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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for GCCUGUC
Z-value: 0.06
Motif logo
miRNA associated with seed GCCUGUC
| Name | miRBASE accession |
|---|---|
|
hsa-miR-214-5p
|
MIMAT0004564 |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr7_-_19157248 Show fit | 0.52 |
ENST00000242261.5
|
twist family bHLH transcription factor 1 |
|
| chr2_+_25015968 Show fit | 0.41 |
ENST00000380834.2
ENST00000473706.1 |
centromere protein O |
|
| chr1_+_54519242 Show fit | 0.38 |
ENST00000234827.1
|
transcription elongation factor A (SII) N-terminal and central domain containing 2 |
|
| chr2_-_217560248 Show fit | 0.38 |
ENST00000233813.4
|
insulin-like growth factor binding protein 5 |
|
| chr13_+_73632897 Show fit | 0.37 |
ENST00000377687.4
|
Kruppel-like factor 5 (intestinal) |
|
| chr4_+_55095264 Show fit | 0.34 |
ENST00000257290.5
|
platelet-derived growth factor receptor, alpha polypeptide |
|
| chr11_+_76494253 Show fit | 0.34 |
ENST00000333090.4
|
tsukushi, small leucine rich proteoglycan |
|
| chrX_-_107979616 Show fit | 0.33 |
ENST00000372129.2
|
insulin receptor substrate 4 |
|
| chr9_-_127533519 Show fit | 0.33 |
ENST00000487099.2
ENST00000344523.4 ENST00000373584.3 |
nuclear receptor subfamily 6, group A, member 1 |
|
| chr6_-_39197226 Show fit | 0.33 |
ENST00000359534.3
|
potassium channel, subfamily K, member 5 |
Network of associatons between targets according to the STRING database.
First level regulatory network of GCCUGUC
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 0.6 | GO:0061073 | ciliary body morphogenesis(GO:0061073) |
| 0.2 | 0.5 | GO:2000276 | negative regulation of peroxisome proliferator activated receptor signaling pathway(GO:0035359) negative regulation of oxidative phosphorylation uncoupler activity(GO:2000276) |
| 0.1 | 0.4 | GO:1904204 | regulation of skeletal muscle hypertrophy(GO:1904204) |
| 0.0 | 0.4 | GO:0032534 | regulation of microvillus assembly(GO:0032534) |
| 0.0 | 0.4 | GO:0034080 | CENP-A containing nucleosome assembly(GO:0034080) CENP-A containing chromatin organization(GO:0061641) |
| 0.1 | 0.3 | GO:0072276 | metanephric glomerulus morphogenesis(GO:0072275) metanephric glomerulus vasculature morphogenesis(GO:0072276) metanephric glomerular capillary formation(GO:0072277) |
| 0.1 | 0.3 | GO:0061055 | myotome development(GO:0061055) positive regulation of mesenchymal cell proliferation involved in ureter development(GO:2000729) |
| 0.1 | 0.3 | GO:1903526 | negative regulation of membrane tubulation(GO:1903526) |
| 0.1 | 0.3 | GO:1904100 | regulation of protein O-linked glycosylation(GO:1904098) positive regulation of protein O-linked glycosylation(GO:1904100) |
| 0.0 | 0.3 | GO:0001574 | ganglioside biosynthetic process(GO:0001574) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.4 | GO:0042567 | insulin-like growth factor ternary complex(GO:0042567) |
| 0.0 | 0.3 | GO:0098554 | cytoplasmic side of endoplasmic reticulum membrane(GO:0098554) |
| 0.0 | 0.3 | GO:0032045 | guanyl-nucleotide exchange factor complex(GO:0032045) |
| 0.0 | 0.3 | GO:0030478 | actin cap(GO:0030478) |
| 0.0 | 0.2 | GO:0002177 | manchette(GO:0002177) |
| 0.0 | 0.2 | GO:0005964 | phosphorylase kinase complex(GO:0005964) |
| 0.0 | 0.1 | GO:0000811 | GINS complex(GO:0000811) |
| 0.0 | 0.1 | GO:0033553 | rDNA heterochromatin(GO:0033553) |
| 0.0 | 0.0 | GO:0034680 | integrin alpha10-beta1 complex(GO:0034680) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.6 | GO:0070888 | E-box binding(GO:0070888) |
| 0.0 | 0.4 | GO:0031995 | insulin-like growth factor II binding(GO:0031995) |
| 0.1 | 0.3 | GO:0005017 | platelet-derived growth factor-activated receptor activity(GO:0005017) |
| 0.1 | 0.3 | GO:0004119 | cGMP-inhibited cyclic-nucleotide phosphodiesterase activity(GO:0004119) |
| 0.1 | 0.3 | GO:0042500 | aspartic endopeptidase activity, intramembrane cleaving(GO:0042500) |
| 0.1 | 0.3 | GO:0004169 | dolichyl-phosphate-mannose-protein mannosyltransferase activity(GO:0004169) |
| 0.0 | 0.3 | GO:0003828 | alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828) |
| 0.0 | 0.3 | GO:0022841 | potassium ion leak channel activity(GO:0022841) |
| 0.0 | 0.3 | GO:0016500 | protein-hormone receptor activity(GO:0016500) |
| 0.0 | 0.3 | GO:0043548 | phosphatidylinositol 3-kinase binding(GO:0043548) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.1 | ST JAK STAT PATHWAY | Jak-STAT Pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.4 | REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| 0.0 | 0.3 | REACTOME COMMON PATHWAY | Genes involved in Common Pathway |
| 0.0 | 0.3 | REACTOME NEPHRIN INTERACTIONS | Genes involved in Nephrin interactions |
| 0.0 | 0.3 | REACTOME CRMPS IN SEMA3A SIGNALING | Genes involved in CRMPs in Sema3A signaling |
| 0.0 | 0.2 | REACTOME RECEPTOR LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR | Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor |