GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)


Results for GLIS3

Z-value: 0.73

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Transcription factors associated with GLIS3

Gene Symbol Gene ID Gene Info
ENSG00000107249.17 GLIS family zinc finger 3

Activity profile of GLIS3 motif

Sorted Z-values of GLIS3 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr19_+_48828582 17.95 ENST00000270221.6
epithelial membrane protein 3
chr18_+_3451584 9.60 ENST00000551541.1
TGFB-induced factor homeobox 1
chr1_-_45987526 9.01 ENST00000372079.1
peroxiredoxin 1
chr1_-_45988542 8.87 ENST00000424390.1
peroxiredoxin 1
chrX_+_64887512 8.76 ENST00000360270.5
chr19_-_41859814 7.89 ENST00000221930.5
transforming growth factor, beta 1
chr21_-_46330545 7.63 ENST00000320216.6
integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
chr5_+_172386419 7.11 ENST00000265100.2
ribosomal protein L26-like 1
chr7_+_150758304 6.87 ENST00000482950.1
solute carrier family 4 (anion exchanger), member 2
chr5_-_180671172 6.75 ENST00000512805.1
guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1
chr18_+_3451646 6.62 ENST00000345133.5
TGFB-induced factor homeobox 1
chr3_-_25824925 5.52 ENST00000396649.3
N-glycanase 1
chr11_+_68451943 5.51 ENST00000265643.3
galanin/GMAP prepropeptide
chr17_-_73178599 5.06 ENST00000578238.1
small ubiquitin-like modifier 2
chr13_+_25670268 4.85 ENST00000281589.3
poly(A) binding protein, cytoplasmic 3
chr3_-_25824872 4.41 ENST00000308710.5
N-glycanase 1
chr6_+_44191507 4.11 ENST00000371724.1
solute carrier family 29 (equilibrative nucleoside transporter), member 1
chr3_+_38029462 3.78 ENST00000283713.6
chr17_-_73179046 3.73 ENST00000314523.7
small ubiquitin-like modifier 2
chr6_+_44191290 3.71 ENST00000371755.3
solute carrier family 29 (equilibrative nucleoside transporter), member 1
chr19_+_46850251 3.45 ENST00000012443.4
protein phosphatase 5, catalytic subunit
chr15_+_91478493 3.27 ENST00000418476.2
unc-45 homolog A (C. elegans)
chr11_-_8680383 3.24 ENST00000299550.6
tripartite motif containing 66
chr19_+_46850320 3.20 ENST00000391919.1
protein phosphatase 5, catalytic subunit
chr4_-_84255935 3.10 ENST00000513463.1
chr1_-_42801540 3.06 ENST00000372573.1
forkhead box J3
chr6_+_33172407 3.03 ENST00000374662.3
hydroxysteroid (17-beta) dehydrogenase 8
chr22_-_50964849 2.99 ENST00000543927.1
SCO2 cytochrome c oxidase assembly protein
chr6_+_89791507 2.76 ENST00000354922.3
proline-rich nuclear receptor coactivator 1
chr14_+_22931924 2.67 ENST00000390477.2
T cell receptor delta constant
chr22_+_50628999 2.56 ENST00000395827.1
TraB domain containing
chr1_-_53018654 2.48 ENST00000257177.4
zinc finger, CCHC domain containing 11
chr5_+_172386517 2.37 ENST00000519522.1
ribosomal protein L26-like 1
chr6_+_24495185 2.34 ENST00000348925.2
aldehyde dehydrogenase 5 family, member A1
chr20_-_30310693 2.30 ENST00000307677.4
BCL2-like 1
chr22_+_31489344 2.25 ENST00000404574.1
chr17_+_7792101 2.23 ENST00000358181.4
chromodomain helicase DNA binding protein 3
chr20_-_30310656 2.03 ENST00000376055.4
BCL2-like 1
chr8_-_74791051 1.88 ENST00000453587.2
ubiquitin-conjugating enzyme E2W (putative)
chrX_-_132549506 1.83 ENST00000370828.3
glypican 4
chr10_+_105314881 1.53 ENST00000437579.1
neuralized E3 ubiquitin protein ligase 1
chr22_+_18834324 1.45 ENST00000342005.4
Uncharacterized protein
chr2_-_208030647 1.40 ENST00000309446.6
Kruppel-like factor 7 (ubiquitous)
chr1_-_42800860 1.21 ENST00000445886.1
forkhead box J3
chrX_+_118370288 1.16 ENST00000535419.1
progesterone receptor membrane component 1
chr19_+_41281060 1.11 ENST00000594436.1
melanoma inhibitory activity
chr17_-_3819751 0.99 ENST00000225538.3
purinergic receptor P2X, ligand-gated ion channel, 1
chr18_+_11752040 0.92 ENST00000423027.3
guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type
chr17_-_5015129 0.89 ENST00000575898.1
zinc finger protein 232
chr20_+_61867235 0.85 ENST00000342412.6
baculoviral IAP repeat containing 7
chr18_+_11751493 0.85 ENST00000269162.5
guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type
chr6_+_24495067 0.83 ENST00000357578.3
aldehyde dehydrogenase 5 family, member A1
chr19_-_10613421 0.82 ENST00000393623.2
kelch-like ECH-associated protein 1
chrX_+_118370211 0.81 ENST00000217971.7
progesterone receptor membrane component 1
chr2_-_211168332 0.66 ENST00000341685.4
myosin, light chain 1, alkali; skeletal, fast
chr3_+_173116225 0.62 ENST00000457714.1
neuroligin 1
chr11_+_66886717 0.50 ENST00000398645.2
lysine (K)-specific demethylase 2A
chr14_+_77228532 0.50 ENST00000167106.4
vasohibin 1
chr21_+_38071430 0.48 ENST00000290399.6
single-minded family bHLH transcription factor 2
chr12_+_132312931 0.45 ENST00000360564.1
matrix metallopeptidase 17 (membrane-inserted)
chr20_+_18447771 0.38 ENST00000377603.4
polymerase (RNA) III (DNA directed) polypeptide F, 39 kDa
chr19_-_48673552 0.34 ENST00000536218.1
ligase I, DNA, ATP-dependent
chr20_-_23969416 0.22 ENST00000335694.4
gamma-glutamyltransferase light chain 1
chr1_+_110527308 0.11 ENST00000369799.5
adenosylhomocysteinase-like 1
chr8_+_27183033 0.05 ENST00000420218.2
protein tyrosine kinase 2 beta

