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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)

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Results for GCCUGUC

Z-value: 0.06

Motif logo

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miRNA associated with seed GCCUGUC

NamemiRBASE accession
hsa-miR-214-5p
MIMAT0004564

Activity profile of GCCUGUC motif

Sorted Z-values of GCCUGUC motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr7_-_19157248 0.52 ENST00000242261.5
TWIST1
twist family bHLH transcription factor 1
chr2_+_25015968 0.41 ENST00000380834.2
ENST00000473706.1
CENPO
centromere protein O
chr1_+_54519242 0.38 ENST00000234827.1
TCEANC2
transcription elongation factor A (SII) N-terminal and central domain containing 2
chr2_-_217560248 0.38 ENST00000233813.4
IGFBP5
insulin-like growth factor binding protein 5
chr13_+_73632897 0.37 ENST00000377687.4
KLF5
Kruppel-like factor 5 (intestinal)
chr4_+_55095264 0.34 ENST00000257290.5
PDGFRA
platelet-derived growth factor receptor, alpha polypeptide
chr11_+_76494253 0.34 ENST00000333090.4
TSKU
tsukushi, small leucine rich proteoglycan
chrX_-_107979616 0.33 ENST00000372129.2
IRS4
insulin receptor substrate 4
chr9_-_127533519 0.33 ENST00000487099.2
ENST00000344523.4
ENST00000373584.3
NR6A1
nuclear receptor subfamily 6, group A, member 1
chr6_-_39197226 0.33 ENST00000359534.3
KCNK5
potassium channel, subfamily K, member 5
chr3_-_114790179 0.33 ENST00000462705.1
ZBTB20
zinc finger and BTB domain containing 20
chr14_-_77787198 0.33 ENST00000261534.4
POMT2
protein-O-mannosyltransferase 2
chr20_-_23030296 0.27 ENST00000377103.2
THBD
thrombomodulin
chr14_-_61116168 0.27 ENST00000247182.6
SIX1
SIX homeobox 1
chr2_-_211036051 0.26 ENST00000418791.1
ENST00000452086.1
ENST00000281772.9
KANSL1L
KAT8 regulatory NSL complex subunit 1-like
chr7_-_123389104 0.26 ENST00000223023.4
WASL
Wiskott-Aldrich syndrome-like
chr15_+_92937058 0.25 ENST00000268164.3
ST8SIA2
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2
chr11_-_57283159 0.25 ENST00000533263.1
ENST00000278426.3
SLC43A1
solute carrier family 43 (amino acid system L transporter), member 1
chr12_-_121342170 0.25 ENST00000353487.2
SPPL3
signal peptide peptidase like 3
chr11_+_14665263 0.25 ENST00000282096.4
PDE3B
phosphodiesterase 3B, cGMP-inhibited
chr20_-_10654639 0.24 ENST00000254958.5
JAG1
jagged 1
chr19_+_39616410 0.24 ENST00000602004.1
ENST00000599470.1
ENST00000321944.4
ENST00000593480.1
ENST00000358301.3
ENST00000593690.1
ENST00000599386.1
PAK4
p21 protein (Cdc42/Rac)-activated kinase 4
chr2_+_27070964 0.24 ENST00000288699.6
DPYSL5
dihydropyrimidinase-like 5
chr19_+_1752372 0.24 ENST00000382349.4
ONECUT3
one cut homeobox 3
chrX_+_49644470 0.22 ENST00000508866.2
USP27X
ubiquitin specific peptidase 27, X-linked
chr19_+_41222998 0.22 ENST00000263370.2
ITPKC
inositol-trisphosphate 3-kinase C
chr5_-_137090028 0.22 ENST00000314940.4
HNRNPA0
heterogeneous nuclear ribonucleoprotein A0
chr16_+_54964740 0.21 ENST00000394636.4
IRX5
iroquois homeobox 5
