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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for GLIS2
Z-value: 0.28
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Transcription factors associated with GLIS2
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr3_-_18466026 Show fit | 11.47 |
ENST00000417717.2
|
SATB homeobox 1 |
|
| chr19_+_45418067 Show fit | 10.99 |
ENST00000589078.1
ENST00000586638.1 |
apolipoprotein C-I |
|
| chr19_+_45409011 Show fit | 10.82 |
ENST00000252486.4
ENST00000446996.1 ENST00000434152.1 |
apolipoprotein E |
|
| chr19_+_45417504 Show fit | 9.43 |
ENST00000588750.1
ENST00000588802.1 |
apolipoprotein C-I |
|
| chr2_+_24272576 Show fit | 9.25 |
ENST00000380986.4
ENST00000452109.1 |
FK506 binding protein 1B, 12.6 kDa |
|
| chr20_+_30640004 Show fit | 8.77 |
ENST00000520553.1
ENST00000518730.1 ENST00000375852.2 |
hemopoietic cell kinase |
|
| chr19_+_45417812 Show fit | 8.62 |
ENST00000592535.1
|
apolipoprotein C-I |
|
| chr6_+_33048222 Show fit | 8.34 |
ENST00000428835.1
|
major histocompatibility complex, class II, DP beta 1 |
|
| chr2_+_24272543 Show fit | 8.34 |
ENST00000380991.4
|
FK506 binding protein 1B, 12.6 kDa |
|
| chr19_+_45417921 Show fit | 7.76 |
ENST00000252491.4
ENST00000592885.1 ENST00000589781.1 |
apolipoprotein C-I |
Network of associatons between targets according to the STRING database.
First level regulatory network of GLIS2
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 9.2 | 36.8 | GO:0010900 | negative regulation of phosphatidylcholine catabolic process(GO:0010900) |
| 1.8 | 17.6 | GO:0061179 | negative regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0061179) |
| 5.2 | 15.6 | GO:0002522 | leukocyte migration involved in immune response(GO:0002522) |
| 0.9 | 13.7 | GO:0090360 | platelet-derived growth factor production(GO:0090360) regulation of platelet-derived growth factor production(GO:0090361) |
| 2.7 | 13.4 | GO:0034124 | regulation of MyD88-dependent toll-like receptor signaling pathway(GO:0034124) |
| 0.8 | 11.5 | GO:0043374 | CD8-positive, alpha-beta T cell differentiation(GO:0043374) |
| 3.6 | 10.8 | GO:1902995 | regulation of phospholipid efflux(GO:1902994) positive regulation of phospholipid efflux(GO:1902995) |
| 2.3 | 9.4 | GO:2000537 | regulation of cGMP-mediated signaling(GO:0010752) regulation of B cell chemotaxis(GO:2000537) positive regulation of B cell chemotaxis(GO:2000538) |
| 2.8 | 8.4 | GO:2001190 | positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell(GO:2001190) |
| 0.9 | 8.3 | GO:0071787 | endoplasmic reticulum tubular network assembly(GO:0071787) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.7 | 37.4 | GO:0042627 | chylomicron(GO:0042627) |
| 0.2 | 23.1 | GO:0031234 | extrinsic component of cytoplasmic side of plasma membrane(GO:0031234) |
| 0.4 | 20.4 | GO:0033017 | sarcoplasmic reticulum membrane(GO:0033017) |
| 0.8 | 16.7 | GO:0042613 | MHC class II protein complex(GO:0042613) |
| 0.0 | 15.6 | GO:0005789 | endoplasmic reticulum membrane(GO:0005789) |
| 0.2 | 15.4 | GO:0101003 | ficolin-1-rich granule membrane(GO:0101003) |
| 0.3 | 11.5 | GO:0005720 | nuclear heterochromatin(GO:0005720) |
| 3.6 | 10.8 | GO:0034365 | discoidal high-density lipoprotein particle(GO:0034365) |
| 0.2 | 10.5 | GO:0005834 | heterotrimeric G-protein complex(GO:0005834) |
| 0.6 | 9.4 | GO:0017146 | NMDA selective glutamate receptor complex(GO:0017146) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 6.0 | 47.6 | GO:0060228 | phosphatidylcholine-sterol O-acyltransferase activator activity(GO:0060228) |
| 3.5 | 17.6 | GO:0005219 | ryanodine-sensitive calcium-release channel activity(GO:0005219) |
| 0.3 | 15.6 | GO:0001784 | phosphotyrosine binding(GO:0001784) |
| 0.0 | 13.8 | GO:0001077 | transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) |
| 3.1 | 9.4 | GO:0043423 | 3-phosphoinositide-dependent protein kinase binding(GO:0043423) |
| 0.8 | 9.3 | GO:0019855 | calcium channel inhibitor activity(GO:0019855) |
| 0.3 | 8.7 | GO:0023026 | MHC class II protein complex binding(GO:0023026) |
| 0.2 | 8.3 | GO:0042605 | peptide antigen binding(GO:0042605) |
| 1.3 | 7.7 | GO:0050291 | sphingosine N-acyltransferase activity(GO:0050291) |
| 0.0 | 7.6 | GO:0045296 | cadherin binding(GO:0045296) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 15.6 | PID IL8 CXCR1 PATHWAY | IL8- and CXCR1-mediated signaling events |
| 0.1 | 13.7 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
| 0.1 | 13.6 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.1 | 12.1 | PID P75 NTR PATHWAY | p75(NTR)-mediated signaling |
| 0.2 | 10.7 | PID IFNG PATHWAY | IFN-gamma pathway |
| 0.3 | 9.4 | SA PTEN PATHWAY | PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. |
| 0.1 | 8.1 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.0 | 7.2 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.2 | 6.7 | ST MYOCYTE AD PATHWAY | Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway. |
| 0.2 | 6.5 | PID RAS PATHWAY | Regulation of Ras family activation |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 15.6 | REACTOME REGULATION OF SIGNALING BY CBL | Genes involved in Regulation of signaling by CBL |
| 0.1 | 13.4 | REACTOME MHC CLASS II ANTIGEN PRESENTATION | Genes involved in MHC class II antigen presentation |
| 0.4 | 11.3 | REACTOME PROSTACYCLIN SIGNALLING THROUGH PROSTACYCLIN RECEPTOR | Genes involved in Prostacyclin signalling through prostacyclin receptor |
| 0.5 | 10.7 | REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT | Genes involved in Chylomicron-mediated lipid transport |
| 0.3 | 9.5 | REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS | Genes involved in Signal regulatory protein (SIRP) family interactions |
| 0.1 | 9.5 | REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
| 0.4 | 8.3 | REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE | Genes involved in Translocation of ZAP-70 to Immunological synapse |
| 0.4 | 7.7 | REACTOME DOPAMINE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Dopamine Neurotransmitter Release Cycle |
| 0.2 | 7.3 | REACTOME CGMP EFFECTS | Genes involved in cGMP effects |
| 0.5 | 7.0 | REACTOME TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING | Genes involved in TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling |