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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for FOXK1_FOXP2_FOXB1_FOXP3
Z-value: 1.04
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Transcription factors associated with FOXK1_FOXP2_FOXB1_FOXP3
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
| ENSG00000164916.9 | forkhead box K1 | |
| ENSG00000128573.18 | forkhead box P2 | |
| ENSG00000171956.5 | forkhead box B1 | |
| ENSG00000049768.10 | forkhead box P3 |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| FOXK1 | hg19_v2_chr7_+_4721885_4721945 | 0.63 | 8.6e-26 | Click! |
| FOXP3 | hg19_v2_chrX_-_49121165_49121288 | 0.41 | 1.7e-10 | Click! |
| FOXB1 | hg19_v2_chr15_+_60296421_60296464 | 0.16 | 2.2e-02 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr5_-_42811986 Show fit | 85.90 |
ENST00000511224.1
ENST00000507920.1 ENST00000510965.1 |
selenoprotein P, plasma, 1 |
|
| chr5_-_42812143 Show fit | 85.77 |
ENST00000514985.1
|
selenoprotein P, plasma, 1 |
|
| chr11_-_111781610 Show fit | 79.23 |
ENST00000525823.1
|
crystallin, alpha B |
|
| chr4_-_88450244 Show fit | 74.72 |
ENST00000503414.1
|
SPARC-like 1 (hevin) |
|
| chr11_-_111781454 Show fit | 74.22 |
ENST00000533280.1
|
crystallin, alpha B |
|
| chr11_-_111781554 Show fit | 69.24 |
ENST00000526167.1
ENST00000528961.1 |
crystallin, alpha B |
|
| chr14_-_21493649 Show fit | 64.36 |
ENST00000553442.1
ENST00000555869.1 ENST00000556457.1 ENST00000397844.2 ENST00000554415.1 |
NDRG family member 2 |
|
| chr12_-_9268707 Show fit | 62.89 |
ENST00000318602.7
|
alpha-2-macroglobulin |
|
| chr13_-_67802549 Show fit | 53.06 |
ENST00000328454.5
ENST00000377865.2 |
protocadherin 9 |
|
| chr12_-_91574142 Show fit | 52.40 |
ENST00000547937.1
|
decorin |
Network of associatons between targets according to the STRING database.
First level regulatory network of FOXK1_FOXP2_FOXB1_FOXP3
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 12.4 | 222.7 | GO:0007021 | tubulin complex assembly(GO:0007021) |
| 13.7 | 164.0 | GO:1900747 | negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747) |
| 10.1 | 162.3 | GO:0090361 | platelet-derived growth factor production(GO:0090360) regulation of platelet-derived growth factor production(GO:0090361) |
| 1.0 | 149.7 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
| 6.4 | 83.6 | GO:0001867 | complement activation, lectin pathway(GO:0001867) |
| 0.3 | 78.0 | GO:0006936 | muscle contraction(GO:0006936) |
| 11.2 | 66.9 | GO:0090131 | mesenchyme migration(GO:0090131) |
| 6.4 | 63.7 | GO:0051611 | negative regulation of neurotransmitter uptake(GO:0051581) serotonin uptake(GO:0051610) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612) |
| 14.3 | 57.2 | GO:0019859 | pyrimidine nucleobase catabolic process(GO:0006208) thymine catabolic process(GO:0006210) thymine metabolic process(GO:0019859) |
| 0.7 | 50.2 | GO:0042472 | inner ear morphogenesis(GO:0042472) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.5 | 304.4 | GO:0030426 | growth cone(GO:0030426) |
| 0.6 | 228.1 | GO:0005578 | proteinaceous extracellular matrix(GO:0005578) |
| 13.9 | 222.7 | GO:0097512 | cardiac myofibril(GO:0097512) |
| 11.7 | 164.0 | GO:0098647 | collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647) |
| 7.3 | 109.0 | GO:0030478 | actin cap(GO:0030478) |
| 0.5 | 84.1 | GO:0055037 | recycling endosome(GO:0055037) |
| 0.1 | 66.9 | GO:0005759 | mitochondrial matrix(GO:0005759) |
| 0.3 | 66.8 | GO:0097060 | synaptic membrane(GO:0097060) |
| 0.7 | 56.3 | GO:0031093 | platelet alpha granule lumen(GO:0031093) |
| 16.5 | 49.6 | GO:0030895 | apolipoprotein B mRNA editing enzyme complex(GO:0030895) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.9 | 285.5 | GO:0050840 | extracellular matrix binding(GO:0050840) |
| 7.2 | 223.0 | GO:0005212 | structural constituent of eye lens(GO:0005212) |
| 3.2 | 88.3 | GO:0005523 | tropomyosin binding(GO:0005523) |
| 6.6 | 85.9 | GO:0001011 | transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087) |
| 0.1 | 80.3 | GO:0005509 | calcium ion binding(GO:0005509) |
| 0.9 | 72.3 | GO:0008307 | structural constituent of muscle(GO:0008307) |
| 21.2 | 63.6 | GO:0019959 | interleukin-8 binding(GO:0019959) |
| 0.4 | 57.7 | GO:0044325 | ion channel binding(GO:0044325) |
| 2.2 | 55.4 | GO:0000062 | fatty-acyl-CoA binding(GO:0000062) |
| 2.1 | 55.0 | GO:0017075 | syntaxin-1 binding(GO:0017075) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 239.9 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 2.9 | 160.0 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.9 | 124.2 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.7 | 117.1 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 1.3 | 72.0 | PID NCADHERIN PATHWAY | N-cadherin signaling events |
| 1.3 | 65.9 | SIG CD40PATHWAYMAP | Genes related to CD40 signaling |
| 0.4 | 45.7 | PID BETA CATENIN NUC PATHWAY | Regulation of nuclear beta catenin signaling and target gene transcription |
| 0.2 | 38.8 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.6 | 38.4 | PID TAP63 PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.5 | 38.3 | PID IL6 7 PATHWAY | IL6-mediated signaling events |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.8 | 181.3 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 5.7 | 154.6 | REACTOME CS DS DEGRADATION | Genes involved in CS/DS degradation |
| 6.1 | 110.1 | REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Norepinephrine Neurotransmitter Release Cycle |
| 1.8 | 88.4 | REACTOME MYOGENESIS | Genes involved in Myogenesis |
| 3.1 | 78.0 | REACTOME HDL MEDIATED LIPID TRANSPORT | Genes involved in HDL-mediated lipid transport |
| 2.5 | 67.0 | REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM | Genes involved in Branched-chain amino acid catabolism |
| 1.3 | 65.0 | REACTOME COMPLEMENT CASCADE | Genes involved in Complement cascade |
| 0.4 | 44.0 | REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |
| 2.0 | 40.0 | REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS | Genes involved in Activation of the AP-1 family of transcription factors |
| 0.7 | 38.7 | REACTOME ION TRANSPORT BY P TYPE ATPASES | Genes involved in Ion transport by P-type ATPases |