chr11_-_118305921 0.20 ENST00000532619.1
RP11-770J1.4
RP11-770J1.4
chr3_-_197686847 0.20 ENST00000265239.6
IQCG
IQ motif containing G
chr22_-_50746027 0.19 ENST00000425954.1
ENST00000449103.1
PLXNB2
plexin B2
chr1_+_39957292 0.19 ENST00000331593.5
BMP8A
bone morphogenetic protein 8a
chrX_+_53078273 0.19 ENST00000332582.4
GPR173
G protein-coupled receptor 173
chr2_+_191273052 0.19 ENST00000417958.1
ENST00000432036.1
ENST00000392328.1
MFSD6
major facilitator superfamily domain containing 6
chrX_-_19002696 0.18 ENST00000379942.4
PHKA2
phosphorylase kinase, alpha 2 (liver)
chr17_-_39890893 0.18 ENST00000393939.2
ENST00000347901.4
ENST00000341193.5
ENST00000310778.5
HAP1
huntingtin-associated protein 1
chr12_-_42632016 0.17 ENST00000442791.3
ENST00000327791.4
ENST00000534854.2
ENST00000380788.3
ENST00000380790.4
YAF2
YY1 associated factor 2
chr11_+_45868957 0.17 ENST00000443527.2
CRY2
cryptochrome 2 (photolyase-like)
chr4_+_87856129 0.17 ENST00000395146.4
ENST00000507468.1
AFF1
AF4/FMR2 family, member 1
chr12_-_111021110 0.17 ENST00000354300.3
PPTC7
PTC7 protein phosphatase homolog (S. cerevisiae)
chr1_+_245133062 0.16 ENST00000366523.1
EFCAB2
EF-hand calcium binding domain 2
chr13_+_114238997 0.16 ENST00000538138.1
ENST00000375370.5
TFDP1
transcription factor Dp-1
chr11_-_82782861 0.16 ENST00000524635.1
ENST00000526205.1
ENST00000527633.1
ENST00000533486.1
ENST00000533276.2
RAB30
RAB30, member RAS oncogene family
chr19_+_30433110 0.16 ENST00000542441.2
ENST00000392271.1
URI1
URI1, prefoldin-like chaperone
chr19_-_15560730 0.15 ENST00000389282.4
ENST00000263381.7
WIZ
widely interspaced zinc finger motifs
chr17_-_45266542 0.13 ENST00000531206.1
ENST00000527547.1
ENST00000446365.2
ENST00000575483.1
ENST00000066544.3
CDC27
cell division cycle 27
chr3_-_50649192 0.13 ENST00000443053.2
ENST00000348721.3
CISH
cytokine inducible SH2-containing protein
chr14_-_76127519 0.13 ENST00000256319.6
C14orf1
chromosome 14 open reading frame 1
chr15_-_50558223 0.13 ENST00000267845.3
HDC
histidine decarboxylase
chr3_+_37493610 0.13 ENST00000264741.5
ITGA9
integrin, alpha 9
chr1_+_117602925 0.13 ENST00000369466.4
TTF2
transcription termination factor, RNA polymerase II
chr15_-_89456593 0.13 ENST00000558029.1
ENST00000539437.1
ENST00000542878.1
ENST00000268151.7
ENST00000566497.1
MFGE8
milk fat globule-EGF factor 8 protein
chr9_-_117568365 0.12 ENST00000374045.4
TNFSF15
tumor necrosis factor (ligand) superfamily, member 15
chr17_-_61523535 0.12 ENST00000584031.1
ENST00000392976.1
CYB561
cytochrome b561
chr9_+_77112244 0.12 ENST00000376896.3
RORB
RAR-related orphan receptor B
chr16_-_85722530 0.12 ENST00000253462.3
GINS2
GINS complex subunit 2 (Psf2 homolog)
chr4_+_128703295 0.11 ENST00000296464.4
ENST00000508549.1
HSPA4L
heat shock 70kDa protein 4-like
chrX_+_24483338 0.11 ENST00000379162.4
ENST00000441463.2
PDK3
pyruvate dehydrogenase kinase, isozyme 3
chr1_-_203055129 0.11 ENST00000241651.4
MYOG
myogenin (myogenic factor 4)
chr10_+_101088836 0.11 ENST00000356713.4
CNNM1
cyclin M1
chr11_-_6624801 0.10 ENST00000534343.1
ENST00000254605.6
