaling mediated by the MAPK pathway |
| 0.1 | 12.1 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.2 | 10.7 | PID RAC1 REG PATHWAY | Regulation of RAC1 activity |
| 0.1 | 8.3 | PID RHOA REG PATHWAY | Regulation of RhoA activity |
| 0.2 | 7.7 | PID TCR PATHWAY | TCR signaling in naïve CD4+ T cells |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 39.3 | REACTOME MYOGENESIS | Genes involved in Myogenesis |
| 0.6 | 19.7 | REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS | Genes involved in Association of TriC/CCT with target proteins during biosynthesis |
| 0.8 | 18.9 | REACTOME UNBLOCKING OF NMDA RECEPTOR GLUTAMATE BINDING AND ACTIVATION | Genes involved in Unblocking of NMDA receptor, glutamate binding and activation |
| 0.4 | 18.8 | REACTOME THE ROLE OF NEF IN HIV1 REPLICATION AND DISEASE PATHOGENESIS | Genes involved in The role of Nef in HIV-1 replication and disease pathogenesis |
| 0.1 | 15.5 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.2 | 14.1 | REACTOME MEIOTIC SYNAPSIS | Genes involved in Meiotic Synapsis |
| 0.2 | 13.1 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.4 | 11.8 | REACTOME DARPP 32 EVENTS | Genes involved in DARPP-32 events |
| 0.6 | 11.6 | REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS | Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors) |
| 0.1 | 11.1 | REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION | Genes involved in Transcriptional Regulation of White Adipocyte Differentiation |