Network of associatons between targets according to the STRING database.

First level regulatory network of GLIS3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
2.6 7.9 GO:0052553 induction by symbiont of host defense response(GO:0044416) induction of host immune response by virus(GO:0046730) active induction of host immune response by virus(GO:0046732) modulation by symbiont of host defense response(GO:0052031) induction by organism of defense response of other organism involved in symbiotic interaction(GO:0052251) modulation by organism of defense response of other organism involved in symbiotic interaction(GO:0052255) positive regulation by symbiont of host defense response(GO:0052509) positive regulation by organism of defense response of other organism involved in symbiotic interaction(GO:0052510) modulation by organism of immune response of other organism involved in symbiotic interaction(GO:0052552) modulation by symbiont of host immune response(GO:0052553) modulation by virus of host immune response(GO:0075528)
1.8 5.5 GO:0051795 cortisol secretion(GO:0043400) regulation of cortisol secretion(GO:0051462) positive regulation of catagen(GO:0051795)
1.6 7.8 GO:0015862 uridine transport(GO:0015862)
1.5 8.8 GO:0022614 membrane to membrane docking(GO:0022614)
1.1 6.6 GO:2000324 positive regulation of glucocorticoid receptor signaling pathway(GO:2000324)
0.9 18.0 GO:0032060 bleb assembly(GO:0032060)
0.7 13.0 GO:0006516 glycoprotein catabolic process(GO:0006516)
0.6 4.3 GO:0060154 cellular process regulating host cell cycle in response to virus(GO:0060154)
0.5 3.2 GO:0006540 glutamate decarboxylation to succinate(GO:0006540) gamma-aminobutyric acid catabolic process(GO:0009450)
0.5 17.9 GO:0042744 hydrogen peroxide catabolic process(GO:0042744)
0.5 2.5 GO:0010587 miRNA catabolic process(GO:0010587)
0.4 7.6 GO:0002523 leukocyte migration involved in inflammatory response(GO:0002523)
0.3 2.8 GO:0031087 deadenylation-independent decapping of nuclear-transcribed mRNA(GO:0031087)
0.2 0.6 GO:0010841 positive regulation of circadian sleep/wake cycle, wakefulness(GO:0010841) retrograde trans-synaptic signaling by soluble gas(GO:0098923) trans-synaptic signaling by soluble gas(GO:0099543) trans-synaptic signaling by trans-synaptic complex(GO:0099545)
0.2 3.0 GO:0006703 estrogen biosynthetic process(GO:0006703)
0.2 1.0 GO:0002442 serotonin production involved in inflammatory response(GO:0002351) serotonin secretion involved in inflammatory response(GO:0002442) serotonin secretion by platelet(GO:0002554)
0.2 8.8 GO:0070911 global genome nucleotide-excision repair(GO:0070911)
0.2 0.5 GO:1901491 negative regulation of lymphangiogenesis(GO:1901491)
0.1 3.0 GO:0006878 cellular copper ion homeostasis(GO:0006878) respiratory chain complex IV assembly(GO:0008535)
0.1 6.9 GO:0015701 bicarbonate transport(GO:0015701)
0.1 9.5 GO:0042273 ribosomal large subunit biogenesis(GO:0042273)
0.1 0.8 GO:0010499 proteasomal ubiquitin-independent protein catabolic process(GO:0010499)
0.1 0.3 GO:0033567 DNA replication, Okazaki fragment processing(GO:0033567)
0.1 3.8 GO:0051693 actin filament capping(GO:0051693)
0.1 1.9 GO:0071218 cellular response to misfolded protein(GO:0071218)
0.1 0.5 GO:0070544 histone H3-K36 demethylation(GO:0070544)