RRP8
ribosomal RNA processing 8, methyltransferase, homolog (yeast)
chr10_-_118032697 0.10 ENST00000439649.3
GFRA1
GDNF family receptor alpha 1
chr16_+_29789561 0.10 ENST00000400752.4
ZG16
zymogen granule protein 16
chr1_-_23857698 0.10 ENST00000361729.2
E2F2
E2F transcription factor 2
chr3_+_113775576 0.09 ENST00000485050.1
ENST00000281273.4
QTRTD1
queuine tRNA-ribosyltransferase domain containing 1
chr8_-_103668114 0.08 ENST00000285407.6
KLF10
Kruppel-like factor 10
chr22_+_30279144 0.08 ENST00000401950.2
ENST00000333027.3
ENST00000445401.1
ENST00000323630.5
ENST00000351488.3
MTMR3
myotubularin related protein 3
chr2_-_114036488 0.07 ENST00000263335.7
ENST00000397647.3
ENST00000348715.5
ENST00000429538.3
PAX8
paired box 8
chr11_+_48002076 0.07 ENST00000418331.2
ENST00000440289.2
PTPRJ
protein tyrosine phosphatase, receptor type, J
chrX_+_99839799 0.07 ENST00000373031.4
TNMD
tenomodulin
chr17_-_36956155 0.07 ENST00000269554.3
PIP4K2B
phosphatidylinositol-5-phosphate 4-kinase, type II, beta
chr12_+_70760056 0.06 ENST00000258111.4
KCNMB4
potassium large conductance calcium-activated channel, subfamily M, beta member 4
chr8_-_71316021 0.06 ENST00000452400.2
NCOA2
nuclear receptor coactivator 2
chr5_-_146833485 0.06 ENST00000398514.3
DPYSL3
dihydropyrimidinase-like 3
chr5_+_167718604 0.06 ENST00000265293.4
WWC1
WW and C2 domain containing 1
chr11_+_118754475 0.05 ENST00000292174.4
CXCR5
chemokine (C-X-C motif) receptor 5
chr3_-_196756646 0.05 ENST00000439320.1
ENST00000296351.4
ENST00000296350.5
MFI2
antigen p97 (melanoma associated) identified by monoclonal antibodies 133.2 and 96.5
chr1_+_145524891 0.04 ENST00000369304.3
ITGA10
integrin, alpha 10
chr7_-_35077653 0.04 ENST00000310974.4
DPY19L1
dpy-19-like 1 (C. elegans)
chr3_-_171178157 0.04 ENST00000465393.1
ENST00000436636.2
ENST00000369326.5
ENST00000538048.1
ENST00000341852.6
TNIK
TRAF2 and NCK interacting kinase
chr2_-_220025548 0.03 ENST00000356853.5
NHEJ1
nonhomologous end-joining factor 1
chr6_+_21593972 0.03 ENST00000244745.1
ENST00000543472.1
SOX4
SRY (sex determining region Y)-box 4
chr6_+_44187242 0.03 ENST00000393844.1
SLC29A1
solute carrier family 29 (equilibrative nucleoside transporter), member 1
chr2_+_36582857 0.03 ENST00000280527.2
CRIM1
cysteine rich transmembrane BMP regulator 1 (chordin-like)
chr20_-_30795511 0.03 ENST00000246229.4
PLAGL2
pleiomorphic adenoma gene-like 2
chr12_-_54673871 0.01 ENST00000209875.4
CBX5
chromobox homolog 5
chr3_-_196159268 0.01 ENST00000381887.3
ENST00000535858.1
ENST00000428095.1
ENST00000296328.4
UBXN7
UBX domain protein 7
chr7_-_127983877 0.01 ENST00000415472.2
ENST00000478061.1
ENST00000223073.2
ENST00000459726.1
RBM28
RNA binding motif protein 28
chr20_+_34894247 0.01 ENST00000373913.3
DLGAP4
discs, large (Drosophila) homolog-associated protein 4
chr17_+_46184911 0.01 ENST00000580219.1
ENST00000452859.2
ENST00000393405.2
ENST00000439357.2
ENST00000359238.2
SNX11
sorting nexin 11
chr11_-_6704513 0.00 ENST00000532203.1
ENST00000288937.6
MRPL17
mitochondrial ribosomal protein L17

