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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for GLIS3
Z-value: 0.73
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Transcription factors associated with GLIS3
Network of associatons between targets according to the STRING database.
First level regulatory network of GLIS3
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 18.0 | GO:0032060 | bleb assembly(GO:0032060) |
| 0.5 | 17.9 | GO:0042744 | hydrogen peroxide catabolic process(GO:0042744) |
| 0.7 | 13.0 | GO:0006516 | glycoprotein catabolic process(GO:0006516) |
| 0.0 | 12.9 | GO:0042493 | response to drug(GO:0042493) |
| 0.1 | 9.5 | GO:0042273 | ribosomal large subunit biogenesis(GO:0042273) |
| 1.5 | 8.8 | GO:0022614 | membrane to membrane docking(GO:0022614) |
| 0.2 | 8.8 | GO:0070911 | global genome nucleotide-excision repair(GO:0070911) |
| 2.6 | 7.9 | GO:0052553 | induction by symbiont of host defense response(GO:0044416) induction of host immune response by virus(GO:0046730) active induction of host immune response by virus(GO:0046732) modulation by symbiont of host defense response(GO:0052031) induction by organism of defense response of other organism involved in symbiotic interaction(GO:0052251) modulation by organism of defense response of other organism involved in symbiotic interaction(GO:0052255) positive regulation by symbiont of host defense response(GO:0052509) positive regulation by organism of defense response of other organism involved in symbiotic interaction(GO:0052510) modulation by organism of immune response of other organism involved in symbiotic interaction(GO:0052552) modulation by symbiont of host immune response(GO:0052553) modulation by virus of host immune response(GO:0075528) |
| 1.6 | 7.8 | GO:0015862 | uridine transport(GO:0015862) |
| 0.4 | 7.6 | GO:0002523 | leukocyte migration involved in inflammatory response(GO:0002523) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 17.9 | GO:0048770 | melanosome(GO:0042470) pigment granule(GO:0048770) |
| 0.0 | 14.7 | GO:0016323 | basolateral plasma membrane(GO:0016323) |
| 0.1 | 9.5 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 0.0 | 9.2 | GO:0005759 | mitochondrial matrix(GO:0005759) |
| 0.1 | 9.0 | GO:0005796 | Golgi lumen(GO:0005796) |
| 0.4 | 8.8 | GO:0031254 | uropod(GO:0001931) cell trailing edge(GO:0031254) |
| 0.1 | 8.8 | GO:0016605 | PML body(GO:0016605) |
| 1.5 | 7.6 | GO:0034688 | integrin alphaM-beta2 complex(GO:0034688) |
| 0.9 | 6.6 | GO:1990635 | proximal dendrite(GO:1990635) |
| 0.0 | 5.5 | GO:0043025 | neuronal cell body(GO:0043025) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.2 | 17.9 | GO:0008379 | thioredoxin peroxidase activity(GO:0008379) |
| 0.6 | 16.2 | GO:0070410 | co-SMAD binding(GO:0070410) |
| 0.1 | 12.2 | GO:0016811 | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides(GO:0016811) |
| 0.0 | 9.5 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.7 | 8.8 | GO:0031386 | protein tag(GO:0031386) |
| 0.1 | 8.8 | GO:0003725 | double-stranded RNA binding(GO:0003725) |
| 2.6 | 7.9 | GO:0034714 | type III transforming growth factor beta receptor binding(GO:0034714) |
| 0.4 | 7.8 | GO:0005337 | nucleoside transmembrane transporter activity(GO:0005337) |
| 1.1 | 7.6 | GO:0030369 | ICAM-3 receptor activity(GO:0030369) |
| 0.4 | 6.9 | GO:0008510 | sodium:bicarbonate symporter activity(GO:0008510) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 17.9 | ST B CELL ANTIGEN RECEPTOR | B Cell Antigen Receptor |
| 0.3 | 15.5 | PID UPA UPAR PATHWAY | Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling |
| 0.1 | 14.5 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 0.1 | 14.4 | PID REG GR PATHWAY | Glucocorticoid receptor regulatory network |
| 0.0 | 10.4 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.2 | 8.3 | PID ER NONGENOMIC PATHWAY | Plasma membrane estrogen receptor signaling |
| 0.2 | 6.8 | PID IGF1 PATHWAY | IGF1 pathway |
| 0.2 | 4.3 | SA PROGRAMMED CELL DEATH | Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. |
| 0.1 | 3.1 | PID SYNDECAN 1 PATHWAY | Syndecan-1-mediated signaling events |
| 0.0 | 2.2 | PID HDAC CLASSI PATHWAY | Signaling events mediated by HDAC Class I |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 16.2 | REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY | Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity |
| 0.1 | 9.5 | REACTOME PEPTIDE CHAIN ELONGATION | Genes involved in Peptide chain elongation |
| 0.2 | 8.8 | REACTOME RECYCLING PATHWAY OF L1 | Genes involved in Recycling pathway of L1 |
| 0.4 | 7.9 | REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION | Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) |
| 0.2 | 7.8 | REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES | Genes involved in Transport of vitamins, nucleosides, and related molecules |
| 0.1 | 7.6 | REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
| 0.1 | 6.9 | REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |
| 0.2 | 4.9 | REACTOME HS GAG DEGRADATION | Genes involved in HS-GAG degradation |
| 0.1 | 4.3 | REACTOME INFLAMMASOMES | Genes involved in Inflammasomes |
| 0.0 | 3.5 | REACTOME PEPTIDE LIGAND BINDING RECEPTORS | Genes involved in Peptide ligand-binding receptors |