0.0 0.9 GO:1990001 inhibition of cysteine-type endopeptidase activity involved in apoptotic process(GO:1990001)
0.0 0.5 GO:0042756 drinking behavior(GO:0042756)
0.0 2.7 GO:0006910 phagocytosis, recognition(GO:0006910)
0.0 3.0 GO:0061077 chaperone-mediated protein folding(GO:0061077)
0.0 2.2 GO:0016575 histone deacetylation(GO:0016575)
0.0 0.1 GO:0042045 epithelial fluid transport(GO:0042045)
0.0 12.9 GO:0042493 response to drug(GO:0042493)
0.0 1.8 GO:0001523 retinoid metabolic process(GO:0001523)
0.0 1.1 GO:0008283 cell proliferation(GO:0008283)
0.0 2.3 GO:0006939 smooth muscle contraction(GO:0006939)
0.0 0.2 GO:1901748 leukotriene D4 metabolic process(GO:1901748) leukotriene D4 biosynthetic process(GO:1901750)
0.0 0.4 GO:0006359 regulation of transcription from RNA polymerase III promoter(GO:0006359)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.5 7.6 GO:0034688 integrin alphaM-beta2 complex(GO:0034688)
0.9 6.6 GO:1990635 proximal dendrite(GO:1990635)
0.4 8.8 GO:0031254 uropod(GO:0001931) cell trailing edge(GO:0031254)
0.3 4.3 GO:0097136 Bcl-2 family protein complex(GO:0097136)
0.1 0.5 GO:0045177 apical part of cell(GO:0045177)
0.1 17.9 GO:0048770 melanosome(GO:0042470) pigment granule(GO:0048770)
0.1 9.5 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.1 2.2 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.1 9.0 GO:0005796 Golgi lumen(GO:0005796)
0.1 3.2 GO:0016235 aggresome(GO:0016235)
0.1 8.8 GO:0016605 PML body(GO:0016605)
0.1 2.7 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.0 1.0 GO:0005639 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229) nuclear membrane part(GO:0044453)
0.0 0.7 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.0 14.7 GO:0016323 basolateral plasma membrane(GO:0016323)
0.0 3.1 GO:0035580 specific granule lumen(GO:0035580)
0.0 2.8 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.0 0.7 GO:0005859 muscle myosin complex(GO:0005859)
0.0 9.2 GO:0005759 mitochondrial matrix(GO:0005759)
0.0 2.0 GO:0035579 specific granule membrane(GO:0035579)
0.0 0.4 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)
0.0 0.8 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 5.5 GO:0043025 neuronal cell body(GO:0043025)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
2.6 7.9 GO:0034714 type III transforming growth factor beta receptor binding(GO:0034714)
2.2 17.9 GO:0008379 thioredoxin peroxidase activity(GO:0008379)
1.4 5.5 GO:0004966 galanin receptor activity(GO:0004966)
1.1 7.6 GO:0030369 ICAM-3 receptor activity(GO:0030369)
0.8 3.1 GO:0030305 beta-glucuronidase activity(GO:0004566) heparanase activity(GO:0030305)
0.7 8.8 GO:0031386 protein tag(GO:0031386)
0.6 2.5 GO:0050265 RNA uridylyltransferase activity(GO:0050265)
0.6 3.0 GO:0070404 NADH binding(GO:0070404)
0.6 16.2 GO:0070410 co-SMAD binding(GO:0070410)
0.4 4.3 GO:0051434 BH3 domain binding(GO:0051434)
0.4 6.9 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.4 7.8 GO:0005337 nucleoside transmembrane transporter activity(GO:0005337)
0.3 1.8 GO:1904929 coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway(GO:1904929)
0.3 3.0 GO:0004645 phosphorylase activity(GO:0004645)
0.2 6.6 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.2 4.8 GO:0008143 poly(A) binding(GO:0008143)