Network of associatons between targets according to the STRING database.

First level regulatory network of GCCUGUC

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.6 GO:0061073 ciliary body morphogenesis(GO:0061073)
0.2 0.5 GO:2000276 negative regulation of peroxisome proliferator activated receptor signaling pathway(GO:0035359) negative regulation of oxidative phosphorylation uncoupler activity(GO:2000276)
0.1 0.4 GO:1904204 regulation of skeletal muscle hypertrophy(GO:1904204)
0.1 0.3 GO:0072276 metanephric glomerulus morphogenesis(GO:0072275) metanephric glomerulus vasculature morphogenesis(GO:0072276) metanephric glomerular capillary formation(GO:0072277)
0.1 0.3 GO:0061055 myotome development(GO:0061055) positive regulation of mesenchymal cell proliferation involved in ureter development(GO:2000729)
0.1 0.3 GO:1903526 negative regulation of membrane tubulation(GO:1903526)
0.1 0.3 GO:1904100 regulation of protein O-linked glycosylation(GO:1904098) positive regulation of protein O-linked glycosylation(GO:1904100)
0.1 0.2 GO:0031587 positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0031587)
0.1 0.2 GO:2000118 regulation of sodium-dependent phosphate transport(GO:2000118)
0.1 0.2 GO:0060040 retinal bipolar neuron differentiation(GO:0060040)
0.0 0.2 GO:0097210 response to gonadotropin-releasing hormone(GO:0097210) cellular response to gonadotropin-releasing hormone(GO:0097211)
0.0 0.1 GO:0001694 histamine biosynthetic process(GO:0001694)
0.0 0.4 GO:0032534 regulation of microvillus assembly(GO:0032534)
0.0 0.1 GO:0014878 response to electrical stimulus involved in regulation of muscle adaptation(GO:0014878)
0.0 0.3 GO:0001574 ganglioside biosynthetic process(GO:0001574)
0.0 0.3 GO:0051533 positive regulation of NFAT protein import into nucleus(GO:0051533)
0.0 0.3 GO:0030322 stabilization of membrane potential(GO:0030322)
0.0 0.3 GO:0051918 negative regulation of fibrinolysis(GO:0051918)
0.0 0.1 GO:0006696 ergosterol biosynthetic process(GO:0006696) ergosterol metabolic process(GO:0008204)
0.0 0.2 GO:0007288 sperm axoneme assembly(GO:0007288)
0.0 0.3 GO:0043951 negative regulation of cell adhesion mediated by integrin(GO:0033629) negative regulation of cAMP-mediated signaling(GO:0043951)
0.0 0.1 GO:2000612 thyroid-stimulating hormone secretion(GO:0070460) regulation of thyroid-stimulating hormone secretion(GO:2000612)
0.0 0.1 GO:0035881 amacrine cell differentiation(GO:0035881)
0.0 0.1 GO:1990086 lens fiber cell apoptotic process(GO:1990086)
0.0 0.1 GO:0000727 double-strand break repair via break-induced replication(GO:0000727)
0.0 0.2 GO:0002024 diet induced thermogenesis(GO:0002024)
0.0 0.1 GO:0035990 tendon cell differentiation(GO:0035990) tendon formation(GO:0035992)
0.0 0.2 GO:0070345 negative regulation of fat cell proliferation(GO:0070345)
0.0 0.2 GO:0010571 positive regulation of nuclear cell cycle DNA replication(GO:0010571)
0.0 0.1 GO:0097411 hypoxia-inducible factor-1alpha signaling pathway(GO:0097411)
0.0 0.1 GO:0046015 regulation of transcription by glucose(GO:0046015)
0.0 0.4 GO:0034080 CENP-A containing nucleosome assembly(GO:0034080) CENP-A containing chromatin organization(GO:0061641)
0.0 0.0 GO:0018103 protein C-linked glycosylation(GO:0018103) peptidyl-tryptophan modification(GO:0018211) protein C-linked glycosylation via tryptophan(GO:0018317) protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan(GO:0018406)
0.0 0.1 GO:1904016 response to Thyroglobulin triiodothyronine(GO:1904016)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 GO:0042567 insulin-like growth factor ternary complex(GO:0042567)
0.0 0.3 GO:0098554 cytoplasmic side of endoplasmic reticulum membrane(GO:0098554)
0.0 0.2 GO:0002177 manchette(GO:0002177)
0.0 0.1 GO:0000811 GINS complex(GO:0000811)
0.0 0.3 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
0.0 0.1 GO:0033553 rDNA heterochromatin(GO:0033553)
0.0 0.2 GO:0005964 phosphorylase kinase complex(GO:0005964)
0.0 0.3 GO:0030478 actin cap(GO:0030478)
0.0 0.0 GO:0034680 integrin alpha10-beta1 complex(GO:0034680)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0005017 platelet-derived growth factor-activated receptor activity(GO:0005017)
0.1 0.3 GO:0004119 cGMP-inhibited cyclic-nucleotide phosphodiesterase activity(GO:0004119)
0.1 0.3 GO:0042500 aspartic endopeptidase activity, intramembrane cleaving(GO:0042500)
0.1 0.3 GO:0004169 dolichyl-phosphate-mannose-protein mannosyltransferase activity(GO:0004169)
0.1 0.2 GO:0070984 SET domain binding(GO:0070984)
0.0 0.2 GO:0008440 inositol-1,4,5-trisphosphate 3-kinase activity(GO:0008440)
0.0 0.3 GO:0003828 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)
0.0 0.2 GO:0005499 vitamin D binding(GO:0005499)
0.0 0.4 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.0 0.3 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.0 0.1 GO:0022865 transmembrane electron transfer carrier(GO:0022865)
0.0 0.1 GO:0004740 pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740)
0.0 0.2 GO:0048403 brain-derived neurotrophic factor binding(GO:0048403)
0.0 0.1 GO:0016309 1-phosphatidylinositol-5-phosphate 4-kinase activity(GO:0016309)
0.0 0.2 GO:1990380 Lys63-specific deubiquitinase activity(GO:0061578) Lys48-specific deubiquitinase activity(GO:1990380)
0.0 0.2 GO:0004689 phosphorylase kinase activity(GO:0004689)
0.0 0.1 GO:0010861 thyroid hormone receptor activator activity(GO:0010861) thyroid hormone receptor coactivator activity(GO:0030375)
0.0 0.2 GO:0070700 BMP receptor binding(GO:0070700)
0.0 0.1 GO:0016167 glial cell-derived neurotrophic factor receptor activity(GO:0016167)
0.0 0.1 GO:0070097 delta-catenin binding(GO:0070097)
0.0 0.3 GO:0016500 protein-hormone receptor activity(GO:0016500)
0.0 0.2 GO:0009881 photoreceptor activity(GO:0009881)
0.0 0.2 GO:0017154 semaphorin receptor activity(GO:0017154)
0.0 0.2 GO:0005112 Notch binding(GO:0005112)
0.0 0.3 GO:0043548 phosphatidylinositol 3-kinase binding(GO:0043548)
0.0 0.6 GO:0070888 E-box binding(GO:0070888)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 ST JAK STAT PATHWAY Jak-STAT Pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 REACTOME RECEPTOR LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.0 0.3 REACTOME COMMON PATHWAY Genes involved in Common Pathway
0.0 0.4 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0 0.3 REACTOME NEPHRIN INTERACTIONS Genes involved in Nephrin interactions
0.0 0.3 REACTOME CRMPS IN SEMA3A SIGNALING Genes involved in CRMPs in Sema3A signaling