0.1 12.2 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides(GO:0016811)
0.1 1.0 GO:0004931 extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381)
0.1 8.8 GO:0003725 double-stranded RNA binding(GO:0003725)
0.1 3.3 GO:0051879 Hsp90 protein binding(GO:0051879)
0.1 0.5 GO:0051864 histone demethylase activity (H3-K36 specific)(GO:0051864)
0.1 3.2 GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor(GO:0016620)
0.0 2.7 GO:0034987 immunoglobulin receptor binding(GO:0034987)
0.0 0.6 GO:0042043 neurexin family protein binding(GO:0042043)
0.0 9.5 GO:0003735 structural constituent of ribosome(GO:0003735)
0.0 0.3 GO:0003910 DNA ligase (ATP) activity(GO:0003910)
0.0 2.9 GO:0008307 structural constituent of muscle(GO:0008307)
0.0 3.8 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.0 0.5 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.0 0.1 GO:0016802 adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.0 0.4 GO:0001056 RNA polymerase III activity(GO:0001056)
0.0 0.0 GO:0043423 3-phosphoinositide-dependent protein kinase binding(GO:0043423)
0.0 0.2 GO:0036374 glutathione hydrolase activity(GO:0036374)
0.0 1.6 GO:0005496 steroid binding(GO:0005496)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 17.9 ST B CELL ANTIGEN RECEPTOR B Cell Antigen Receptor
0.3 15.5 PID UPA UPAR PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.2 4.3 SA PROGRAMMED CELL DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.2 8.3 PID ER NONGENOMIC PATHWAY Plasma membrane estrogen receptor signaling
0.2 6.8 PID IGF1 PATHWAY IGF1 pathway
0.1 14.5 PID AR PATHWAY Coregulation of Androgen receptor activity
0.1 14.4 PID REG GR PATHWAY Glucocorticoid receptor regulatory network
0.1 3.1 PID SYNDECAN 1 PATHWAY Syndecan-1-mediated signaling events
0.0 10.4 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 2.2 PID HDAC CLASSI PATHWAY Signaling events mediated by HDAC Class I
0.0 1.5 PID NOTCH PATHWAY Notch signaling pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 7.9 REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.3 16.2 REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.2 8.8 REACTOME RECYCLING PATHWAY OF L1 Genes involved in Recycling pathway of L1
0.2 4.9 REACTOME HS GAG DEGRADATION Genes involved in HS-GAG degradation
0.2 7.8 REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.1 4.3 REACTOME INFLAMMASOMES Genes involved in Inflammasomes
0.1 3.2 REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation
0.1 1.0 REACTOME ELEVATION OF CYTOSOLIC CA2 LEVELS Genes involved in Elevation of cytosolic Ca2+ levels
0.1 7.6 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.1 9.5 REACTOME PEPTIDE CHAIN ELONGATION Genes involved in Peptide chain elongation
0.1 6.9 REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.1 1.5 REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.0 0.3 REACTOME PROCESSIVE SYNTHESIS ON THE LAGGING STRAND Genes involved in Processive synthesis on the lagging strand
0.0 3.5 REACTOME PEPTIDE LIGAND BINDING RECEPTORS Genes involved in Peptide ligand-binding receptors
0.0 0.4 REACTOME RNA POL III CHAIN ELONGATION Genes involved in RNA Polymerase III Chain Elongation
0.0 0.5 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.0 2.7 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation